Burden of early-onset candidemia: analysis of culture-positive bloodstream infections from a large U.S. database
Abstract
OBJECTIVES: : To characterize the epidemiology and burden of early-onset, nonnosocomial candidemia. DESIGN: : Retrospective review of Cardinal Health Outcomes Research Database, which comprises all acute care admissions at participating hospitals. SETTING: : A total of 176 acute care hospitals. PATIENTS: : All patients admitted from 2000 through 2005 who had early-onset bloodstream infection, defined as presence of both a positive blood culture drawn within 1 day before or within 48 hrs after hospital admission and an appropriate diagnostic code for infection. INTERVENTION: : None. MEASUREMENTS AND MAIN RESULTS: : To evaluate the impact of different pathogens on clinical and economic outcomes, we performed mixed-effect logistic and linear regression analyses and controlled for potential confounding factors. Of 64,307 early-onset bloodstream infections, 738 (1.2%) were positive for Candida. The rate of early-onset candidemia nearly doubled between 2000 and 2003 (p < .001) and then stabilized. Crude in-hospital mortality was higher for candidemia than for bacterial bloodstream infection (28.3% vs. 15.0%; p < .0001). Compared with patients with bacterial bloodstream infections, patients with candidemia were more likely to have been admitted within 30 days and to have been transferred from another healthcare facility. Compared with Gram-negative bacterial bloodstream infection and after controlling for other risk factors, candidemia was associated with increased mortality risk (odds ratio, 2.38; 95% confidence interval, 1.94-2.91; p < .0001), longer attributable hospital stay (4.8 days; 95% confidence interval, 4.1-5.5; p < .0001), and higher attributable hospital costs ($12,617; 95% confidence Interval, $10,755-$14,479; p < .0001). CONCLUSIONS: : Early-onset candidemia seems to be a distinct entity, which is increasing in frequency and is associated with increased mortality risk, longer hospital stay, and higher hospital costs relative to bacterial bloodstream infection.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Current rates of Candida bloodstream infection are estimated at 25 to 30 per 100,000 persons.
“The shift in the epidemiology of this health care-associated infection has continued in the current decade, with rates now estimated to be between 25 and 30 per 100,000 persons.16,24”
From Fungal Sepsis: Optimizing Antifungal Therapy in the Critical Care Setting (2011) · cites this paper as [16]
Cites
A Prediction Rule to Identify Low-Risk Patients with Community-Acquired Pneumonia
Fine, M. J., Auble, T. E., Yealy, D. M., Hanusa, B. H., Weissfeld, L. A., Singer, D. E., Coley, C. M., Marrie, T. J., & Kapoor, W. N. (1997) · New England Journal of Medicine · doi:10.1056/nejm199701233360402 · Cited by 4,560 · see citing works
Wisplinghoff, H., Bischoff, T., Tallent, S. M., Seifert, H., Wenzel, R. P., & Edmond, M. B. (2004) · Clinical Infectious Diseases · doi:10.1086/421946 · Cited by 4,496 · see citing works
Morrell, M., Fraser, V. J., & Kollef, M. H. (2005) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.49.9.3640-3645.2005 · Cited by 1,286 · see citing works
