Antifungal Activity of Amphotericin B Cochleates against Candida albicans Infection in a Mouse Model
Open accessAbstract
Cochleates are lipid-based supramolecular assemblies composed of natural products, negatively charged phospholipid, and a divalent cation. Cochleates can encapsulate amphotericin B (AmB), an important antifungal drug. AmB cochleates (CAMB) have a unique shape and the ability to target AmB to fungi. The minimal inhibitory concentration and the minimum lethal concentration against Candida albicans are similar to that for desoxycholate AmB (DAMB; Fungizone). In vitro, CAMB induced no hemolysis of human red blood cells at concentrations of as high as 500 microg of AmB/ml, and DAMB was highly hemolytic at 10 microg of AmB/ml. CAMB protect ICR mice infected with C. albicans when the agent is administered intraperitoneally at doses of as low as 0.1 mg/kg/day. In a tissue burden study, CAMB, DAMB, and AmBisome (liposomal AmB; LAMB) were effective in the kidneys, but in the spleen CAMB was more potent than DAMB at 1 mg/kg/day and was equivalent to LAMB at 10 mg/kg/day. In summary, CAMB are highly effective in treating murine candidiasis and compare well with AmBisome and AmB.
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Orally administered MAT2203 reduced tissue fungal burden in mice with invasive candidiasis.
“reduced tissue fungal burden in mice with invasive candidiasis [119,120]”
From Treatment of Invasive Candidiasis: A Narrative Review (2018) · cites this paper as [120]
Orally administered MAT2203 prevented death in mice with invasive candidiasis.
“Orally administered MAT2203 prevented death”
From Treatment of Invasive Candidiasis: A Narrative Review (2018) · cites this paper as [120]
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- Authors
- Zarif, L., Graybill, J. R., Perlin, D., Najvar, L., Bocanegra, R., & Mannino, R. J.
- Affiliations
- Rutgers New Jersey Medical School (US)
- The University of Texas at San Antonio Health Science Center (US)
- <!--label omitted: 3-->Public Health Research Institute, New York, New York 100163
- ORCID
- Perlin, David
- Venue
- Antimicrobial Agents and Chemotherapy
- Publisher
- American Society for Microbiology
- Published
- 2000-06
- Volume
- 44
- Issue
- 6
- Pages
- 1463-1469
- ISSN
- 0066-4804 (ISSN-L)
- 1098-6596
- PMC
- PMC89898
- OpenAlex
- W2141746397
- Cited by
- 122
- References
- 18
- Citations by year
- 2025: 6 · 2024: 8 · 2023: 7 · 2022: 6 · 2021: 10 · 2020: 3 · 2019: 5 · 2018: 4 · 2017: 8 · 2016: 5 · 2015: 3 · 2014: 7 · 2013: 6 · 2012: 4
- FWCI
- 3.12
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Antimicrobial Agents and Chemotherapy (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- U.S. Public Health Service (1-A1-025141)
- National Institute of Allergy and Infectious Diseases
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
- Keywords
- Candida albicans, antifungal activity, liposomal amphotericin B, hemolysis, tissue distribution, drug delivery
- MeSH terms
- Amphotericin B, Animals, Antifungal Agents, Candida albicans, Candidiasis, Humans, Mice
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