Cited by 1,154Tuberculosis Research and EpidemiologyInfectious Diseases and TuberculosisMycobacterium research and diagnosis

The DOI matches its Crossref record; 322 of the 322 references it cites were found in a registry or an index.

Mycobacterium tuberculosis Pathogenesis and Molecular Determinants of Virulence

Open access

Smith, Issar·2003·Clinical Microbiology Reviews

DOI 10.1128/cmr.16.3.463-496.2003PMC PMC164219

Open this paper in CoChat — free account

Abstract

Tuberculosis (TB), one of the oldest known human diseases. is still is one of the major causes of mortality, since two million people die each year from this malady. TB has many manifestations, affecting bone, the central nervous system, and many other organ systems, but it is primarily a pulmonary disease that is initiated by the deposition of Mycobacterium tuberculosis, contained in aerosol droplets, onto lung alveolar surfaces. From this point, the progression of the disease can have several outcomes, determined largely by the response of the host immune system. The efficacy of this response is affected by intrinsic factors such as the genetics of the immune system as well as extrinsic factors, e.g., insults to the immune system and the nutritional and physiological state of the host. In addition, the pathogen may play a role in disease progression since some M. tuberculosis strains are reportedly more virulent than others, as defined by increased transmissibility as well as being associated with higher morbidity and mortality in infected individuals. Despite the widespread use of an attenuated live vaccine and several antibiotics, there is more TB than ever before, requiring new vaccines and drugs and more specific and rapid diagnostics. Researchers are utilizing information obtained from the complete sequence of the M. tuberculosis genome and from new genetic and physiological methods to identify targets in M. tuberculosis that will aid in the development of these sorely needed antitubercular agents.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1128/cmr.16.3.463-496.2003

Cites

322 of 322 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence
Cole, S. T., Brosch, R., Parkhill, J., Garnier, T., Churcher, C., Harris, D., Gordon, S. V., Eiglmeier, K., Gas, S., Barry, C. E., et al. (1998) · Nature · doi:10.1038/31159 · Cited by 7,847
Molecular Beacons: Probes that Fluoresce upon Hybridization
Tyagi, S., & Kramer, F. R. (1996) · Nature Biotechnology · doi:10.1038/nbt0396-303 · Cited by 4,164
Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)
Bentley, S. D., Chater, K. F., Cerdeño-Tárraga, A. M., Challis, G. L., Thomson, N. R., James, K., Harris, D. E., Quail, M. A., Kieser, H. M., Harper, D., et al. (2002) · Nature · doi:10.1038/417141a · Cited by 3,226
Functional Discovery via a Compendium of Expression Profiles
Hughes, T. R., Marton, M. J., Jones, A. R., Roberts, C. J., Stoughton, R. B., Armour, C. D., Bennett, H. A., Coffey, E. M., Dai, H. A., He, Y. D., et al. (2000) · Cell · doi:10.1016/s0092-8674(00)00015-5 · Cited by 2,534
Aromatic-dependent Salmonella typhimurium are non-virulent and effective as live vaccines
Hoiseth, S. K., & Stocker, B. A. D. (1981) · Nature · doi:10.1038/291238a0 · Cited by 2,088
THE ENVELOPE OF MYCOBACTERIA
Brennan, P. J., & Nikaido, H. (1995) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.64.070195.000333 · Cited by 2,045
Massive gene decay in the leprosy bacillus.
Cole, S. T., Eiglmeier, K., Parkhill, J., James, K. D., Thomson, N. R., Wheeler, P. R., Honoré, N., Garnier, T., Churcher, C., Harris, D., et al. (2001) · Nature · doi:10.1038/35059006 · Cited by 1,777
Host Defense Mechanisms Triggered by Microbial Lipoproteins Through Toll-Like Receptors
Brightbill, H. D., Libraty, D. H., Krutzik, S. R., Yang, R., Belisle, J. T., Bleharski, J. R., Maitland, M. L., Norgard, M. V., Plevy, S. E., Smale, S. T., et al. (1999) · Science · doi:10.1126/science.285.5428.732 · Cited by 1,659
A new evolutionary scenario for the Mycobacterium tuberculosis complex
Brosch, R., Gordon, S. V., Marmiesse, M., Brodin, P. M., Buchrieser, C., Eiglmeier, K., Garnier, T., Gutierrez, C., Hewinson, R. G., Kremer, K., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.052548299 · Cited by 1,645
Comparative Genomics of BCG Vaccines by Whole-Genome DNA Microarray
Behr, M. A., Wilson, M. A., Gill, W., Salamon, H., Schoolnik, G. K., Rane, S., & Small, P. M. (1999) · Science · doi:10.1126/science.284.5419.1520 · Cited by 1,527