Garey, K. W., Rege, M., Pai, M. P., Mingo, D. E., Suda, K. J., Turpin, R. S., & Bearden, D. T. (2006) · Clinical Infectious Diseases · doi:10.1086/504810 · Cited by 1,171 · see citing works
Attributable Mortality of Nosocomial Candidemia, Revisited
Gudlaugsson, O., Gillespie, S., Lee, K., Berg, J. V., Hu, J., Messer, S., Herwaldt, L., Pfaller, M., & Diekema, D. (2003) · Clinical Infectious Diseases · doi:10.1086/378745 · Cited by 1,140 · see citing works
Nosocomial Infections in Combined Medical-Surgical Intensive Care Units in the United States
Richards, M. J., Edwards, J. R., Culver, D. H., Gaynes, R. P., & System, N. N. I. S. (2000) · Infection Control and Hospital Epidemiology · doi:10.1086/501795 · Cited by 1,028 · see citing works
Epidemiology and Outcomes of Health-care–Associated Pneumonia
Kollef, M. H., Shorr, A., Tabak, Y. P., Gupta, V., Liu, L. Z., & Johannes, R. S. (2005) · Chest · doi:10.1378/chest.128.6.3854 · Cited by 948 · see citing works
Self-citationHajjeh, R. A., Sofair, A. N., Harrison, L. H., Lyon, G. M., Arthington-Skaggs, B. A., Mirza, S. A., Phelan, M., Morgan, J., Lee-Yang, W., Ciblak, M. A., et al. (2004) · Journal of Clinical Microbiology · doi:10.1128/jcm.42.4.1519-1527.2004 · Cited by 649 · see citing works
Kao, A. S., Brandt, M. E., Pruitt, W. R., Conn, L. A., Perkins, B. A., Stephens, D. S., Baughman, W. S., Reingold, A. L., Rothrock, G. A., Pfaller, M. A., et al. (1999) · Clinical Infectious Diseases · doi:10.1086/313450 · Cited by 457 · see citing works
Morgan, J., Meltzer, M. I., Plikaytis, B. D., Sofair, A. N., Huie-White, S., Wilcox, S., Harrison, L. H., Seaberg, E. C., Hajjeh, R. A., & Teutsch, S. M. (2005) · Infection Control & Hospital Epidemiology · doi:10.1086/502581 · Cited by 437 · see citing works
Pfaller, M. A., Jones, R. N., Messer, S. A., Edmond, M. B., & Wenzel, R. P. (1998) · Diagnostic Microbiology and Infectious Disease · doi:10.1016/s0732-8893(97)00240-x · Cited by 332 · see citing works
Silber, J. H. (1995) · JAMA · doi:10.1001/jama.1995.03530040045039 · Cited by 316 · see citing works
The Impact of Candidemia on Length of Hospital Stay, Outcome, and Overall Cost of Illness
Rentz, A. M., Halpern, M. T., & Bowden, R. (1998) · Clinical Infectious Diseases · doi:10.1086/514955 · Cited by 310 · cited 4× · see citing works
“A study, using claims data, showed that the higher hospital costs of candidemia were related to increased LOS (11).”
BackgroundResultInfluentialAttributable mortality of candidemia: a systematic review of matched cohort and case-control studies
Falagas, M. E., Apostolou, K. E., & Pappas, V. D. (2006) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-006-0159-2 · Cited by 294 · see citing works
Healthcare-associated bloodstream infection: A distinct entity? Insights from a large U.S. database*
Shorr, A. F., Tabak, Y. P., Killian, A. D., Gupta, V., Liu, L. Z., & Kollef, M. H. (2006) · Critical Care Medicine · doi:10.1097/01.ccm.0000239121.09533.09 · Cited by 283 · see citing works
Self-citationAn introduction to hierarchical linear modelling
