Student or educator? Sign up with your school email and get 6 months of Pro free.
Cited by 1,181

The DOI matches its Crossref record.

Structures of Toxoplasma gondii Tachyzoites, Bradyzoites, and Sporozoites and Biology and Development of Tissue Cysts

Open access
Dubey, J. P., Lindsay, D. S., Speer, C. A.·1998·Clinical Microbiology Reviews

Abstract

SUMMARY: Infections by the protozoan parasite Toxoplasma gondii are widely prevalent worldwide in animals and humans. This paper reviews the life cycle; the structure of tachyzoites, bradyzoites, oocysts, sporocysts, sporozoites and enteroepithelial stages of T. gondii; and the mode of penetration of T. gondii. The review provides a detailed account of the biology of tissue cysts and bradyzoites including in vivo and in vitro development, methods of separation from host tissue, tissue cyst rupture, and relapse. The mechanism of in vivo and in vitro stage conversion from sporozoites to tachyzoites to bradyzoites and from bradyzoites to tachyzoites to bradyzoites is also discussed.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1128/cmr.11.2.267

Cites

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

No references could be resolved yet.

Research works printed but not linked: 183

  1. Appleford P. J. Smith J. E. Toxoplasma gondii: the growth characteristics of three virulent strains. Acta Trop. 65 1997 97 104 · DOI
  2. 10.1083/jcb.127.4.947 · DOI
  3. Bertoli F. Espino M. Arosemena J. R. Fishback J. L. Frenkel J. K. A spectrum in the pathology of toxoplasmosis in patients with acquired immunodeficiency syndrome. Arch. Pathol. Lab. Med. 119 1995 214 224
  4. Beverley J. K. A. A rational approach to the treatment of toxoplasmic uveitis. Trans. Ophthalmol. Soc. U. K. 78 1958 109 121
  5. Bjerkås I. Neuropathology and host-parasite relationship of acute experimental toxoplasmosis of the blue fox (Alopex lagopus). Vet. Pathol. 27 1990 381 390 · DOI
  6. 10.1111/j.1365-3024.1993.tb00616.x · DOI
  7. Blewett D. A. Miller J. K. Harding J. Simple technique for the direct isolation of toxoplasma tissue cysts from fetal ovine brain. Vet. Rec. 112 1983 98 100 · DOI
  8. Bohne W. Gross U. Ferguson D. J. P. Heeseman J. Cloning and characterization of a bradyzoite-specifically expressed gene (hsp30/bag1) of Toxoplasma gondii, related to genes encoding small heat-shock proteins of plants. Mol. Microbiol. 16 1995 1221 1230 · DOI
  9. 10.1128/iai.61.3.1141-1145.1993 · DOI
  10. Bohne W. Heesemann J. Gross U. Coexistence of heterogenous populations of Toxoplasma gondii parasites within parasitophorous vacuoles of murine macrophages as revealed by a bradyzoite-specific monoclonal antibody. Parasitol. Res. 79 1993 485 487 · DOI
  11. 10.1128/iai.62.5.1761-1767.1994 · DOI · Paper page
  12. Bohne W. Roos D. S. Stage-specific expression of a selectable marker in Toxoplasma gondii permits selective inhibition of either tachyzoites or bradyzoites. Mol. Biochem. Parasitol. 88 1997 115 126 · DOI
  13. 10.1016/S0166-6851(96)02814-9 · DOI
  14. Bommer W. The life cycle of virulent Toxoplasma in cell cultures. Aust. J. Exp. Biol. Med. Sci. 47 1969 505 512 · DOI
  15. Bonhomme A. Pingret L. Pinon J. M. Review: Toxoplasma gondii cellular invasion. Parassitologia 54 1992 31 43
  16. Brown C. R. David C. S. Khare S. J. McLeod R. Effects of human class I transgenes on Toxoplasma gondii cyst formation. J. Immunol. 152 1994 4537 4541 · DOI
