Interactions between Oral Bacteria: Inhibition of Streptococcus mutans Bacteriocin Production by Streptococcus gordonii
Open accessAbstract
Streptococcus mutans has been recognized as an important etiological agent in human dental caries. Some strains of S. mutans also produce bacteriocins. In this study, we sought to demonstrate that bacteriocin production by S. mutans strains GS5 and BM71 was mediated by quorum sensing, which is dependent on a competence-stimulating peptide (CSP) signaling system encoded by the com genes. We also demonstrated that interactions with some other oral streptococci interfered with S. mutans bacteriocin production both in broth and in biofilms. The inhibition of S. mutans bacteriocin production by oral bacteria was stronger in biofilms than in broth. Using transposon Tn 916 mutagenesis, we identified a gene ( sgc ; named for Streptococcus gordonii challisin) responsible for the inhibition of S. mutans bacteriocin production by S. gordonii Challis. Interruption of the sgc gene in S. gordonii Challis resulted in attenuated inhibition of S. mutans bacteriocin production. The supernatant fluids from the sgc mutant did not inactivate the exogenous S. mutans CSP as did those from the parent strain Challis. S. gordonii Challis did not inactivate bacteriocin produced by S. mutans GS5. Because S. mutans uses quorum sensing to regulate virulence, strategies designed to interfere with these signaling systems may have broad applicability for biological control of this caries-causing organism.
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The S. gordonii serine protease Challisin can interfere with S. mutans cell-cell communication by degrading competence-stimulating peptide.
“the S. gordonii serine protease Challisin can interfere with S. mutans cell-cell communication by degrading competence-stimulating peptide263”
From The dental plaque biofilm matrix (2021) · cites this paper as [263]
The protease termed challisin was first discovered in a certain S gordonii strain and was thought to be specific to this organism.
“This protease, termed challisin, was first discovered in a certain S gordonii strain and was thought to be specific to this organism.”
From The oral microbiome: Role of key organisms and complex networks in oral health and disease (2021) · cites this paper as [317]
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Cites
Bacteriocins of gram-positive bacteria
Jack, R. W., Tagg, J. R., & Ray, B. (1995) · Microbiological Reviews · doi:10.1128/mr.59.2.171-200.1995 · Cited by 2,711 · see citing works
How bacteria talk to each other: regulation of gene expression by quorum sensing
Bassler, B. L. (1999) · Current Opinion in Microbiology · doi:10.1016/s1369-5274(99)00025-9 · Cited by 1,034 · see citing works
Dong, Y.-H., Xu, J., Li, X., & Zhang, L. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.7.3526 · Cited by 803 · see citing works
Kleerebezem, M., Quadri, L. E. N., Kuipers, O. P., & de Vos, W. M. (1997) · Molecular Microbiology · doi:10.1046/j.1365-2958.1997.4251782.x · Cited by 791 · see citing works
Dong, Y. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.060023897 · Cited by 783 · see citing works
Håvarstein, L. S., Coomaraswamy, G., & Morrison, D. A. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.24.11140 · Cited by 737 · see citing works
Natural Genetic Transformation of Streptococcus mutans Growing in Biofilms
Li, Y.-H., Lau, P. C. Y., Lee, J. H., Ellen, R. P., & Cvitkovitch, D. G. (2001) · Journal of Bacteriology · doi:10.1128/jb.183.3.897-908.2001 · Cited by 526 · see citing works
Li, Y.-H., Tang, N., Aspiras, M., Lau, P. C. Y., Lee, J. H., Ellen, R. P., & Cvitkovitch, D. G. (2002) · Journal of Bacteriology · doi:10.1128/jb.184.10.2699-2708.2002 · Cited by 480 · see citing works
Bacteriocins of gram-positive bacteria
Tagg, J. R., Dajani, A. S., & Wannamaker, L. W. (1976) · Bacteriological Reviews · doi:10.1128/br.40.3.722-756.1976 · Cited by 480 · see citing works
CELL-CELL COMMUNICATION IN GRAM-POSITIVE BACTERIA
Dunny, G. M., & Buttaro, B. A. (1997) · Annual Review of Microbiology · doi:10.1146/annurev.micro.51.1.527 · Cited by 454 · see citing works
Quorum sensing and biofilm formation in Streptococcal infections
