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Delaying the Empiric Treatment of Candida Bloodstream Infection until Positive Blood Culture Results Are Obtained: a Potential Risk Factor for Hospital Mortality
Open accessAbstract
Fungal bloodstream infections are associated with significant patient mortality and health care costs. Nevertheless, the relationship between a delay of the initial empiric antifungal treatment until blood culture results are known and the clinical outcome is not well established. A retrospective cohort analysis with automated patient medical records and the pharmacy database at Barnes-Jewish Hospital was conducted. One hundred fifty-seven patients with a Candida bloodstream infection were identified over a 4-year period (January 2001 through December 2004). Fifty (31.8%) patients died during hospitalization. One hundred thirty-four patients had empiric antifungal treatment begun after the results of fungal cultures were known. From the time that the first blood sample for culture that was positive was drawn, 9 (5.7%) patients received antifungal treatment within 12 h, 10 (6.4%) patients received antifungal treatment between 12 and 24 h, 86 (54.8%) patients received antifungal treatment between 24 and 48 h, and 52 (33.1%) patients received antifungal treatment after 48 h. Multiple logistic regression analysis identified Acute Physiology and Chronic Health Evaluation II scores (one-point increments) (adjusted odds ratio [AOR], 1.24; 95% confidence interval [CI], 1.18 to 1.31; P < 0.001), prior antibiotic treatment (AOR, 4.05; 95% CI, 2.14 to 7.65; P = 0.028), and administration of antifungal treatment 12 h after having the first positive blood sample for culture (AOR, 2.09; 95% CI, 1.53 to 2.84; P = 0.018) as independent determinants of hospital mortality. Administration of empiric antifungal treatment 12 h after a positive blood sample for culture is drawn is common among patients with Candida bloodstream infections and is associated with greater hospital mortality. Delayed treatment of Candida bloodstream infections could be minimized by the development of more rapid diagnostic techniques for the identification of Candida bloodstream infections. Alternatively, increased use of empiric antifungal treatment in selected patients at high risk for fungal bloodstream infection could also reduce delays in treatment.
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“Finally, in a study of 10,811 patients treated in four Utah hospitals, each hour delay in time from ED arrival to administration of antimicrobials was associated with 1.16 increased odds of in-hospital and 1.10 increased odds of 1-year mortality (1.13 in patients with hypotension vs 1.09 in patients without hypotension) (111).”
From Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2021. (2021) · cites this paper as [111]
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“Observational studies do, however, suggest that mortality may increase after intervals exceeding 3-5 hours from hospital arrival and/or sepsis recognition (98,111,119,120).”
From Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2021. (2021) · cites this paper as [111]
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In the citing paper
“As mentioned previously, diagnosis of invasive candidiasis and candidemia remains a great challenge, since symptoms and signs are usually non-specific, microbiological cultures are difficult to analyze, and histological specimens require invasive procedures [29,30,46].”
From Management of invasive candidiasis and candidemia in adult non-neutropenic intensive care unit patients: part I. Epidemiology and diagnosis (2009) · cites this paper as [30]
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In the citing paper
“Attributable mortality from IC remains high and increases with delays in treatment.”
From Epidemiology of Invasive Candidiasis (2024) · cites this paper as [136]
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In the citing paper
“Blood cultures take an average of 2–3 days to grow Candida, or longer depending on the species.”
From Epidemiology of Invasive Candidiasis (2024) · cites this paper as [136]
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In the citing paper
“Some observational studies suggested that prompt initiation of appropriate empiric antifungal therapy may be associated with a reduction in mortality, however these studies do not prove a causal relationship between antifungal therapy and outcome, nor do they clarify the role of timing of treatment, and some other studies have failed to show this association [167, 171–173].”
From Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021 (2021) · cites this paper as [173]
In the citing paper
“Another single-center retrospective cohort of 157 consecutive patients with a Candida BSI showed a trend toward improved survival when appropriate antifungal therapy was administered within 12 hours of blood culture collection (mortality 11.1% vs 33.1%; P 5 .169).45”
From Fungal Sepsis: Optimizing Antifungal Therapy in the Critical Care Setting (2011) · cites this paper as [45]
In the citing paper
“In multivariate analysis the odds of death was 2-fold higher if adequate therapy was delayed more than 12 hours (P 5 .018).”