Show all 322 references

Research works printed but not linked: 14

Butcher P. D. J. A. Mangan and I. M. Monahan. 1998. Intracellular gene expression p. 285-306. In T. Parish and N. G. Stoker (ed.) Mycobacterium tuberculosis protocols. Humana Press Totowa N.J.
Derbyshire, K. M., C. Takacs, and J. Huang. 2000. Using the EZ:TNTMTransposomeTM for transposon mutagenesis in Mycobacterium smegmatis.Epicentre Forum7:1-4.
Friedman L. N. (ed.). 2001. Tuberculosis: current concepts and treatment 2nd ed. CRC Press Inc. Boca Raton Fla.
Garay. S. 1996. Pulmonary tuberculosis. p. 373-412. In W. N. Rom and S. Garay (ed.) Tuberculosis. Little Brown and Co. Boston Mass.
Gomez M. and I. Smith. 2000. Determinants of mycobacterial gene expression p. 111-129. In G. F. Hatfull and W. R. Jacobs Jr (ed.) Molcular genetics of mycobacteria. American Society for Microbiology Washington. D.C.
Haas F. and S. S. Haas. 1996. The origins of Mycobacterium tuberculosis and the notion of its contagiousness p. 3-19. In W. N. Rom and S. Garay (ed.) Tuberculosis. Little Brown and Co. Boston Mass.
Hatfull G. F. and W. R. Jacobs Jr. (ed.). 2000. Molecular genetics of mycobacteria. American Society for Microbiology Washington D.C.
Jagirdar J. and D. ZagZag. 1996. Pathology and insights into pathogenesis of tuberculosis p. 467-491. In W. N. Rom and S. Garay (ed.) Tuberculosis. Little Brown and Co. Boston Mass.
Kamholz S. L. 1996. Pleural tuberculosis p. 483-491. In W. N. Rom and S. Garay (ed.) Tuberculosis. Little Brown and Co. Boston Mass.
Munger J. S. and J. H. A. Chapman. 1996. Tissue destruction by proteases p. 353-361. In W. N. Rom and S. Garay (ed.) Tuberculosis. Little Brown and Co. Boston Mass.
Rom W. N. and S. Garay (ed.). 1996. Tuberculosis. Little Brown and Co. Boston Mass.
Talavera W. R. Miranda K. Lessnau and L. Klapholz. 2001. Extrapulmonary tuberculosis p. 139-190. In L. N. Friedman (ed.) Tuberculosis: current concepts and treatment 2nd ed. CRC Press Inc. Boca Raton Fla.
Tyagi A. K. S. K. D. Gupta and S. Jain. 2000. Gene expression: reporter technologies p. 131-147. In G. F. Hatfull and W. R. Jacobs Jr. (ed.) Molecular genetics of mycobacteria. American Society for Microbiology Washington D.C.
Zugar A. and F. D. Lowy. 1996. Tuberculosis of the brain meninges and the spinal cord p. 541-556. In W. N. Rom and S. Gary (ed.) Tuberculosis. Little Brown and Co. Boston Mass.