SULLIVAN, L. M., Dukes, K. A., & Losina, E. (1999) · Statistics in Medicine · doi:10.1002/(sici)1097-0258(19990415)18:7 · Cited by 252 · see citing works
Colombo, A. L., Guimarães, T., Silva, L. R. B. F., de Almeida, L. P., Cunha, A. K. B., Rady, P., Alves, T., & Rosas, R. C. (2007) · Infection Control and Hospital Epidemiology · doi:10.1086/513615 · Cited by 161 · see citing works
Shorr, A. F., Tabak, Y. P., Gupta, V., Johannes, R., Liu, L. Z., & Kollef, M. H. (2006) · Critical Care · doi:10.1186/cc4934 · Cited by 160 · see citing works
Self-citationA clinical assessment of MedisGroups
Iezzoni, L. I. (1988) · JAMA · doi:10.1001/jama.260.21.3159 · Cited by 134 · see citing works
Macphail, G. L. P., Taylor, G. D., Buchanan‐Chell, M., Ross, C., Wilson, S., & Kureishi, A. (2002) · Mycoses · doi:10.1046/j.1439-0507.2002.00741.x · Cited by 119 · see citing works
On the use of survival analysis techniques to estimate medical care costs
Etzioni, R., Feuer, E. J., Sullivan, S. D., Lin, D. Y., Hu, C., & Ramsey, S. D. (1999) · Journal of Health Economics · doi:10.1016/s0167-6296(98)00056-3 · Cited by 114 · see citing works
Dudley, R., Harrell, F. E. J., Smith, L., Mark, D., Califf, R., Pryor, D., Glower, D., Lipscomb, J., & Hlatky, M. (1993) · Journal of Clinical Epidemiology · doi:10.1016/0895-4356(93)90074-b · Cited by 112 · see citing works
Using Automated Clinical Data for Risk Adjustment
Tabak, Y. P., Johannes, R. S., & Silber, J. H. (2007) · Medical Care · doi:10.1097/mlr.0b013e31803d3b41 · Cited by 94 · see citing works
Self-citationHas the Epidemiology of Nosocomial Candidemia Changed?
Puzniak, L., Teutsch, S. M., Powderly, W. G., & Polish, L. B. (2004) · Infection Control and Hospital Epidemiology · doi:10.1086/502452 · Cited by 79 · see citing works
Epidemiology of Community‐Onset Candidemia in Connecticut and Maryland
Sofair, A. N., Lyon, G. M., Huie‐White, S., Reiss, E., Harrison, L. H., Sanza, L. T., Arthington, B. A., & Fridkin, S. K. (2006) · Clinical Infectious Diseases · doi:10.1086/504807 · Cited by 55 · see citing works
Community-onset candidemia at a university hospital, 1995-2005.
Kung, H., Wang, J., Chang, S., Wang, J., Sun, H., Hsueh, P., & Chen, Y. (2007) · PubMed · Cited by 23 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Pfaller, M. A., Neofytos, D., Diekema, D. J., Azie, N. E., Meier‐Kriesche, H., Quan, S.-P., & Horn, D. (2012) · Diagnostic Microbiology and Infectious Disease · doi:10.1016/j.diagmicrobio.2012.10.003 · Cited by 391 · see citing works
Pfaller, M. A., Moet, G. J., Messer, S. A., Jones, R. N., & Castanheira, M. (2011) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01079-10 · Cited by 238 · see citing works
Nosocomial Candidiasis: Antifungal Stewardship and the Importance of Rapid Diagnosis
Pfaller, M. A., & Castanheira, M. (2015) · Medical Mycology · doi:10.1093/mmy/myv076 · Cited by 161 · see citing works
Scorzoni, L., de Lucas, M. P., Mesa-Arango, A. C., Fusco‐Almeida, A. M., Lozano, E., Cuenca‐Estrella, M., Mendes‐Giannini, M. J. S., & Zaragoza, Ó. (2013) · PLoS ONE · doi:10.1371/journal.pone.0060047 · Cited by 150 · see citing works
