The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Epigallocatechin-Gallate Enhances the Activity of Tetracycline in Staphylococci by Inhibiting Its Efflux from Bacterial Cells
Open accessAbstract
Epigallocatechin-gallate (EGCg), the major catechin present in green tea extracts, has been shown to have several antibacterial activities, limiting bacterial growth and invasion and acting in synergy with β-lactam antibiotics. In this article, we report that EGCg at doses half and below its calculated MIC of 100 μg/ml, is able to reverse tetracycline resistance in staphylococcal isolates expressing the specific efflux pump Tet(K) and appears to improve the MICs of tetracycline for susceptible staphylococcal isolates as well. The visible effect of EGCg is an increased accumulation of tetracycline inside bacterial cells. This effect is likely due to the inhibition of pump activity, and it is evident not only for Tet(K) pumps but also for efflux pumps of a different class [Tet(B)]. In summary, our data indicate that the observed dramatic enhancement by EGCg of tetracycline activity for resistant staphylococcal isolates is caused by impairment of tetracycline efflux pump activity and increased intracellular retention of the drug, suggesting a possible use of EGCg as an adjuvant in antibacterial therapy.
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Cites
Tea catechins and polyphenols: Health effects, metabolism, and antioxidant functions
Higdon, J. V., & Frei, B. (2003) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408690390826464 · Cited by 1,854 · cited 1×
“genicity, and have antioxidant actions (5).”
Tetracyclines: Antibiotic action, uptake, and resistance mechanisms
Schnappinger, D., & Hillen, W. (1996) · Archives of Microbiology · doi:10.1007/s002030050339 · Cited by 484
Tetracycline resistance mediated by ribosomal protection
Taylor, D. E., & Chau, A. (1996) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.40.1.1 · Cited by 153
Sanchez-Pescador, R., Brown, J. T., Roberts, M., & Urdea, M. S. (1988) · Nucleic Acids Research · doi:10.1093/nar/16.3.1218 · Cited by 87
Cited by
Synergism between natural products and antibiotics against infectious diseases
Hemaiswarya, S., Kruthiventi, A. K., & Doble, M. (2008) · Phytomedicine · doi:10.1016/j.phymed.2008.06.008 · Cited by 916
Friedman, M. (2007) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200600173 · Cited by 641
Antimicrobial properties of green tea catechins
Taylor, P. W., Hamilton-Miller, J. M. T., & Stapleton, P. D. (2005) · Food Science <html_ent glyph="@amp;" ascii="&"/> Technology Bulletin: Functional Foods · doi:10.1616/1476-2137.14184 · Cited by 373
Antibiotic resistance breakers: can repurposed drugs fill the antibiotic discovery void?
Brown, D. (2015) · Nature Reviews Drug Discovery · doi:10.1038/nrd4675 · Cited by 359
Epigallocatechin Gallate Supplementation Alleviates Diabetes in Rodents
Wolfram, S., Raederstorff, D., Preller, M., Wang, Y., Teixeira, S. R., Riegger, C., & Weber, P. (2006) · The Journal of Nutrition · doi:10.1093/jn/136.10.2512 · Cited by 331
Metadata
- Authors
- Sudano Roccaro, A., Blanco, A. R., Giuliano, F., Rusciano, D., & Enea, V.
- Venue
- Antimicrobial Agents and Chemotherapy
- Publisher
- American Society for Microbiology
- Published
- 2004-06
- Volume
- 48
- Issue
- 6
- Pages
- 1968-1973
- ISSN
- 0066-4804 (ISSN-L)
- 1098-6596
- OpenAlex
- W2033491946
- Cited by
- 263
- References
- 4
- FWCI
- 3.31
- Type
- journal article
- Language
- en
- Open access
- green
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- Sudano Roccaro, A., Blanco, A. R., Giuliano, F., Rusciano, D., & Enea, V. (2004). Epigallocatechin-Gallate Enhances the Activity of Tetracycline in Staphylococci by Inhibiting Its Efflux from Bacterial Cells. Antimicrobial Agents and Chemotherapy. https://doi.org/10.1128/aac.48.6.1968-1973.2004
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