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Abdominal Candidiasis Is a Hidden Reservoir of Echinocandin Resistance
Open accessAbstract
FKS mutant Candida isolates were recovered from 24% (6/25) of abdominal candidiasis patients exposed to echinocandin. Candida glabrata (29%) and Candida albicans (14%) mutants were identified. Multidrug-resistant bacteria were recovered from 83% of FKS mutant infections. Mutations were associated with prolonged echinocandin exposure ( P = 0.01), breakthrough infections ( P = 0.03), and therapeutic failures despite source control interventions (100%). Abdominal candidiasis is a hidden reservoir for the emergence of echinocandin-resistant Candida .
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“Rezafungin has a prolonged half-life (around 133 h) that allows extended-interval dosing and provides high plasma drug concentrations early in therapy.”
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“Intra-abdominal candidiasis tends to progress to abscesses that are persistent and recalcitrant, and if undrained may predispose for the development of drug-resistance [5,104].”
From Treatment of Invasive Candidiasis: A Narrative Review (2018) · cites this paper as [104]
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Metadata
- Authors
- Shields, R. K., Nguyen, M. H., Press, E. G., & Clancy, C. J.
- Affiliations
- University of Pittsburgh (US)
- Venue
- Antimicrobial Agents and Chemotherapy
- Publisher
- American Society for Microbiology
- Published
- 2014-12
- Volume
- 58
- Issue
- 12
- Pages
- 7601-7605
- ISSN
- 0066-4804 (ISSN-L)
- 1098-6596
- PMC
- PMC4249510
- OpenAlex
- W2163948261
- Cited by
- 118
- References
- 19
- Citations by year
- 2026: 1 · 2025: 10 · 2024: 10 · 2023: 14 · 2022: 5 · 2021: 20 · 2020: 6 · 2019: 7 · 2018: 14 · 2017: 13 · 2016: 8 · 2015: 10
- FWCI
- 7.24
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Antimicrobial Agents and Chemotherapy (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Astellas Pharma
- National Institutes of Health (UL1TR000005, KL2TR000146)
- Medical Center, University of Pittsburgh
- National Center for Advancing Translational Sciences
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Fungal Plant Pathogen Control
- Health Sciences › Medicine › Microbiology (medical) › Antibiotic Resistance in Bacteria
- Keywords
- echinocandin resistance, Candida glabrata, Candida albicans, multidrug resistance, breakthrough infection, source control
- MeSH terms
- Adult, Aged, Antifungal Agents, Candida albicans, Candidiasis, Female, Humans, Male, Microbial Sensitivity Tests, Middle Aged, Mutation, Peritonitis, Survival Analysis, Abdominal Abscess, Drug Resistance, Fungal, Candida glabrata, Echinocandins
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