De Novo Acquisition of Resistance to SCY-078 in Candida glabrata Involves FKS Mutations That both Overlap and Are Distinct from Those Conferring Echinocandin Resistance

SCY-078 is an orally active antifungal whose target is the β-(1,3)- d -glucan synthase (GS). We evaluated the spontaneous emergence of SCY-078-resistant Candida glabrata isolates following drug exposure in vitro . Resistant isolates were analyzed using broth microdilution methodology and FKS sequ…