From Fungal Sepsis: Optimizing Antifungal Therapy in the Critical Care Setting (2011) · cites this paper as [45]
In the citing paper
“Invasive candidiasis occurs frequently in hospitalized patients, and is associated with high mortality rates due to delays in recognition and initiation of appropriate antifungals.”
From Treatment of Invasive Candidiasis: A Narrative Review (2018) · cites this paper as [70]
In the citing paper
“There is extensive clinical evidence that delayed initiation of appropriate antifungal treatment is associated with increased mortality in patients with invasive candidiasis [70,71,72].”
From Treatment of Invasive Candidiasis: A Narrative Review (2018) · cites this paper as [70]
In the citing paper
“Mortality rates are estimated to be as high as 45% [16], probably due to inefficient diagnostic methods and inappropriate initial antifungal therapies [17].”
From Candida Infections, Causes, Targets, and Resistance Mechanisms: Traditional and Alternative Antifungal Agents (2013) · cites this paper as [17]
In the citing paper
“The Clinical and Laboratory Standards Institute (CLSI) Subcommittee for Antifungal Testing has developed standardized broth microdilution (BMD) (169) and disk diffusion (170) methods for in vitro susceptibility testing of Candida spp.”
From Epidemiology of Invasive Candidiasis: a Persistent Public Health Problem (2007) · cites this paper as [170]
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Citations
Cites
Knaus, W. A., Draper, E. A., Wagner, D. P., & Zimmerman, J. E. (1985) · Critical Care Medicine · doi:10.1097/00003246-198510000-00009 · Cited by 15,518
APACHE II-A Severity of Disease Classification System
Knaus, W. A., Draper, E. A., Wagner, D. P., & Zimmerman, J. E. (1986) · Critical Care Medicine · doi:10.1097/00003246-198608000-00028 · Cited by 13,379
APACHE II: a severity of disease classification system.
Knaus, W. A., Draper, E. S., Wagner, D. P., & Zimmerman, J. E. (1985) · PubMed · Cited by 6,034
Wisplinghoff, H., Bischoff, T., Tallent, S. M., Seifert, H., Wenzel, R. P., & Edmond, M. B. (2004) · Clinical Infectious Diseases · doi:10.1086/421946 · Cited by 4,496
Inadequate Antimicrobial Treatment of Infections
Kollef, M. H., Sherman, G., Ward, S., & Fraser, V. J. (1999) · Chest · doi:10.1378/chest.115.2.462 · Cited by 1,805
Self-citationIbrahim, E. H., Sherman, G., Ward, S., Fraser, V. J., & Kollef, M. H. (2000) · Chest · doi:10.1378/chest.118.1.146 · Cited by 1,779
Self-citationComparison of Caspofungin and Amphotericin B for Invasive Candidiasis
Mora-Duarte, J., Betts, R., Rotstein, C., Colombo, A. L., Thompson-Moya, L., Smietana, J., Lupinacci, R., Sable, C., Kartsonis, N., & Perfect, J. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa021585 · Cited by 1,380
Weinstein, M. P., Towns, M., Quartey, S. M., Mirrett, S., Reimer, L. G., Parmigiani, G., & Reller, L. B. (1997) · Clinical Infectious Diseases · doi:10.1093/clind/24.4.584 · Cited by 1,225
Secular Trends in the Epidemiology of Nosocomial Fungal Infections in the United States, 1980-1990
Beck‐Sagué, C. M., Jarvis, W. R., & System, N. N. I. S. (1993) · The Journal of Infectious Diseases · doi:10.1093/infdis/167.5.1247 · Cited by 1,140
The Risk of Determining Risk with Multivariable Models
Concato, J., Feinstein, A. R., & Holford, T. R. (1993) · Annals of Internal Medicine · doi:10.7326/0003-4819-118-3-199302010-00009 · Cited by 1,129
Cited by
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Items 201–300 of 1,000