  17. Brown C. R. Hunter C. A. Estes R. G. Beckmann E. Forman J. David C. Remington J. S. McLeod R. Definitive identification of a gene that confers resistance against Toxoplasma cyst burden and encephalitis. Immunology 85 1995 419 428
  18. Brown C. R. McLeod R. Class I MHC genes and CD8+ T-cells determine cyst number in Toxoplasma gondii infection. J. Immunol. 145 1990 3438 3441 · DOI
  19. Chiappino M. L. Nichols B. A. O’Connor G. R. Scanning electron microscopy of Toxoplasma gondii: parasite torsion and host-cell responses during invasion. J. Protozool. 31 1984 288 292 · DOI
  20. Christie E. Pappas P. W. Dubey J. P. Ultrastructure of excystment of Toxoplasma gondii oocysts. J. Protozool. 25 1978 438 443 · DOI
  21. 10.1017/S0031182000050071 · DOI
  22. Dardé M. L. Bouteille B. Leboutet M. J. Loubet A. Pestre-Alexander M. Toxoplasma gondii: étude ultrastructurale des formations kystiques observées en culture de fribroblastes humains. Ann. Parasitol. Hum. Comp. 64 1989 403 411 · DOI
  23. De Champs C. Imbert-Bernard C. Belmeguenai A. Ricard J. Pelloux H. Brambilla E. Ambroise-Thomas P. Toxoplasma gondii: in vivo and in vitro cystogenesis of virulent RH strain. J. Parasitol. 83 1997 152 155 · DOI
  24. 10.1007/s004360050242 · DOI
  25. de Souza W. Chagas M. C. Mise en évidence et structure du systéme microtubulaire de Toxoplasma gondii. C. R. Acad. Sci. Paris Ser. D 275 1972 2899 2901
  26. de Souza W. Souto-Padrón T. Ultrastructural localization of basic proteins on the conoid, rhoptries and micronemes of Toxoplasma gondii. Z. Parasitenkd. 56 1978 123 129 · DOI
  27. Dubey J. P. Toxoplasma Hammondia Besnoitia Sarcocystis and other tissue cyst-forming coccidia of man and animals Parasitic protozoa 3rd ed. Kreier J. P. 1977 101 237 Academic Press Inc. New York N.Y
  28. Dubey J. P. Induced Toxoplasma gondii,Toxocara canis and Isospora canis infections in coyotes. J. Am. Vet. Med. Assoc. 181 1982 1268 1269 · DOI
  29. Dubey J. P. Repeat transplacental transfer of Toxoplasma gondii in goats. Am. J. Vet. Med. 180 1982 1220 1221 · DOI
  30. Dubey J. P. Experimental infection of a bison with Toxoplasma gondii oocysts. J. Wildl. Dis. 19 1983 148 149 · DOI
  31. Dubey J. P. Distribution of cysts and tachyzoites in calves and pregnant cows inoculated with Toxoplasma gondii oocysts. Vet. Parasitol. 13 1983 199 211 · DOI
  32. Dubey J. P. Experimental toxoplasmosis in sheep fed Toxoplasma gondii oocysts. Int. Goat Sheep Res. 2 1984 93 104
  33. Dubey J. P. Toxoplasmosis in dogs. Canine Pract. 12 1985 7 28
  34. Dubey J. P. Persistence of encysted Toxoplasma gondii in equids fed oocysts. Am. J. Vet. Res. 46 1985 1753 1754 · DOI
  35. Dubey J. P. Long term persistence of Toxoplasma gondii in tissues of pigs inoculated with T. gondii oocysts and effect of freezing on viability of tissue cysts in pork. Am. J. Vet. Res. 49 1988 910 913 · DOI
  36. Dubey J. P. Toxoplasma,Neospora,Sarcocystis, and other tissue cyst-forming coccidia of humans and animals Parasitic protozoa Kreier J. P. 6 1993 1 158 Academic Press, Inc. New York, N.Y
  37. Dubey J. P. Infectivity and pathogenicity of Toxoplasma gondii oocysts for cats. J. Parasitol. 82 1996 957 960 · DOI
  38. Dubey J. P. Pathogenicity and infectivity of Toxoplasma gondii oocysts for rats. J. Parasitol. 82 1996 951 956 · DOI
  39. 10.1017/S0031182097008949 · DOI
  40. Dubey J. P. Distribution of tissue cysts in tissues of rats fed oocysts. J. Parasitol. 83 1997 755 757 · DOI
