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Plasmid-associated hemolysin and aggregation substance production contribute to virulence in experimental enterococcal endocarditis
Open accessAbstract
A rabbit endocarditis model was utilized to evaluate the virulence conferred by the conjugative plasmid pAD1 with the following strains: Enterococcus faecalis plasmid-free FA2-2 and FA2-2 containing plasmids pAD1 (hemolysin and aggregation substance positive), pAM9058 (insertional inactivation of hemolysin), and pAM944 or pAM947 (insertional inactivation of aggregation substance). All isolates were similar in ability to produce endocarditis. Mean vegetation weight was greater in animals inoculated with strains that produced aggregation substance (P < 0.01). Mortality was significantly increased in animals given FA2-2 containing pAD1 compared with those given all other strains (P < 0.01). These results suggest that the combination of hemolysin and aggregation substance is associated with increased mortality and that vegetation weight is associated with production of aggregation substance in experimental E. faecalis endocarditis.
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Cited by
The role and application of enterococci in food and health
Foulquié Moreno, M. R., Sarantinopoulos, P., Tsakalidou, E., & De Vuyst, L. (2006) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2005.06.026 · Cited by 1,080
Enterococci as probiotics and their implications in food safety
Franz, C. M. A. P., Huch, M., Abriouel, H., Holzapfel, W., & Gálvez, A. (2011) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2011.08.014 · Cited by 788
Vankerckhoven, V., Van Autgaerden, T., Vael, C., Lammens, C., Chapelle, S., Rossi, R., Jabes, D., & Goossens, H. (2004) · Journal of Clinical Microbiology · doi:10.1128/jcm.42.10.4473-4479.2004 · Cited by 594
Fiore, E., Van Tyne, D., & Gilmore, M. S. (2019) · Microbiology Spectrum · doi:10.1128/microbiolspec.gpp3-0053-2018 · Cited by 503
Shankar, V., Baghdayan, A. S., Huycke, M. M., Lindahl, G., & Gilmore, M. S. (1999) · Infection and Immunity · doi:10.1128/iai.67.1.193-200.1999 · Cited by 435
Metadata
- Authors
- Chow, J. W., Thal, L. A., Perri, M. B., Vazquez, J. A., Donabedian, S. M., Clewell, D. B., & Zervos, M. J.
- Venue
- Antimicrobial Agents and Chemotherapy
- Publisher
- American Society for Microbiology
- Published
- 1993-11
- Volume
- 37
- Issue
- 11
- Pages
- 2474-2477
- ISSN
- 0066-4804 (ISSN-L)
- 1098-6596
- OpenAlex
- W2061181988
- Cited by
- 325
- References
- 0
- FWCI
- 4.75
- Type
- journal article
- Language
- en
- Open access
- green
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- Chow, J. W., Thal, L. A., Perri, M. B., Vazquez, J. A., Donabedian, S. M., Clewell, D. B., & Zervos, M. J. (1993). Plasmid-associated hemolysin and aggregation substance production contribute to virulence in experimental enterococcal endocarditis. Antimicrobial Agents and Chemotherapy. https://doi.org/10.1128/aac.37.11.2474
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