Rivers, E. P., & Ahrens, T. S. (2008) · Critical Care Clinics · doi:10.1016/j.ccc.2008.04.002 · Cited by 78
Zhao, Y., Park, S., Kreiswirth, B. N., Ginocchio, C. C., Veyret, R., Laayoun, A., Troesch, A., & Perlin, D. S. (2009) · Journal of Clinical Microbiology · doi:10.1128/jcm.02230-08 · Cited by 79
Epidemiology, Incidence and Risk Factors for Invasive Candidiasis in High-Risk Patients
Concia, E., Azzini, A. M., & Conti, M. (2009) · Drugs · doi:10.2165/11315500-000000000-00000 · Cited by 77
Candidemia and invasive candidiasis: A review of the literature for the burns surgeon
Ha, J. F., Italiano, C. M., Heath, C. H., Shih, S., Rea, S. M., & Wood, F. M. (2010) · Burns · doi:10.1016/j.burns.2010.01.005 · Cited by 77
Invasive Fungal Infections in the Intensive Care Unit
Ostrosky-Zeichner, L., & Al-Obaidi, M. (2017) · Infectious Disease Clinics of North America · doi:10.1016/j.idc.2017.05.005 · Cited by 76
T2 magnetic resonance for the diagnosis of bloodstream infections: charting a path forward
Clancy, C. J., & Nguyen, M. H. (2018) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dky050 · Cited by 79
Romanelli, A. M., Fu, J., Herrera, M. L., & Wickes, B. L. (2014) · Mycoses · doi:10.1111/myc.12208 · Cited by 76
Pfaller, M. A., Diekema, D. J., Procop, G. W., & Rinaldi, M. G. (2007) · Journal of Clinical Microbiology · doi:10.1128/jcm.01986-06 · Cited by 76
Shah, D. N., Yau, R., Weston, J., Lasco, T. M., Salazar, M., Palmer, H. R., & Garey, K. W. (2011) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkr244 · Cited by 75
Emerging trends in candidemia: A higher incidence but a similar outcome
Fortün, J., Martín‐Dávila, P., de la Pedrosa, E. G., Pintado, V., Cobo, J., Fresco, G., Meije, Y., Ros, L., Álvarez, M. E. D., Luengo, J. D. M. L., et al. (2012) · Journal of Infection · doi:10.1016/j.jinf.2012.02.011 · Cited by 78
Beyda, N. D., Alam, M. J., & Garey, K. W. (2013) · Diagnostic Microbiology and Infectious Disease · doi:10.1016/j.diagmicrobio.2013.07.007 · Cited by 75
Friedrich, R., Rappold, E., Bogdan, C., & Held, J. (2018) · Journal of Clinical Microbiology · doi:10.1128/jcm.00464-18 · Cited by 75
Ruhnke, M., Cornely, O. A., Schmidt‐Hieber, M., Alakel, N., Boell, B., Buchheidt, D., Christopeit, M., Hasenkamp, J., Heinz, W., Hentrich, M., et al. (2020) · Mycoses · doi:10.1111/myc.13082 · Cited by 76
Severe sepsis and septic shock
Schorr, C., Zanotti, S. L., & Dellinger, R. P. (2013) · Virulence · doi:10.4161/viru.27409 · Cited by 78
Yang, S.-P., Chen, Y.-Y., Hsu, H., Wang, F., Chen, L.-Y., & Fung, C.-P. (2013) · BMC Infectious Diseases · doi:10.1186/1471-2334-13-10 · Cited by 74
Aguado, J. M., Ruíz-Camps, I., Muñóz, P., Mensa, J., Almirante, B., Vázquez, L., Rovira, M., Martín‐Dávila, P., Moreno, A., Álvarez-Lerma, F., et al. (2011) · Enfermedades Infecciosas y Microbiología Clínica · doi:10.1016/j.eimc.2011.01.008 · Cited by 74
Lau, A. F., Kabir, M., Chen, S. C. ‐., Playford, E. G., Marriott, D. J. E., Jones, M., Lipman, J., McBryde, E. S., Gottlieb, T., Cheung, W., et al. (2015) · Journal of Clinical Microbiology · doi:10.1128/jcm.03239-14 · Cited by 74
Steenkiste, T. V., Ruyssinck, J., Baets, L. D., Decruyenaere, J. M. A., Turck, F. D., Ongenae, F., & Dhaene, T. (2018) · Artificial Intelligence in Medicine · doi:10.1016/j.artmed.2018.10.008 · Cited by 74
Use of Galleria mellonella larvae to evaluate the in vivo anti-fungal activity of [Ag2(mal)(phen)3]
Rowan, R., Moran, C., McCann, M., & Kavanagh, K. A. (2008) · BioMetals · doi:10.1007/s10534-008-9182-3 · Cited by 74
Preventing invasive candida infections. Where could we do better?
