Role of Fks1p and Matrix Glucan in Candida albicans Biofilm Resistance to an Echinocandin, Pyrimidine, and Polyene

Nett, Jeniel E.; Crawford, Kyler; Marchillo, Karen; Andes, David R.

doi:10.1128/aac.00227-10

Cited by 207Antifungal resistance and susceptibilityFungal and yeast genetics researchFungal Plant Pathogen Control

Role of Fks1p and Matrix Glucan in Candida albicans Biofilm Resistance to an Echinocandin, Pyrimidine, and Polyene

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Nett, Jeniel E., Crawford, Kyler, Marchillo, Karen, Andes, David R.·2010·Antimicrobial Agents and Chemotherapy

DOI 10.1128/aac.00227-10PMC PMC2916329

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Abstract

Candida infections frequently involve drug-resistant biofilm growth on device surfaces. Glucan synthase gene FKS1 has been linked to triazole resistance in Candida biofilms. We tested the impact of FKS1 modulation on susceptibility to additional antifungal classes. Reduction of FKS1 expression rendered biofilms more susceptible to amphotericin B, anidulafungin, and flucytosine. Increased resistance to anidulafungin and amphotericin B was observed for biofilms overexpressing FKS1 . These findings suggest that Candida biofilm glucan sequestration is a multidrug resistance mechanism.

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Genes involved in production and delivery of β-1,3-glucans include the synthase-encoding gene FKS1 and the genes BGL2, XOG1, and PHR1.
“Genes involved in production and delivery of β-1,3-glucans include the synthase-encoding gene FKS1 and the genes BGL2, XOG1, and PHR1, which encode proteins involved in the modification and transport of β-glucans (132, 189).”
From Candida albicans Biofilms and Human Disease (2015) · cites this paper as [132]

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Authors: Nett, J. E., Crawford, K., Marchillo, K., & Andes, D. R.
Affiliations: University of Wisconsin–Madison (US)
Departments of Medicine
Corresponding author: Andes, David R.
ORCID: Nett, Jeniel E.
Crawford, Kyler
Andes, David R.
Venue: Antimicrobial Agents and Chemotherapy
Publisher: American Society for Microbiology
Published: 2010-08
Volume: 54
Issue: 8
Pages: 3505-3508
ISSN: 0066-4804 (ISSN-L)
1098-6596
DOI: 10.1128/aac.00227-10
PMC: PMC2916329
OpenAlex: W2157946772
Cited by: 207
References: 22
Citations by year: 2026: 6 · 2025: 7 · 2024: 14 · 2023: 16 · 2022: 11 · 2021: 10 · 2020: 17 · 2019: 13 · 2018: 11 · 2017: 17 · 2016: 16 · 2015: 19 · 2014: 14 · 2013: 10 · 2012: 9
FWCI: 7.44
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Antimicrobial Agents and Chemotherapy (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Heart, Lung, and Blood Institute (T32HL007899)
National Institute of Allergy and Infectious Diseases (R01AI073289)
Topics: Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Fungal Plant Pathogen Control
Keywords: Candida albicans, biofilm, FKS1, glucan synthase, echinocandin resistance, anidulafungin, amphotericin B, 5-fluorocytosine, triazole resistance, antifungal resistance, multidrug resistance, antifungal susceptibility
MeSH terms: Anidulafungin, Amphotericin B, Antifungal Agents, Candida albicans, Flucytosine, Fungal Proteins, Glucans, Glucosyltransferases, Humans, Microbial Sensitivity Tests, Polyenes, Pyrimidines, Biofilms, Drug Resistance, Fungal, Echinocandins

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Role of Fks1p and Matrix Glucan in Candida albicans Biofilm Resistance to an Echinocandin, Pyrimidine, and Polyene

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