Klebsiella pneumoniae carbapenemase variants: the new threat to global public health

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First Report of Ceftazidime-Avibactam Resistance in a KPC-3-Expressing Klebsiella pneumoniae Isolate

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The β‐Lactams Strike Back: Ceftazidime‐Avibactam

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Successive Emergence of Ceftazidime-Avibactam Resistance through Distinct Genomic Adaptations in bla KPC-2 -Harboring Klebsiella pneumoniae Sequence Type 307 Isolates

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Association Between Carbapenem Resistance and Mortality Among Adult, Hospitalized Patients With Serious Infections Due to Enterobacteriaceae: Results of a Systematic Literature Review and Meta-analysis

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Meropenem-Vaborbactam Tested against Contemporary Gram-Negative Isolates Collected Worldwide during 2014, Including Carbapenem-Resistant, KPC-Producing, Multidrug-Resistant, and Extensively Drug-Resistant Enterobacteriaceae

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Potential of Tetracycline Resistance Proteins To Evolve Tigecycline Resistance

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Multisite Evaluation of Cepheid Xpert Carba-R Assay for Detection of Carbapenemase-Producing Organisms in Rectal Swabs

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Identifying Spectra of Activity and Therapeutic Niches for Ceftazidime-Avibactam and Imipenem-Relebactam against Carbapenem-Resistant Enterobacteriaceae

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Phenotypic and Enzymatic Comparative Analysis of the Novel KPC Variant KPC-5 and Its Evolutionary Variants, KPC-2 and KPC-4

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Pandemic spread of bla among Klebsiella pneumoniae ST11 in China is associated with horizontal transfer mediated by IncFII-like plasmids

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Results from the China Antimicrobial Surveillance Network (CHINET) in 2017 of the In Vitro Activities of Ceftazidime-Avibactam and Ceftolozane-Tazobactam against Clinical Isolates of Enterobacteriaceae and Pseudomonas aeruginosa

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Relebactam Is a Potent Inhibitor of the KPC-2 β-Lactamase and Restores Imipenem Susceptibility in KPC-Producing Enterobacteriaceae

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In vitro activity of meropenem/vaborbactam and characterisation of carbapenem resistance mechanisms among carbapenem-resistant Enterobacteriaceae from the 2015 meropenem/vaborbactam surveillance programme

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Evolutionary Trajectories toward Ceftazidime-Avibactam Resistance in Klebsiella pneumoniae Clinical Isolates

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Meropenem-Vaborbactam as Salvage Therapy for Ceftazidime-Avibactam-Resistant Klebsiella pneumoniae Bacteremia and Abscess in a Liver Transplant Recipient

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Current status and trends of antimicrobial resistance among clinical isolates in China: a retrospective study of CHINET from 2018 to 2022

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Evaluation of the NG-Test CARBA 5 multiplex immunochromatographic assay for the detection of KPC, OXA-48-like, NDM, VIM and IMP carbapenemases

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Phenotypic, Biochemical, and Genetic Analysis of KPC-41, a KPC-3 Variant Conferring Resistance to Ceftazidime-Avibactam and Exhibiting Reduced Carbapenemase Activity

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A carbapenem-resistant Klebsiella pneumoniae epidemic clone in Jerusalem: sequence type 512 carrying a plasmid encoding aac(6')-Ib

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Structural Characterization of the D179N and D179Y Variants of KPC-2 β-Lactamase: Ω-Loop Destabilization as a Mechanism of Resistance to Ceftazidime-Avibactam

Alsenani, T. A., Viviani, S. L., Kumar, V., Taracila, M. A., Bethel, C. R., Barnes, M. D., Papp‐Wallace, K. M., Shields, R. K., Nguyen, M. H., Clancy, C. J., et al. (2022) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.02414-21 · Cited by 66 · see citing works

Meropenem-Vaborbactam Activity against Carbapenem-Resistant Enterobacterales Isolates Collected in U.S. Hospitals during 2016 to 2018

Castanheira, M., Doyle, T. B., Kantro, V., Mendes, R. E., & Shortridge, D. (2019) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01951-19 · Cited by 65 · see citing works

Complete Sequence of a bla KPC-2 -Harboring IncFII K1 Plasmid from a Klebsiella pneumoniae Sequence Type 258 Strain

Chen, L., Chavda, K. D., Melano, R. G., Jacobs, M. R., Levi, M. H., Bonomo, R. A., & Kreiswirth, B. N. (2013) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.02332-12 · Cited by 63 · see citing works

