Cited by 1,154Tuberculosis Research and EpidemiologyInfectious Diseases and TuberculosisMycobacterium research and diagnosis

The DOI matches its Crossref record; 322 of the 322 references it cites were found in a registry or an index.

Mycobacterium tuberculosis Pathogenesis and Molecular Determinants of Virulence

Open access

Smith, Issar·2003·Clinical Microbiology Reviews

DOI 10.1128/cmr.16.3.463-496.2003PMC PMC164219

Open this paper in CoChat — free account

Abstract

Tuberculosis (TB), one of the oldest known human diseases. is still is one of the major causes of mortality, since two million people die each year from this malady. TB has many manifestations, affecting bone, the central nervous system, and many other organ systems, but it is primarily a pulmonary disease that is initiated by the deposition of Mycobacterium tuberculosis, contained in aerosol droplets, onto lung alveolar surfaces. From this point, the progression of the disease can have several outcomes, determined largely by the response of the host immune system. The efficacy of this response is affected by intrinsic factors such as the genetics of the immune system as well as extrinsic factors, e.g., insults to the immune system and the nutritional and physiological state of the host. In addition, the pathogen may play a role in disease progression since some M. tuberculosis strains are reportedly more virulent than others, as defined by increased transmissibility as well as being associated with higher morbidity and mortality in infected individuals. Despite the widespread use of an attenuated live vaccine and several antibiotics, there is more TB than ever before, requiring new vaccines and drugs and more specific and rapid diagnostics. Researchers are utilizing information obtained from the complete sequence of the M. tuberculosis genome and from new genetic and physiological methods to identify targets in M. tuberculosis that will aid in the development of these sorely needed antitubercular agents.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1128/cmr.16.3.463-496.2003

Cites

322 of 322 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence
Cole, S. T., Brosch, R., Parkhill, J., Garnier, T., Churcher, C., Harris, D., Gordon, S. V., Eiglmeier, K., Gas, S., Barry, C. E., et al. (1998) · Nature · doi:10.1038/31159 · Cited by 7,847
Molecular Beacons: Probes that Fluoresce upon Hybridization
Tyagi, S., & Kramer, F. R. (1996) · Nature Biotechnology · doi:10.1038/nbt0396-303 · Cited by 4,164
Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)
Bentley, S. D., Chater, K. F., Cerdeño-Tárraga, A. M., Challis, G. L., Thomson, N. R., James, K., Harris, D. E., Quail, M. A., Kieser, H. M., Harper, D., et al. (2002) · Nature · doi:10.1038/417141a · Cited by 3,226
Functional Discovery via a Compendium of Expression Profiles
Hughes, T. R., Marton, M. J., Jones, A. R., Roberts, C. J., Stoughton, R. B., Armour, C. D., Bennett, H. A., Coffey, E. M., Dai, H. A., He, Y. D., et al. (2000) · Cell · doi:10.1016/s0092-8674(00)00015-5 · Cited by 2,534
Aromatic-dependent Salmonella typhimurium are non-virulent and effective as live vaccines
Hoiseth, S. K., & Stocker, B. A. D. (1981) · Nature · doi:10.1038/291238a0 · Cited by 2,088
THE ENVELOPE OF MYCOBACTERIA
Brennan, P. J., & Nikaido, H. (1995) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.64.070195.000333 · Cited by 2,045
Massive gene decay in the leprosy bacillus.
Cole, S. T., Eiglmeier, K., Parkhill, J., James, K. D., Thomson, N. R., Wheeler, P. R., Honoré, N., Garnier, T., Churcher, C., Harris, D., et al. (2001) · Nature · doi:10.1038/35059006 · Cited by 1,777
Host Defense Mechanisms Triggered by Microbial Lipoproteins Through Toll-Like Receptors
Brightbill, H. D., Libraty, D. H., Krutzik, S. R., Yang, R., Belisle, J. T., Bleharski, J. R., Maitland, M. L., Norgard, M. V., Plevy, S. E., Smale, S. T., et al. (1999) · Science · doi:10.1126/science.285.5428.732 · Cited by 1,659
A new evolutionary scenario for the Mycobacterium tuberculosis complex
Brosch, R., Gordon, S. V., Marmiesse, M., Brodin, P. M., Buchrieser, C., Eiglmeier, K., Garnier, T., Gutierrez, C., Hewinson, R. G., Kremer, K., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.052548299 · Cited by 1,645
Comparative Genomics of BCG Vaccines by Whole-Genome DNA Microarray
Behr, M. A., Wilson, M. A., Gill, W., Salamon, H., Schoolnik, G. K., Rane, S., & Small, P. M. (1999) · Science · doi:10.1126/science.284.5419.1520 · Cited by 1,527