Cvitkovitch, D. G., Li, Y.-H., & Ellen, R. P. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200320430 · Cited by 358 · see citing works
Self perception in bacteria: quorum sensing with acylated homoserine lactones
Fuqua, C., & Greenberg, E. P. (1998) · Current Opinion in Microbiology · doi:10.1016/s1369-5274(98)80009-x · Cited by 302 · see citing works
FUNCTIONS OF SECONDARY METABOLITES
Vining, L. C. (1990) · Annual Review of Microbiology · doi:10.1146/annurev.mi.44.100190.002143 · Cited by 291 · see citing works
Quorum sensing and biofilm formation in Streptococcal infections
Cvitkovitch, D. G., Li, Y.-H., & Ellen, R. P. (2003) · Journal of Clinical Investigation · doi:10.1172/jci20430 · Cited by 289 · see citing works
Cloning of a Streptococcus mutans glucosyltransferase gene coding for insoluble glucan synthesis
Aoki, H., Shiroza, T., Hayakawa, M., Sato, S., & Kuramitsu, H. K. (1986) · Infection and Immunity · doi:10.1128/iai.53.3.587-594.1986 · Cited by 273 · see citing works
Self-citationLi, Y.-H., Hanna, M. N., Svensäter, G., Ellen, R. P., & Cvitkovitch, D. G. (2001) · Journal of Bacteriology · doi:10.1128/jb.183.23.6875-6884.2001 · Cited by 239 · see citing works
Li, Y.-H., Lau, P. C. Y., Tang, N., Svensäter, G., Ellen, R. P., & Cvitkovitch, D. G. (2002) · Journal of Bacteriology · doi:10.1128/jb.184.22.6333-6342.2002 · Cited by 211 · see citing works
Qi, F., Chen, P., & Caufield, P. W. (2001) · Applied and Environmental Microbiology · doi:10.1128/aem.67.1.15-21.2001 · Cited by 204 · see citing works
Kleerebezem, M., & Quadri, L. E. N. (2001) · Peptides · doi:10.1016/s0196-9781(01)00493-4 · Cited by 202 · see citing works
Pheromone Cross-Inhibition between Staphylococcus aureus and Staphylococcus epidermidis
Otto, M. J., Echner, H., Voelter, W., & Götz, F. (2001) · Infection and Immunity · doi:10.1128/iai.69.3.1957-1960.2001 · Cited by 202 · see citing works
Multiple Streptococcus mutans Genes Are Involved in Biofilm Formation
Yoshida, A., & Kuramitsu, H. K. (2002) · Applied and Environmental Microbiology · doi:10.1128/aem.68.12.6283-6291.2002 · Cited by 194 · see citing works
Self-citationSequence analysis of the gtfC gene from Streptococcus mutans GS-5
Ueda, S., Shiroza, T., & Kuramitsu, H. K. (1988) · Gene · doi:10.1016/0378-1119(88)90382-4 · Cited by 156 · see citing works
Self-citationSequence analysis of the Streptococcus mutans fructosyltransferase gene and flanking regions
Shiroza, T., & Kuramitsu, H. K. (1988) · Journal of Bacteriology · doi:10.1128/jb.170.2.810-816.1988 · Cited by 120 · see citing works
Self-citationQi, F., Chen, P., & Caufield, P. W. (1999) · Applied and Environmental Microbiology · doi:10.1128/aem.65.9.3880-3887.1999 · Cited by 117 · see citing works
Streptococcal Competence for Genetic Transformation: Regulation by Peptide Pheromones
Morrison, D. A. (1997) · Microbial Drug Resistance · doi:10.1089/mdr.1997.3.27 · Cited by 80 · see citing works
Chen, P., Qi, F., Novák, J., & Caufield, P. W. (1999) · Applied and Environmental Microbiology · doi:10.1128/aem.65.3.1356-1360.1999 · Cited by 64 · see citing works
Paul, D., & Slade, H. D. (1975) · Infection and Immunity · doi:10.1128/iai.12.6.1375-1385.1975 · Cited by 52 · see citing works
Ueda, S., & Kuramitsu, H. K. (1988) · Molecular Microbiology · doi:10.1111/j.1365-2958.1988.tb00014.x · Cited by 51 · see citing works
Self-citationBacteriocins as Factors in the In Vitro Interaction Between Oral Streptococci in Plaque
Weerkamp, A. H., Bongaerts-Larik, L., & Vogels, G. D. (1977) · Infection and Immunity · doi:10.1128/iai.16.3.773-780.1977 · Cited by 47 · see citing works
Effect of the Medium on Bacteriocin Production Among Strains of Streptococcus mutans
Rogers, A. H. (1972) · Applied Microbiology · doi:10.1128/am.24.2.294-295.1972 · Cited by 46 · see citing works
Harris, G. S., Michalek, S. M., & Curtiss, R. (1992) · Infection and Immunity · doi:10.1128/iai.60.8.3175-3185.1992 · Cited by 37 · see citing works
Genetic Exchange Between Oral Streptococci During Mixed Growth
Kuramitsu, H. K., & Trapa, V. (1984) · Microbiology · doi:10.1099/00221287-130-10-2497 · Cited by 34 · see citing works
Self-citationSojar, H. T., Lee, J. Y., Bedi, G. S., & Genco, R. J. (1993) · Infection and Immunity · doi:10.1128/iai.61.6.2369-2376.1993 · Cited by 30 · see citing works
Production of bacteriocin-like substances by human oral streptococci.