Combined effect of Polymyxin B and Tigecycline to overcome Heteroresistance in Carbapenem-Resistant Klebsiella pneumoniae

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Emergence of ceftazidime-avibactam-resistant Klebsiella pneumoniae during treatment, Finland, December 2018

Räisänen, K., Koivula, I., Ilmavirta, H., Puranen, S., Kallonen, T., Lyytikäinen, O., & Jalava, J. (2019) · Eurosurveillance · doi:10.2807/1560-7917.es.2019.24.19.1900256 · Cited by 60 · see citing works

Enhanced Klebsiella pneumoniae Carbapenemase Expression from a Novel Tn 4401 Deletion

Cheruvanky, A., Stoesser, N. E., Sheppard, A. E., Crook, D. W., Hoffman, P. S., Weddle, E. A., Carroll, J., Sifri, C. D., Chai, W., Barry, K., et al. (2017) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00025-17 · Cited by 59 · see citing works

Meropenem-Vaborbactam as Salvage Therapy for Ceftazidime-Avibactam-, Cefiderocol-Resistant ST-512 Klebsiella pneumoniae –Producing KPC-31, a D179Y Variant of KPC-3

Tiseo, G., Falcone, M., Leonildi, A., Giordano, C., Barnini, S., Arcari, G., Carattoli, A., & Menichetti, F. (2021) · Open Forum Infectious Diseases · doi:10.1093/ofid/ofab141 · Cited by 59 · see citing works

Rapid Identification of Five Classes of Carbapenem Resistance Genes Directly from Rectal Swabs by Use of the Xpert Carba-R Assay

Moore, N. M., Cantón, R., Carretto, E., Peterson, L. R., Sautter, R. L., & Traczewski, M. M. (2017) · Journal of Clinical Microbiology · doi:10.1128/jcm.00137-17 · Cited by 58 · see citing works

In Vitro Activity of Cefepime-Zidebactam, Ceftazidime-Avibactam, and Other Comparators against Clinical Isolates of Enterobacterales , Pseudomonas aeruginosa, and Acinetobacter baumannii: Results from China Antimicrobial Surveillance Network (CHINET) in 2018

Yang, Y., Guo, Y. P., Yin, D., Zheng, Y., Wu, S., Zhu, D., & Hu, F. (2020) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01726-20 · Cited by 58 · see citing works

Genomic characterization of a KPC-23-producing Klebsiella pneumoniae ST258 clinical isolate resistant to ceftazidime-avibactam

Galani, I., Antoniadou, A., Karaiskos, I., Κοντοπούλου, Κ., Giamarellou, H., & Souli, M. (2019) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2019.03.011 · Cited by 56 · see citing works

KPC-31 expressed in a ceftazidime/avibactam-resistant Klebsiella pneumoniae is associated with relevant detection issues

Antonelli, A., Giani, T., Pilato, V. D., Riccobono, E., Perriello, G., Mencacci, A., & Rossolini, G. M. (2019) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkz156 · Cited by 55 · see citing works

RamA upregulates multidrug resistance efflux pumps AcrAB and OqxAB in Klebsiella pneumoniae

Xu, Q., Sheng, Z.-K., Hao, M., Jiang, J., Ye, M., Chen, Y., Xu, X., Guo, Q., & Wang, M. (2020) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2020.106251 · Cited by 55 · see citing works

Use of carbapenems in the combined treatment of emerging ceftazidime/avibactam-resistant and carbapenem-susceptible KPC-producing Klebsiella pneumoniae infections: Report of a case and review of the literature

Cano, Á., Guzmán-Puche, J., García‐Gutiérrez, M., Castón, J. J., Gracia-Ahufinger, I., Pérez‐Nadales, E., Recio, M., Natera, A. M., Marfil, E., Martı́nez-Martı́nez, L., et al. (2019) · Journal of Global Antimicrobial Resistance · doi:10.1016/j.jgar.2019.11.007 · Cited by 53 · see citing works

In Vitro Activity of New β-Lactam–β-Lactamase Inhibitor Combinations and Comparators against Clinical Isolates of Gram-Negative Bacilli: Results from the China Antimicrobial Surveillance Network (CHINET) in 2019