Show all 322 references

Research works printed but not linked: 14

Butcher P. D. J. A. Mangan and I. M. Monahan. 1998. Intracellular gene expression p. 285-306. In T. Parish and N. G. Stoker (ed.) Mycobacterium tuberculosis protocols. Humana Press Totowa N.J.
Derbyshire, K. M., C. Takacs, and J. Huang. 2000. Using the EZ:TNTMTransposomeTM for transposon mutagenesis in Mycobacterium smegmatis.Epicentre Forum7:1-4.
Friedman L. N. (ed.). 2001. Tuberculosis: current concepts and treatment 2nd ed. CRC Press Inc. Boca Raton Fla.
Garay. S. 1996. Pulmonary tuberculosis. p. 373-412. In W. N. Rom and S. Garay (ed.) Tuberculosis. Little Brown and Co. Boston Mass.
Gomez M. and I. Smith. 2000. Determinants of mycobacterial gene expression p. 111-129. In G. F. Hatfull and W. R. Jacobs Jr (ed.) Molcular genetics of mycobacteria. American Society for Microbiology Washington. D.C.
Haas F. and S. S. Haas. 1996. The origins of Mycobacterium tuberculosis and the notion of its contagiousness p. 3-19. In W. N. Rom and S. Garay (ed.) Tuberculosis. Little Brown and Co. Boston Mass.
Hatfull G. F. and W. R. Jacobs Jr. (ed.). 2000. Molecular genetics of mycobacteria. American Society for Microbiology Washington D.C.
Jagirdar J. and D. ZagZag. 1996. Pathology and insights into pathogenesis of tuberculosis p. 467-491. In W. N. Rom and S. Garay (ed.) Tuberculosis. Little Brown and Co. Boston Mass.
Kamholz S. L. 1996. Pleural tuberculosis p. 483-491. In W. N. Rom and S. Garay (ed.) Tuberculosis. Little Brown and Co. Boston Mass.
Munger J. S. and J. H. A. Chapman. 1996. Tissue destruction by proteases p. 353-361. In W. N. Rom and S. Garay (ed.) Tuberculosis. Little Brown and Co. Boston Mass.
Rom W. N. and S. Garay (ed.). 1996. Tuberculosis. Little Brown and Co. Boston Mass.
Talavera W. R. Miranda K. Lessnau and L. Klapholz. 2001. Extrapulmonary tuberculosis p. 139-190. In L. N. Friedman (ed.) Tuberculosis: current concepts and treatment 2nd ed. CRC Press Inc. Boca Raton Fla.
Tyagi A. K. S. K. D. Gupta and S. Jain. 2000. Gene expression: reporter technologies p. 131-147. In G. F. Hatfull and W. R. Jacobs Jr. (ed.) Molecular genetics of mycobacteria. American Society for Microbiology Washington D.C.
Zugar A. and F. D. Lowy. 1996. Tuberculosis of the brain meninges and the spinal cord p. 541-556. In W. N. Rom and S. Gary (ed.) Tuberculosis. Little Brown and Co. Boston Mass.

