The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Antimicrobial Resistance and Virulence: a Successful or Deleterious Association in the Bacterial World?
Open accessAbstract
SUMMARY: Hosts and bacteria have coevolved over millions of years, during which pathogenic bacteria have modified their virulence mechanisms to adapt to host defense systems. Although the spread of pathogens has been hindered by the discovery and widespread use of antimicrobial agents, antimicrobial resistance has increased globally. The emergence of resistant bacteria has accelerated in recent years, mainly as a result of increased selective pressure. However, although antimicrobial resistance and bacterial virulence have developed on different timescales, they share some common characteristics. This review considers how bacterial virulence and fitness are affected by antibiotic resistance and also how the relationship between virulence and resistance is affected by different genetic mechanisms (e.g., coselection and compensatory mutations) and by the most prevalent global responses. The interplay between these factors and the associated biological costs depend on four main factors: the bacterial species involved, virulence and resistance mechanisms, the ecological niche, and the host. The development of new strategies involving new antimicrobials or nonantimicrobial compounds and of novel diagnostic methods that focus on high-risk clones and rapid tests to detect virulence markers may help to resolve the increasing problem of the association between virulence and resistance, which is becoming more beneficial for pathogenic bacteria.
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Cites
Molecular Basis of Bacterial Outer Membrane Permeability Revisited
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Pseudomonas biofilm formation and antibiotic resistance are linked to phenotypic variation
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Efflux-Mediated Resistance to Tigecycline (GAR-936) in Pseudomonas aeruginosa PAO1
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Complete and SOS-Mediated Response of Staphylococcus aureus to the Antibiotic Ciprofloxacin
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Resistance Development to Bacteriophages Occurring during Bacteriophage Therapy
Oechslin, F. (2018) · Viruses · doi:10.3390/v10070351 · Cited by 594
Evolutionary Rationale for Phages as Complements of Antibiotics
Torres-Barceló, C., & Hochberg, M. E. (2016) · Trends in Microbiology · doi:10.1016/j.tim.2015.12.011 · Cited by 308
Sony, M., Sumithra, T. G., Anusree, V. N., Amala, P. V., Reshma, K. J., Alex, S., & Sanil, N. K. (2021) · Aquaculture · doi:10.1016/j.aquaculture.2021.736608 · Cited by 106
New roles of fluoxetine in pharmacology: Antibacterial effect and modulation of antibiotic activity
Karine de Sousa, A., Rocha, J. E., Gonçalves de Souza, T., Sampaio de Freitas, T., Ribeiro-Filho, J., & Melo Coutinho, H. D. (2018) · Microbial Pathogenesis · doi:10.1016/j.micpath.2018.07.040 · Cited by 88
Metadata
- Authors
- Beceiro, A., Tomás, M., & Bou, G.
- Venue
- Clinical Microbiology Reviews
- Publisher
- American Society for Microbiology
- Published
- 2013-04
- Volume
- 26
- Issue
- 2
- Pages
- 185-230
- ISSN
- 0893-8512 (ISSN-L)
- 1098-6618
- OpenAlex
- W2101996554
- Cited by
- 1,070
- References
- 12
- FWCI
- 17.71
- Type
- journal article
- Language
- en
- Open access
- green
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