The DOI matches its Crossref record; 98 of the 98 references it cites were found in a registry or an index.
Energetics and Application of Heterotrophy in Acetogenic Bacteria
Open accessAbstract
Acetogenic bacteria are a diverse group of strictly anaerobic bacteria that utilize the Wood-Ljungdahl pathway for CO 2 fixation and energy conservation. These microorganisms play an important part in the global carbon cycle and are a key component of the anaerobic food web. Their most prominent metabolic feature is autotrophic growth with molecular hydrogen and carbon dioxide as the substrates. However, most members also show an outstanding metabolic flexibility for utilizing a vast variety of different substrates. In contrast to autotrophic growth, which is hardly competitive, metabolic flexibility is seen as a key ability of acetogens to compete in ecosystems and might explain the almost-ubiquitous distribution of acetogenic bacteria in anoxic environments. This review covers the latest findings with respect to the heterotrophic metabolism of acetogenic bacteria, including utilization of carbohydrates, lactate, and different alcohols, especially in the model acetogen Acetobacterium woodii. Modularity of metabolism, a key concept of pathway design in synthetic biology, together with electron bifurcation, to overcome energetic barriers, appears to be the basis for the amazing substrate spectrum. At the same time, acetogens depend on only a relatively small number of enzymes to expand the substrate spectrum. We will discuss the energetic advantages of coupling CO 2 reduction to fermentations that exploit otherwise-inaccessible substrates and the ecological advantages, as well as the biotechnological applications of the heterotrophic metabolism of acetogens.
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Cites
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Cited by
Wainaina, S., Lukitawesa, Kumar Awasthi, M., & Taherzadeh, M. J. (2019) · Bioengineered · doi:10.1080/21655979.2019.1673937 · Cited by 555
RetractedIntegrative modeling of gene and genome evolution roots the archaeal tree of life
Williams, T. A., Szöllősi, G. J., Spang, A., Foster, P. G., Heaps, S. E., Boussau, B., Ettema, T. J. G., & Embley, T. M. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1618463114 · Cited by 233
Spang, A., Stairs, C. W., Dombrowski, N., Eme, L., Lombard, J., Caceres, E. F., Greening, C., Baker, B. J., & Ettema, T. J. G. (2019) · Nature Microbiology · doi:10.1038/s41564-019-0406-9 · Cited by 200
New Horizons in Acetogenic Conversion of One-Carbon Substrates and Biological Hydrogen Storage
Müller, V. (2019) · Trends in Biotechnology · doi:10.1016/j.tibtech.2019.05.008 · Cited by 135
Self-citationDeconstructing Methanosarcina acetivorans into an acetogenic archaeon
Schöne, C., Poehlein, A., Jehmlich, N., Adlung, N., Daniel, R., von Bergen, M., Scheller, S., & Rother, M. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2113853119 · Cited by 51
Metadata
- Authors
- Schuchmann, K., & Müller, V.
- Venue
- Applied and Environmental Microbiology
- Publisher
- American Society for Microbiology
- Published
- 2016-07-15
- Volume
- 82
- Issue
- 14
- Pages
- 4056-4069
- ISSN
- 0099-2240 (ISSN-L)
- 1098-5336
- OpenAlex
- W2384560189
- Cited by
- 285
- References
- 98
- FWCI
- 7.22
- Type
- journal article
- Language
- en
- Open access
- green
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