Sorted by citations

Items 501–600 of 1,000

Mycobacteriophages and Tuberculosis
Hatfull, G. F. (2004) · doi:10.1128/9781555817657.ch14 · Cited by 13
Computational design of MmpL3 inhibitors for tuberculosis therapy
Chaitra, R., Gandhi, R., Jayanna, N., Satyanath, S., Pavadai, P., & Murahari, M. (2022) · Molecular Diversity · doi:10.1007/s11030-022-10436-2 · Cited by 12
Systematic Determination of the Impact of Structural Edits on Peptide Accumulation into Mycobacteria
Dash, R., Liu, Z., Lepori, I., Chordia, M. D., Ocius, K. L., Holsinger, K. A., Zhang, H., Kenyon, R., Im, W., Siegrist, M. S., et al. (2025) · ACS Chemical Biology · doi:10.1021/acschembio.5c00330 · Cited by 10
Excavating the surface-associated and secretory proteome ofMycobacterium lepraefor identifying vaccines and diagnostic markers relevant immunodominant epitopes
Rana, A., Thakur, S., Bhardwaj, N., Kumar, D., & Akhter, Y. (2016) · Pathogens and Disease · doi:10.1093/femspd/ftw110 · Cited by 12
Targeting Intracellular Pathogenic Bacteria Through N-Terminal Modification of Cationic Amphiphilic Polyproline Helices
Dietsche, T. A., Eldesouky, H. E., Zeiders, S. M., Seleem, M. N., & Chmielewski, J. A. (2020) · The Journal of Organic Chemistry · doi:10.1021/acs.joc.0c00871 · Cited by 12
Insight into the drug resistance whole genome of Mycobacterium tuberculosis isolates from Khyber Pakhtunkhwa, Pakistan
Khan, M. T., Ali, S., Khan, A. S., Ali, A., Khan, A., Kaushik, A. C., Irfan, M., Chinnasamy, S., Zhang, S., Zhang, Y., et al. (2021) · Infection Genetics and Evolution · doi:10.1016/j.meegid.2021.104861 · Cited by 12
Insights into therapeutic liquid mixtures and formulations towards tuberculosis therapy
Santos, F., Pires, D., Anes, E., & Duarte, A. R. C. (2023) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2023.122862 · Cited by 11
Factores de virulencia de Mycobacterium tuberculosis
Maulén, N. P. (2011) · Revista médica de Chile · doi:10.4067/s0034-98872011001200012 · Cited by 12
Metal cofactors play a dual role in Mycobacterium tuberculosis inorganic pyrophosphatase
Rodina, E. V., Vainonen, L., Vorobyeva, N. N., Kurilova, S. A., Ситник, Т. С., & Nazarova, T. I. (2008) · Biochemistry (Moscow) · doi:10.1134/s0006297908080075 · Cited by 12
Matrix-assisted refolding and redox properties of WhiB3/Rv3416 of Mycobacterium tuberculosis H37Rv
Alam†, M. S., & Agrawal, P. (2008) · Protein Expression and Purification · doi:10.1016/j.pep.2008.04.010 · Cited by 12
Synthesis, SAR study and evaluation of mannich and schiff bases of pyrazol-5(4H)-one moiety containing 3-(hydrazinyl)-2-phenylquinazolin-4(3H)-one
Sivakumar, K., Rajasekharan, A., Rao, R. S., & Narasimhan, B. (2013) · Indian Journal of Pharmaceutical Sciences · doi:10.4103/0250-474x.119832 · Cited by 12
Clinico-pathological features of tuberculosis due to Mycobacterium tuberculosis Uganda genotype in patients with tuberculous lymphadenitis: a cross sectional study
Wamala, D., Asiimwe, B. B., Kigozi, E., Mboowa, G., Joloba, M. L., & Källenius, G. (2014) · BMC Clinical Pathology · doi:10.1186/1472-6890-14-14 · Cited by 12
Treponemal Disease, Tuberculosis and Subsistence‐settlement Pattern in the Late Woodland Period West‐central Illinois
Mosher, G. M., Smith, M. O., Albrecht, J. L., & Salaka, V. P. (2013) · International Journal of Osteoarchaeology · doi:10.1002/oa.2344 · Cited by 12
The genetics of vulnerability
Jabado, N., & Gros, P. (2005) · Nature · doi:10.1038/434709a · Cited by 12
Single nucleotide polymorphisms in cell wall biosynthesis-associated genes and phylogeny of Mycobacterium tuberculosis lineages