  41. Dubey J. P. Survival of Toxoplasma gondii tissue cysts in 0.85–6% NACl solutions at 4–20 C. J. Parasitol. 83 1997 946 949 · DOI
  42. Dubey J. P. Bradyzoites-induced murine toxoplasmosis: stage conversion, pathogenesis, and tissue cyst formation in mice fed bradyzoites of different strains of Toxoplasma gondii. J. Eukaryot. Microbiol. 44 1997 592 602 · DOI
  43. Dubey J. P. Reexamination of resistance of Toxoplasma gondii tachyzoites to pepsin digestion. Parasitology 116 1998 43 50 · DOI
  44. Dubey J. P. Advances in the life cycle of Toxoplasma gondii . Int. J. Parasitol. in press.
  45. Dubey J. P. Beattie C. P. Toxoplasmosis of animals and man. 1988 CRC Press Inc. Boca Raton Fla
  46. Dubey J. P. Fenner W. R. Clinical segmental myelitis associated with an unidentified Toxoplasma-like parasite in a cat. J. Vet. Diagn. Invest. 5 1993 472 480 · DOI
  47. Dubey J. P. Frenkel J. K. Cyst-induced toxoplasmosis in cats. J. Protozool. 19 1972 155 177 · DOI · Paper page
  48. Dubey J. P. Frenkel J. K. Feline toxoplasmosis from acutely infected mice and the development of Toxoplasma cysts. J. Protozool. 23 1976 537 546 · DOI
  49. 10.2307/3284082 · DOI
  50. Dubey J. P. Murrell K. D. Fayer R. Persistence of encysted Toxoplasma gondii in tissues of pigs fed oocysts. Am. J. Vet. Res. 45 1984 1941 1943 · DOI
  51. Dubey J. P. Speer C. A. Fayer R. Sarcocystosis of animals and man. 1989 CRC Press Inc. Boca Raton Fla
  52. 10.2307/3284282 · DOI
  53. Dubey J. P. Thorne E. T. Sharma S. P. Experimental toxoplasmosis in elk (Cervus canadensis). Am. J. Vet. Res. 41 1980 792 793 · DOI
  54. Dubremetz J. F. Swartzman J. D. Subcellular organelles of Toxoplasma gondii and host cell invasion. Res. Immunol. 144 1993 31 33 · DOI
  55. Escajadillo A. Frenkel J. K. Experimental toxoplasmosis and vaccine tests in Aotus monkeys. Am. J. Trop. Med. Hyg. 44 1991 382 389 · DOI
  56. Ferguson D. J. P. Birch-Andersen A. Siim J. C. Hutchison W. M. Observations on the ultrastructure of the sporocyst and the initiation of sporozoite formation in Toxoplasma gondii. Acta Pathol. Microbiol. Scand. Sect. B 86 1978 165 167
  57. Ferguson D. J. P. Birch-Andersen A. Siim J. C. Hutchison W. M. Ultrastructural studies on the sporulation of oocysts of Toxoplasma gondii. II. Formation of the sporocysts and structure of the sporocysts wall. Acta Pathol. Microbiol. Scand. B 87 1979 183 190
  58. Ferguson D. J. P. Birch-Andersen A. Siim J. C. Hutchison W. M. Ultrastructural studies on the sporulation of oocysts of Toxoplasma gondii III. Formation of sporozoites within the sporocysts. Acta Pathol. Microbiol. Scand. Sect. B 87 1979 253 260
  59. Ferguson D. J. P. Birch-Andersen A. Siim J. C. Hutchison W. M. Ultrastructural studies on the sporulation of oocysts of Toxoplasma gondii. I. Development of the zygote and formation of sporoblasts. Acta Pathol. Microbiol. Scand. Sect. B 87 1979 171 181
  60. Ferguson D. J. P. Birch-Andersen A. Siim J. C. Hutchison W. M. An ultrastructural study on the excystation of the sporozoites of Toxoplasma gondii. Acta Pathol. Microbiol. Scand. Sect. B 87 1979 277 283
  61. Ferguson D. J. P. Dunachie, J. F. W. M. Siim J. C. Ultrastructural study of early stages of asexual multiplication and microgametogony of Toxoplasma gondii in the small intestine of the cat. Acta Pathol. Microbiol. Scand. Sect. B 82 1974 167 181
  62. 10.1007/BF00932696 · DOI