Guo, Y. P., Han, R., Jiang, B., Ding, L., Yang, F., Zheng, B., Yang, Y., Wu, S., Yin, D., Zhu, D., et al. (2022) · Microbiology Spectrum · doi:10.1128/spectrum.01854-22 · Cited by 52 · see citing works

Carbapenemase detection testing in the era of ceftazidime/avibactam-resistant KPC-producing Enterobacterales: A 2-year experience

Bianco, G., Boattini, M., Iannaccone, M., Bondi, A., Ghibaudo, D., Zanotto, E., Peradotto, M., Cavallo, R., & Costa, C. S. (2021) · Journal of Global Antimicrobial Resistance · doi:10.1016/j.jgar.2021.02.008 · Cited by 49 · see citing works

Comparison of Four Carbapenemase Detection Methods for bla KPC-2 Variants

Ding, L., Shi, Q., Han, R., Yin, D., Wu, S., Yang, Y., Guo, Y., Zhu, D., & Hu, F. (2021) · Microbiology Spectrum · doi:10.1128/spectrum.00954-21 · Cited by 48 · see citing works

KPC-50 Confers Resistance to Ceftazidime-Avibactam Associated with Reduced Carbapenemase Activity

Poirel, L., Vuillemin, X., Juhas, M., Masseron, A., Bechtel-Grosch, U., Tiziani, S., Mancini, S., & Nordmann, P. (2020) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00321-20 · Cited by 47 · see citing works

Phenotypic and genotypic analysis of KPC-51 and KPC-52, two novel KPC-2 variants conferring resistance to ceftazidime/avibactam in the KPC-producing Klebsiella pneumoniae ST11 clone background

Sun, L., Chen, W., Li, H., Li, L., Zou, X., Zhao, J., Lu, B., Li, B., Wang, C., Li, H., et al. (2020) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkaa241 · Cited by 44 · see citing works

Emergence of ceftazidime-avibactam resistance through distinct genomic adaptations in KPC-2-producing Klebsiella pneumoniae of sequence type 39 during treatment

Galani, I., Karaiskos, I., Angelidis, E., Papoutsaki, V., Galani, L., Souli, M., Antoniadou, A., & Giamarellou, H. (2020) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-020-04000-9 · Cited by 43 · see citing works

Impact of Ceftazidime-Avibactam Treatment in the Emergence of Novel KPC Variants in the ST307-Klebsiella pneumoniae High-Risk Clone and Consequences for Their Routine Detection

Hernández-García, M., Castillo-Polo, J. A., Cordero, D., Pérez-Viso, B., García-Castillo, M., de la Fuente, J. S., Morosini, M. I., Cantón, R., & Ruíz-Garbajosa, P. (2022) · Journal of Clinical Microbiology · doi:10.1128/jcm.02245-21 · Cited by 43 · see citing works

Multiple Novel Ceftazidime-Avibactam-Resistant Variants of bla KPC-2 -Positive Klebsiella pneumoniae in Two Patients

Shi, Q., Han, R., Guo, Y. P., Yang, Y., Wu, S., Ding, L., Zhang, R., Yin, D., & Hu, F. (2022) · Microbiology Spectrum · doi:10.1128/spectrum.01714-21 · Cited by 41 · see citing works

Klebsiella pneumoniae and Klebsiella quasipneumoniae define the population structure of blaKPC-2Klebsiella: a 5 year retrospective genomic study in Singapore

Octavia, S., Marimuthu, K., Venkatachalam, I., Ng, O. T., Wei-zhen, X., Sridatta, P. S. R., Ong, Y. F., Wang, L. D., Chua, A., Cheng, B., et al. (2019) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkz332 · Cited by 38 · see citing works

Rapid molecular tests for detection of antimicrobial resistance determinants in Gram-negative organisms from positive blood cultures: a systematic review and meta-analysis

Angelis, G. D., Grossi, A., Menchinelli, G., Boccia, S., Sanguinetti, M., & Posteraro, B. (2019) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2019.11.009 · Cited by 38 · see citing works

Bloodstream infection by two subpopulations of Klebsiella pneumoniae ST1685 carrying KPC-33 or KPC-14 following ceftazidime/avibactam treatment: considerations regarding acquired heteroresistance and choice of carbapenemase detection assay

Bianco, G., Boattini, M., Iannaccone, M., Cavallo, R., & Costa, C. S. (2020) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkaa283 · Cited by 36 · see citing works

Insights into the Lignocellulose-Degrading Enzyme System of Humicola grisea var. thermoidea Based on Genome and Transcriptome Analysis.