Chuang, P., Chen, Y.-M. A., Chen, H.-Y., & Jou, R. (2010) · Infection Genetics and Evolution · doi:10.1016/j.meegid.2010.03.003 · Cited by 12
In vitro and intra-macrophage gene expression by Rhodococcus equi strain 103
Rahman, M. T., Parreira, V. R., & Prescott, J. F. (2005) · Veterinary Microbiology · doi:10.1016/j.vetmic.2005.08.005 · Cited by 12
HIV/AIDS, TB and Nutrition
Mendelow, B., Cegielski, P., Dhansay, M. A., Gevers, W., Gray, C. M., Gray, G., Grobler, L., Hussey, G. D., McMurray, D. N., Msamanga, G., et al. (2007) · SUNScholar (Stellenbosch University) · Cited by 12
Advancing Tuberculosis Chemotherapy: Targeted Nanomedicines for the Mycobacterium TB Granuloma
Singh, S. R., Makatini, M. M., Marimuthu, T., & Choonara, Y. E. (2025) · Small · doi:10.1002/smll.202506381 · Cited by 12
Drug resistant tuberculosis: Current scenario and impending challenges
Dewhare, S. S. (2021) · Indian Journal of Tuberculosis · doi:10.1016/j.ijtb.2021.04.008 · Cited by 12
Synchronization of Mycobacterium life cycle: A possible novel mechanism of antimycobacterial drug resistance evolution and its manipulation
Verma, H., Chauhan, A., Kumar, A., Kumar, M., & Kanchan, K. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.122632 · Cited by 11
Synthesis, characterisation, X-ray diffraction and biological evaluation of new thiourea derivatives against Mycobacterium tuberculosis and cervical cancer
Makhakhayi, L., Malan, F. P., Senzani, S., Tukulula, M., Davison, C., de la Mare, J., Nkambule, C. M., Tembu, V. J., & Manicum, A.-L. E. (2024) · Journal of Molecular Structure · doi:10.1016/j.molstruc.2024.138818 · Cited by 11
A review on biomacromolecular ligand-directed nanoparticles: New era in macrophage targeting
Swami, R., Popli, P., Sal, K., Challa, R. R., Vallamkonda, B., Garg, M., & Dora, C. P. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.141740 · Cited by 11
Interaction of the CD43 Sialomucin with the Mycobacterium tuberculosis Cpn60.2 Chaperonin Leads to Tumor Necrosis Factor Alpha Production
Torres-Huerta, A., Villaseñor, T., Flores‐Alcantar, A., Parada, C., Alemán-Navarro, E., Espitia, C., Pedraza‐Alva, G., & Rosenstein, Y. (2017) · Infection and Immunity · doi:10.1128/iai.00915-16 · Cited by 11
The Existence of Mycobacterium tuberculosis in Microenvironment of Bone
Jabir, R. A., Rukmana, A., Saleh, I., & Kurniawati, T. (2018) · InTech eBooks · doi:10.5772/intechopen.69394 · Cited by 11
Dendrimer-based drug delivery systems for tuberculosis treatment
Shukla, R., Sethi, A., Handa, M., Mohan, M., Tripathi, P. K., & Kesharwani, P. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-819811-7.00010-2 · Cited by 11
Resistant Tuberculosis: the Latest Advancements of Second-line Antibiotic Inhalation Products
Rossi, I., Bettini, R., & Buttini, F. (2021) · Current Pharmaceutical Design · doi:10.2174/1381612827666210122143214 · Cited by 11
The impact of single-cell genomics on the field of mycobacterial infection
Geraldes, I., Fernandes, M., Fraga, A. G., & Osório, N. S. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.989464 · Cited by 11
Multi-omics Investigation into the Mechanism of Action of an Anti-tubercular Fatty Acid Analogue
Sakallioglu, I. T., Maroli, A. S., Leite, A. D. L., Marshall, D. D., Evans, B. W., Zinniel, D. K., Dussault, P. H., Barletta, R. G., & Powers, R. (2022) · Journal of the American Chemical Society · doi:10.1021/jacs.2c08238 · Cited by 11
Drug Delivery by Micro, Nanoemulsions in Tuberculosis
Khunt, D., Prajapati, B. G., Prajapti, M., Misra, M., Salave, S., Patel, J. K., & Patel, R. J. (2023) · Springer eBooks · doi:10.1007/978-3-031-14100-3_9 · Cited by 11