Eggimann, P., Que, Y., Revelly, J., & Pagani, J. (2014) · Journal of Hospital Infection · doi:10.1016/j.jhin.2014.11.006 · Cited by 76
Time to positivity of blood cultures of different Candida species causing fungaemia
Lai, C., Wang, C.-Y., Liu, W., Huang, Y., & Hsueh, P. (2012) · Journal of Medical Microbiology · doi:10.1099/jmm.0.038166-0 · Cited by 75
Therapy and outcome of Candida glabrata versus Candida albicans bloodstream infection
Klevay, M. J., Ernst, E. J., Hollanbaugh, J. L., Miller, J. G., Pfaller, M. A., & Diekema, D. J. (2008) · Diagnostic Microbiology and Infectious Disease · doi:10.1016/j.diagmicrobio.2007.10.001 · Cited by 73
The Importance of Early Treatment With Doxycycline in Human Ehrlichiosis
Hamburg, B. J., Storch, G. A., Micek, S. T., & Kollef, M. H. (2008) · Medicine · doi:10.1097/md.0b013e318168da1d · Cited by 73
Self-citationHope, W. W., Petraitis, V., Petraitienė, R., Aghamolla, T., Bacher, J. D., & Walsh, T. J. (2010) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00673-10 · Cited by 73
Current Status and Future Perspectives on Molecular and Serological Methods in Diagnostic Mycology
Lau, A. F., Chen, W., Sleiman, S., & Sorrell, T. C. (2009) · Future Microbiology · doi:10.2217/fmb.09.70 · Cited by 74
Polymerase Chain Reaction-Based Assays for the Diagnosis of Invasive Fungal Infections
Kourkoumpetis, T. K., Fuchs, B. B., Coleman, J. J., Desalermos, A. P., & Mylonakis, E. E. (2012) · Clinical Infectious Diseases · doi:10.1093/cid/cis132 · Cited by 73
European expert opinion on the management of invasive candidiasis in adults
Kullberg, B. J., Verweij, P. E., Akova, M., Arendrup, M. C., Billé, J., Calandra, T., Cuenca‐Estrella, M., Herbrecht, R., Jacobs, F., Kalin, M., et al. (2011) · Clinical Microbiology and Infection · doi:10.1111/j.1469-0691.2011.03615.x · Cited by 72
Biosensors and Diagnostics for Fungal Detection
Hussain, K. K., Malavia, D., Johnson, E. M., Littlechild, J. A., Winlove, C. P., Vollmer, F., & Gow, N. A. R. (2020) · Journal of Fungi · doi:10.3390/jof6040349 · Cited by 75
Pletz, M. W., Wellinghausen, N., & Welte, T. (2011) · Intensive Care Medicine · doi:10.1007/s00134-011-2245-x · Cited by 72
Davis, S. L., Vazquez, J. A., & Mckinnon, P. S. (2007) · Annals of Pharmacotherapy · doi:10.1345/aph.1h516 · Cited by 71
Occurrence, presentation and treatment of candidemia
Mikulska, M., Del Bono, V., Ratto, S., & Viscoli, C. (2012) · Expert Review of Clinical Immunology · doi:10.1586/eci.12.52 · Cited by 71
Invasive Mycoses: Strategies for Effective Management
Kontoyiannis, D. P. (2011) · The American Journal of Medicine · doi:10.1016/j.amjmed.2011.10.009 · Cited by 70
Horn, D. L., Ostrosky-Zeichner, L., Morris, M. I., Ullmann, A. J., Wu, C., Buell, D. N., Kovanda, L. L., & Cornely, O. A. (2010) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-009-0843-0 · Cited by 69
Metzgar, D., Frinder, M., Rothman, R. E., Peterson, S., Carroll, K. C., Zhang, S. X., Avornu, G. D., Rounds, M. A., Carolan, H. E., TOLENO, D. M., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0158186 · Cited by 70
Yaman, G., Akyar, I., & Can, S. (2012) · Diagnostic Microbiology and Infectious Disease · doi:10.1016/j.diagmicrobio.2012.01.013 · Cited by 72