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Meropenem-vaborbactam: a carbapenem and beta-lactamase inhibitor with activity against carbapenem-resistant Enterobacteriaceae

Lee, Y. R., & Baker, N. T. (2018) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-018-3260-4 · Cited by 33 · see citing works

Activity of imipenem/relebactam against carbapenemase-producing Enterobacteriaceae with high colistin resistance

Carpenter, J., Neidig, N., Campbell, A., Thornsberry, T., Truex, T., Fortney, T., Zhang, Y., & Bush, K. (2019) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkz354 · Cited by 33 · see citing works

A Ceftazidime-Avibactam-Resistant and Carbapenem-Susceptible Klebsiella pneumoniae Strain Harboring bla KPC-14 Isolated in New York City

Niu, S., Chavda, K. D., Wei, J., Zou, C., Marshall, S. H., Dhawan, P., Wang, D., Bonomo, R. A., Kreiswirth, B. N., & Chen, L. (2020) · mSphere · doi:10.1128/msphere.00775-20 · Cited by 33 · see citing works

Emergence of a KPC Variant Conferring Resistance to Ceftazidime-Avibactam in a Widespread ST11 Carbapenem-Resistant Klebsiella pneumoniae Clone in China

Li, X., Quan, J., Ke, H., Wu, W., Feng, Y., Yu, Y., & Jiang, Y. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.724272 · Cited by 31 · see citing works

KPC-53, a KPC-3 Variant of Clinical Origin Associated with Reduced Susceptibility to Ceftazidime-Avibactam

Pilato, V. D., Aiezza, N., Viaggi, V., Antonelli, A., Principe, L., Giani, T., Luzzaro, F., & Rossolini, G. M. (2020) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01429-20 · Cited by 30 · see citing works

A novel KPC-113 variant conferring carbapenem and ceftazidime-avibactam resistance in a multidrug-resistant Pseudomonas aeruginosa isolate

Yang, Q., Li, Y., Li, F., Lei, T., Cai, H., Hua, X., Zheng, M., & Yu, Y. (2022) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2022.10.013 · Cited by 30 · see citing works

Multicenter Performance Assessment of Carba NP Test

Cunningham, S. A., Limbago, B. M., Traczewski, M. M., Anderson, K. F., Hackel, M., Hindler, J. A., Sahm, D., Alyanak, E., Lawsin, A., Gulvik, C. A., et al. (2017) · Journal of Clinical Microbiology · doi:10.1128/jcm.00244-17 · Cited by 29 · see citing works

Outbreak by KPC-62-producing ST307 Klebsiella pneumoniae isolates resistant to ceftazidime/avibactam and cefiderocol in a university hospital in Madrid, Spain

Castillo-Polo, J. A., Hernández-García, M., Morosini, M. I., Pérez-Viso, B., Soriano, C., Pablo, R. D., Cantón, R., & Ruíz-Garbajosa, P. (2023) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkad086 · Cited by 29 · see citing works

Genomic characterization of a Klebsiella pneumoniae ST1519 resistant to ceftazidime/avibactam carrying a novel KPC variant (KPC-36)

Gaibani, P., Ambretti, S., Campoli, C., Viale, P., & Re, M. C. (2019) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2019.09.020 · Cited by 28 · see citing works

Evaluating NG-Test CARBA 5 Multiplex Immunochromatographic and Cepheid Xpert CARBA-R Assays among Carbapenem-Resistant Enterobacterales Isolates Associated with Bloodstream Infection

Huang, Y., Kuo, Y.-W., Lee, N., Tien, N., Liao, C., Teng, L., Ko, W., & Hsueh, P. (2022) · Microbiology Spectrum · doi:10.1128/spectrum.01728-21 · Cited by 28 · see citing works

Emergence of the New KPC-49 Variant Conferring an ESBL Phenotype with Resistance to Ceftazidime-Avibactam in the ST131-H30R1 Escherichia coli High-Risk Clone

Hernández-García, M., López, J. S., Martínez-García, L., Becerra-Aparicio, F., Morosini, M. I., Ruíz-Garbajosa, P., & Cantón, R. (2021) · Pathogens · doi:10.3390/pathogens10010067 · Cited by 27 · see citing works

Characterization of a Multidrug-Resistant Porcine Klebsiella pneumoniae Sequence Type 11 Strain Coharboring bla KPC-2 and fosA3 on Two Novel Hybrid Plasmids