Fabio, U., Bondi, M., Manicardi, G. C., Messi, P., & Neglia, R. G. (1987) · PubMed · Cited by 25 · see citing works
Plasmid-mediated transformation of Streptococcus mutans
Kuramitsu, H. K., & Long, C.-F. (1982) · Infection and Immunity · doi:10.1128/iai.36.1.435-436.1982 · Cited by 11 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Bacterial competition: surviving and thriving in the microbial jungle
Hibbing, M. E., Fuqua, C., Parsek, M. R., & Peterson, S. B. (2009) · Nature Reviews Microbiology · doi:10.1038/nrmicro2259 · Cited by 2,658 · see citing works
Bacteriocins: Developing innate immunity for food
Cotter, P. D., Hill, C., & Ross, R. P. (2005) · Nature Reviews Microbiology · doi:10.1038/nrmicro1273 · Cited by 2,380 · see citing works
Oral multispecies biofilm development and the key role of cell–cell distance
Kolenbrander, P. E., Palmer, R. J., Periasamy, S., & Jakubovics, N. S. (2010) · Nature Reviews Microbiology · doi:10.1038/nrmicro2381 · Cited by 1,309 · see citing works
The oral microbiome: Role of key organisms and complex networks in oral health and disease
Sedghi, L., DiMassa, V., Harrington, A., Lynch, S. V., & Kapila, Y. L. (2021) · Periodontology 2000 · doi:10.1111/prd.12393 · Cited by 755 · see citing works
Biosynthesis and Mode of Action of Lantibiotics
Chatterjee, C., Paul, M., Xie, L., & van der Donk, W. A. (2005) · Chemical Reviews · doi:10.1021/cr030105v · Cited by 727 · see citing works
<i>Streptococcus</i> Adherence and Colonization
Nobbs, A. H., Lamont, R. J., & Jenkinson, H. F. (2009) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00014-09 · Cited by 657 · see citing works
Lantibiotics: Peptides of Diverse Structure and Function
Willey, J. M., & van der Donk, W. A. (2007) · Annual Review of Microbiology · doi:10.1146/annurev.micro.61.080706.093501 · Cited by 621 · see citing works
Interspecies Interactions within Oral Microbial Communities
Kuramitsu, H. K., He, X., Lux, R., Anderson, M. H., & Shi, W. (2007) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00024-07 · Cited by 595 · see citing works
Self-citationEcology and evolution of metabolic cross-feeding interactions in bacteria
D’Souza, G. G., Shitut, S., Preußger, D., Yousif, G., Waschina, S., & Kost, C. (2018) · Natural Product Reports · doi:10.1039/c8np00009c · Cited by 556 · see citing works
Abranches, J., Zeng, L., Kajfasz, J. K., Palmer, S. R., Chakraborty, B., Wen, Z. T., Richards, V. P., Brady, L. J., & Lemos, J. A. C. (2018) · Microbiology Spectrum · doi:10.1128/microbiolspec.gpp3-0042-2018 · Cited by 558 · see citing works
Gross, E. L., Beall, C. J., Kutsch, S. R., Firestone, N. D., Leys, E. J., & Griffen, A. L. (2012) · PLoS ONE · doi:10.1371/journal.pone.0047722 · Cited by 508 · see citing works
The dental plaque biofilm matrix
Jakubovics, N. S., Goodman, S. D., Mashburn‐Warren, L., Stafford, G. P., & Cieplik, F. (2021) · Periodontology 2000 · doi:10.1111/prd.12361 · Cited by 488 · see citing works
Bacterial 16S Sequence Analysis of Severe Caries in Young Permanent Teeth
Gross, E. L., Leys, E. J., Gasparovich, S. R., Firestone, N. D., Schwartzbaum, J., Janies, D. A., Asnani, K. M., & Griffen, A. L. (2010) · Journal of Clinical Microbiology · doi:10.1128/jcm.01232-10 · Cited by 351 · see citing works
Ren, D., Madsen, J. S., Sørensen, S. J., & Burmølle, M. (2014) · The ISME Journal · doi:10.1038/ismej.2014.96 · Cited by 334 · see citing works
The Genotypic View of Social Interactions in Microbial Communities
Mitri, S., & Foster, K. R. (2013) · Annual Review of Genetics · doi:10.1146/annurev-genet-111212-133307 · Cited by 291 · see citing works
