Homology of the TetM with translational elongation factors: implications for potential modes of tetM conferred tetracycline resistance
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Ray Sanchez-Pescador, Janice T. Brown, Marilyn Roberts, Mickey S. Urdea; Homology of the TetM with translational elongation factors: implications for poten
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Tet(O) is a translational GTPase with significant sequence and structural similarity to EF-G.
“Tetracycline resistance protein Tet(O), which protects the bacterial ribosome from binding the antibiotic tetracycline, is a translational GTPase with significant similarity in both sequence and structure to the elongation factor EF-G.”
From Mechanism of tetracycline resistance by ribosomal protection protein Tet(O) (2013) · cites this paper as [11]
The high degree of sequence homology shared by Tet(O) and EF-G makes it possible to build an atomic model of Tet(O) based on the X-ray structure of EF-G, using a cryo-EM map as constraint, provided its resolution is sufficient.
“The high degree of sequence homology shared by Tet(O) and EF-G 11 makes it possible to build an atomic model of Tet(O) based on the X-ray structure of EF-G, using a cryo-EM map as constraint, provided its resolution is sufficient.”
From Mechanism of tetracycline resistance by ribosomal protection protein Tet(O) (2013) · cites this paper as [11]
RPPs display sequence similarity to EF-G and EF-Tu and are grouped into the translation factor superfamily of GTPases.
“The RPPs display sequence similarity to the ribosomal elongation factors, EF-G and EF-Tu (41), and are grouped into the translation factor superfamily of GTPases (27).”
From Ribosomal Protection Proteins and Their Mechanism ofTetracyclineResistance (2003) · cites this paper as [41]
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- Authors
- Sanchez-Pescador, R., Brown, J. T., Roberts, M., & Urdea, M. S.
- Affiliations
- University of Washington (US)
- ORCID
- Roberts, Marilyn
- Venue
- Nucleic Acids Research
- Publisher
- Oxford University Press (OUP)
- Published
- 1988
- Volume
- 16
- Issue
- 3
- Pages
- 1218-1218
- ISSN
- 0305-1048 (ISSN-L)
- 1362-4962
- PMC
- PMC334767
- OpenAlex
- W1997207030
- Cited by
- 87
- References
- 3
- Citations by year
- 2025: 1 · 2023: 1 · 2021: 2 · 2020: 4 · 2019: 3 · 2018: 4 · 2017: 4 · 2016: 1 · 2015: 1 · 2014: 2 · 2013: 3 · 2012: 2
- FWCI
- 1.52
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Nucleic Acids Research (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Antibiotic Resistance in Bacteria
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Keywords
- tetM, tetracycline resistance, protein homology, antibiotic resistance mechanisms
- MeSH terms
- Amino Acid Sequence, Animals, Bacterial Proteins, Escherichia coli, Euglena gracilis, Peptide Elongation Factors, Protein Binding, Ribosomal Proteins, Saccharomyces cerevisiae, Sequence Homology, Nucleic Acid, Species Specificity, Streptococcus pneumoniae, Tetracycline Resistance, Ureaplasma
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