Zilberberg, M. D., Kollef, M. H., Arnold, H., Labelle, A., Micek, S. T., Kothari, S., & Shorr, A. F. (2010) · BMC Infectious Diseases · doi:10.1186/1471-2334-10-150 · Cited by 128 · see citing works
Self-citationTabak, Y. P., Sun, X., Nunez, C. M., & Johannes, R. S. (2014) · Journal of the American Medical Informatics Association · doi:10.1136/amiajnl-2013-001790 · Cited by 107 · see citing works
Self-citationHeld, J., Kohlberger, I., Rappold, E., Grawitz, A. B., & Häcker, G. A. (2013) · Journal of Clinical Microbiology · doi:10.1128/jcm.02473-12 · Cited by 102 · see citing works
Choi, H., Kim, K., & Lee, D. G. (2016) · Fungal Biology · doi:10.1016/j.funbio.2016.09.001 · Cited by 89 · see citing works
Chalupka, A. N., & Talmor, D. S. (2011) · Critical Care Clinics · doi:10.1016/j.ccc.2011.09.003 · Cited by 86 · see citing works
Risk Factors for Invasive Candidiasis in Infants >1500 g Birth Weight
Lee, J. H., Hornik, C. P. V., Benjamin, D. K., Herring, A. H., Clark, R. H., Cohen‐Wolkowiez, M., & Smith, P. B. (2012) · The Pediatric Infectious Disease Journal · doi:10.1097/inf.0b013e3182769603 · Cited by 65 · see citing works
Fungal Sepsis: Optimizing Antifungal Therapy in the Critical Care Setting
Lepak, A., & Andes, D. (2011) · Critical Care Clinics · doi:10.1016/j.ccc.2010.11.001 · Cited by 62 · see citing works
Fortun, J., Meije, Y., Buitrago, M. J., Gago, S., Bernal-Martinez, L., Peman, J., Perez, M., Gomez-G Pedrosa, E., Madrid, N., Pintado, V., et al. (2014) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dku225 · Cited by 61 · see citing works
Improving the management of candidemia through antimicrobial stewardship interventions
Reed, E. E., West, J. E., Keating, E. A., Pancholi, P., Balada-Llasat, J.-M., Mangino, J. E., Bauer, K. A. A., & Goff, D. A. (2013) · Diagnostic Microbiology and Infectious Disease · doi:10.1016/j.diagmicrobio.2013.11.012 · Cited by 62 · see citing works
Decker, S., Sigl, A., Grumaz, C., Stevens, P., Vainshtein, Y., Zimmermann, S., Weigand, M. A., Hofer, S., Sohn, K., & Brenner, T. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18081796 · Cited by 58 · see citing works
Risk factors predicting Candida infective endocarditis in patients with candidemia
Foong, K. S., Sung, A., Burnham, J. P., Kronen, R., Lian, Q., Zetina, A. S., Hsueh, K., Lin, C., Powderly, W. G., & Spec, A. (2019) · Medical Mycology · doi:10.1093/mmy/myz104 · Cited by 51 · see citing works
Mortality in patients with early- or late-onset candidaemia
Rosa, F. G. D., Trecarichi, E. M., Montrucchio, C., Losito, A. R., Raviolo, S., Posteraro, B., Corcione, S., Giambenedetto, S. D., Fossati, L., Sanguinetti, M., et al. (2012) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dks480 · Cited by 49 · see citing works
Décanis, N., Tazi, N., Correia, A., Vilanova, M., & Rouabhia, M. (2011) · The Open Microbiology Journal · doi:10.2174/1874285801105010119 · Cited by 42 · see citing works
Zilberberg, M. D., & Shorr, A. F. (2009) · Infectious Disease Clinics of North America · doi:10.1016/j.idc.2009.04.008 · Cited by 42 · see citing works
Self-citationCandidemia on presentation to the hospital: development and validation of a risk score
