Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 357

The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.

Insertion Sequence IS Ecp1B Is Involved in Expression and Mobilization of a bla CTX-M β-Lactamase Gene

Open access
Poirel, Laurent, Decousser, Jean-Winoc, Nordmann, Patrice·2003·Antimicrobial Agents and Chemotherapy
DOI 10.1128/aac.47.9.2938-2945.2003
Open this paper in CoChat — free account

Abstract

The genetic structures (ca. 10-kb DNA fragment) surrounding the plasmid-borne extended-spectrum β-lactamase bla CTX-M-19 gene in a Klebsiella pneumoniae clinical isolate were determined. This β-lactamase gene was part of a 4,797-bp transposon inserted inside orf1 of Tn 1721. Inside this transposon, bla CTX-M-19 was bracketed upstream and downstream by insertion sequences IS E cp1B and IS 903D, respectively, and further downstream by a truncated gene encoding an outer membrane protein for iron transport. The single-copy IS Ecp1B element was probably involved alone in the mobilization process that led to a 5-bp duplication at the target site of the transposed fragment. This mobilization event probably involved one inverted repeat of IS E cp1B and a second sequence farther away, resembling its second inverted repeat. Additionally, IS Ecp1B provided −35 and −10 promoter sequences, contributing to the high-level expression of the bla CTX-M-19 gene. Southern blot analysis failed to identify a reservoir of IS Ecp1 -like sequences among a series of gram-negative and gram-positive bacterial species usually found in the skin and intestinal human floras. The ability of IS Ecp1 -like elements to mobilize and to promote the expression of β-lactamase genes may explain, in part, the current spread of CTX-M-type enzymes worldwide.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1128/aac.47.9.2938-2945.2003

Cites

32 of 32 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 32 references

Cited by

See all 357

Metadata

Authors
Poirel, L., Decousser, J.-W., & Nordmann, P.
Venue
Antimicrobial Agents and Chemotherapy
Publisher
American Society for Microbiology
Published
2003-09
Volume
47
Issue
9
Pages
2938-2945
ISSN
  • 0066-4804 (ISSN-L)
  • 1098-6596
DOI
10.1128/aac.47.9.2938-2945.2003
OpenAlex
W2166339024
Cited by
357
References
32
FWCI
7.73
Type
journal article
Language
en
Open access
green

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Insertion Sequence IS Ecp1B Is Involved in Expression and Mobilization of a bla CTX-M β-Lactamase Gene. https://app.cochat.ai/papers/10.1128/aac.47.9.2938-2945.2003
The paper
Poirel, L., Decousser, J.-W., & Nordmann, P. (2003). Insertion Sequence IS Ecp1B Is Involved in Expression and Mobilization of a bla CTX-M β-Lactamase Gene. Antimicrobial Agents and Chemotherapy. https://doi.org/10.1128/aac.47.9.2938-2945.2003

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.