Righi, E. (2018) · World Journal of Gastroenterology · doi:10.3748/wjg.v24.i38.4311 · Cited by 71
Canadian Clinical Practice Guidelines for Invasive Candidiasis in Adults
Bow, E. J., Evans, G. A., Fuller, J., Laverdière, M., Rotstein, C., Rennie, R. P., Shafran, S. D., Sheppard, D. C., Carle, S., Phillips, P., et al. (2010) · Canadian Journal of Infectious Diseases and Medical Microbiology · doi:10.1155/2010/357076 · Cited by 70
Chen, Y., Lehman, V. N., Averette, A. F., Perfect, J. R., & Heitman, J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0057672 · Cited by 69
Changing pattern of fungal infection in burn patients
Sarabahi, S., Tiwari, V. K., Arora, S., Capoor, M. R., & Pandey, A. (2011) · Burns · doi:10.1016/j.burns.2011.09.013 · Cited by 69
Novel strategies to fightCandidaspecies infection
Rodrigues, M. E., Silva, S. M., Azeredo, J., & Henriques, M. (2014) · Critical Reviews in Microbiology · doi:10.3109/1040841x.2014.974500 · Cited by 69
Theel, E. S., Jespersen, D. J., Iqbal, S., Bestrom, J. E., Rollins, L. O., Misner, L., Markley, B., Mandrekar, J. N., Baddour, L. M., LIMPER, A. H., et al. (2012) · Mycopathologia · doi:10.1007/s11046-012-9579-y · Cited by 68
Kollef, M. H., Napolitano, L. M., Solomkin, J. S., Wunderink, R. G., Bae, I., Fowler, V. G., BALK, R. A., Stevens, D. L., Rahal, J. J., Shorr, A. F., et al. (2008) · Clinical Infectious Diseases · doi:10.1086/590937 · Cited by 70
Self-citationClinical impact of time to positivity for Candida species on mortality in patients with candidaemia
Kim, S., Yoon, Y. K., Kim, M. J., & Sohn, J. W. (2013) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkt256 · Cited by 69
Gautier‐Veyret, E., Fonrose, X., Tonini, J., Thiébaut, A., Bartoli, M., Quésada, J.-L., Bulabois, C., Cahn, J.-Y. Y., & Stanke‐Labesque, F. (2015) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.04838-14 · Cited by 68
Diagnosing invasive fungal disease in critically ill patients
Hsu, J. L., Ruoss, S. J., Bower, N. D., Lin, M., Holodniy, M., & Stevens, D. A. (2011) · Critical Reviews in Microbiology · doi:10.3109/1040841x.2011.581223 · Cited by 69
Discontinuation of empirical antifungal therapy in ICU patients using 1,3-β-d-glucan
Nucci, M., Nouér, S. A., Esteves, P., Guimarães, T., Breda, G. L., de Miranda, B. G., Queiroz‐Telles, F., & Colombo, A. L. (2016) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkw188 · Cited by 67
Hirano, R., Sakamoto, Y., Kudo, K., & Ohnishi, M. (2015) · Infection and Drug Resistance · doi:10.2147/idr.s80677 · Cited by 65
de Molina, F. J. G., León, C., Ruiz‐Santana, S., Saavedra, P., & the CAVA I Study Group (2012) · Critical Care · doi:10.1186/cc11388 · Cited by 66
Greenberg, R. G., Benjamin, D. K., Gantz, M. G., Cotten, C. M., Stoll, B. J., Walsh, M. C., Sánchez, P. J., Shankaran, S., Das, A., Higgins, R. D., et al. (2012) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2012.01.053 · Cited by 66
Pharmacologic and clinical evaluation of posaconazole
Moore, J. N., Healy, J., & Kraft, W. K. (2015) · Expert Review of Clinical Pharmacology · doi:10.1586/17512433.2015.1034689 · Cited by 68
B, V. H., Bruynseels, P., Bensaid, M., Boekhout, T., Baere, T. D., Surmont, I., & Mertens, A. (2011) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-011-1383-y · Cited by 65