Sorted by citations

Items 201–300 of 1,000

Comparative transcriptomic analysis of THP‐1‐derived macrophages infected with Mycobacterium tuberculosis H37Rv, H37Ra and BCG
Pu, W., Zhao, C. N., Wazir, J., Su, Z., Niu, M., Song, S., Wei, L., Li, L., Zhang, X., Shi, X., et al. (2021) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.16980 · Cited by 45
Characterization of the putative operon containing arylamine N‐acetyltransferase (nat) in Mycobacterium bovis BCG
Anderton, M. C., Bhakta, S., Besra, G. S., Jeavons, P., Eltis, L. D., & Sim, E. (2005) · Molecular Microbiology · doi:10.1111/j.1365-2958.2005.04945.x · Cited by 45
Isoniazid and host immune system interactions: A proposal for a novel comprehensive mode of action
Khan, S. R., Manialawy, Y. M., & Siraki, A. G. (2019) · British Journal of Pharmacology · doi:10.1111/bph.14867 · Cited by 46
Anti-mycobacterial natural products and mechanisms of action
Han, J., Liu, X., Zhang, L., Quinn, R. J., & Feng, Y. (2021) · Natural Product Reports · doi:10.1039/d1np00011j · Cited by 43
A narrative review of nontuberculous mycobacterial pulmonary disease: microbiology, epidemiology, diagnosis, and management challenges
Hamed, K. A., & Tillotson, G. (2023) · Expert Review of Respiratory Medicine · doi:10.1080/17476348.2023.2283135 · Cited by 44
Role of P27-P55 operon from Mycobacterium tuberculosis in the resistance to toxic compounds
Bianco, M. V., Blanco, F. C., Imperiale, B. R., Forrellad, M. A., Rocha, R. V., Klepp, L. I., Cataldi, A. A., Morcillo, N., & Bigi, F. (2011) · BMC Infectious Diseases · doi:10.1186/1471-2334-11-195 · Cited by 44
Comparative Phylogenomics of Pathogenic and Non-Pathogenic Mycobacterium
Prasanna, A. N., & Mehra, S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0071248 · Cited by 44
Long-acting antituberculous therapeutic nanoparticles target macrophage endosomes
Edagwa, B. J., Guo, D.-W., Puligujja, P., Chen, H., McMillan, J., Liu, X.-M., Gendelman, H., & Narayanasamy, P. (2014) · The FASEB Journal · doi:10.1096/fj.14-255786 · Cited by 44
Effector Mechanisms of Neutrophils within the Innate Immune System in Response to Mycobacterium tuberculosis Infection
Warren, E., Teskey, G., & Venketaraman, V. (2017) · Journal of Clinical Medicine · doi:10.3390/jcm6020015 · Cited by 44
Glutamate mediated metabolic neutralization mitigates propionate toxicity in intracellular Mycobacterium tuberculosis
Lee, J. J., Lim, J., Gao, S., Lawson, C. P. A. T., Odell, M., Raheem, S., Woo, J., Kang, S.-H., Kang, S.-S., Jeon, B., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-26950-z · Cited by 41
Odoriferous Therapy: A Review Identifying Essential Oils against Pathogens of the Respiratory Tract
Rapper, S. L., & van Vuuren, S. F. (2020) · Chemistry & Biodiversity · doi:10.1002/cbdv.202000062 · Cited by 46
Antimycobacterial Effects of Everolimus in a Human Granuloma Model
Ashley, D., Hernandez, J., Cao, R., To, K., Yegiazaryan, A., Abrahem, R., Nguyen, T. K., Owens, J., Lambros, M. P., Subbian, S., et al. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9072043 · Cited by 44
Advances in Aptamer-Based Biosensors and Cell-Internalizing SELEX Technology for Diagnostic and Therapeutic Application
Gan, Z., Roslan, M. A. M., Shukor, M. Y., Halim, M., Yasid, N. A., Abdullah, J., Yasin, I. S. M., & Wasoh, H. (2022) · Biosensors · doi:10.3390/bios12110922 · Cited by 43
Involvement of the autophagy pathway in trafficking ofMycobacterium tuberculosisbacilli through cultured human type II epithelial cells
Fine, K. L., Metcalfe, M. G., WHITE, E. H., Virji, M., Karls, R. K., & Quinn, F. D. (2012) · Cellular Microbiology · doi:10.1111/j.1462-5822.2012.01804.x · Cited by 44
Evaluation of the role of Mycobacterium tuberculosis pili (MTP) as an adhesin, invasin, and cytokine inducer of epithelial cells
Ramsugit, S., Pillay, B., & Pillay, M. (2015) · The Brazilian Journal of Infectious Diseases · doi:10.1016/j.bjid.2015.11.002 · Cited by 43
Role of Metal-Dependent Regulation of ESX-3 Secretion in Intracellular Survival of Mycobacterium tuberculosis
Tinaztepe, E., Wei, J.-R., Raynowska, J., Portal‐Celhay, C., Thompson, V., & Philips, J. A. (2016) · Infection and Immunity · doi:10.1128/iai.00197-16 · Cited by 41
Model Systems for Pulmonary Infectious Diseases: Paradigms of Anthrax and Tuberculosis
Arora, G., Misra, R., & Sajid, A. (2017) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026617666170130111324 · Cited by 43
Nanomaterials in the Prevention, Diagnosis, and Treatment of Mycobacterium Tuberculosis Infections
Xu, K., Liang, Z. C., Ding, X., Hu, H., Liu, S., Nurmik, M., Bi, S., Hu, F.-S., Ji, Z., Ren, J., et al. (2017) · Advanced Healthcare Materials · doi:10.1002/adhm.201700509 · Cited by 44
Host-Pathogen Interaction as a Novel Target for Host-Directed Therapies in Tuberculosis
Abreu, R. B., Giri, P. K., & Quinn, F. D. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01553 · Cited by 44
Identification of Autophagy-Inhibiting Factors of Mycobacterium tuberculosis by High-Throughput Loss-of-Function Screening
Strong, E. J., Smith, K. L. J., Saini, N. K., Ng, T. W., Porcelli, S. A., & Lee, S. (2020) · Infection and Immunity · doi:10.1128/iai.00269-20 · Cited by 41