Shorr, A. F., Tabak, Y. P., Johannes, R. S., Sun, X., Spalding, J. R., & Kollef, M. H. (2009) · Critical Care · doi:10.1186/cc8110 · Cited by 42 · see citing works
Self-citationTabak, Y. P., Sun, X., Derby, K. G., Kurtz, S. G., & Johannes, R. S. (2010) · Health Services Research · doi:10.1111/j.1475-6773.2010.01126.x · Cited by 37 · see citing works
Self-citationEmerging drugs and vaccines for Candidemia
Moriyama, B., Gordon, L. A., McCarthy, M. W., Henning, S. A., Walsh, T. J., & Penzak, S. R. (2014) · Mycoses · doi:10.1111/myc.12265 · Cited by 38 · see citing works
Impact of First-Line Antifungal Agents on the Outcomes and Costs of Candidemia
Ha, Y. E., Peck, K. R., Joo, E., Kim, S., Jung, S., Chang, H., Park, K. H., & Han, S. H. (2012) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.06258-11 · Cited by 35 · see citing works
The Epidemiology of Invasive Candidiasis
Pfaller, M. A., & Diekema, D. J. (2014) · ASM Press eBooks · doi:10.1128/9781555817176.ch29 · Cited by 33 · see citing works
the CAVA Trem Study Group, Parra-Sánchez, M., Breval, I. Z.-Y., Méndez, C. C., García-Rey, S., Vázquez, A. L., Úbeda, A., Guerrero, D. M., Mejías, A. R., Gil, C. L., et al. (2017) · Mycopathologia · doi:10.1007/s11046-017-0125-9 · Cited by 32 · see citing works
Fungemias en hospitales de la Ciudad de Buenos Aires, Argentina
Moral, L. L., Tiraboschi, I. N., Schijman, M., Bianchi, M., Guelfand, L. I., & Cataldi, S. (2011) · Revista Iberoamericana de Micología · doi:10.1016/j.riam.2011.11.001 · Cited by 23 · see citing works
Current aspects of invasive candidiasis and aspergillosis in adult intensive care patients
Glöckner, A., & Karthaus, M. (2010) · Mycoses · doi:10.1111/j.1439-0507.2010.01885.x · Cited by 23 · see citing works
A high-throughput assay of yeast cell lysis for drug discovery and genetic analysis
DiDone, L., Scrimale, T., Baxter, B. K., & Krysan, D. J. (2010) · Nature Protocols · doi:10.1038/nprot.2010.47 · Cited by 22 · see citing works
Nieto, M., Robles, J. C., Causse, M., Gutiérrez, L., Perez, M. C., Ferrer, R., Xercavins, M., Herrero, E., Sirvent, E., Fernández, C., et al. (2019) · Infectious Diseases and Therapy · doi:10.1007/s40121-019-0248-z · Cited by 21 · see citing works
Jones, T. M., Drew, R. H., Wilson, D. T., Sarubbi, C., & Anderson, D. J. (2017) · American Journal of Health-System Pharmacy · doi:10.2146/ajhp170113 · Cited by 20 · see citing works
Detailed β-(1→3)-D-glucan and mannan antigen kinetics in patients with candidemia
Träger, J., Dräger, S., Mihai, S., Cipa, F., Grawitz, A. B., Epting, T., Meyer, R., Rappold, E., & Held, J. (2023) · Journal of Clinical Microbiology · doi:10.1128/jcm.00598-23 · Cited by 19 · see citing works
Rouabhia, M., Semlali, A., Chandra, J., Mukherjee, P. K., Chmielewski, W., & Ghannoum, M. A. (2012) · Mediators of Inflammation · doi:10.1155/2012/398207 · Cited by 19 · see citing works
Chen, L., Xie, Z., & Jian, J. (2024) · Infection and Drug Resistance · doi:10.2147/idr.s471171 · Cited by 19 · see citing works
Miyazaki, T., & Kohno, S. (2015) · Expert Review of Anti-infective Therapy · doi:10.1586/14787210.2015.1058157 · Cited by 18 · see citing works
The critical role of Dectin-1 in host controlling systemic Candida krusei infection.