  63. Ferguson D. J. P. Hutchison W. M. Comparison of the development of avirulent and virulent strains of Toxoplasma gondii in the peritoneal exudate of mice. Ann. Trop. Med. Parasitol. 75 1981 539 546 · DOI
  64. Ferguson D. J. P. Hutchison W. M. The host-parasite relationship of Toxoplasma gondii in the brains of chronically infected mice. Virchows Arch. A 411 1987 39 43 · DOI
  65. 10.1007/BF00535321 · DOI
  66. 10.1007/BF00930955 · DOI
  67. Ferguson D. J. P. Hutchison W. M. Siim J. C. The ultrastructural development of the macrogamete and formation of the oocyst wall of Toxoplasma gondii. Acta Pathol. Microbiol. Scand. Sect. B 83 1975 491 505
  68. Fischer H. G. Nitzgen B. Reichmann G. Gross U. Hadding U. Host cells of Toxoplasma gondii encystation in infected primary culture form mouse brain. Parasitol. Res. 83 1997 637 641 · DOI
  69. Fortier B. Coignard-Chatain C. Soete M. Dubremetz J. F. Structure et biologie des bradyzoı̈tes de Toxoplasma gondii. C. R. Soc. Biol. 190 1996 385 394
  70. Frenkel J. K. Pathogenesis of toxoplasmosis and of infections with organisms resembling Toxoplasma. Ann. N. Y. Acad. Sci. 64 1956 215 251 · DOI
  71. Frenkel J. K. Adoptive immunity to intracellular infection. J. Immunol. 98 1967 1309 1319 · DOI
  72. Frenkel J. K. Pursuing Toxoplasma. J. Infect. Dis. 122 1970 553 559 · DOI
  73. Frenkel J. K. Toxoplasma in and around us. BioScience 23 1973 343 352 · DOI
  74. Frenkel J. K. The stage-conversion time of Toxoplasma gondii: interpretation of chemical-biologic data out of parasitologic or host context. Parasitol. Res. 82 1996 656 658 · DOI
  75. Frenkel J. K. Dubey J. P. Hoff R. L. Loss of stages after continuous passage of Toxoplasma gondii and Besnoitia jellisoni. J. Protozool. 23 1976 421 424 · DOI
  76. Frenkel J. K. Dubey J. P. Miller N. L. Toxoplasma gondii in cats: fecal stages identified as coccidian oocysts. Science 167 1970 893 896 · DOI · Paper page
  77. 10.4269/ajtmh.1987.36.517 · DOI
  78. Frenkel J. K. Nelson B. M. Arias-Stella J. Immunosuppression and toxoplasmic encephalitis. Clinical and experimental aspects. Hum. Pathol. 6 1975 97 111 · DOI
  79. Freyre A. Separation of Toxoplasma cysts from brain tissue and liberation of viable bradyzoites. J. Parasitol. 81 1995 1008 1010 · DOI
  80. Freyre A. Dubey J. P. Smith D. D. Frenkel J. K. Oocyst-induced Toxoplasma gondii infections in cats. J. Parasitol. 75 1989 750 755 · DOI
  81. Gazzinelli R. Denkers E. Y. Sher A. Host resistance to Toxoplasma gondii: model for studying the selective induction of cell-mediated immunity by intracellular parasites. Infect. Agents Dis. 2 1993 139 149
  82. Gazzinelli R. Xu Y. Hieny S. Cheever A. Sher A. Simultaneous depletion of CD4+ and CD8+ T lymphocytes is required to reactivate chronic infection with Toxoplasma gondii. J. Immunol. 149 1992 175 180 · DOI · Paper page
  83. Gross U. Bohne W. Toxoplasma gondii: strain- and host cell-dependent induction of stage differentiation. J. Eukaryot. Microbiol. 41 1994 10S 11S
  84. Gross U. Bohne W. Lüder C. G. K. Lugert R. Seeber F. Dittrich C. Pohl F. Ferguson D. J. P. Regulation of developmental differentiation in the protozoan parasite Toxoplasma gondii. J. Eukaryot. Microbiol. 43 1996 114 116S · DOI
  85. Gross U. Bohne W. Soête M. Dubremetz J. F. Developmental differentiation between tachyzoites and bradyzoites of Toxoplasma gondii. Parasitol. Today 12 1996 30 33 · DOI
  86. 10.1128/cdli.2.5.542-548.1995 · DOI