Biological Implications of Mycobacterium leprae Gene Expression during Infection
Williams, D. L., Torrero, M. N., Wheeler, P. R., Truman, R. W., Yoder, M. A., Morrison, N., Bishai, W. R., & Gillis, T. P. (2004) · Microbial Physiology · doi:10.1159/000082081 · Cited by 43
Mouse Models for Mycobacterium tuberculosis Pathogenesis: Show and Do Not Tell
Soldevilla, P., Vilaplana, C., & Cardona, P.-J. (2022) · Pathogens · doi:10.3390/pathogens12010049 · Cited by 46
M ycobacterium tuberculosis ori C sequestration by MtrA response regulator
Gorla, P., Sarva, K., Blaszczyk, E., Rajagopalan, M. R., & Madiraju, M. V. V. S. (2015) · Molecular Microbiology · doi:10.1111/mmi.13144 · Cited by 42
Antituberculosis study of organotin(IV) complexes: A review
Iqbal, H., Ali, S., & Shahzadi, S. (2015) · Cogent Chemistry · doi:10.1080/23312009.2015.1029039 · Cited by 42
Host genome polymorphisms and tuberculosis infection: What we have to say?
Khalilullah, S. A., Harapan, H., Hasan, N. A., Winardi, W., Ichsan, I., & Mulyadi, M. (2013) · Egyptian Journal of Chest Diseases and Tuberculosis · doi:10.1016/j.ejcdt.2013.12.002 · Cited by 42
Massive gene acquisitions in Mycobacterium indicus pranii provide a perspective on mycobacterial evolution
Saini, V., Raghuvanshi, S., Khurana, J. P., Ahmed, N., Hasnain, S. E., Tyagi, A. K., & Tyagi, A. K. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks793 · Cited by 42
16S rRNA gene based bacterial community structure of wastewater treatment plant effluents
Thùy, T., Delaney, S. R., & Walsh, F. (2019) · FEMS Microbiology Letters · doi:10.1093/femsle/fnz017 · Cited by 39
Recent advances in antituberculous drug development and novel drug targets
Tomioka, H., Tatano, Y., Yasumoto, K., & Shimizu, T. (2008) · Expert Review of Respiratory Medicine · doi:10.1586/17476348.2.4.455 · Cited by 40
Binding of pyrazole-based inhibitors to Mycobacterium tuberculosis pantothenate synthetase: docking and MM-GB(PB)SA analysis
Ntie‐Kang, F., Kannan, S., Wichapong, K., Owono, L. C. O., Sippl, W., & Megnassan, E. (2013) · Molecular BioSystems · doi:10.1039/c3mb70449a · Cited by 41
Mycobacterium avium MAV2054 protein induces macrophage apoptosis by targeting mitochondria and reduces intracellular bacterial growth
Lee, K.-I., Whang, J., Choi, H., Son, Y., Jeon, H. S., Back, Y. W., Park, H., Paik, S., Park, J., Choi, C. H., et al. (2016) · Scientific Reports · doi:10.1038/srep37804 · Cited by 41
Mycobacterium leprae’s evolution and environmental adaptation
Chavarro, B., Soto, C. Y., & Guerrero, M. I. (2019) · Acta Tropica · doi:10.1016/j.actatropica.2019.105041 · Cited by 42
Tuberculosis of the spine and drug resistance: a review article
Kumar, V., Neradi, D., Sherry, B., Gaurav, A., & Dhatt, S. S. (2021) · Neurosurgical Review · doi:10.1007/s10143-021-01595-1 · Cited by 41
A Saudi Arabian Public Health Perspective of Tuberculosis
Saati, A. A., Khurram, M., Faidah, H. S., Haseeb, A., & Iriti, M. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph181910042 · Cited by 40
Mycobacterium tuberculosis TlyA Protein Negatively Regulates T Helper (Th) 1 and Th17 Differentiation and Promotes Tuberculosis Pathogenesis
Rahman, M. A., Sobia, P., Dwivedi, V. P., Bhawsar, A., Singh, D. K., Sharma, P., Moodley, P., Kaer, L. V., Bishai, W. R., & Das, G. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.653600 · Cited by 44
Mycobacterium tuberculosis alters the differentiation of monocytes into macrophages in vitro
Castaño, D., Barrera, L. F., & Rojas, M. (2011) · Cellular Immunology · doi:10.1016/j.cellimm.2011.02.006 · Cited by 40
Prevalence of Multi Drug Resistant Tuberculosis among Presumptive Multi Drug Resistant Tuberculosis Cases in Amhara National Regional State, Ethiopia
Nigus, D. M. (2014) · Mycobacterial Diseases · doi:10.4172/2161-1068.1000152 · Cited by 40
The emerging role of gasotransmitters in the pathogenesis of tuberculosis
Chinta, K. C., Saini, V., Glasgow, J. N., Mazorodze, J. H., Rahman, M. A., Reddy, D., Lancaster, J. R., & Steyn, A. J. C. (2016) · Nitric Oxide · doi:10.1016/j.niox.2016.06.009 · Cited by 41
Depletion of M. tuberculosis GlmU from Infected Murine Lungs Effects the Clearance of the Pathogen
Soni, V., Upadhayay, S., Suryadevara, P., Samla, G., Singh, A. K., Yogeeswari, P., Sriram, D., & Nandicoori, V. K. (2015) · PLoS Pathogens · doi:10.1371/journal.ppat.1005235 · Cited by 38
Detection of anti-HspX antibodies and HspX protein in patient sera for the identification of recent latent infection by Mycobacterium tuberculosis
Castro‐Garza, J., García-Jacobo, P. J., Rivera-Morales, L. G., Quinn, F. D., Barber, J. P., Karls, R. K., Haas, D. L., Helms, S., Gupta, T., Blumberg, H. M., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0181714 · Cited by 38
Heparin inhibits intracellular Mycobacterium tuberculosis bacterial replication by reducing iron levels in human macrophages
Abreu, R. B., Essler, L., Loy, A., Quinn, F. D., & Giri, P. K. (2018) · Scientific Reports · doi:10.1038/s41598-018-25480-y · Cited by 39
TLR 8 gene polymorphism and association in bacterial load in southern P unjab of P akistan: an association study with pulmonary tuberculosis