Chen, S. M., Zou, Z., Qiu, X. R., Hou, W.-T., Zhang, Y., Fang, W. Y., Chen, Y. L., Wang, Y. D., Jiang, Y. Y., Shen, H., et al. (2019) · Europe PMC (PubMed Central) · Cited by 16 · see citing works
Li, R., YAN, X.-H., LU, Y.-B., LU, Y.-L., Zhang, H., Chen, S., Liu, S., & Lu, Z. (2015) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2015.2731 · Cited by 16 · see citing works
Li, R., Zhang, L., Zhang, H., Yi, Y., Wang, L., Chen, L., & Zhang, L. (2017) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2017.4290 · Cited by 16 · see citing works
Yang, Y., Guo, F., Kang, Y., Zang, B., Cui, W., Qin, B., Qin, Y.-Z., Fang, Q., Qin, T., Jiang, D., et al. (2017) · Medicine · doi:10.1097/md.0000000000007830 · Cited by 15 · see citing works
Early-Onset Candidemia in Adult Intensive Care Units
Mouratidou, C., Tsakiri, K., Dourliou, V., Marneri, A. G., Stougianni, M., & Pavlidis, E. T. (2025) · Diagnostics · doi:10.3390/diagnostics15111402 · Cited by 8 · see citing works
Echinocandin Use in Hospitalized Patients: A Multi-institutional Study
Garey, K. W., Aitken, S. L., Dima-Ala, A., Beyda, N. D., Kuper, K. M., Xie, Y., & Koo, H. L. (2015) · The American Journal of the Medical Sciences · doi:10.1097/maj.0000000000000412 · Cited by 8 · see citing works
Armaganidis, A., Nanas, S., Antoniadou, E., Mandragos, K. E., Liakou, K., Koutsoukou, A., Baltopoulos, G. J., Nakos, G., Kounougeri, A., Ganas, K., et al. (2017) · Mycoses · doi:10.1111/myc.12616 · Cited by 6 · see citing works
Decker, S., Incamps, A., Sigl, A., Uhle, F., Bruckner, T. M., Heininger, A., Zimmermann, S., Hirtz, C., Weigand, M. A., & Brenner, T. (2020) · Mediators of Inflammation · doi:10.1155/2020/3470163 · Cited by 5 · see citing works
Jung, Y. J. (2024) · Pediatrics & Neonatology · doi:10.1016/j.pedneo.2024.01.006 · Cited by 4 · see citing works
Invasive Candidiasis in the Neutropenic Cancer Patient
Gamaletsou, M. N., Sipsas, N. V., & Kontoyiannis, D. P. (2010) · Current Fungal Infection Reports · doi:10.1007/s12281-010-0044-4 · Cited by 4 · see citing works
Antibacterial Mechanism of N‐PMI and the Characteristics of PMMA‐Co‐N‐PMI Copolymer**
Shi, H., Zhuang, Q., Zheng, A., Zhan, P., Guan, Y. P., Wei, D., Xu, X., & Wu, T. (2022) · Chemistry & Biodiversity · doi:10.1002/cbdv.202100753 · Cited by 4 · see citing works
Jaruvongvanich, V., Worasilchai, N., Kongnatthasate, K., Jaruvongvanich, S., Damkerngsuntorn, W., Atikarnbodee, D., Thammahong, A., Lerdlitruangsin, S., & Chindamporn, A. (2016) · Asian Biomedicine · doi:10.5372/1905-7415.1001.468 · Cited by 4 · see citing works
Use and outcome of empiric echinocandins in critically ill patients
Ylipalosaari, P., Ala-Kokko, T. I., Koskenkari, J. K., Laurila, J. J., Ämmälä, S., & Syrjälä, H. (2021) · Acta Anaesthesiologica Scandinavica · doi:10.1111/aas.13783 · Cited by 3 · see citing works
The value of a risk model for early-onset candidemia
Sandrock, C., & Siddiqui, J. (2009) · Critical Care · doi:10.1186/cc8127 · Cited by 3 · see citing works
Rashki, A., Ghalehnoo, Z. R., & Ghalehnoo, M. R. (2013) · Comparative Clinical Pathology · doi:10.1007/s00580-013-1713-9 · Cited by 2 · see citing works
The Impact of Antifungal Drug Resistance in the Clinic
Lewis, R. E., & Kontoyiannis, D. P. (2014) · ASM Press eBooks · doi:10.1128/9781555817176.ch23 · Cited by 2 · see citing works
Epidemiology of Bloodstream Infections
