Cited by 118Antifungal resistance and susceptibilityFungal Plant Pathogen ControlAntibiotic Resistance in Bacteria

The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.

Abdominal Candidiasis Is a Hidden Reservoir of Echinocandin Resistance

Open access
Shields, Ryan K., Nguyen, M. Hong, Press, Ellen G., Clancy, Cornelius J.·2014·Antimicrobial Agents and Chemotherapy

Abstract

FKS mutant Candida isolates were recovered from 24% (6/25) of abdominal candidiasis patients exposed to echinocandin. Candida glabrata (29%) and Candida albicans (14%) mutants were identified. Multidrug-resistant bacteria were recovered from 83% of FKS mutant infections. Mutations were associated with prolonged echinocandin exposure ( P = 0.01), breakthrough infections ( P = 0.03), and therapeutic failures despite source control interventions (100%). Abdominal candidiasis is a hidden reservoir for the emergence of echinocandin-resistant Candida .

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Crossref · 10.1128/aac.04134-14

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19 of 19 references verified0 citation errors · 0 not checkable

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Metadata

Authors
Shields, R. K., Nguyen, M. H., Press, E. G., & Clancy, C. J.
Affiliations
University of Pittsburgh (US)
Venue
Antimicrobial Agents and Chemotherapy
Published
2014-12
Volume
58
Issue
12
Pages
7601-7605
ISSN
  • 0066-4804 (ISSN-L)
  • 1098-6596
OpenAlex
W2163948261
Cited by
118
References
19
Citations by year
2026: 1 · 2025: 10 · 2024: 10 · 2023: 14 · 2022: 5 · 2021: 20 · 2020: 6 · 2019: 7 · 2018: 14 · 2017: 13 · 2016: 8 · 2015: 10
FWCI
7.24
Type
journal article
Language
en
Open access
Locations
  • Antimicrobial Agents and Chemotherapy (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Astellas Pharma
  • National Institutes of Health (UL1TR000005, KL2TR000146)
  • Medical Center, University of Pittsburgh
  • National Center for Advancing Translational Sciences
Topics
  • Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Fungal Plant Pathogen Control
  • Health Sciences › Medicine › Microbiology (medical) › Antibiotic Resistance in Bacteria
Keywords
echinocandin resistance, Candida glabrata, Candida albicans, multidrug resistance, breakthrough infection, source control
MeSH terms
Adult, Aged, Antifungal Agents, Candida albicans, Candidiasis, Female, Humans, Male, Microbial Sensitivity Tests, Middle Aged, Mutation, Peritonitis, Survival Analysis, Abdominal Abscess, Drug Resistance, Fungal, Candida glabrata, Echinocandins

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