  87. Halonen S. K. Lyman W. D. Chiu F. C. Growth and development of Toxoplasma gondii in human neurons and astrocytes. J. Neuropathol. Exp. Neurol. 55 1996 1150 1156 · DOI
  88. 10.2307/3279864 · DOI
  89. Hogan M. J. Yoneda C. Feeney L. Zweigart P. Lewis A. Morphology and culture of Toxoplasma. Arch. Ophthalmol. 64 1960 655 667 · DOI
  90. 10.1093/infdis/172.6.1561 · DOI · Paper page
  91. 10.1093/infdis/164.1.170 · DOI
  92. Jacobs L. Moyle G. G. Ris R. R. The prevalence of toxoplasmosis in New Zealand sheep and cattle. Am. J. Vet. Res. 24 1963 673 675
  93. Jacobs L. Remington J. S. Melton M. L. The resistance of the encysted form of Toxoplasma gondii. J. Parasitol. 46 1960 11 21 · DOI
  94. Johnson A. M. Speculation on possible life-cycles for the clonal lineages in the genus Toxoplasma. Parasitol. Today 13 1997 393 397 · DOI
  95. Joiner K. Cell entry by Toxoplasma gondii: all paths do not lead to success. Res. Immunol. 144 1993 34 48 · DOI
  96. Joiner K. A. Beckers C. J. M. Bermudes D. Ossorio P. N. Schwab J. C. Dubremetz J. F. Structure and function of the parasitophorous vacuole membrane surrounding Toxoplasma gondii. Ann. N. Y. Acad. Sci. 730 1994 1 6 · DOI
  97. 10.1128/iai.51.1.147-156.1986 · DOI
  98. Kambara H. Enriquez G. L. Takayanagi T. The effects of antiserum on the cyst formation of Toxoplasma gondii in tissue culture. Jpn. J. Parasitol. 20 1971 91 94
  99. 10.1128/iai.57.3.668-672.1989 · DOI
  100. Kasper L. H. Mineo J. R. Attachment and invasion of host cells by Toxoplasma gondii. Parasitol. Today 10 1994 184 188 · DOI
  101. Kaufman H. E. Maloney E. D. Multiplication of three strains of Toxoplasma gondii in tissue culture. J. Parasitol. 48 1962 358 361 · DOI
  102. 10.1242/jcs.88.2.231 · DOI
  103. 10.1126/science.275.5305.1485 · DOI · Paper page
  104. Lainson R. Observations on the development and nature of pseudocysts and cysts of Toxoplasma gondii. Trans. R. Soc. Trop. Med. Hyg. 52 1958 396 407 · DOI
  105. Lane A. Soete M. Dubremetz J. F. Smith J. E. Toxoplasma gondii: appearance of specific markers during the development of tissue cysts in vitro. Parasitol Res. 82 1996 340 346 · DOI
  106. Leriche M. A. Dubremetz J. F. Exocytosis of dense granules after host-cell invasion by Toxoplasma gondii. Parasitol. Res. 76 1990 559 562 · DOI
  107. Levaditi C. Schoen R. Sanchis Bayarri V. L’encéphalomyélite toxoplasmique chronique du lapin et de la souris. C. R. Seances Soc. Biol. Fil. 99 1928 37 40
  108. Lindsay D. S. Dubey J. P. Blagburn B. L. Toivio-Kinnucan M. A. Examination of tissue cyst formation by Toxoplasma gondii in cell cultures using bradyzoites, tachyzoites, and sporozoites. J. Parasitol. 77 1991 126 132 · DOI
  109. Lindsay D. S. Dubey J. P. Butler J. M. Blagburn B. L. Mechanical transmission of Toxoplasma gondii oocysts by dogs. Vet. Parasitol. 73 1997 27 33 · DOI
  110. Lindsay D. S. Mitschler R. R. Toivio-Kinnucan M. A. Upton S. J. Dubey J. P. Blagburn B. L. Association of host cell mitochondria with developing Toxoplasma gondii tissue cysts. Am. J. Vet. Res. 54 1993 1663 1667 · DOI
  111. Lindsay D. S. Rippey N. S. Toivio-Kinnucan M. A. Blagburn B. L. Ultrastructural effects of diclazuril against Toxoplasma gondii and investigation of a diclazuril resistant mutant. J. Parasitol. 81 1995 459 466 · DOI
  112. 10.2307/3283523 · DOI
  113. Matsubayashi H. Akao S. Morphological studies on the development of the Toxoplasma cyst. Am. J. Trop. Med. Hyg. 12 1963 321 333 · DOI
  114. 10.1111/j.1574-6968.1993.tb06593.x · DOI