McMullen, A. R., Wilen, C. B., & Burnham, C. D. (2017) · doi:10.1128/9781555819811.ch9 · Cited by 2 · see citing works
Early-onset candidemia: An increasing problem?*
Corona, A., & Singer, M. (2009) · Critical Care Medicine · doi:10.1097/ccm.0b013e3181abf8e6 · Cited by 2 · see citing works
Invasive Candidiasis in the Intensive Care Unit
Krishnan, S., & Ostrosky‐Zeichner, L. (2010) · Hospital Practice · doi:10.3810/hp.2010.04.298 · Cited by 1 · see citing works
Analysis of fungal diversity in the feces of Arborophila rufipectus
Ma, X., Li, J., Li, Z., Chen, B., Ling, Z., Feng, S., Zhong, Z., Peng, G., Wang, Y., Jiang, Y., et al. (2024) · Frontiers in Veterinary Science · doi:10.3389/fvets.2024.1430518 · Cited by 1 · see citing works
Nucci, M., & Lyon, S. (2014) · Current Fungal Infection Reports · doi:10.1007/s12281-014-0173-2 · Cited by 1 · see citing works
Stride, P., Stare, M. R., Kelly, L., Horvath, R. L., Wood, T., & Alexander, C. (2012) · The Journal of the Royal College of Physicians of Edinburgh · doi:10.4997/jrcpe.2012.409 · Cited by 1 · see citing works
Fungal infections in Intensive Care Service of a specialized hospital Adults
Gill, G. (2016) · Revista del Nacional (Itaguá) · doi:10.18004/rdn2015.0007.02.007-014 · Cited by 1 · see citing works
Candida spp.: the burden of a microorganism in a microbiology department
Soriano-Martín, A., Alonso, R., Machado, M., Reigadas, E., Muñóz, P., & Bouza, E. (2024) · Microbiology Spectrum · doi:10.1128/spectrum.03860-23 · Cited by 1 · see citing works
Healthcare-Associated Candidemia: Is It a Distinct Syndrome?
Shorr, A. F., Chan, C. M., & Zilberberg, M. D. (2012) · Current Fungal Infection Reports · doi:10.1007/s12281-012-0095-9
Self-citationEconomics in medicine: a physician's perspective
Chen, C. (2017)
(2009) · Nursing Critical Care · doi:10.1097/01.ccn.0000363765.09249.72
Unmasking Candidiasis: A Mechanistic Model for Innate Immune-Fungal Cell Wall Dynamics
Hidu, E. E. (2012) · DigitalCommons (California Polytechnic State University)
- Authors
- Shorr, A. F., Gupta, V., Sun, X., Johannes, R. S., Spalding, J., & Tabak, Y. P.
- Affiliations
- Astellas Pharma (United States) (US)
- Cardinal Health (United States) (US)
- Venue
- Critical Care Medicine
- Published
- 2009-09
- Volume
- 37
- Issue
- 9
- Pages
- 2519-2526
- ISSN
- 0090-3493 (ISSN-L)
- OpenAlex
- W2008234991
- Semantic Scholar
- 1748ed52f44bbc0bc4bdfebdf5bcf331c6459bff
- Cited by
- 62
- References
- 26
- Citations by year
- 2025: 1 · 2024: 4 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 4 · 2017: 8 · 2016: 3 · 2015: 4 · 2014: 5 · 2013: 5 · 2012: 8
- FWCI
- 5.50
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Critical Care Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Cardinal Health
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Health Sciences › Medicine › Epidemiology › Infective Endocarditis Diagnosis and Management
- Health Sciences › Medicine › Ophthalmology › Ocular Infections and Treatments
- Keywords
- bloodstream infection, Candida, in-hospital mortality, length of hospital stay, hospital costs, bacterial bloodstream infection, acute care hospitals
- MeSH terms
- Aged, Aged, 80 and over, Candidiasis, Female, Hospitalization, Humans, Male, Middle Aged, Retrospective Studies, Time Factors, United States, Databases, Factual, Fungemia
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
