Cited by 144Bacterial biofilms and quorum sensingOral microbiology and periodontitis researchBacterial Genetics and Biotechnology

Interactions between Oral Bacteria: Inhibition of Streptococcus mutans Bacteriocin Production by Streptococcus gordonii

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Wang, Bing-Yan, Kuramitsu, Howard K.·2005·Applied and Environmental Microbiology

Abstract

Streptococcus mutans has been recognized as an important etiological agent in human dental caries. Some strains of S. mutans also produce bacteriocins. In this study, we sought to demonstrate that bacteriocin production by S. mutans strains GS5 and BM71 was mediated by quorum sensing, which is dependent on a competence-stimulating peptide (CSP) signaling system encoded by the com genes. We also demonstrated that interactions with some other oral streptococci interfered with S. mutans bacteriocin production both in broth and in biofilms. The inhibition of S. mutans bacteriocin production by oral bacteria was stronger in biofilms than in broth. Using transposon Tn 916 mutagenesis, we identified a gene ( sgc ; named for Streptococcus gordonii challisin) responsible for the inhibition of S. mutans bacteriocin production by S. gordonii Challis. Interruption of the sgc gene in S. gordonii Challis resulted in attenuated inhibition of S. mutans bacteriocin production. The supernatant fluids from the sgc mutant did not inactivate the exogenous S. mutans CSP as did those from the parent strain Challis. S. gordonii Challis did not inactivate bacteriocin produced by S. mutans GS5. Because S. mutans uses quorum sensing to regulate virulence, strategies designed to interfere with these signaling systems may have broad applicability for biological control of this caries-causing organism.

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Crossref · 10.1128/aem.71.1.354-362.2005

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  • The S. gordonii serine protease Challisin can interfere with S. mutans cell-cell communication by degrading competence-stimulating peptide.

    “the S. gordonii serine protease Challisin can interfere with S. mutans cell-cell communication by degrading competence-stimulating peptide263”

    From The dental plaque biofilm matrix (2021) · cites this paper as [263]

  • The protease termed challisin was first discovered in a certain S gordonii strain and was thought to be specific to this organism.

    “This protease, termed challisin, was first discovered in a certain S gordonii strain and was thought to be specific to this organism.”

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Authors
Wang, B.-Y., & Kuramitsu, H. K.
Affiliations
  • Department of Oral Biology, State University of New York, Buffalo, New York
  • University at Buffalo, State University of New York (US)
Venue
Applied and Environmental Microbiology
Published
2005-01
Volume
71
Issue
1
Pages
354-362
ISSN
  • 0099-2240 (ISSN-L)
  • 1098-5336
OpenAlex
W2128381319
Cited by
144
References
34
Citations by year
2026: 6 · 2025: 7 · 2024: 7 · 2023: 5 · 2022: 7 · 2021: 8 · 2020: 7 · 2019: 7 · 2018: 8 · 2017: 5 · 2016: 5 · 2015: 7 · 2014: 8 · 2013: 3 · 2012: 6
FWCI
2.14
Type
journal article
Language
en
Open access
Locations
  • Applied and Environmental Microbiology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Dental and Craniofacial Research (T32‐DE07034, R01DE003258, DE 03258, T32DE007034)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
  • Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Keywords
Streptococcus mutans, Streptococcus gordonii, bacteriocin production, quorum sensing, competence-stimulating peptide, oral streptococci, bacterial interactions, dental plaque, dental caries
MeSH terms
Antibiosis, Bacterial Proteins, Bacteriocins, Culture Media, Humans, Mouth, Mutation, Peptide Hydrolases, Protein Precursors, Streptococcus, Streptococcus mutans, Signal Transduction, Gene Expression Regulation, Bacterial, Biofilms, Protein Sorting Signals

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