Bukhari, M., Aslam, M. A., Khan, A. U. H., Iram, Q., Akbar, A., Naz, A., Ahmad, S., Ahmad, M. M., Ashfaq, U. A., Aziz, H., et al. (2015) · International Journal of Immunogenetics · doi:10.1111/iji.12170 · Cited by 37
New bithiazolyl hydrazones: Novel synthesis, characterization and antitubercular evaluation
Bhalerao, M. B., Dhumal, S. T., Deshmukh, A. R., Nawale, L., Khedkar, V. M., Sarkar, D. M., & Mane, R. A. (2016) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2016.11.056 · Cited by 37
Was the First Public Health Campaign Successful?
Anderson, D. M., Charles, K. K., Olivares, C. L. H., & Rees, D. I. (2019) · American Economic Journal Applied Economics · doi:10.1257/app.20170411 · Cited by 44
Design and Synthesis of 1,3,4-Thiadiazole Derivatives as Novel Anticancer and Antitubercular Agents
Sekhar, D. C., Rao, D. V. V., Rao, A. T., Kumar, U., & Jha, A. (2019) · Russian Journal of General Chemistry · doi:10.1134/s1070363219040224 · Cited by 37
UtilisingGalleria mellonella larvae for studying in vivo activity of conventional and novel antimicrobial agents
Piatek, M. E., Sheehan, G., & Kavanagh, K. A. (2020) · Pathogens and Disease · doi:10.1093/femspd/ftaa059 · Cited by 40
Clofazimine functionalized polymeric nanoparticles for brain delivery in the tuberculosis treatment
de Castro, R. R., do Carmo, F. A., Martins, C., Simon, A., de Sousa, V. P., Rodrigues, C. R., Cabral, L. M., & Sarmento, B. F. C. C. (2021) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2021.120655 · Cited by 37
New perspectives in biomolecular paleopathology of ancient tuberculosis: a proteomic approach
Boros-Major, A., Bona, A., Lovasz, G., Molnar, E., Marcsik, A., Palfi, G., & Mark, L. (2011) · Journal of Archaeological Science · doi:10.1016/j.jas.2010.09.008 · Cited by 28
Alterations in Phospholipid Catabolism in Mycobacterium Tuberculosis LysX Mutant
Maloney, E., Lun, S., Stankowska, D. L., Guo, H., Rajagoapalan, M., Bishai, W. R., & Madiraju, M. V. V. S. (2011) · Frontiers in Microbiology · doi:10.3389/fmicb.2011.00019 · Cited by 37
Humoral immunity in tuberculin skin test anergy and its role in high-risk persons exposed to active tuberculosis
Encinales, L., Zúñiga, J., Granados‐Montiel, J., Yunis, M., Granados, J., Almeciga, I., Clavijo, O. P., Awad, C. E., Collazos, V., Vargas-Rojas, M. I., et al. (2009) · Molecular Immunology · doi:10.1016/j.molimm.2009.11.005 · Cited by 37
The role of ABC efflux pump, Rv1456c-Rv1457c-Rv1458c, from Mycobacterium tuberculosis clinical isolates in China
Hao, P., Shi-Liang, Z., Ju, L., Ya-Xin, D., Biao, H., Wang, X., Min-Tao, H., Shou-Gang, K., & Wang, K. (2011) · Folia Microbiologica · doi:10.1007/s12223-011-0080-7 · Cited by 37
Killing of Mycolic Acid-Containing Bacteria Aborted Induction of Antibiotic Production by Streptomyces in Combined-Culture
Asamizu, S., Ozaki, T., Teramoto, K., Satoh, K., & Onaka, H. (2015) · PLoS ONE · doi:10.1371/journal.pone.0142372 · Cited by 39
Nitric Oxide and KLF4 Protein Epigenetically Modify Class II Transactivator to Repress Major Histocompatibility Complex II Expression during Mycobacterium bovis Bacillus Calmette-Guérin Infection
Ghorpade, D. S., Holla, S., Sinha, A. Y., Alagesan, S., & Balaji, K. N. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.472183 · Cited by 36
Rifampin Stability and Solution Concentration Enhancement Through Amorphous Solid Dispersion in Cellulose ω-Carboxyalkanoate Matrices
Arca, H. Ç., Mosquera-Giraldo, L. I., Pereira, J. M., Sriranganathan, N., Taylor, L. S., & Edgar, K. J. (2017) · Journal of Pharmaceutical Sciences · doi:10.1016/j.xphs.2017.05.036 · Cited by 36
Have archaeal genes contributed to bacterial virulence?
Gophna, U., Charlebois, R. L., & Doolittle, W. F. (2004) · Trends in Microbiology · doi:10.1016/j.tim.2004.03.002 · Cited by 36
Tuberculous Lymphadenitis and Parotitis.
Cataño, J. C., & Robledo, J. (2016) · Microbiology Spectrum · doi:10.1128/microbiolspec.tnmi7-0008-2016 · Cited by 35
Facing multi-drug resistant tuberculosis
Sotgiu, G., & Migliori, G. B. (2014) · Pulmonary Pharmacology & Therapeutics · doi:10.1016/j.pupt.2014.04.006 · Cited by 35
Systematic Expression Profiling Analysis Identifies Specific MicroRNA-Gene Interactions that May Differentiate between Active and Latent Tuberculosis Infection
Wu, L. S., Lee, S., Huang, K., Lee, T.-Y., Hsu, P. W.-C., & Weng, J. T.-Y. (2014) · BioMed Research International · doi:10.1155/2014/895179 · Cited by 35
Genotypic detection of rifampicin and isoniazid resistant Mycobacterium tuberculosis strains by DNA sequencing: a randomized trial
Abd‐Elaal, A. M., El-Ghaffar, H. A., Zaghloul, H., El-Mashad, N., Badran, E., & Fathy, A. (2009) · Annals of Clinical Microbiology and Antimicrobials · doi:10.1186/1476-0711-8-4 · Cited by 35
The Role of Complement System and the Immune Response to Tuberculosis Infection
Jagatia, H., & Tsolaki, A. G. (2021) · Medicina · doi:10.3390/medicina57020084 · Cited by 35
Evolution of the Mycobacterial SigK Regulon
Veyrier, F. J., Saïd‐Salim, B., & Behr, M. A. (2008) · Journal of Bacteriology · doi:10.1128/jb.01452-07 · Cited by 35
