Isolation and Characterization of Tetracycline-Resistant Clinical Isolates of Helicobacter pylori
Open accessAbstract
Tetracycline is an important component of combination therapies for Helicobacter pylori eradication. Twenty-nine tetracycline-resistant isolates requiring MICs ranging from 4 to 16 μg/ml were isolated from Korean (22 of 460) and Japanese (7 of 105) patients. Interestingly, all of the 29 tetracycline-resistant isolates exhibited cross-resistance to metronidazole, and the cross-resistance was transferred to tetracycline-sensitive H. pylori strains.
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Resistance to both tetracycline and metronidazole was transferred to susceptible strains by transformation with the genomic DNA of the resistant organisms.
“Furthermore, the resistance to both tetracycline and metronidazole was transferred to susceptible strains by transformation with the genomic DNA of the resistant organisms.”
From Mutations in the 16S rRNA Genes of<i>Helicobacter pylori</i>Mediate Resistance to Tetracycline (2002) · cites this paper as [14]
Cross-resistance to tetracycline and metronidazole was identified in a study of tetracycline-resistant H. pylori isolates from Korea and Japan.
“This cross-resistance to tetracycline and metronidazole was also identified in a study of tetracycline-resistant H. pylori isolates from Korea and Japan (14).”
From Mutations in the 16S rRNA Genes of<i>Helicobacter pylori</i>Mediate Resistance to Tetracycline (2002) · cites this paper as [14]
Tetracycline-resistant H. pylori isolates are also resistant to metronidazole.
“Tetracycline-resistant H. pylori isolates are also resistant to metronidazole (14, 18).”
From Mutations in the 16S rRNA Genes of<i>Helicobacter pylori</i>Mediate Resistance to Tetracycline (2002) · cites this paper as [14]
In a previous study, transformation of susceptible strains with genomic DNA generated only isolates with both metronidazole and tetracycline resistance.
“In a previous study transformation of susceptible strains with genomic DNA generated only isolates with both metronidazole and tetracycline resistance (14).”
From Mutations in the 16S rRNA Genes of<i>Helicobacter pylori</i>Mediate Resistance to Tetracycline (2002) · cites this paper as [14]
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- Authors
- Kwon, D. H., Kim, J. J., Lee, M., Yamaoka, Y., Kato, M., Osato, M. S., El-Zaatari, F. A. K., & Graham, D. Y.
- Affiliations
- Baylor College of Medicine (US)
- Samsung Medical Center (KR)
- Hokkaido University (JP)
- Venue
- Antimicrobial Agents and Chemotherapy
- Publisher
- American Society for Microbiology
- Published
- 2000-11
- Volume
- 44
- Issue
- 11
- Pages
- 3203-3205
- ISSN
- 0066-4804 (ISSN-L)
- 1098-6596
- PMC
- PMC101634
- OpenAlex
- W2022806382
- Cited by
- 61
- References
- 19
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2021: 1 · 2019: 3 · 2018: 1 · 2016: 2 · 2014: 2 · 2012: 4
- FWCI
- 3.60
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Antimicrobial Agents and Chemotherapy (publishedVersion)
- PubMed Central (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Helicobacter pylori-related gastroenterology studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Antibiotic Resistance in Bacteria
- Life Sciences › Agricultural and Biological Sciences › Food Science › Salmonella and Campylobacter epidemiology
- Keywords
- Helicobacter pylori, tetracycline resistance, antimicrobial resistance, clinical isolates, minimum inhibitory concentration, eradication therapy
- MeSH terms
- Humans, Japan, Korea, Metronidazole, Microbial Sensitivity Tests, Tetracycline, Tetracycline Resistance, Helicobacter pylori, Drug Resistance, Multiple
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