Recommendations for the treatment of established fungal infections
Thursky, K., Playford, E. G., Seymour, J. F., Sorrell, T. C., Ellis, D. H., Guy, S., Gilroy, N. M., Chu, J., & Shaw, D. (2008) · Internal Medicine Journal · doi:10.1111/j.1445-5994.2008.01725.x · Cited by 66
Candida biomarkers in patients with candidaemia and bacteraemia
Martínez‐Jiménez, M. D. C., Muñóz, P., Valerio, M., Alonso, R., Martos, C., Guinea, J., & Bouza, E. (2015) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkv090 · Cited by 65
Martínez‐Jiménez, M. D. C., Muñóz, P., Valerio, M., Vena, A., Guinea, J., & Bouza, E. (2015) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkv241 · Cited by 64
Garey, K. W., Pai, M. P., Suda, K. J., Turpin, R. S., Rege, M., Mingo, D. E., & Bearden, D. T. (2007) · Pharmacoepidemiology and Drug Safety · doi:10.1002/pds.1365 · Cited by 63
The Impact of Anti-infective Drug Shortages on Hospitals in the United States: Trends and Causes
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Locke, J. B., Almaguer, A. L., Zuill, D. E., & Bartizal, K. F. (2016) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00620-16 · Cited by 66
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Shorr, A. F., Gupta, V., Sun, X., Johannes, R. S., Spalding, J., & Tabak, Y. P. (2009) · Critical Care Medicine · doi:10.1097/ccm.0b013e3181a0f95d · Cited by 62
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Fortun, J., Meije, Y., Buitrago, M. J., Gago, S., Bernal-Martinez, L., Peman, J., Perez, M., Gomez-G Pedrosa, E., Madrid, N., Pintado, V., et al. (2014) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dku225 · Cited by 61
Infrared Spectroscopy of Blood
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Clancy, C. J., Nguyen, M.-L., Cheng, S., Huang, H., Fan, G.-X., Jaber, R. A., Wingard, J. R., Cline, C. L., & Nguyen, M. H. (2008) · Journal of Clinical Microbiology · doi:10.1128/jcm.02018-07 · Cited by 62
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Neonatal fungal infections: when to treat?
Hsieh, E., Smith, P. B., Jacqz-Aigrain, É., Kaguelidou, F., Cohen‐Wolkowiez, M., Manzoni, P., & Benjamin, D. K. (2012) · Early Human Development · doi:10.1016/s0378-3782(12)70004-x · Cited by 62
Factors related to outcome of bloodstream infections due to Candida parapsilosis complex
Barchiesi, F., Orsetti, E., Osimani, P., Catassi, C., Santelli, F., & Manso, E. (2016) · BMC Infectious Diseases · doi:10.1186/s12879-016-1704-y · Cited by 61
Tolerability profile of the current antifungal armoury
Mourad, A., & Perfect, J. R. (2017) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkx446 · Cited by 67
Al‐Dorzi, H. M., Sakkijha, H., Khan, R., Aldabbagh, T., Toledo, A., Ntinika, P., Johani, S. M. A., & Arabi, Y. M. (2018) · Journal of Intensive Care Medicine · doi:10.1177/0885066618767835 · Cited by 63
Empiric Antimicrobial Therapy in Severe Sepsis and Septic Shock: Optimizing Pathogen Clearance
Liang, S. Y., & Kumar, A. (2015) · Current Infectious Disease Reports · doi:10.1007/s11908-015-0493-6 · Cited by 63
Helminths and their implication in sepsis - a new branch of their immunomodulatory behaviour?