Standard Microbiological Techniques (Staining, Morphological and Cultural Characteristics, Biochemical Properties, and Serotyping) in the Detection of ESKAPE Pathogens
Parasuraman, P., Busi, S., & Lee, J.-K. (2024) · Springer eBooks · doi:10.1007/978-981-99-8799-3_4 · Cited by 12
Expression ofNocardia brasiliensissuperoxide dismutase during the early infection of murine peritoneal macrophages
Revol, A., Espinoza-Ruiz, M., Medina-Villanueva, I., & Salinas-Carmona, M. C. (2006) · Canadian Journal of Microbiology · doi:10.1139/w06-075 · Cited by 11
Nanocarrier-Assisted Antimicrobial Therapy Against Intracellular Pathogens
Kumar, L., Verma, S., Vaidya, B., & Mehra, N. K. (2017) · Elsevier eBooks · doi:10.1016/b978-0-323-46152-8.00013-5 · Cited by 11
Recent Trends in System-Scale Integrative Approaches for Discovering Protective Antigens Against Mycobacterial Pathogens
Rana, A., Thakur, S., Kumar, G., & Akhter, Y. (2018) · Frontiers in Genetics · doi:10.3389/fgene.2018.00572 · Cited by 11
Protein–protein interaction of Rv0148 with Htdy and its predicted role towards drug resistance in Mycobacterium tuberculosis
Bhargavi, G., Hassan, S., Subramanyam, B., Tripathy, S. P., & Palaniyandi, K. (2020) · BMC Microbiology · doi:10.1186/s12866-020-01763-1 · Cited by 10
Bcl2 negatively regulates Protective Immune Responses During Mycobacterial Infection
Singh, A., Anang, V., Verma, C., Saraswati, S. S. K., Rana, A. K., Bandyopadhyay, U., Chadha, A., & Natarajan, K. (2021) · BioMolecular Concepts · doi:10.1515/bmc-2021-0010 · Cited by 11
Introduction to Chronic Respiratory Diseases: A Pressing Need for Novel Therapeutic Approaches
Chan, Y., Ng, S. W., Liew, H. S., Pua, L. J. W., Soon, L., Lim, J. S., Dua, K., & Chellappan, D. K. (2021) · Springer eBooks · doi:10.1007/978-981-33-6850-7_2 · Cited by 11
Targeting the cytochrome bc1 complex for drug development in M. tuberculosis: review
Wani, M. A., & Dhaked, D. K. (2021) · Molecular Diversity · doi:10.1007/s11030-021-10335-y · Cited by 11
Comparative Transcriptional Study of the Putative Mannose Donor Biosynthesis Genes in Virulent Mycobacterium tuberculosis and Attenuated Mycobacterium bovis BCG Strains
Keiser, T., Azad, A., Guirado, E., Bonacci, R. A., & Schlesinger, L. (2011) · Infection and Immunity · doi:10.1128/iai.05635-11 · Cited by 10
Development of new antituberculous agents based on new drug targets and structure–activity relationship
Tomioka, H. (2007) · Expert Opinion on Drug Discovery · doi:10.1517/17460441.3.1.21 · Cited by 12
Synthetic utility of sydnones to couple pharmacologically important heterocycles for antitubercular activity
Taj, T., Raikar, S. V., & Kamble, R. R. (2011) · Arabian Journal of Chemistry · doi:10.1016/j.arabjc.2011.01.029 · Cited by 11
Identification and Characterization of Two Novel Methyltransferase Genes That Determine the Serotype 12-Specific Structure of Glycopeptidolipids of Mycobacterium intracellulare
Nakata, N., Fujiwara, N., Naka, T., Yano, I., Kobayashi, K., & Maeda, S. (2007) · Journal of Bacteriology · doi:10.1128/jb.01370-07 · Cited by 11
Specific PIWI-Interacting Small Noncoding RNA Expression Patterns in Pulmonary Tuberculosis Patients
Zhang, X., Liang, Z., Zhang, Y., Zhu, M., Zhu, Y., Li, S., Zhao, W., Hu, X., & Wang, J. (2019) · Epigenomics · doi:10.2217/epi-2018-0142 · Cited by 11
Novel Biomarker Panel of Let-7d-5p and MiR-140-5p Can Distinguish Latent Tuberculosis Infection from Active Tuberculosis Patients