  115. McHugh T. D. Holliman R. E. Butcher P. D. The in vitro model of tissue cyst formation in Toxoplasma gondii. Parasitol. Today 10 1994 281 285 · DOI
  116. McLeod R. Skamene E. Brown C. R. Eisenhauer P. Mack D. G. Genetic regulation on early survival and cyst number after peroral Toxoplasma gondii infection of AxB/BxA recombinant inbred and B10 congenic mice. J. Immunol. 143 1989 3031 3034 · DOI
  117. Melhorn H. Frenkel J. K. Ultrastructural comparison of cysts and zoites of Toxoplasma gondii,Sarcocystsis muris, and Hammondia hammondi in skeletal muscle of mice. J. Parasitol. 66 1980 59 67 · DOI
  118. Miédougé M. Bessiéres M. H. Cassaing S. Swierczynski B. Séguéla J. P. Parasitemia and parasitic loads in acute infection and after anti-gamma-interferon treatment in a toxoplasmic mouse model. Parasitol. Res 83 1997 339 344 · DOI
  119. 10.1242/jcs.108.6.2457 · DOI · Paper page
  120. 10.1242/jcs.110.1.35 · DOI
  121. 10.1128/iai.64.10.4188-4196.1996 · DOI
  122. Nichols B. A. Chiappino M. L. O’Connor G. R. Secretion from the rhoptries of Toxoplasma gondii during host-cell invasion. J. Ultrastruct. Res. 83 1983 85 98 · DOI
  123. Nichols B. A. Chiappino M. L. Pravesio C. E. N. Endocytosis at the micropore of Toxoplasma gondii. Parasitol. Res. 80 1994 91 98 · DOI
  124. Nichols B. A. O’Connor G. R. Penetration of mouse peritoneal macrophages by the protozoon Toxoplasma gondii. Lab. Invest. 44 1981 324 335
  125. Nicoll S. Wright S. Maley S. W. Burns S. Buxton D. A mouse model of recrudescence of Toxoplasma gondii infection. J. Med. Microbiol. 46 1997 263 266 · DOI
  126. 10.1007/BF03035408 · DOI
  127. Omata Y. Igarashi M. Ramos M. I. Nakabayashi T. Toxoplasma gondii: antigenic differences between endozoites and cystozoites defined by monoclonal antibodies. Parasitol. Res. 75 1989 189 193 · DOI
  128. Pavesio C. E. N. Chiappino M. L. Setzer P. Y. Nichols B. A. Toxoplasma gondii: differentiation and death of bradyzoites. Parasitol. Res. 78 1992 1 9 · DOI
  129. Pettersen E. K. Destruction of Toxoplasma gondii by HCl solution. Acta Pathol. Microbiol. Scand. Sect. B 87 1979 217 220
  130. Pettersen E. K. Transmission of toxoplasmosis via milk from lactating mice. Acta Pathol. Microbiol. Scand. Sect. B 92 1984 175 176
  131. Pettersen E. K. Resistance to avirulent Toxoplasma gondii in normal and vaccinated rats. Acta Pathol. Microbiol. Immunol. Scand. 96 1988 820 824 · DOI
  132. 10.1007/BF00259583 · DOI
  133. Popiel I. Gold M. C. Booth K. S. Quantification of Toxoplasma gondii bradyzoites. J. Parasitol 82 1996 330 332 · DOI
  134. Popiel I. Gold M. C. Chromanski L. Tissue cyst formation of Toxoplasma gondii T-263 in cell culture. J. Eukaryot. Microbiol. 41 1994 17S
  135. Porchet-Hennere E. Vivier E. Torpier G. Origine des membranes de la paroi chez Toxoplasma. Ann. Parasitol. Hum. Comp. 60 1985 101 110 · DOI
  136. Remington J. S. Section of discussion, R. Lainson. Observations on the nature and transmission of Toxoplasma in the light of its wide host and geographical range. Surv. Ophthalmol. 6 1961 730
  137. Ricard J. Pelloux H. Pathak S. Pipy B. Ambroise-Thomas P. TNF enhances Toxoplasma gondii cyst formation in human fibroblasts through the sphingomyelinase pathway. Cell. Signalling 8 1996 439 442 · DOI
  138. Rondanelli E. G. Carosi G. Filice G. Minoli L. Scaglia M. Binary fission as a mode of reproduction of Toxoplasma gondii, RH strain—an electron microscope study. Boll. Ist. Sieroter. Milan. 53 1974 336 341