Di Stefano, M., Polizzi, A., Santonocito, S., Romano, A., Lombardi, T., & Isola, G. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23095142 · Cited by 292 · see citing works
Bacterial and Host Interactions of Oral Streptococci
Kreth, J., Merritt, J. L., & Qi, F. (2009) · DNA and Cell Biology · doi:10.1089/dna.2009.0868 · Cited by 241 · see citing works
van der Ploeg, J. R. (2005) · Journal of Bacteriology · doi:10.1128/jb.187.12.3980-3989.2005 · Cited by 237 · see citing works
Streptococcus Sanguinis Biofilm Formation & Interaction with Oral Pathogens
Zhu, B., Macleod, L. C., Kitten, T. O., & Xu, P. (2018) · Future Microbiology · doi:10.2217/fmb-2018-0043 · Cited by 228 · see citing works
Bacterial interactions in biofilms
Moons, P., Michiels, C. W., & Aertsen, A. (2009) · Critical Reviews in Microbiology · doi:10.1080/10408410902809431 · Cited by 210 · see citing works
Correlations of oral bacterial arginine and urea catabolism with caries experience
Nascimento, M. M., Gordan, V. V., Garvan, C. W., Browngardt, C. M., & Burne, R. A. (2009) · Oral Microbiology and Immunology · doi:10.1111/j.1399-302x.2008.00477.x · Cited by 196 · see citing works
Microbial interactions in building of communities
Wright, C. J., Burns, L. H., Jack, A. A., Back, C. R., Dutton, L. C., Nobbs, A. H., Lamont, R. J., & Jenkinson, H. F. (2013) · Molecular Oral Microbiology · doi:10.1111/omi.12012 · Cited by 185 · see citing works
Bacteriocins : ecology and evolution
Riley, M. A., & Chavan, M. A. (2007) · doi:10.1007/978-3-540-36604-1 · Cited by 137 · see citing works
A Highly Arginolytic Streptococcus Species That Potently Antagonizes Streptococcus mutans
Huang, X., Palmer, S. R., Ahn, S.-J., Richards, V. P., Williams, M. L., Nascimento, M. M., & Burne, R. A. (2016) · Applied and Environmental Microbiology · doi:10.1128/aem.03887-15 · Cited by 127 · see citing works
Competence in Streptococcus pneumoniae and Close Commensal Relatives: Mechanisms and Implications
Salvadori, G., Junges, R., Morrison, D. A., & Petersen, F. C. (2019) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2019.00094 · Cited by 118 · see citing works
Community Interactions of Oral Streptococci
Jakubovics, N. S., Yassin, S. A., & Rickard, A. H. (2014) · Advances in Applied Microbiology · doi:10.1016/b978-0-12-800261-2.00002-5 · Cited by 107 · see citing works
Antimicrobial effects of commensal oral species are regulated by environmental factors
Herrero, E. R., Slomka, V., Bernaerts, K., Boon, N., Hernandez‐Sanabria, E., Passoni, B. B., Quirynen, M., & Teughels, W. (2016) · Journal of Dentistry · doi:10.1016/j.jdent.2016.02.007 · Cited by 105 · see citing works
He, J., Kim, D., Zhou, X., Ahn, S., Burne, R. A., Richards, V. P., & Koo, H. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.01036 · Cited by 100 · see citing works
Association between the gut and oral microbiome with obesity
Benahmed, A. G., Gasmi, A., Doşa, A., Chirumbolo, S., Mujawdiya, P. K., Aaseth, J., Dadar, M., & Bjørklund, G. (2020) · Anaerobe · doi:10.1016/j.anaerobe.2020.102248 · Cited by 102 · see citing works
Cariogenic microbiome and microbiota of the early primary dentition: A contemporary overview
Fakhruddin, K. S., Ngo, H. C., & Samaranayake, L. P. (2018) · Oral Diseases · doi:10.1111/odi.12932 · Cited by 95 · see citing works
Hossain, M. S., & Biswas, I. (2012) · Journal of Bacteriology · doi:10.1128/jb.01381-12 · Cited by 93 · see citing works
Inhibition of Streptococcus mutans Biofilm Formation by Streptococcus salivarius FruA
