The DOI matches its Crossref record; 55 of the 55 references it cites were found in a registry or an index.
The human Lactobacillus acidophilus strain LA1 secretes a nonbacteriocin antibacterial substance(s) active in vitro and in vivo
Open accessAbstract
The adhering human Lactobacillus acidophilus strain LA1 inhibits the cell association and cell invasion of enteropathogens in cultured human intestinal Caco-2 cells (M. F. Bernet, D. Brassard, J. R. Neeser, and A. L. Servin, Gut 35:483-489, 1994). Here, we demonstrate that strain LA1 developed its antibacterial activity in conventional or germ-free mouse models orally infected by Salmonella typhimurium. We present evidence that the spent culture supernatant of strain LA1 (LA1-SCS) contained antibacterial components active against S. typhimurium infecting the cultured human intestinal Caco-2 cells. The LA1-SCS antibacterial activity was observed in vitro against a wide range of gram-negative and gram-positive pathogens, such as Staphylococcus aureus, Listeria monocytogenes, S. typhimurium, Shigella flexneri, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Enterobacter cloacae. By contrast, no activity was observed against species of the normal gut flora, such as lactobacilli and bifidobacteria. The LA1-SCS antibacterial activity was insensitive to proteases and independent of lactic acid production.
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Cites
Bacteriocins of gram-positive bacteria
Jack, R. W., Tagg, J. R., & Ray, B. (1995) · Microbiological Reviews · doi:10.1128/mr.59.2.171-200.1995 · Cited by 2,711
Genetics of bacteriocins produced by lactic acid bacteria
Klaenhammer, T. (1993) · FEMS Microbiology Reviews · doi:10.1016/0168-6445(93)90057-g · Cited by 2,029
Pinto, M. (1983) · HAL · Cited by 1,752
One Hundred and Twenty-Seven Cultured Human Tumor Cell Lines Producing Tumors in Nude Mice23
Fogh, J., Fogh, J. M., & Orfeo, T. (1977) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/59.1.221 · Cited by 1,599
Isberg, R. R., & Leong, J. M. (1990) · Cell · doi:10.1016/0092-8674(90)90099-z · Cited by 798
Bernet, M. F., Brassart, D., Neeser, J. R., & Servin, A. L. (1994) · Gut · doi:10.1136/gut.35.4.483 · Cited by 751
Self-citationKaila, M., Isolauri, E., Soppi, E., Virtanen, E., Laine, S., & Arvilommi, H. (1992) · Pediatric Research · doi:10.1203/00006450-199208000-00002 · Cited by 700
Isolauri, E., Juntunen, M., Rautanen, T., Sillanaukee, P., & Koivula, T. (1991) · PubMed · Cited by 684
Ultrasensitive assays for endogenous antimicrobial polypeptides
Lehrer, R. I., Rosenman, M., Harwig, S. S. S. L., Jackson, R., & Eisenhauer, P. (1991) · Journal of Immunological Methods · doi:10.1016/0022-1759(91)90021-7 · Cited by 671
Antimicrobial substance from a human Lactobacillus strain
Silva, M., Jacobus, N. V., Deneke, C., & Gorbach, S. L. (1987) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.31.8.1231 · Cited by 558
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Probiotic bacteria: safety, functional and technological properties
Saarela, M., Mogensen, G., Fondén, R., Mättö, J., & Mattila-Sandholm, T. (2000) · Journal of Biotechnology · doi:10.1016/s0168-1656(00)00375-8 · Cited by 1,202
Probiotic potential of Lactobacillus strains isolated from dairy products
Maragkoudakis, P. A., Zoumpopoulou, G., Miaris, C., Kalantzopoulos, G., Pot, B., & Tsakalidou, E. (2006) · International Dairy Journal · doi:10.1016/j.idairyj.2005.02.009 · Cited by 618
Lactic acid bacteria as starter cultures: An update in their metabolism and genetics
Bintsis, T., & Department of Agricultural Technology, T. O. W. M. (2018) · AIMS Microbiology · doi:10.3934/microbiol.2018.4.665 · Cited by 570
Liévin-Le Moal, V., & Servin, A. L. (2006) · Clinical Microbiology Reviews · doi:10.1128/cmr.19.2.315-337.2006 · Cited by 568
Self-citationGranato, D., Bergonzelli, G. E., Pridmore, R. D., Marvin, L., Rouvet, M., & Corthésy-Theulaz, I. E. (2004) · Infection and Immunity · doi:10.1128/iai.72.4.2160-2169.2004 · Cited by 410
Metadata
- Authors
- Bernet-Camard, M. F., Liévin, V, Brassart, D., Neeser, J. R., Servin, A. L., & Hudault, S.
- Venue
- Applied and Environmental Microbiology
- Publisher
- American Society for Microbiology
- Published
- 1997-07
- Volume
- 63
- Issue
- 7
- Pages
- 2747-2753
- ISSN
- 0099-2240 (ISSN-L)
- 1098-5336
- OpenAlex
- W1952460190
- Cited by
- 306
- References
- 55
- FWCI
- 19.08
- Type
- journal article
- Language
- en
- Open access
- green
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- Bernet-Camard, M. F., Liévin, V, Brassart, D., Neeser, J. R., Servin, A. L., & Hudault, S. (1997). The human Lactobacillus acidophilus strain LA1 secretes a nonbacteriocin antibacterial substance(s) active in vitro and in vivo. Applied and Environmental Microbiology. https://doi.org/10.1128/aem.63.7.2747-2753.1997
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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