Cited by 118Antifungal resistance and susceptibilityFungal Plant Pathogen ControlAntibiotic Resistance in Bacteria

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Abdominal Candidiasis Is a Hidden Reservoir of Echinocandin Resistance

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Shields, Ryan K., Nguyen, M. Hong, Press, Ellen G., Clancy, Cornelius J.·2014·Antimicrobial Agents and Chemotherapy

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Abstract

FKS mutant Candida isolates were recovered from 24% (6/25) of abdominal candidiasis patients exposed to echinocandin. Candida glabrata (29%) and Candida albicans (14%) mutants were identified. Multidrug-resistant bacteria were recovered from 83% of FKS mutant infections. Mutations were associated with prolonged echinocandin exposure ( P = 0.01), breakthrough infections ( P = 0.03), and therapeutic failures despite source control interventions (100%). Abdominal candidiasis is a hidden reservoir for the emergence of echinocandin-resistant Candida .

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Authors: Shields, R. K., Nguyen, M. H., Press, E. G., & Clancy, C. J.
Affiliations: University of Pittsburgh (US)
ORCID: Shields, Ryan K.
Nguyen, M. Hong
Clancy, Cornelius J.
Venue: Antimicrobial Agents and Chemotherapy
Publisher: American Society for Microbiology
Published: 2014-12
Volume: 58
Issue: 12
Pages: 7601-7605
ISSN: 0066-4804 (ISSN-L)
1098-6596
DOI: 10.1128/aac.04134-14
PMC: PMC4249510
OpenAlex: W2163948261
Cited by: 118
References: 19
Citations by year: 2026: 1 · 2025: 10 · 2024: 10 · 2023: 14 · 2022: 5 · 2021: 20 · 2020: 6 · 2019: 7 · 2018: 14 · 2017: 13 · 2016: 8 · 2015: 10
FWCI: 7.24
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Antimicrobial Agents and Chemotherapy (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Astellas Pharma
National Institutes of Health (UL1TR000005, KL2TR000146)
Medical Center, University of Pittsburgh
National Center for Advancing Translational Sciences
Topics: Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
Life Sciences › Agricultural and Biological Sciences › Plant Science › Fungal Plant Pathogen Control
Health Sciences › Medicine › Microbiology (medical) › Antibiotic Resistance in Bacteria
Keywords: echinocandin resistance, Candida glabrata, Candida albicans, multidrug resistance, breakthrough infection, source control
MeSH terms: Adult, Aged, Antifungal Agents, Candida albicans, Candidiasis, Female, Humans, Male, Microbial Sensitivity Tests, Middle Aged, Mutation, Peritonitis, Survival Analysis, Abdominal Abscess, Drug Resistance, Fungal, Candida glabrata, Echinocandins

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Abdominal Candidiasis Is a Hidden Reservoir of Echinocandin Resistance

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