Zhang, W., Zhu, Y., Wang, C., Liu, W., Li, R., Chen, F., Luan, T., Zhang, Y., Schwarz, Š., & Liu, S. (2019) · mSphere · doi:10.1128/msphere.00590-19 · Cited by 26 · see citing works

Ceftazidime–Avibactam Resistance Mutations V240G, D179Y, and D179Y/T243M in KPC-3 β-Lactamase Do Not Alter Cefpodoxime–ETX1317 Susceptibility

Shapiro, A. B., Moussa, S. H., Carter, N., Gao, N., & Miller, A. A. (2020) · ACS Infectious Diseases · doi:10.1021/acsinfecdis.0c00575 · Cited by 26 · see citing works

Genome characterization of a Klebsiella pneumoniae co-producing OXA-181 and KPC-121 resistant to ceftazidime/avibactam, meropenem/vaborbactam, imipenem/relebactam and cefiderocol isolated from a critically ill patient

Gaibani, P., Amadesi, S., Lazzarotto, T., & Ambretti, S. (2022) · Journal of Global Antimicrobial Resistance · doi:10.1016/j.jgar.2022.06.021 · Cited by 26 · see citing works

Outbreak of Klebsiella pneumoniae ST11 Resistant To Ceftazidime-Avibactam Producing KPC-31 and the Novel Variant KPC-115 during COVID-19 Pandemic in Argentina

Nicola, F., Cejas, D., González-Espinosa, F., Relloso, S., Herrera, F., Bonvehí, P., Smayevsky, J., Figueroa-Espinosa, R. A., Gutkind, G., & Radice, M. A. (2022) · Microbiology Spectrum · doi:10.1128/spectrum.03733-22 · Cited by 26 · see citing works

KPC-39-Mediated Resistance to Ceftazidime-Avibactam in a Klebsiella pneumoniae ST307 Clinical Isolate

Jousset, A. B., Oueslati, S., Emeraud, C., Bonnin, R. A., Dortet, L., Iorga, B. I., & Naas, T. (2021) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01160-21 · Cited by 25 · see citing works

First Description of Ceftazidime/Avibactam Resistance in a ST13 KPC-70-Producing Klebsiella pneumoniae Strain from Portugal

Mendes, G., Ramalho, J. F., Bruschy-Fonseca, A., Lito, L., Duarte, A., Melo‐Cristino, J., & Caneiras, C. S. G. (2022) · Antibiotics · doi:10.3390/antibiotics11020167 · Cited by 25 · see citing works

Emergence of a Fatal ST11-KL64 Tigecycline-Resistant Hypervirulent Klebsiella pneumoniae Clone Cocarrying bla NDM and bla KPC in Plasmids

Huang, J., Yi, M., Yuan, Y., Xia, P., Yang, B., Liao, J., Dang, Z., Luo, S., & Xia, Y. (2022) · Microbiology Spectrum · doi:10.1128/spectrum.02539-22 · Cited by 25 · see citing works

Omic insights into various ceftazidime-avibactam-resistant Klebsiella pneumoniae isolates from two southern Italian regions

Bongiorno, D., Bivona, D. A., Cicino, C., Trecarichi, E. M., Russo, A., Marascio, N., Mezzatesta, M. L., Musso, N., Privitera, G. F., Quirino, A., et al. (2023) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.1010979 · Cited by 25 · see citing works

Comparison of the NG-Test Carba 5, Colloidal Gold Immunoassay (CGI) Test, and Xpert Carba-R for the Rapid Detection of Carbapenemases in Carbapenemase-Producing Organisms

Gu, D., Yan, Z., Cai, C., Li, J., Zhang, Y., Wu, Y., Yang, J., Huang, Y., Zhang, R., & Wu, Y. (2023) · Antibiotics · doi:10.3390/antibiotics12020300 · Cited by 25 · see citing works

Comparative Analysis of bla KPC Expression in Tn 4401 Transposons and the Tn 3 -Tn 4401 Chimera

Huang, J., Hu, X., Zhao, Y., Shi, Y., Ding, H., Wu, R., Zhao, Z., & Ji, J. (2019) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.02434-18 · Cited by 24 · see citing works

Patient-to-Patient Transmission of Klebsiella pneumoniae Carbapenemase Variants with Reduced Ceftazidime-Avibactam Susceptibility

