The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Abdominal Candidiasis Is a Hidden Reservoir of Echinocandin Resistance
Open accessAbstract
FKS mutant Candida isolates were recovered from 24% (6/25) of abdominal candidiasis patients exposed to echinocandin. Candida glabrata (29%) and Candida albicans (14%) mutants were identified. Multidrug-resistant bacteria were recovered from 83% of FKS mutant infections. Mutations were associated with prolonged echinocandin exposure ( P = 0.01), breakthrough infections ( P = 0.03), and therapeutic failures despite source control interventions (100%). Abdominal candidiasis is a hidden reservoir for the emergence of echinocandin-resistant Candida .
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“Rezafungin has a prolonged half-life (around 133 h) that allows extended-interval dosing and provides high plasma drug concentrations early in therapy.”
In the citing paper
“Intra-abdominal candidiasis tends to progress to abscesses that are persistent and recalcitrant, and if undrained may predispose for the development of drug-resistance [5,104].”
From Treatment of Invasive Candidiasis: A Narrative Review (2018) · cites this paper as [104]
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Cites
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Clinical and Laboratory Standards Institute
Gressner, A. M., & Arndt, T. (2019) · Springer Reference Medizin · doi:10.1007/978-3-662-48986-4_300416 · Cited by 5,092
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FKS Mutant Candida glabrata: Risk Factors and Outcomes in Patients With Candidemia
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Self-citationEschenauer, G. A., Nguyen, M. H., Shoham, S., Vazquez, J. A., Morris, A. J., Pasculle, W. A., Kubin, C. J., Klinker, K. P., Carver, P. L., Hanson, K. E., et al. (2014) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.02163-13 · Cited by 61
Self-citationCandida Peritonitis: An Update on the Latest Research and Treatments
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Shields, R. K., Nguyen, M. H., Press, E. G., Updike, C. L., & Clancy, C. J. (2013) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01451-13 · Cited by 56
Self-citationDisposition of Caspofungin, a Novel Antifungal Agent, in Mice, Rats, Rabbits, and Monkeys
Sandhu, P., Xu, X., Bondiskey, P. J., Balani, S. K., Morris, M. L., Tang, Y. S., Miller, A. R., & Pearson, P. G. (2004) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.48.4.1272-1280.2004 · Cited by 49
Distribution of micafungin in the tissue fluids of patients with invasive fungal infections
Yamada, N., Kumada, K., Ogura, S., Kishino, S., Mochizuki, N., & Ohno, K. (2011) · Journal of Infection and Chemotherapy · doi:10.1007/s10156-011-0240-3 · Cited by 42
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Self-citationCheng, S., Clancy, C. J., Hartman, D. J., Hao, B., & Nguyen, M. H. (2014) · Infection and Immunity · doi:10.1128/iai.00062-14 · Cited by 39
Self-citationClancy, C. J., Staley, B. J., & Nguyen, M. H. (2006) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00741-06 · Cited by 39
Self-citationGoicoechea, M., Fierer, J., & Johns, S. T. (2004) · Clinical Infectious Diseases · doi:10.1086/382082 · Cited by 20
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Kullberg, B. J., & Arendrup, M. C. (2015) · New England Journal of Medicine · doi:10.1056/nejmra1315399 · Cited by 1,315
The global problem of antifungal resistance: prevalence, mechanisms, and management
Perlin, D. S., Rautemaa-Richardson, R., & Alastruey-Izquierdo, A. (2017) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(17)30316-x · Cited by 1,055
Multidrug-Resistant Candida: Epidemiology, Molecular Mechanisms, and Treatment
Arendrup, M. C., & Patterson, T. F. (2017) · The Journal of Infectious Diseases · doi:10.1093/infdis/jix131 · Cited by 707
Candidemia and invasive candidiasis in adults: A narrative review
Antinori, S., Milazzo, L., Sollima, S., Galli, M., & Corbellino, M. (2016) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2016.06.029 · Cited by 259
Cornely, O. A., Hoenigl, M., Lass‐Flörl, C., Chen, S. C. ‐., Kontoyiannis, D. P., Morrissey, C. O., & Thompson, G. R. (2019) · Mycoses · doi:10.1111/myc.12960 · Cited by 229
Metadata
- Authors
- Shields, R. K., Nguyen, M. H., Press, E. G., & Clancy, C. J.
- Affiliations
- University of Pittsburgh (US)
- Venue
- Antimicrobial Agents and Chemotherapy
- Publisher
- American Society for Microbiology
- Published
- 2014-12
- Volume
- 58
- Issue
- 12
- Pages
- 7601-7605
- ISSN
- 0066-4804 (ISSN-L)
- 1098-6596
- PMC
- PMC4249510
- OpenAlex
- W2163948261
- Cited by
- 118
- References
- 19
- Citations by year
- 2026: 1 · 2025: 10 · 2024: 10 · 2023: 14 · 2022: 5 · 2021: 20 · 2020: 6 · 2019: 7 · 2018: 14 · 2017: 13 · 2016: 8 · 2015: 10
- FWCI
- 7.24
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Antimicrobial Agents and Chemotherapy (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Astellas Pharma
- National Institutes of Health (UL1TR000005, KL2TR000146)
- Medical Center, University of Pittsburgh
- National Center for Advancing Translational Sciences
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Fungal Plant Pathogen Control
- Health Sciences › Medicine › Microbiology (medical) › Antibiotic Resistance in Bacteria
- Keywords
- echinocandin resistance, Candida glabrata, Candida albicans, multidrug resistance, breakthrough infection, source control
- MeSH terms
- Adult, Aged, Antifungal Agents, Candida albicans, Candidiasis, Female, Humans, Male, Microbial Sensitivity Tests, Middle Aged, Mutation, Peritonitis, Survival Analysis, Abdominal Abscess, Drug Resistance, Fungal, Candida glabrata, Echinocandins
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