Killing Kinetics of Caspofungin, Micafungin, and Amphotericin B against Candida guilliermondii
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Amphotericin B (AMB), micafungin, and caspofungin MICs, minimal fungicidal concentrations, and time-killing curves were determined in the presence and absence of 10% inactivated serum. AMB was the only agent with consistent killing activity (time required to achieve 99.9% of growth reduction was 2.1 to 3.2 h). The presence of serum enhanced caspofungin activity but lowered those of micafungin and AMB.
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Intrinsic echinocandin resistance of C. parapsilosis, C. orthopsilosis, C. metapsilosis, and C. guilliermondii has been described.
“In addition, intrinsic echinocandin resistance of C. parapsilosis, C. orthopsilosis, C. metapsilosis, and C. guilliermondii has been described [117, 118].”
From <i>Candida</i>Infections, Causes, Targets, and Resistance Mechanisms: Traditional and Alternative Antifungal Agents (2013) · cites this paper as [118]
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- Authors
- Cantón, E., Pemán, J., Sastre, M., Romero, M., & Espinel-Ingroff, A.
- Affiliations
- Unidad de Microbiología Experimental-Centro de Investigación
- Servicio de Microbiología, Hospital Universitario La Fe, 46009 Valencia, Spain
- Division of Infectious Disease, VCU Medical Center, Richmond, Virginia 23298-0049
- Venue
- Antimicrobial Agents and Chemotherapy
- Publisher
- American Society for Microbiology
- Published
- 2006-08
- Volume
- 50
- Issue
- 8
- Pages
- 2829-2832
- ISSN
- 0066-4804 (ISSN-L)
- 1098-6596
- OpenAlex
- W2068776047
- Cited by
- 37
- References
- 25
- Citations by year
- 2025: 2 · 2023: 1 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 1 · 2016: 1 · 2014: 3 · 2013: 1 · 2012: 3
- FWCI
- 3.10
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Antimicrobial Agents and Chemotherapy (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Fungal Plant Pathogen Control
- Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
- Keywords
- caspofungin, micafungin, amphotericin B, Candida guilliermondii, antifungal agents, minimum fungicidal concentration, serum inactivation, fungal killing
- MeSH terms
- Caspofungin, Micafungin, Amphotericin B, Antifungal Agents, Candida, Candidiasis, Kinetics, Lipoproteins, Microbial Sensitivity Tests, Peptides, Cyclic, Echinocandins, Lipopeptides
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