Truncated Hemoglobin, HbN, Is Post-translationally Modified in Mycobacterium tuberculosis and Modulates Host-Pathogen Interactions during Intracellular Infection
Arya, S., Sethi, D., Singh, S., Hade, M. D., Singh, V., Raju, P., Chodisetti, S. B., Verma, D., Varshney, G. C., Agrewala, J. N., et al. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.507301 · Cited by 35
Orbital and external ocular manifestations of Mycobacterium tuberculosis: A review of the literature
Dalvin, L. A., & Smith, W. M. (2015) · Journal of Clinical Tuberculosis and Other Mycobacterial Diseases · doi:10.1016/j.jctube.2015.11.001 · Cited by 34
Characterizing the Effects of Glutathione as an Immunoadjuvant in the Treatment of Tuberculosis
Cao, R., Teskey, G., Islamoglu, H., Abrahem, R., Munjal, S., Gyurjian, K., Zhong, L., & Venketaraman, V. (2018) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01132-18 · Cited by 34
Synthesis, characterization, antimicrobial, and MOE evaluation of nano 1,2,4‐triazole‐based Schiff base ligand with some d‐block metal ions
Mahmoud, N. F., Abbas, A. A., & Mohamed, G. G. (2021) · Applied Organometallic Chemistry · doi:10.1002/aoc.6219 · Cited by 34
Deciphering the genes involved in pathogenesis of Mycobacterium tuberculosis
Singh, R., Singh, A., & Tyagi, A. K. (2005) · Tuberculosis · doi:10.1016/j.tube.2005.08.015 · Cited by 34
Application of optical imaging to study of extrapulmonary spread by tuberculosis
Kong, Y., Subbian, S., Cirillo, S. L. G., & Cirillo, J. D. (2009) · Tuberculosis · doi:10.1016/s1472-9792(09)70006-x · Cited by 34
Participation of fad and mbt Genes in Synthesis of Mycobactin in Mycobacterium smegmatis
LaMarca, B. B., Zhu, W., Arceneaux, J. E. L., Byers, B. R., & Lundrigan, M. D. (2003) · Journal of Bacteriology · doi:10.1128/jb.186.2.374-382.2004 · Cited by 34
Peroxiredoxin Systems in Mycobacteria
Jaeger, T. (2007) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-1-4020-6051-9_9 · Cited by 34
Updated Review on the Mechanisms of Pathogenicity in Mycobacterium abscessus, a Rapidly Growing Emerging Pathogen
López-Roa, P., Esteban, J., & Muñoz-Egea, M.-C. (2022) · Microorganisms · doi:10.3390/microorganisms11010090 · Cited by 33
NMR-based metabonomics for understanding the influence of dormant female genital tuberculosis on metabolism of the human endometrium
Subramani, E., Jothiramajayam, M., Dutta, M., Chakravorty, D., Joshi, M. V., Srivastava, S., Mukherjee, A., Ray, C. D., Chakravarty, B. N., & Chaudhury, K. (2016) · Human Reproduction · doi:10.1093/humrep/dew003 · Cited by 33
TiO2 nanowires as an effective sensing platform for rapid fluorescence detection of single-stranded DNA and double-stranded DNA
Ding, W., Song, C., Li, T., Ma, H., Yao, Y., & Yao, C. (2019) · Talanta · doi:10.1016/j.talanta.2019.02.002 · Cited by 33
Handling the Hurdles on the Way to Anti-tuberculosis Drug Development
Dalberto, P. F., de Souza, E. V., Abbadi, B. L., Neves, C. E., Rambo, R. S., Ramos, A. S., Macchi, F. S., Machado, P., Bizarro, C. V., & Basso, L. A. (2020) · Frontiers in Chemistry · doi:10.3389/fchem.2020.586294 · Cited by 33
In silico identification of novel chemical compounds with antituberculosis activity for the inhibition of InhA and EthR proteins from Mycobacterium tuberculosis
Halder, S. K., & Elma, F. (2021) · Journal of Clinical Tuberculosis and Other Mycobacterial Diseases · doi:10.1016/j.jctube.2021.100246 · Cited by 35
Tuberculosis: The success tale of less explored dormant Mycobacterium tuberculosis
Verma, A., Ghoshal, A., Dwivedi, V. P., & Bhaskar, A. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.1079569 · Cited by 36
Smear positive extra pulmonary tuberculosis disease at University of Gondar Hospital, Northwest Ethiopia
Zenebe, Y., Anagaw, B., Tesfay, W., Debebe, T., & Gelaw, B. (2013) · BMC Research Notes · doi:10.1186/1756-0500-6-21 · Cited by 33
Legionella Pneumonia and HIV: Case Reports and Review of the Literature
Sandkovsky, U., Sandkovsky, G., Suh, J., Smith, B., Sharp, V. J. A., & Polsky, B. (2008) · AIDS Patient Care and STDs · doi:10.1089/apc.2007.0111 · Cited by 32
Mixed micelles of Lecithin–Tyloxapol as pharmaceutical nanocarriers for anti-tubercular drug delivery
Mehta, S. K., & Jindal, N. (2013) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2013.05.015 · Cited by 32
Mycobacterium tuberculosis Zinc Metalloprotease-1 Assists Mycobacterial Dissemination in Zebrafish
Vemula, M. H., Medishetti, R., Ganji, R., Jakkala, K., Sankati, S., Chatti, K., & Banerjee, S. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.01347 · Cited by 30
Structure Guided Lead Generation toward Nonchiral M. tuberculosis Thymidylate Kinase Inhibitors
Song, L., Merceron, R., Gracia, B., Lucía, A., Risseeuw, M., Hulpia, F., Cos, P., Aínsa, J. A., Munier‐Lehmann, H., Savvides, S. N., et al. (2018) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.7b01570 · Cited by 32
ZnO nano-cages derived from ZIF-8 with enhanced anti mycobacterium-tuberculosis activities
Cui, J., Wang, L., Han, Y., Liu, W., Li, Z., Guo, Z., Hu, Y., Chang, Z., Yuan, Q., & Wang, J. (2018) · Journal of Alloys and Compounds · doi:10.1016/j.jallcom.2018.06.339 · Cited by 32