Ogawa, A., Furukawa, S., Fujita, S., Mitobe, J., Kawarai, T., Narisawa, N., Sekizuka, T., Kuroda, M., Ochiai, K., Ogihara, H., et al. (2011) · Applied and Environmental Microbiology · doi:10.1128/aem.02066-10 · Cited by 85 · see citing works
The road less traveled – defining molecular commensalism with Streptococcus sanguinis
Kreth, J., Giacaman, R. A., Raghavan, R., & Merritt, J. L. (2016) · Molecular Oral Microbiology · doi:10.1111/omi.12170 · Cited by 83 · see citing works
Interspecies Communication among Commensal and Pathogenic Streptococci
Cook, L. C., LaSarre, B., & Federle, M. J. (2013) · mBio · doi:10.1128/mbio.00382-13 · Cited by 81 · see citing works
TAMURA, S., Yonezawa, H., Motegi, M., Nakao, R., Yoneda, S., Watanabe, H., Yamazaki, T., & Senpuku, H. (2009) · Oral Microbiology and Immunology · doi:10.1111/j.1399-302x.2008.00489.x · Cited by 78 · see citing works
Intercellular communications in multispecies oral microbial communities
Guo, L., He, X., & Shi, W. (2014) · Frontiers in Microbiology · doi:10.3389/fmicb.2014.00328 · Cited by 77 · see citing works
Effects of Arginine on Streptococcus mutans Growth, Virulence Gene Expression, and Stress Tolerance
Chakraborty, B., & Burne, R. A. (2017) · Applied and Environmental Microbiology · doi:10.1128/aem.00496-17 · Cited by 76 · see citing works
Streptococcus mutans et les streptocoques buccaux dans la plaque dentaire
Nicolas, G. G., & Lavoie, M. C. (2011) · Canadian Journal of Microbiology · doi:10.1139/w10-095 · Cited by 74 · see citing works
Identification of a signalling molecule involved in bacterial intergeneric communication
Xie, H., Lin, X., Wang, B.-Y., Wu, J., & Lamont, R. J. (2007) · Microbiology · doi:10.1099/mic.0.2007/009050-0 · Cited by 73 · see citing works
Self-citationTalk of the town: interspecies communication in oral biofilms
Jakubovics, N. S. (2010) · Molecular Oral Microbiology · doi:10.1111/j.2041-1014.2009.00563.x · Cited by 72 · see citing works
Studying bacterial infections through culture-independent approaches
Rogers, G. B., Carroll, M. P., & Bruce, K. D. (2009) · Journal of Medical Microbiology · doi:10.1099/jmm.0.013334-0 · Cited by 72 · see citing works
Differential response of Streptococcus mutans towards friend and foe in mixed-species cultures
Liu, J., Wu, C., Huang, I., Merritt, J. L., & Qi, F. (2011) · Microbiology · doi:10.1099/mic.0.048314-0 · Cited by 69 · see citing works
Antibiotic discovery through microbial interactions
Zhang, C., & Straight, P. D. (2019) · Current Opinion in Microbiology · doi:10.1016/j.mib.2019.06.006 · Cited by 57 · see citing works
Dziedzic, A. M., Wojtyczka, R. D., & Kubina, R. (2015) · Molecules · doi:10.3390/molecules200813705 · Cited by 56 · see citing works
Competence-Dependent Bacteriocin Production by Streptococcus gordonii DL1 (Challis)
Heng, N. C. K., Tagg, J. R., & Tompkins, G. R. (2007) · Journal of Bacteriology · doi:10.1128/jb.01174-06 · Cited by 52 · see citing works
Identification of novel LPXTG-linked surface proteins from Streptococcus gordonii
Davies, J. R., Svensäter, G., & Herzberg, M. C. (2009) · Microbiology · doi:10.1099/mic.0.027854-0 · Cited by 50 · see citing works
Li, C., Kurniyati, Hu, B., Bian, J., Sun, J., Zhang, W., Liu, J., Pan, Y., & Li, C. (2011) · Infection and Immunity · doi:10.1128/iai.05773-11 · Cited by 49 · see citing works
Liu, Y., & Burne, R. A. (2011) · Journal of Bacteriology · doi:10.1128/jb.00056-11 · Cited by 49 · see citing works
Virulence properties of cariogenic bacteria
Kuramitsu, H. K., & Wang, B. (2006) · BMC Oral Health · doi:10.1186/1472-6831-6-s1-s11 · Cited by 44 · see citing works
Self-citationEnhancing the utility of existing antibiotics by targeting bacterial behaviour?