Liu, J., Ye, L., Liu, T., Shi, Y., Wang, Y., Wu, J., & Qi, Y. (2023) · Infection and Drug Resistance · doi:10.2147/idr.s412116 · Cited by 10
Temporal and cellular analysis of granuloma development in mycobacterial infected adult zebrafish
Luo, G., Zeng, D., Liu, J., Li, D., Takiff, H. E., Song, S., Gao, Q., & Yan, B. (2023) · Journal of Leukocyte Biology · doi:10.1093/jleuko/qiad145 · Cited by 10
Genomic and Proteomic Analyses of Extracellular Products Reveal Major Virulence Factors Likely Accounting for Differences in Pathogenicity to Bivalves between Vibrio mediterranei Strains
Fan, C., Dai, W., Zhang, H., Liu, S., Lin, Z., & Xue, Q. (2024) · Animals · doi:10.3390/ani14050692 · Cited by 10
Ajoene: a natural compound with enhanced antimycobacterial and antibiofilm properties mediated by efflux pump modulation and ROS generation against M. Smegmatis
Sarangi, A., Das, B. S., Pahuja, I., Ojha, S., Singh, V., Giri, S., Bhaskar, A., & Bhattacharya, D. (2024) · Archives of Microbiology · doi:10.1007/s00203-024-04189-9 · Cited by 10
Benzothiazinone analogs as Anti-Mycobacterium tuberculosis DprE1 irreversible inhibitors: Covalent docking, validation, and molecular dynamics simulations
Ibrahim, M. A. A., Mahmoud, D. G. M., Abdelrahman, A. H. M., Abdeljawaad, K. A. A., Mekhemer, G. A. H., Shoeib, T., El‐Tayeb, M. A., Sidhom, P. A., Paré, P. W., & Hegazy, M. F. (2024) · PLoS ONE · doi:10.1371/journal.pone.0314422 · Cited by 10
The Recent Development in the Diagnosis of Mycobacterium tuberculosis
Temur, N., EREN, E. E., Çelik, İ., Yıldız, İ. E., Nisari, M., ÜNAL, İ. S., Çelik, Ç., Ildiz, N., & Öçsoy, İ. (2025) · Smart Medicine · doi:10.1002/smmd.70007 · Cited by 10
Fitness-compensatory mutations facilitate the spread of drug-resistant F15/LAM4/KZN and F28 Mycobacterium tuberculosis strains in KwaZulu-Natal, South Africa
Naidoo, C. C., & Pillay, M. (2017) · Journal of Genetics · doi:10.1007/s12041-017-0805-8 · Cited by 10
Treatment outcome of tuberculosis among Human Immunodeficiency Virus positive patients in Eastern Ethiopia: a retrospective study
Weldegebreal, F., Mitiku, H., & Teklemariam, Z. (2018) · Pan African Medical Journal · doi:10.11604/pamj.2018.30.32.12554 · Cited by 10
Extra-central nervous system tuberculosis in HIV-uninfected patients of tuberculous meningitis: A prospective evaluation
Sahoo, H., Garg, R. K., Rizvi, I., Malhotra, H. S., Kumar, N., Jain, A., Garg, R., Kohli, N., Verma, R. K., Sharma, P. K., et al. (2020) · Journal of Infection and Public Health · doi:10.1016/j.jiph.2020.04.011 · Cited by 10
Mycobacterium tuberculosis complex and human coadaptation: a two-way street complicating host susceptibility to TB
Uren, C., Hoal, E. G., & Möller, M. (2020) · Human Molecular Genetics · doi:10.1093/hmg/ddaa254 · Cited by 12
Polyethylene imine conjugated supramolecular stereocomplexed nanomicelles for intracellular delivery of rifampicin against Mycobacterium bovis
Kiani, M. H., Ali, S., Qadry, A., Arshad, R., Aslam, A., & Shahnaz, G. (2021) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2021.111976 · Cited by 10
Identification of target cells of a European equine arteritis virus strain in experimentally infected ponies
Vairo, S., Favoreel, H. W., Scagliarini, A., & Nauwynck, H. (2013) · Veterinary Microbiology · doi:10.1016/j.vetmic.2013.07.020 · Cited by 10
Nonclinical data supporting orphan medicinal product designations in the area of rare infectious diseases
Sheean, M. E., Malikova, E., Duarte, D. M., Capovilla, G., Fregonese, L., Hofer, M. P., Magrelli, A., Mariz, S., Mendez-Hermida, F., Nisticò, R., et al. (2019) · Drug Discovery Today · doi:10.1016/j.drudis.2019.10.015 · Cited by 10
