Cited by 87Antibiotic Resistance in BacteriaBacterial Genetics and BiotechnologyDrug Transport and Resistance Mechanisms

Homology of the TetM with translational elongation factors: implications for potential modes of tetM conferred tetracycline resistance

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Sanchez-Pescador, Ray, Brown, Janice T., Roberts, Marilyn, Urdea, Mickey S.·1988·Nucleic Acids Research

Abstract

Ray Sanchez-Pescador, Janice T. Brown, Marilyn Roberts, Mickey S. Urdea; Homology of the TetM with translational elongation factors: implications for poten

Integrity signals

Registry

Crossref · 10.1093/nar/16.3.1218

Cites

3 of 3 references verified0 citation errors · 0 not checkable

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  • Tet(O) is a translational GTPase with significant sequence and structural similarity to EF-G.

    “Tetracycline resistance protein Tet(O), which protects the bacterial ribosome from binding the antibiotic tetracycline, is a translational GTPase with significant similarity in both sequence and structure to the elongation factor EF-G.”
  • The high degree of sequence homology shared by Tet(O) and EF-G makes it possible to build an atomic model of Tet(O) based on the X-ray structure of EF-G, using a cryo-EM map as constraint, provided its resolution is sufficient.

    “The high degree of sequence homology shared by Tet(O) and EF-G 11 makes it possible to build an atomic model of Tet(O) based on the X-ray structure of EF-G, using a cryo-EM map as constraint, provided its resolution is sufficient.”
  • RPPs display sequence similarity to EF-G and EF-Tu and are grouped into the translation factor superfamily of GTPases.

    “The RPPs display sequence similarity to the ribosomal elongation factors, EF-G and EF-Tu (41), and are grouped into the translation factor superfamily of GTPases (27).”

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Authors
Sanchez-Pescador, R., Brown, J. T., Roberts, M., & Urdea, M. S.
Affiliations
University of Washington (US)
Venue
Nucleic Acids Research
Published
1988
Volume
16
Issue
3
Pages
1218-1218
ISSN
  • 0305-1048 (ISSN-L)
  • 1362-4962
OpenAlex
W1997207030
Cited by
87
References
3
Citations by year
2025: 1 · 2023: 1 · 2021: 2 · 2020: 4 · 2019: 3 · 2018: 4 · 2017: 4 · 2016: 1 · 2015: 1 · 2014: 2 · 2013: 3 · 2012: 2
FWCI
1.52
Type
journal article
Language
en
Open access
Locations
  • Nucleic Acids Research (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Antibiotic Resistance in Bacteria
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
  • Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
Keywords
tetM, tetracycline resistance, protein homology, antibiotic resistance mechanisms
MeSH terms
Amino Acid Sequence, Animals, Bacterial Proteins, Escherichia coli, Euglena gracilis, Peptide Elongation Factors, Protein Binding, Ribosomal Proteins, Saccharomyces cerevisiae, Sequence Homology, Nucleic Acid, Species Specificity, Streptococcus pneumoniae, Tetracycline Resistance, Ureaplasma

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