  139. 10.1016/S0091-679X(08)61845-2 · DOI · Paper page
  140. Saffer L. D. Mercareau-Puijalon O. Dubrematz J.-F. Schwartzman J. D. Localization of a Toxoplasma gondii rhoptry protein by immunoelectron microscopy during and after host cell penetration. J. Protozool. 39 1992 526 530 · DOI
  141. Sahm M. Fischer H. G. Gross U. Reiter-Owona I. Seitz H. M. Cyst formation by Toxoplasma gondii in vivo and in brain-cell culture: a comparative morphology and immunocytochemistry study. Parasitol. Res. 83 1997 659 665 · DOI
  142. 10.1073/pnas.91.2.509 · DOI · Paper page
  143. Sharma S. P. Dubey J. P. Quantitative survival of Toxoplasma gondii tachyzoites and bradyzoites in pepsin and trypsin solutions. Am. J. Vet. Res. 42 1981 128 130 · DOI
  144. Sheffield H. G. Schizogony in Toxoplasma gondii. An electron microscopic study. Proc. Helminthol. Soc. Wash. 37 1970 237 242
  145. Sheffield H. G. Melton M. L. The fine structure and reproduction of Toxoplasma gondii. J. Parasitol. 54 1968 209 226 · DOI · Paper page
  146. Shimada K. O’Connor G. R. Yoneda C. Cyst formation by Toxoplasma gondii (RH strain) in vitro. Arch. Ophthalmol. 92 1974 496 500 · DOI
  147. 10.1016/S0962-8924(00)88964-3 · DOI
  148. 10.1038/359082a0 · DOI · Paper page
  149. Sibley L. D. Krahenbuhl J. L. Adams G. M. W. Weidner E. Toxoplasma modifies macrophage phagosomes by secretion of a vesticular network rich in surface proteins. J. Cell Biol. 103 1986 867 874 · DOI
  150. Sibley L. D. Niesman I. R. Parmley S. F. Cesbron-Delauw M. F. Regulated secretion of multi-lamellar vesicles leads to formation of a tubulo-vesicular network in host-cell vacuoles occupied by Toxoplasma gondii. J. Cell Sci. 108 1995 1667 1677 · DOI
  151. 10.1038/315416a0 · DOI · Paper page
  152. Silva S. R. L. Meirelles S. S. de Souza W. Mechanism of entry of Toxoplasma gondii into vertebrate cells. J. Submicrosc. Cytol. 14 1982 471 482
  153. Sims T. A. Hay J. Talbot I. C. Host-parasite relationship in the brains of mice with congenital toxoplasmosis. J. Pathol. 156 1988 255 261 · DOI
  154. Smith J. E. Lewis E. K. The growth and development of Toxoplasma gondii tissue cysts in vitro. NATO ASI Ser. Ser. H 78 1993 99 108
  155. 10.1006/expr.1994.1039 · DOI
  156. Soête M. Fortier B. Camus D. Dubremetz J. F. Toxoplasma gondii: kinetics of bradyzoite-tachyzoite interconversion in vitro. Exp. Parasitol. 76 1993 259 264 · DOI
  157. Soête M. Fortier B. Camus D. Dubremetz J. F. Toxoplasma gondii: Patterns of bradyzoite-tachyzoite interconversion in vitro. NATO ASI Ser. Ser. H 78 1993 93 98
  158. 10.1017/S0031182097001959 · DOI
  159. Speer C. A. S. Clarke and J. P. Dubey. Ultrastructure of the oocysts sporocysts and sporozoites of the VEG strain of Toxoplasma gondii . J. Parasitol. in press.
  160. Speer C. A. Dubey J. P. Blixt J. A. Prokop K. Time lapse video microscopy and ultrastructure of penetrating sporozoites, types 1 and 2 parasitophorous vacuoles, and the transformation of sporozites to tachyzoites of the VEG strain of Toxoplasma gondii. J. Parasitol. 83 1997 565 574 · DOI
  161. Speer C. A. Tilley M. Temple M. E. Blixt J. A. Dubey J. P. White M. W. Sporozoites of Toxoplasma gondii lack dense-granule protein GRA3 and form a unique parasitophorous vacuole. Mol. Biochem. Parasitol. 75 1995 75 86 · DOI
  162. Stahl W. Matsubayashi H. Akao S. Experimental toxoplasmosis: effects of suppression of the immune response of mice by cortisone and splenectomy. Keio J. Med. 15 1966 1 12 · DOI