Hübner, M. P., Layland, L. E., & Hoerauf, A. M. (2013) · Pathogens and Disease · doi:10.1111/2049-632x.12080 · Cited by 61
Candida in Burns: Risk Factors and Outcomes
Moore, E. C., Padiglione, A. A., Wasiak, J., Paul, E. M., & Cleland, H. J. (2010) · Journal of Burn Care & Research · doi:10.1097/bcr.0b013e3181d0f536 · Cited by 61
Pfaller, M. A., Boyken, L. B., Hollis, R. J., Kroeger, J. S., Messer, S. A., Tendolkar, S., & Diekema, D. J. (2010) · Journal of Clinical Microbiology · doi:10.1128/jcm.02161-10 · Cited by 61
van der Elst, K. C. M., Span, L. F. R., van Hateren, K., Vermeulen, K. M., van der Werf, T. S., Greijdanus, B., Kosterink, J. G. W., Uges, D. R. A., & Alffenaar, J. C. (2013) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00707-13 · Cited by 63
T2Candida Provides Rapid and Accurate Species Identification in Pediatric Cases of Candidemia
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Low Caspofungin Exposure in Patients in Intensive Care Units
van der Elst, K. C. M., Veringa, A., Zijlstra, J. G., Beishuizen, A., Klont, R., Brummelhuis-Visser, P., Uges, D. R. A., Touw, D. J., Kosterink, J. G. W., van der Werf, T. S., et al. (2016) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01582-16 · Cited by 62
Chen, T., Feng, Y., Sun, W., Zhao, G., Wu, H., Cheng, X., Zhao, F., Zhang, L., Zheng, Y., Zhan, P., et al. (2023) · Immunity · doi:10.1016/j.immuni.2023.06.002 · Cited by 60
Gedık, H., Şimşek, F., Yıldırmak, T., Kantürk, A., Arica, D. A., Aydın, D., Yokuş, O., & Demirel, N. (2014) · Therapeutics and Clinical Risk Management · doi:10.2147/tcrm.s68450 · Cited by 59
Arendrup, M. C., Fisher, B. T., & Zaoutis, T. E. (2009) · Clinical Microbiology and Infection · doi:10.1111/j.1469-0691.2009.02909.x · Cited by 59
Siopi, M., Tarpatzi, A., Kalogeropoulou, E., Damianidou, S., Vasilakopoulou, A., Vourli, S., Pournaras, S., & Meletiadis, J. (2019) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01516-19 · Cited by 61
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Aittakorpi, A., Kuusela, P., Koukila-Kähkölä, P., Vaara, M., Petrou, M. A., Gant, V. A., & Mäki, M. (2012) · Journal of Clinical Microbiology · doi:10.1128/jcm.01461-12 · Cited by 59
Ganapathy, A. S., Swetha, T. K., Prasanth, M. I., Balamurugan, K., & Pandian, S. K. (2017) · Microbiological Research · doi:10.1016/j.micres.2017.11.002 · Cited by 61
Arastehfar, A. A., Fang, W., Pan, W., Lackner, M., Liao, W., Badiee, P., Zomorodian, K., Badali, H., Hagen, F., Lass‐Flörl, C., et al. (2018) · Diagnostic Microbiology and Infectious Disease · doi:10.1016/j.diagmicrobio.2018.09.007 · Cited by 59
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Zeidler, U., Bougnoux, M.-E., Lupan, A., Helynck, O., Doyen, A., Garcia, Z., Sertour, N., Clavaud, C., Munier-Lehmann, H., Saveanu, C., et al. (2013) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dks538 · Cited by 58
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Bhatt, V. R., Viola, G. M., & Ferrajoli, A. (2011) · Therapeutic Advances in Hematology · doi:10.1177/2040620711410098 · Cited by 71
Dupont, B., Lortholary, O., Ostrosky-Zeichner, L. L., Stucker, F., & Yeldandi, V. V. (2009) · Critical Care · doi:10.1186/cc8117 · Cited by 59