Rogers, G. B., Carroll, M. P., & Bruce, K. D. (2012) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01643.x · Cited by 42 · see citing works
Stefano, M. D., Santonocito, S., Polizzi, A., Mauceri, R., Troiano, G., Giudice, A. L., Romano, A., Mascitti, M., & Isola, G. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24021084 · Cited by 44 · see citing works
Role of VltAB, an ABC Transporter Complex, in Viologen Tolerance in Streptococcus mutans
Biswas, S., & Biswas, I. (2011) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01094-10 · Cited by 39 · see citing works
Cai, J.-N., & Kim, D. (2023) · Advances in applied microbiology · doi:10.1016/bs.aambs.2023.02.001 · Cited by 41 · see citing works
Chen, L., Chakraborty, B., Zou, J., Burne, R. A., & Zeng, L. (2019) · Applied and Environmental Microbiology · doi:10.1128/aem.00370-19 · Cited by 37 · see citing works
Proteases of an Early Colonizer Can Hinder Streptococcus mutans Colonization in vitro
Wang, B.-Y., Deutch, A., Hong, J., & Kuramitsu, H. K. (2010) · Journal of Dental Research · doi:10.1177/0022034510388808 · Cited by 36 · see citing works
Self-citationMicrobial cell surface proteins and secreted metabolites involved in multispecies biofilms.
Demuyser, L., Jabra-Rizk, M., & van Dijck, P. (2014) · Pathogens and Disease · doi:10.1111/2049-632x.12123 · Cited by 37 · see citing works
Engineering chemical interactions in microbial communities
Kenny, D. J., & Balskus, E. P. (2017) · Chemical Society Reviews · doi:10.1039/c7cs00664k · Cited by 37 · see citing works
Guardian genes ensuring subsistence of oral Streptococcus mutans
Shanmugam, K., Sarveswari, H. B., Udayashankar, A., Swamy, S. S., Pudipeddi, A., Shanmugam, T., Solomon, A. P., & Neelakantan, P. (2020) · Critical Reviews in Microbiology · doi:10.1080/1040841x.2020.1796579 · Cited by 35 · see citing works
Lee, K., Walker, A. R., Chakraborty, B., Kaspar, J. R., Nascimento, M. M., & Burne, R. A. (2019) · Applied and Environmental Microbiology · doi:10.1128/aem.01335-19 · Cited by 31 · see citing works
Kaspar, J. R., Lee, K., Richard, B., Walker, A. R., & Burne, R. A. (2020) · The ISME Journal · doi:10.1038/s41396-020-00789-7 · Cited by 31 · see citing works
Widyarman, A. S., Udawatte, N. S., Theodorea, C. F., Apriani, A., Richi, M., Astoeti, T. E., & Seneviratne, C. J. (2021) · Journal of Dentistry · doi:10.1016/j.jdent.2021.103582 · Cited by 31 · see citing works
Kuramitsu, H. K., & Wang, B. (2011) · PubMed · Cited by 31 · see citing works
Self-citationGetting to Know “The Known Unknowns”: Heterogeneity in the Oral Microbiome
Burne, R. A. (2018) · Advances in Dental Research · doi:10.1177/0022034517735293 · Cited by 30 · see citing works
The rest of the story: the microbiome and gastrointestinal infections
Leslie, J. L., & Young, V. B. (2014) · Current Opinion in Microbiology · doi:10.1016/j.mib.2014.11.010 · Cited by 30 · see citing works
Abranches, J., Zeng, L., Kajfasz, J. K., Palmer, S. R., Chakraborty, B., Wen, Z. T., Richards, V. P., Brady, L. J., & Lemos, J. A. C. (2019) · ASM Press eBooks · doi:10.1128/9781683670131.ch26 · Cited by 27 · see citing works
Anticariogenic potentials of clove, tobacco and bitter kola
Dibua, E. U., & Nnamani, P. O. (2011) · Asian Pacific Journal of Tropical Medicine · doi:10.1016/s1995-7645(11)60200-9 · Cited by 24 · see citing works
Cui, G., Li, P., Wu, R., & Lin, H. (2022) · AMB Express · doi:10.1186/s13568-022-01499-3 · Cited by 24 · see citing works