Tracking down the White Plague. Chapter two: The role of endocranial abnormal blood vessel impressions and periosteal appositions in the paleopathological diagnosis of tuberculous meningitis
Spekker, O., Schultz, M., Paja, L., Váradi, O. A., Molnár, E., Pálfi, G., & Hunt, D. R. (2020) · PLoS ONE · doi:10.1371/journal.pone.0238444 · Cited by 32
The pathogenic mechanism of Mycobacterium tuberculosis: implication for new drug development
Yan, W., Zheng, Y., Dou, C. R., Zhang, G., Arnaout, T., & Cheng, W. (2022) · Molecular Biomedicine · doi:10.1186/s43556-022-00106-y · Cited by 35
The virulence factors of Mycobacterium tuberculosis: Genetic control, new conceptions
Prozorov, A. A., Fedorova, I. A., Bekker, O. B., & Даниленко, В. Н. (2014) · Russian Journal of Genetics · doi:10.1134/s1022795414080055 · Cited by 34
Novel technologies: A weapon against tuberculosis
Hari, B. V., Chitra, K., Bhimavarapu, R., Karunakaran, P., Muthukrishnan, N., & Rani, B. S. (2010) · Indian Journal of Pharmacology · doi:10.4103/0253-7613.71887 · Cited by 32
Vaccine innovation, translational research and the management of knowledge accumulation
Yaqub, O., & Nightingale, P. (2012) · Social Science & Medicine · doi:10.1016/j.socscimed.2012.07.023 · Cited by 31
Virulence-Dependent Alterations in the Kinetics of Immune Cells during Pulmonary Infection by Mycobacterium tuberculosis
Kim, W. S., Kim, J.-S., Bin, S., Han, S. J., Kim, H., Kwon, K. W., Kim, S. J., Eum, S.-Y., Cho, S.-N., & Shin, S. J. (2015) · PLoS ONE · doi:10.1371/journal.pone.0145234 · Cited by 31
Secretome Prediction of Two M. tuberculosis Clinical Isolates Reveals Their High Antigenic Density and Potential Drug Targets
Cornejo‐Granados, F., Zatarain-Barrón, Z. L., Cantu-Robles, V. A., Mendoza-Vargas, A., Molina-Romero, C., Sánchez, F., del Pozo‐Yauner, L., Hernández‐Pando, R., & Ochoa‐Leyva, A. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.00128 · Cited by 31
Designing of phenol-based β−carbonic anhydrase1 inhibitors through QSAR, molecular docking, and MD simulation approach
Ahamad, S., Hassan, M. I., & Dwivedi, N. (2018) · 3 Biotech · doi:10.1007/s13205-018-1278-z · Cited by 31
Nanomedicines towards targeting intracellular Mtb for the treatment of tuberculosis
Donnellan, S., & Giardiello, M. (2019) · Journal of Interdisciplinary Nanomedicine · doi:10.1002/jin2.61 · Cited by 31
Point‐of‐critical‐care diagnostics for sepsis enabled by multiplexed micro and nano sensing technologies
Ashley, B. K., & Hassan, U. (2021) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1701 · Cited by 30
Probing the architecture of the Mycobacterium marinum arylamine N-acetyltransferase active site
Abuhammad, A., Lowe, E. D., Fullam, E., Noble, M. E. M., Garman, E. F., & Sim, E. (2010) · Protein & Cell · doi:10.1007/s13238-010-0037-7 · Cited by 31
Identification of novel scaffolds targeting Mycobacterium tuberculosis
Molin, M. D., Selchow, P., Schäfle, D., Tschumi, A., Ryckmans, T., Laage-Witt, S., & Sander, P. (2019) · Journal of Molecular Medicine · doi:10.1007/s00109-019-01840-7 · Cited by 33
Mycolic acid-containing bacteria trigger distinct types of membrane vesicles through different routes
Nagakubo, T., Tahara, Y. O., Miyata, M., Nomura, N., & Toyofuku, M. (2021) · iScience · doi:10.1016/j.isci.2020.102015 · Cited by 32
Designing live bacterial therapeutics for cancer
Lee, J., McClure, S., Weichselbaum, R. R., & Mimee, M. (2025) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2025.115579 · Cited by 31
Possible allosteric binding site on Gyrase B, a key target for novel anti-TB drugs: homology modelling and binding site identification using molecular dynamics simulation and binding free energy calculations
Chetty, S., & Soliman, M. E. S. (2014) · Medicinal Chemistry Research · doi:10.1007/s00044-014-1279-3 · Cited by 30
A Network Biology Approach to Decipher Stress Response in Bacteria Using Escherichia coli As a Model
Nagar, S. D., Aggarwal, B., Joon, S., Bhatnagar, R., & Bhatnagar, S. (2016) · OMICS A Journal of Integrative Biology · doi:10.1089/omi.2016.0028 · Cited by 30
Profile of tuberculosis and its response to anti-TB drugs among tuberculosis patients treated under the TB control programme at Felege-Hiwot Referral Hospital, Ethiopia
Zenebe, Y., Adem, Y., Mekonnen, D. S., Derbie, A., Bereded, F., Bantie, M., Tulu, B., Hailu, D., & Biadglegne, F. (2016) · BMC Public Health · doi:10.1186/s12889-016-3362-9 · Cited by 33
Mycobacterium tuberculosis PPE44 (Rv2770c) is involved in response to multiple stresses and promotes the macrophage expression of IL-12 p40 and IL-6 via the p38, ERK, and NF-κB signaling axis
Yu, Z., Zhang, C., Zhou, M., Li, Q., Li, H., Duan, W., Li, X., Feng, Y., & Xie, J. (2017) · International Immunopharmacology · doi:10.1016/j.intimp.2017.06.028 · Cited by 30
Using Mycobacterium marinum and its hosts to study tuberculosis
Ramakrishnan, L. (2004) · Cited by 30
Structural Characterization of a Specific Glycopeptidolipid Containing a Novel N -Acyl-Deoxy Sugar from Mycobacterium intracellulare Serotype 7 and Genetic Analysis of Its Glycosylation Pathway
Fujiwara, N., Nakata, N., Maeda, S., Naka, T., Doe, M., Yano, I., & Kobayashi, K. (2006) · Journal of Bacteriology · doi:10.1128/jb.01471-06 · Cited by 30