Simon, S. P., Li, R., Silver, M. P., Andrade, J., Tharian, B., Fu, L. H., Villanueva, D. M., Abascal, D. G., Mayer, A., Truong, J. Q., et al. (2022) · Clinical Infectious Diseases · doi:10.1093/cid/ciac735 · Cited by 61
Playford, E. G., Lipman, J., Kabir, M., McBryde, E. S., Nimmo, G. R., Lau, A. F., & Sorrell, T. C. (2009) · Intensive Care Medicine · doi:10.1007/s00134-009-1619-9 · Cited by 58
Rosenvinge, F. S., Dzajic, E., Knudsen, E., Malig, S., Andersen, L. B., Løvig, A., Arendrup, M. C., Jensen, T. G., Gahrn‐Hansen, B., & Kemp, M. (2012) · Mycoses · doi:10.1111/myc.12000 · Cited by 58
Bono, V. D., Delfino, E., Furfaro, E., Mikulska, M., Nicco, E., Bruzzi, P., Mularoni, A., Bassetti, M., & Viscoli, C. (2011) · Clinical and Vaccine Immunology · doi:10.1128/cvi.05408-11 · Cited by 58
Guinea, J., Recio, S., Escribano, P., Torres-Narbona, M., Peláez, T., Sánchez‐Carrillo, C., Rodríguez‐Créixems, M., & Bouza, E. (2010) · Journal of Clinical Microbiology · doi:10.1128/jcm.02321-09 · Cited by 58
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Bench-to-bedside review: Therapeutic management of invasive candidiasis in the intensive care unit
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Hsu, D. I., Nguyen, M., Nguyen, L., Law, A. V., & Wong‐Beringer, A. (2010) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkq216 · Cited by 56
Decker, S., Sigl, A., Grumaz, C., Stevens, P., Vainshtein, Y., Zimmermann, S., Weigand, M. A., Hofer, S., Sohn, K., & Brenner, T. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18081796 · Cited by 58
Metadata
- Authors
- Morrell, M., Fraser, V. J., & Kollef, M. H.
- Affiliations
- Washington University in St. Louis (US)
- Pulmonary and Critical Care Division
- Corresponding author
- Kollef, Marin H.
- Venue
- Antimicrobial Agents and Chemotherapy
- Publisher
- American Society for Microbiology
- Published
- 2005-09
- Volume
- 49
- Issue
- 9
- Pages
- 3640-3645
- ISSN
- 0066-4804 (ISSN-L)
- 1098-6596
- PMC
- PMC1195428
- OpenAlex
- W2137575148
- Cited by
- 1,286
- References
- 47
- Citations by year
- 2026: 33 · 2025: 33 · 2024: 41 · 2023: 33 · 2022: 53 · 2021: 51 · 2020: 58 · 2019: 63 · 2018: 65 · 2017: 67 · 2016: 71 · 2015: 77 · 2014: 97 · 2013: 75 · 2012: 78
- FWCI
- 27.08
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Antimicrobial Agents and Chemotherapy (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Digital Commons@Becker (Washington University School of Medicine) (submittedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Infective Endocarditis Diagnosis and Management
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Sepsis Diagnosis and Treatment
- Keywords
- candidemia, fungemia, empirical antifungal therapy, treatment delay, blood culture, in-hospital mortality, APACHE II score, prior antibiotic use, rapid diagnostic tests
- MeSH terms
- Adult, Aged, Aged, 80 and over, Candidiasis, Cross Infection, Female, Humans, Male, Middle Aged, Retrospective Studies, Risk Factors, Cohort Studies, Logistic Models, Fungemia, Treatment Outcome
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