Drobni, M., Li, T., Krüger, C., Loimaranta, V., Kilian, M., Hammarström, L. L. G., Jörnvall, H., Bergman, T., & Strömberg, N. (2006) · Infection and Immunity · doi:10.1128/iai.00068-06 · Cited by 24 · see citing works
Zhu, L., & Kreth, J. (2010) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2010.03.012 · Cited by 23 · see citing works
Tian, X., Syvitski, R. T., Liu, T., Livingstone, N., Jakeman, D. L., & Li, Y.-H. (2009) · Biological Procedures Online · doi:10.1007/s12575-009-9009-9 · Cited by 22 · see citing works
van der Ploeg, J. R. (2008) · Microbiology · doi:10.1099/mic.0.2008/018739-0 · Cited by 22 · see citing works
Wang, B., Alvarez, P., Hong, J., & Kuramitsu, H. K. (2010) · Journal of Periodontal Research · doi:10.1111/j.1600-0765.2010.01319.x · Cited by 22 · see citing works
Self-citationHanel, A., Herzog, H. M., James, M. G., & Cuadra, G. A. (2020) · Dentistry Journal · doi:10.3390/dj8020039 · Cited by 20 · see citing works
Biosynthesis and Mode of Action of Lantibiotics
Cooper, L. E., Ли, Б., & van der Donk, W. A. (2010) · Elsevier eBooks · doi:10.1016/b978-008045382-8.00116-7 · Cited by 20 · see citing works
Yoshida, A., Niki, M., Yamamoto, Y., Yasunaga, A., & Ansai, T. (2015) · PLoS ONE · doi:10.1371/journal.pone.0121176 · Cited by 19 · see citing works
Amino Sugars Reshape Interactions between Streptococcus mutans and Streptococcus gordonii
Chen, L., Walker, A. R., Burne, R. A., & Zeng, L. (2020) · Applied and Environmental Microbiology · doi:10.1128/aem.01459-20 · Cited by 19 · see citing works
Nabert‐Georgi, C., Rodloff, A. C., Jentsch, H. F. R., Reissmann, D. R., Schaumann, R., & Stîngu, C. S. (2018) · Clinical and Experimental Dental Research · doi:10.1002/cre2.107 · Cited by 18 · see citing works
Mohammed, W. K., Krasnogor, N., & Jakubovics, N. S. (2018) · FEMS Microbiology Ecology · doi:10.1093/femsec/fiy043 · Cited by 17 · see citing works
Georgalaki, M. D., Papadelli, M., Chassioti, E., Anastasiou, R., Aktypis, A., Vuyst, L. D., Driessche, G. V., Devreese, B. V., & Tsakalidou, E. (2009) · Applied and Environmental Microbiology · doi:10.1128/aem.00151-09 · Cited by 16 · see citing works
Su, X., Wang, M., Wu, Y., He, Y. Q., & Fu, Z. (2017) · Talanta · doi:10.1016/j.talanta.2017.11.004 · Cited by 15 · see citing works
Cummins, D. (2006) · PubMed · Cited by 14 · see citing works
Pezzotti, G., Ofuji, S., Imamura, H., Adachi, T., Yamamoto, T., Kanamura, N., Ohgitani, E., Marin, E., Zhu, W., Mazda, O., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24076694 · Cited by 14 · see citing works
Wei, Y., Joyce, L. R., Wall, A. M., Guan, Z., & Palmer, K. L. (2021) · mSphere · doi:10.1128/msphere.01099-20 · Cited by 14 · see citing works
Conserved Pheromone Production, Response and Degradation by Streptococcus mutans
Ricomini-Filho, A. P., Khan, R. S., Åmdal, H. A., & Petersen, F. C. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.02140 · Cited by 14 · see citing works
Bacteriocins' Role in Bacterial Communication
Gillor, O. (2006) · Springer eBooks · doi:10.1007/978-3-540-36604-1_7 · Cited by 14 · see citing works
Davey, L. E., Halperin, S. A., & Lee, S. F. (2016) · PLoS ONE · doi:10.1371/journal.pone.0166656 · Cited by 13 · see citing works
Interactions between probiotic and oral pathogenic strains
Horváth-Gönczi, N. N., Strang, O., Bagi, Z., Rákhely, G., & Kovács, K. L. (2021) · Biologia Futura · doi:10.1007/s42977-021-00091-3 · Cited by 12 · see citing works
Boulay, M., Metton, C., Mézange, C., Correia, L. O., Meylheuc, T., Monnet, V., Gardan, R., & Juillard, V. (2021) · Applied and Environmental Microbiology · doi:10.1128/aem.01292-21 · Cited by 12 · see citing works
