The DOI matches its Crossref record; 48 of the 49 references it cites were found in a registry or an index.
Fluoxetine Is a Potent Inhibitor of Coxsackievirus Replication
Open accessAbstract
No antiviral drugs currently exist for the treatment of enterovirus infections, which are often severe and potentially life threatening. Molecular screening of small molecule libraries identified fluoxetine, a selective serotonin reuptake inhibitor, as a potent inhibitor of coxsackievirus replication. Fluoxetine did not interfere with either viral entry or translation of the viral genome. Instead, fluoxetine and its metabolite norfluoxetine markedly reduced the synthesis of viral RNA and protein. In view of its favorable pharmacokinetics and safety profile, fluoxetine warrants additional study as a potential antiviral agent for enterovirus infections.
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“Indeed, this drug was able to inhibit the viral RNA and proteins of Coxsackievirus [66].”
From Antimicrobial Properties of Antidepressants and Antipsychotics—Possibilities and Implications (2021) · cites this paper as [66]
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Cites
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Molecular Epidemiology and Evolution of Enterovirus 71 Strains Isolated from 1970 to 1998
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Selective inhibitors of picornavirus replication
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Flagged first, then by citations
1 of the 49 references couldn’t be matched to a known paper.
Research works printed but not linked: 2
- FryEE StuartDI. 2010. Virion structure, p 59–72. In EhrenfeldDE RoosRP (ed), The picornaviruses. ASM Press, Washington, DC.
- KhetsurianiN Lamonte-FowlkesA OberstS PallanschMA. 2006. Enterovirus surveillance—United States, 1970–2005. MMWR Surveill. Summ. 55:1–20.
Cited by
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Items 101–105 of 105
Bohmer, M., Gnarra, J., Binzel, D. W., Weitao, T., & Guo, P. (2026) · Frontiers in RNA Research · doi:10.3389/frnar.2026.1870177
Psychotropic Drugs: A Promising Non‐Antibiotic Agent to Combat Multi‐Drug‐Resistant Microorganisms
Singh, I. P., Singh, H., Sharma, D., Keshri, A., Gaurav, N., Dhakad, M. S., & Beg, M. M. A. (2026) · Drug Development Research · doi:10.1002/ddr.70380
La reconversion thérapeutique de médicaments pour traiter les maladies infectieuses virales
Faucher, M. O., Barral, K., & Coutard, B. (2026) · médecine/sciences · doi:10.1051/medsci/2026123
BindingDB Entry 50023684: Structural Chemistry of Helicase Inhibition.
BindingDB (2026) · UC San Diego · doi:10.7270/q2d223m3
Metadata
- Authors
- Zuo, J., Quinn, K. K., Kye, S., Cooper, P., Damoiseaux, R., & Krogstad, P.
- Affiliations
- University of California, Los Angeles (US)
- California NanoSystems Institute (US)
- Venue
- Antimicrobial Agents and Chemotherapy
- Publisher
- American Society for Microbiology
- Published
- 2012-09
- Volume
- 56
- Issue
- 9
- Pages
- 4838-4844
- ISSN
- 0066-4804 (ISSN-L)
- 1098-6596
- PMC
- PMC3421851
- OpenAlex
- W2131952231
- Cited by
- 104
- References
- 49
- Citations by year
- 2026: 8 · 2025: 4 · 2024: 4 · 2023: 5 · 2022: 17 · 2021: 14 · 2020: 12 · 2019: 10 · 2018: 6 · 2017: 1 · 2016: 8 · 2015: 8 · 2014: 5 · 2013: 2
- FWCI
- 3.09
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Antimicrobial Agents and Chemotherapy (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Food and Drug Administration
- Topics
- Health Sciences › Medicine › Infectious Diseases › Viral Infections and Immunology Research
- Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Mosquito-borne diseases and control
- Keywords
- fluoxetine, Coxsackie virus, enterovirus infection, antiviral agents, viral RNA synthesis, norfluoxetine, selective serotonin reuptake inhibitors, small molecule screening, viral replication inhibition
- MeSH terms
- Antidepressive Agents, Antiviral Agents, Enterovirus, Fluoxetine, HeLa Cells, Humans, RNA, Viral, Transfection, Virus Replication, Genes, Reporter, Inhibitory Concentration 50, Green Fluorescent Proteins, Small Molecule Libraries, High-Throughput Screening Assays
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