Authors: Smith, I.
Affiliations: International Center for Public Health (US)
Corresponding author: Smith, Issar
Venue: Clinical Microbiology Reviews
Publisher: American Society for Microbiology
Published: 2003-07
Volume: 16
Issue: 3
Pages: 463-496
ISSN: 0893-8512 (ISSN-L)
1098-6618
DOI: 10.1128/cmr.16.3.463-496.2003
PMC: PMC164219
OpenAlex: W2157638040
Cited by: 1,154
References: 322
Citations by year: 2026: 29 · 2025: 56 · 2024: 57 · 2023: 87 · 2022: 87 · 2021: 87 · 2020: 84 · 2019: 76 · 2018: 73 · 2017: 54 · 2016: 57 · 2015: 54 · 2014: 46 · 2013: 54 · 2012: 33
FWCI: 3.73
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Clinical Microbiology Reviews (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Heart, Lung, and Blood Institute (R01 HL 68513, R01HL064544, R01 HL 64544, R01HL068513)
National Institute of Allergy and Infectious Diseases (R01 AI 48856, R01AI048856)
Topics: Health Sciences › Medicine › Infectious Diseases › Tuberculosis Research and Epidemiology
Health Sciences › Medicine › Infectious Diseases › Infectious Diseases and Tuberculosis
Health Sciences › Medicine › Epidemiology › Mycobacterium research and diagnosis
Keywords: Mycobacterium tuberculosis, tuberculosis pathogenesis, bacterial virulence factors, host immune response, pulmonary tuberculosis, transmissibility, host genetics, host nutritional status, tuberculosis vaccine, tuberculosis drug targets, tuberculosis diagnosis
MeSH terms: Animals, Antitubercular Agents, Disease Models, Animal, Humans, Macrophages, Mycobacterium tuberculosis, Transcription, Genetic, Tuberculosis, Virulence, Genome, Bacterial, Proteomics

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Mycobacterium tuberculosis Pathogenesis and Molecular Determinants of Virulence

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks