Enhanced Efflux Pump Activity in Old Candida glabrata Cells
Open accessAbstract
We investigated the effect of replicative aging on antifungal resistance in Candida glabrata . Our studies demonstrate significantly increased transcription of ABC transporters and efflux pump activity in old versus young C. glabrata cells of a fluconazole-sensitive and -resistant strain. In addition, higher tolerance to killing by micafungin and amphotericin B was noted and is associated with higher transcription of glucan synthase gene FKS1 and lower ergosterol content in older cells.
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MFS transporters facilitate enhanced fluconazole efflux particularly in ageing C. glabrata cells.
“MFS transporters facilitate enhanced fluconazole efflux particularly in ageing C. glabrata cells [76].”
From Candida glabrata: pathogenicity and resistance mechanisms for adaptation and survival (2021) · cites this paper as [76]
Neutrophils in the host selectively kill younger cells, leaving old yeast cells to accumulate.
“The in vivo study by Bhattacharya et al. [76] viewed that the neutrophils cells in the host selectively kill younger cells, leaving the old yeast cells to accumulate.”
From Candida glabrata: pathogenicity and resistance mechanisms for adaptation and survival (2021) · cites this paper as [76]
Mutations in ERG11 and PDR1 can mediate azole resistance; daughter cells inherit the mutations and persist.
“Mutations in ERG11 and PDR1 can mediate azole resistance; daughter cells will inherit the mutations and persist [76].”
From Candida glabrata: pathogenicity and resistance mechanisms for adaptation and survival (2021) · cites this paper as [76]
Replicative ageing in C. glabrata causes higher tolerance to killing by amphotericin B and micafungin due to higher transcription of glucan synthase gene FKS1.
“According to the findings of Bhattacharya et al. [76], replicative ageing in C. glabrata causes higher tolerance to killings by AmB and micafungin due to the higher transcription of glucan synthase gene, FKS1.”
From Candida glabrata: pathogenicity and resistance mechanisms for adaptation and survival (2021) · cites this paper as [76]
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Candida glabrata: pathogenicity and resistance mechanisms for adaptation and survival
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Self-citation
- Authors
- Bhattacharya, S., & Fries, B. C.
- Affiliations
- Stony Brook University (US)
- Venue
- Antimicrobial Agents and Chemotherapy
- Publisher
- American Society for Microbiology
- Published
- 2018-03
- Volume
- 62
- Issue
- 3
- ISSN
- 0066-4804 (ISSN-L)
- 1098-6596
- PMC
- PMC5826134
- OpenAlex
- W2783389157
- Semantic Scholar
- c93b8c1e17899ce82b3257fe3c8886062d05944d
- Cited by
- 19
- References
- 26
- Citations by year
- 2026: 2 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 5 · 2020: 4 · 2019: 4 · 2018: 1
- FWCI
- 2.65
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Antimicrobial Agents and Chemotherapy (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- HHS | National Institutes of Health (1R01AI127704-01A1)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Keywords
- Candida glabrata, replicative senescence, efflux pumps, ABC transporters, antifungal resistance, fluconazole resistance, micafungin, amphotericin B, FKS1, glucan synthase, ergosterol
- MeSH terms
- Micafungin, Amphotericin B, Antifungal Agents, Biological Transport, Cell Division, Ergosterol, Fungal Proteins, Glucosyltransferases, Microbial Sensitivity Tests, Fluconazole, Gene Expression Regulation, Fungal, ATP-Binding Cassette Transporters, Genes, MDR, Drug Resistance, Fungal, Candida glabrata
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