Streptococcus mutans dexA affects exopolysaccharides production and biofilm homeostasis
Yang, Y. L., Hailun, H., Fenghui, Y., Liu, P., Lei, L., Zhili, Z., & Hu, T. (2022) · Molecular Oral Microbiology · doi:10.1111/omi.12395 · Cited by 10 · see citing works
Kriswandini, I. L., Sidarningsih, S., Hermanto, A. C., Tyas, P. R., & Aljunaid, M. (2024) · European Journal of Dentistry · doi:10.1055/s-0044-1782215 · Cited by 10 · see citing works
The human microbiome: opportunities and challenges for clinical care
Rogers, G. B. (2014) · Internal Medicine Journal · doi:10.1111/imj.12650 · Cited by 10 · see citing works
Fu, Y., Cannon, R. D., Li, K. C., Ekambaram, M., Cooper, P. R., & Mei, M. L. (2025) · Journal of Dentistry · doi:10.1016/j.jdent.2025.105927 · Cited by 8 · see citing works
Conserved and divergent functions of RcrRPQ inStreptococcus gordoniiandS. mutans
Shields, R. C., & Burne, R. A. (2015) · FEMS Microbiology Letters · doi:10.1093/femsle/fnv119 · Cited by 8 · see citing works
Kreth, J., Merritt, J. L., Qi, F., Dong, X., & Shi, W. (2011) · doi:10.1128/9781555817107.ch22 · Cited by 8 · see citing works
Kimijima, M., Narisawa, N., Hori, E., Mandokoro, K., Ito, T., Ota, Y., Sashida, M., Kawai, Y., & TAKENAGA, F. (2024) · Pathogens · doi:10.3390/pathogens13040286 · Cited by 7 · see citing works
Lüthy, L., Thies, L. G. S., Beitl, K. N., Hansen, M., McManus, J., Afzal, M., Schrangl, L., Bloch, S., Subbiahdoss, G., Reimhult, E., et al. (2025) · ACS Central Science · doi:10.1021/acscentsci.4c02184 · Cited by 7 · see citing works
Alkhalifah, D. H. M. (2021) · Saudi Journal of Biological Sciences · doi:10.1016/j.sjbs.2021.06.092 · Cited by 7 · see citing works
Dishonest Signaling in Microbial Conflicts
Hashem, I., & van Impe, J. F. M. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.812763 · Cited by 7 · see citing works
Harty, D. W. S., & Hunter, N. (2011) · Microbiology · doi:10.1099/mic.0.048710-0 · Cited by 7 · see citing works
Davey, L. E., Halperin, S. A., & Lee, S. F. (2015) · Journal of Bacteriology · doi:10.1128/jb.00800-15 · Cited by 7 · see citing works
- Authors
- Wang, B.-Y., & Kuramitsu, H. K.
- Affiliations
- Department of Oral Biology, State University of New York, Buffalo, New York
- University at Buffalo, State University of New York (US)
- Venue
- Applied and Environmental Microbiology
- Publisher
- American Society for Microbiology
- Published
- 2005-01
- Volume
- 71
- Issue
- 1
- Pages
- 354-362
- ISSN
- 0099-2240 (ISSN-L)
- 1098-5336
- PMC
- PMC544254
- OpenAlex
- W2128381319
- Cited by
- 144
- References
- 34
- Citations by year
- 2026: 6 · 2025: 7 · 2024: 7 · 2023: 5 · 2022: 7 · 2021: 8 · 2020: 7 · 2019: 7 · 2018: 8 · 2017: 5 · 2016: 5 · 2015: 7 · 2014: 8 · 2013: 3 · 2012: 6
- FWCI
- 2.14
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Applied and Environmental Microbiology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Dental and Craniofacial Research (T32‐DE07034, R01DE003258, DE 03258, T32DE007034)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Keywords
- Streptococcus mutans, Streptococcus gordonii, bacteriocin production, quorum sensing, competence-stimulating peptide, oral streptococci, bacterial interactions, dental plaque, dental caries
- MeSH terms
- Antibiosis, Bacterial Proteins, Bacteriocins, Culture Media, Humans, Mouth, Mutation, Peptide Hydrolases, Protein Precursors, Streptococcus, Streptococcus mutans, Signal Transduction, Gene Expression Regulation, Bacterial, Biofilms, Protein Sorting Signals
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