Munoz-Price, L. S., Reeme, A. E., Buchan, B. W., Mettus, R. T., Mustapha, M. M., Tyne, D. V., Shields, R. K., & Doi, Y. (2019) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00955-19 · Cited by 23 · see citing works

Characterization of KPC-82, a KPC-2 Variant Conferring Resistance to Ceftazidime-Avibactam in a Carbapenem-Nonsusceptible Clinical Isolate of Citrobacter koseri

Lebreton, F., Corey, B. W., McElheny, C. L., Iovleva, A., Preston, L. N., Margulieux, K. R., Cybulski, R. J., McGann, P., Doi, Y., & Bennett, J. W. (2021) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00150-21 · Cited by 23 · see citing works

In vivo selection of KPC-94 and KPC-95 in Klebsiella pneumoniae isolates from patients treated with ceftazidime/avibactam

Guzmán-Puche, J., Pérez‐Nadales, E., Pérez-Vázquez, M. D., Causse, M., Gracia-Ahufinger, I., Natera, A. M., Allalou-Ruiz, Y., Elías-López, C., Oteo, J., Torre‐Cisneros, J., et al. (2022) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2022.106524 · Cited by 22 · see citing works

Emergence of Escherichia coli Sequence Type 131 (ST131) and ST3948 with KPC-2, KPC-3 and KPC-8 carbapenemases from a Long-Term Care and Rehabilitation Facility (LTCRF) in Northern Italy

Piazza, A., Caltagirone, M., Bitar, I., Nucleo, E., Spalla, M., Fogato, E., D’Angelo, R., Pagani, L., & Migliavacca, R. (2015) · Advances in experimental medicine and biology · doi:10.1007/5584_2015_5017 · Cited by 21 · see citing works

Interplay between Klebsiella pneumoniae producing KPC-31 and KPC-3 under treatment with high dosage meropenem: a case report

Arcari, G., Oliva, A., Sacco, F., Lella, F. M. D., Raponi, G., Tomolillo, D., Curtolo, A., Venditti, M., & Carattoli, A. (2022) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-021-04388-y · Cited by 21 · see citing works

Insertion sequence mediating mrgB disruption is the major mechanism of polymyxin resistance in carbapenem-resistant Klebsiella pneumoniae isolates from China

Chen, X., Li, P., Sun, Z., Xu, X., Jiang, J., & Su, J. (2022) · Journal of Global Antimicrobial Resistance · doi:10.1016/j.jgar.2022.07.002 · Cited by 19 · see citing works

Ceftazidime–Avibactam in Combination with Imipenem as Salvage Therapy for ST11 KPC-33-Producing Klebsiella pneumoniae

Ding, L., Shen, S., Han, R., Yin, D., Guo, Y. P., & Hu, F. (2022) · Antibiotics · doi:10.3390/antibiotics11050604 · Cited by 18 · see citing works

Identification of KPC-112 from an ST15 Klebsiella pneumoniae Strain Conferring Resistance to Ceftazidime-Avibactam

Shen, S., Tang, C., Ding, L., Han, R., Yin, D., Yang, W., Guo, Y. P., & Hu, F. (2022) · mSphere · doi:10.1128/msphere.00487-22 · Cited by 18 · see citing works

The changing face of Klebsiella pneumoniae carbapenemase: in-vivo mutation in patient with chest infection

Shen, S., Shi, Q., & Hu, F. (2022) · The Lancet · doi:10.1016/s0140-6736(22)01011-x · Cited by 16 · see citing works

Ceftazidime-Avibactam (C/A) Resistant, Meropenem Sensitive KPC-Producing Klebsiella pneumoniae in ICU Setting: We Are What We Are Treated with?

Corcione, S., Benedetto, I. D., Shbaklo, N., Torsello, G., Lupia, T., Bianco, G., Cavallo, R., Brazzi, L., Montrucchio, G. G., & Rosa, F. G. D. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24054767 · Cited by 16 · see citing works

A Novel KPC Variant KPC-55 in Klebsiella pneumoniae ST307 of Reinforced Meropenem-Hydrolyzing Activity

Yoon, E.-J., Choi, Y. J., Park, S. H., Shin, J. H., Park, S. G., Choi, J. R., & Jeong, S. H. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.561317 · Cited by 12 · see citing works

Identification of a Novel Ceftazidime-Avibactam-Resistant KPC-2 Variant, KPC-123, in Citrobacter koseri Following Ceftazidime-Avibactam Treatment

