The DOI matches its Crossref record; 285 of the 285 references it cites were found in a registry or an index.
Molecular Pathogenesis of Shigella spp.: Controlling Host Cell Signaling, Invasion, and Death by Type III Secretion
Open accessAbstract
SUMMARY: Shigella spp. are gram-negative pathogenic bacteria that evolved from harmless enterobacterial relatives and may cause devastating diarrhea upon ingestion. Research performed over the last 25 years revealed that a type III secretion system (T3SS) encoded on a large plasmid is a key virulence factor of Shigella flexneri. The T3SS determines the interactions of S. flexneri with intestinal cells by consecutively translocating two sets of effector proteins into the target cells. Thus,S. flexneri controls invasion into EC, intra- and intercellular spread, macrophage cell death, as well as host inflammatory responses. Some of the translocated effector proteins show novel biochemical activities by which they intercept host cell signal transduction pathways. An understanding of the molecular mechanisms underlying Shigella pathogenesis will foster the development of a safe and efficient vaccine, which, in parallel with improved hygiene, should curb infections by this widespread pathogen.
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Cites
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Cited by
Strategies Used by Bacteria to Grow in Macrophages
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Metadata
- Authors
- Schroeder, G. N., & Hilbi, H.
- Venue
- Clinical Microbiology Reviews
- Publisher
- American Society for Microbiology
- Published
- 2008-01
- Volume
- 21
- Issue
- 1
- Pages
- 134-156
- ISSN
- 0893-8512 (ISSN-L)
- 1098-6618
- OpenAlex
- W2170644493
- Cited by
- 621
- References
- 285
- FWCI
- 16.28
- Type
- journal article
- Language
- en
- Open access
- green
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- Schroeder, G. N., & Hilbi, H. (2008). Molecular Pathogenesis of Shigella spp.: Controlling Host Cell Signaling, Invasion, and Death by Type III Secretion. Clinical Microbiology Reviews. https://doi.org/10.1128/cmr.00032-07
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