  163. Stahl W. Matsubayashi H. Akao S. Murine toxoplasmosis: development of bizarre clusters of cysts. Jpn. J. Parasitol. 15 1966 44 47
  164. Sulzer A. J. Strobel P. L. Springer E. L. Roth I. L. Callaway C. S. A comparative electron microscopic study of the morphology of Toxoplasma gondii by freeze-etch replication and thin sectioning technic. J. Protozool. 21 1974 710 714 · DOI
  165. Sumyuen M. H. Garin Y. J. F. Derouin F. Effect of immunosuppressive drug regimens on acute and chronic murine toxoplasmosis. Parasitol. Res. 82 1996 681 686 · DOI
  166. 10.1007/BF00933779 · DOI
  167. Suzuki Y. Conley F. K. Remington J. S. Importance of endogenous IFN-gamma for prevention of toxoplasmic encephalitis in mice. J. Immunol. 143 1989 2045 2050 · DOI · Paper page
  168. 10.1126/science.3128869 · DOI · Paper page
  169. 10.1128/iai.61.6.2284-2288.1993 · DOI
  170. 10.1016/0020-7519(95)00066-B · DOI
  171. 10.1128/iai.59.10.3750-3753.1991 · DOI
  172. 10.1006/expr.1993.1056 · DOI
  173. Torpier G. Dardé M. L. Charon H. Darcy F. Capron A. Toxoplasma gondii: membrane structure differences between zoites demonstrated by freeze fracture analysis. Exp. Parasitol. 72 1991 99 102 · DOI
  174. van der Waaij D. Formation, growth and multiplication of Toxoplasma gondii cysts in mouse brains. Trop. Geogr. Med. 11 1959 345 360
  175. Vivier E. Observations nouvelles sur la reproduction asexuée de Toxoplasma gondii et considérations sur la notion d’endogenèse. C. R. Seances Acad. Sci. 271 1970 2123 2126
  176. Vivier E. Petitprez A. Données ultrastructurales complémentaires, morphologiques et cytochimques, sur Toxoplasma gondii. Protistologica 8 1972 199 221
  177. Wanko T. Jacobs L. Gavin M. A. Electron microscope study of Toxoplasma cysts in mouse brain. J. Protozool. 9 1962 235 242 · DOI
  178. Weiss L. M. LaPlace D. Takvorian P. M. Calli A. Tanowitz H. B. Wittner M. Development of bradyzoites of Toxoplasma gondii in vitro. J. Eukaryot. Microbiol. 41 1994 18S
  179. 10.1111/j.1550-7408.1995.tb01556.x · DOI
  180. Weiss L. M. Laplace D. Takvorian P. M. Tanowitz H. B. Wittner M. The association of the stress response and Toxoplasma gondii bradyzoite development. J. Eukaryot. Microbiol. 43 1996 120S · DOI
  181. 10.1093/infdis/166.1.213 · DOI
  182. Werk R. How does Toxoplasma gondii enter host cells. Rev. Infect. Dis. 7 1985 449 457 · DOI
  183. Zhang Y. W. Smith J. E. Toxoplasma gondii: identification and characterization of a cyst molecule. Exp. Parasitol. 80 1995 228 233 · DOI

Cited by

See all 1,181

Metadata

Authors
Dubey, J. P., Lindsay, D. S., & Speer, C. A.
Venue
Clinical Microbiology Reviews
Published
1998-04
Volume
11
Issue
2
Pages
267-299
ISSN
  • 0893-8512 (ISSN-L)
  • 1098-6618
OpenAlex
W2142713800
Cited by
1,181
References
0
FWCI
11.51
Type
journal article
Language
en
Open access
green
Licence
journals.asm.org/non-commercial-tdm-license (tdm)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Structures of Toxoplasma gondii Tachyzoites, Bradyzoites, and Sporozoites and Biology and Development of Tissue Cysts. https://app.cochat.ai/papers/10.1128/cmr.11.2.267
The paper
Dubey, J. P., Lindsay, D. S., & Speer, C. A. (1998). Structures of Toxoplasma gondii Tachyzoites, Bradyzoites, and Sporozoites and Biology and Development of Tissue Cysts. Clinical Microbiology Reviews. https://doi.org/10.1128/cmr.11.2.267

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.