Wang, L., Shen, W., Zhang, R., & Cai, J. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.930777 · Cited by 12 · see citing works

KPC-12 with a L169M substitution in the Ω loop has reduced carbapenemase activity

Qin, J., Feng, Y., Lu, X., & Zong, Z. (2021) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-021-04198-2 · Cited by 10 · see citing works

A Two Amino Acid Duplication, L167E168, in the Ω-Loop Drastically Decreases Carbapenemase Activity of KPC-53, a Natural Class A β-Lactamase

Piccirilli, A., Cherubini, S., Celenza, G., Rossolini, G. M., Brisdelli, F., Segatore, B., Principe, L., Luzzaro, F., Andriani, L., Amicosante, G., et al. (2022) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.02402-21 · Cited by 6 · see citing works

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Medicinal plants: bioactive compounds, biological activities, combating multidrug-resistant microorganisms, and human health benefits - a comprehensive review

El‐Saadony, M. T., Saad, A. M., Mohammed, D. M., Korma, S. A., Alshahrani, M. Y., Ahmed, A. E., Ibrahim, E. H., Salem, H. M., Alkafaas, S. S., Saif, A. M., et al. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1491777 · Cited by 269 · see citing works

Hypervirulent and carbapenem-resistant Klebsiella pneumoniae: A global public health threat

Lei, T.-Y., Liao, B.-B., Yang, L.-R., Wang, Y., & Chen, X.-B. (2024) · Microbiological Research · doi:10.1016/j.micres.2024.127839 · Cited by 140 · see citing works

ESKAPE in China: epidemiology and characteristics of antibiotic resistance

Luo, Q., Lu, P., Chen, Y., Shen, P., Zheng, B., Ji, J., Ying, C., Liu, Z., & Xiao, Y. (2024) · Emerging Microbes & Infections · doi:10.1080/22221751.2024.2317915 · Cited by 122 · see citing works

Epidemiology and Genetic Traits of Carbapenemase-Producing Enterobacterales: A Global Threat to Human Health

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AIE‐Active Antibacterial Photosensitizer Disrupting Bacterial Structure: Multicenter Validation against Drug‐Resistant Pathogens

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Global phylogeography and genetic characterization of carbapenem and ceftazidime-avibactam resistant KPC-33-producing Pseudomonas aeruginosa

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Raising the Bar of PK/PD Target Attainment of Beta-Lactams in Daily Clinical Practice: An Effective Strategy to Overcome Resistance Development to Novel Beta-Lactams?

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Molecular Epidemiological Characteristics of blaIMP-4-Carrying Klebsiella pneumoniae ST-11 in Hospitalized Patients

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Beyond the Spotlight: Enterobacter spp. as Overlooked Carbapenemase Producers in Europe

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Spontaneous Emergence of Cefiderocol Resistance in Klebsiella pneumoniae KPC-163: Genomic and Transcriptomic Insights

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Characterization of genetic context of blaKPC in Pseudomonas aeruginosa

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Environmental reservoirs account for high levels of carbapenem resistance genes in wastewater

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Investigation of the susceptibility rates to ceftazidime-avibactam and colistin, clonal relationships, and clinical data of patients with carbapenem-resistant Klebsiella pneumoniae isolates detected in the ICUs of a hospital in İstanbul

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In vivo evolution of resistance to contemporary β-lactam/β-lactamase inhibitor combinations during treatment of a KPC-producing Serratia marcescens infection

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Detection of β-lactam resistance genes in Gram-negative bacteria from positive blood cultures using a microchip-based molecular assay

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CRISPR-Cas9 targeting the blaKPC gene in a clinical isolate of Klebsiella michiganensis: Reduction of imipenem resistance and changes in genomic carbapenem resistance determinants

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Bovine Neutrophil β-Defensin-5 Provides Protection against Multidrug-Resistant Klebsiella pneumoniae via Regulating Pulmonary Inflammatory Response and Metabolic Response

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Emergence of Ceftazidime‐Avibactam‐Induced KPC Variants (KPC‐25/127) in Intracranial Infection and Implications for Clinical Management

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Klebsiella pneumoniae Carbapenemase Variants Resistant to Ceftazidime-Avibactam: an Evolutionary Overview

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Molecular characterisation of two novel KPC variants mediating ceftazidime-avibactam resistance in ST11 Klebsiella pneumoniae

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