Design, synthesis, and evaluation of substituted 2-acylamide-1,3-benzo[d]zole analogues as agents against MDR- and XDR-MTB
Li, D., Liu, C., Jiang, X., Lin, Y., Zhang, J., Li, Y., You, X., Jiang, W., Chen, M., Xu, Y., et al. (2020) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2020.112898 · Cited by 10
Computational approaches for molecular characterization and structure-based functional elucidation of a hypothetical protein from Mycobacterium tuberculosis
Saikat, A. S. M. (2023) · Genomics & Informatics · doi:10.5808/gi.23001 · Cited by 10
Rhomboid homologs in mycobacteria: insights from phylogeny and genomic analysis
Kateete, D. P., Okee, M. S., Katabazi, F. A., Okeng, A., Asiimwe, J., Boom, H. W., Eisenach, K. D., & Joloba, M. L. (2010) · BMC Microbiology · doi:10.1186/1471-2180-10-272 · Cited by 10
Modulation of human T cell cytokines by the Mycobacterium tuberculosis -secreted protein Wag31
Samten, B., Fannin, S., Sarva, K., Yi, N., Madiraju, M. V. V. S., & Rajagopalan, M. R. (2016) · Tuberculosis · doi:10.1016/j.tube.2016.09.017 · Cited by 10
Risk factors for mortality among tuberculosis patients on treatment at Bugando Medical Centre in north-western Tanzania: a retrospective cross-sectional study
Gunda, D. W., Kilonzo, S. B., Bulegesi, S. M., Mpondo, B. C. T., & Shao, E. R. (2016) · Tanzania journal of health research/Tanzania Journal of Health Research · doi:10.4314/thrb.v18i4.1 · Cited by 10
Study of Isoniazid-Pyridoxine biomolecular complex using spectroscopic (Raman, SERS, FTIR, UV-vis) and quantum chemical calculation
Sonia, C., Devi, T. G., & Karlo, T. (2023) · Journal of Molecular Structure · doi:10.1016/j.molstruc.2023.136087 · Cited by 9
The PPE2 protein of Mycobacterium tuberculosis is secreted during infection and facilitates mycobacterial survival inside the host
Bisht, M. K., Pal, R. K., Dahiya, P., Naz, S., Sanyal, P., Nandicoori, V. K., Ghosh, S., & Mukhopadhyay, S. (2023) · Tuberculosis · doi:10.1016/j.tube.2023.102421 · Cited by 9
Unearthing phytochemicals as natural inhibitors for pantothenate synthetase in Mycobacterium tuberculosis: A computational approach
Chouhan, M., Tiwari, P. K., Mishra, R., Gupta, S. K., Kumar, M., Almuqri, E. A., Ibrahim, N. A., Basher, N. S., Chaudhary, A. A., Dwivedi, V. D., et al. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1403900 · Cited by 9
Global epidemiology of Mycobacterium tuberculosis lineage 4 insights from Ecuadorian genomic data
Gabriel Morey-León, G., Mejía‐Ponce, P. M., Fernández‐Cadena, J. C., Moreira, E. G. S., Andrade-Molina, D., Licona‐Cassani, C., Fresia, P., & Berná, L. (2025) · Scientific Reports · doi:10.1038/s41598-025-86079-8 · Cited by 9
The Multifaceted Antimicrobial Profile of Piperine in Infectious Disease Management: Current Perspectives and Potential
Periferakis, A.-T., Adalis, G.-M., Periferakis, A., Troumpata, L., Periferakis, K., Dragosloveanu, C. D. M., Căruntu, A., Săvulescu-Fiedler, I., Dragosloveanu, Ş., Scheau, A.-E., et al. (2025) · Pharmaceuticals · doi:10.3390/ph18101581 · Cited by 18
Tuberculosis: Molecular Basis of Pathogenesis
Salvatore, P. P., & Zhang, Y. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.95697-6 · Cited by 9
Computational Deorphaning of Mycobacterium tuberculosis Targets
Bishi, L. Y., Vedithi, S. C., Blundell, T. L., & Mugumbate, G. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.82374 · Cited by 9
Spatial modeling of individual‐level infectious disease transmission: Tuberculosis data in Manitoba, Canada
Amiri, L., Torabi, M., Deardon, R., & Pickles, M. (2021) · Statistics in Medicine · doi:10.1002/sim.8863 · Cited by 9
Novel Controlled Release Pulmonary Drug Delivery Systems: Current updates and Challenges
Dhanjal, D. S., Mehta, M., Chopra, C., Singh, R., Sharma, P., Chellappan, D. K., Tambuwala, M. M., Bakshi, H. A., Aljabali, A. A. A., Gupta, G., et al. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-821185-4.00001-4 · Cited by 10
Nanotechnology-based Colorimetric Approaches for Pathogenic Virus Sensing: A Review
Fılık, H., & Avan, A. A. (2021) · Current Medicinal Chemistry · doi:10.2174/0929867328666210714154051 · Cited by 9
Characterization of Clofazimine Metabolism in Human Liver Microsomal Incubation In Vitro
Saurav, H., Kim, M., Jony, M. R., Long, N. P., Cho, Y., Kim, D., & Shin, J. (2022) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00565-22 · Cited by 9
Quinolone-3-amidoalkanol: A New Class of Potent and Broad-Spectrum Antimicrobial Agent
Dube, P. S., Angula, K. T., Legoabe, L. J., Jordaan, A., Zarella, J. M. B., Warner, D. F., Doggett, J. S., & Beteck, R. M. (2023) · ACS Omega · doi:10.1021/acsomega.3c01406 · Cited by 9
Differential Immune Responses to Segniliparus rotundus and Segniliparus rugosus Infection and Analysis of Their Comparative Virulence Profiles
Kim, J. S., Kim, W. S., Lee, K., Won, C.-J., Kim, J., Eum, S.-Y., Koh, W., & Shin, S. J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0059646 · Cited by 9
Disease mapping of tuberculosis prevalence in Eastern Cape Province, South Africa
Obaromi, D. A., Ndege, J., & Qin, Y. (2018) · Journal of Public Health · doi:10.1007/s10389-018-0931-7 · Cited by 9
Structural insights into phosphopantetheinyl hydrolase PptH from Mycobacterium tuberculosis
Mosior, J., Bourland, R., Soma, S., Nathan, C., & Sacchettini, J. C. (2019) · Protein Science · doi:10.1002/pro.3813 · Cited by 9
TUBERCULOSIS CAUSED BY MYCOBACTERIUM ORYGIS IN A GREATER ONE-HORNED RHINOCEROS (RHINOCEROS UNICORNIS): FIRST REPORT IN THE WESTERN HEMISPHERE
Love, D. M., Garner, M. M., Lyashchenko, K. P., Sikar-Gang, A., Bradway, D. S., Robbe‐Austerman, S., Miller, M. A., & Ramer, J. C. (2020) · Journal of Zoo and Wildlife Medicine · doi:10.1638/2018-0084 · Cited by 9
Mycobacterium tuberculosis Rv0341 Promotes Mycobacterium Survival in In Vitro Hostile Environments and within Macrophages and Induces Cytokines Expression
Abdalla, A. E., Yan, S., Zeng, J., Deng, W., Xie, L., & Xie, J. (2020) · Pathogens · doi:10.3390/pathogens9060454 · Cited by 10
The role of properdin and Factor H in disease
Cortés, C., Desler, C., Mazzoli, A., Chen, J. Y., & Ferreira, V. P. (2022) · Advances in immunology · doi:10.1016/bs.ai.2021.12.001 · Cited by 10
Reversing BCG-mediated autophagy inhibition and mycobacterial survival to improve vaccine efficacy
González-Orozco, M., Strong, E. J., Paroha, R., & Lee, S. (2022) · BMC Immunology · doi:10.1186/s12865-022-00518-z · Cited by 9
Calmodulin-like protein from M. tuberculosis H37Rv is required during infection
Advani, M. J., Rajagopalan, M. R., & Reddy, P. H. (2014) · Scientific Reports · doi:10.1038/srep06861 · Cited by 9
cytotoxicity and antitubercular activity of allium sativum and lantana camara against mycobacterial isolates from people living with HIV/AIDS
(2010) · The Internet Journal of Infectious Diseases · doi:10.5580/26a8 · Cited by 9
Epidemiological perspective of drug resistant extrapulmonary tuberculosis
Singh, P. K. (2015) · World Journal of Clinical Infectious Diseases · doi:10.5495/wjcid.v5.i4.77 · Cited by 9
Novel Nanotechnology Based Delivery Systems for Chemotherapy and Prophylaxis of Tuberculosis
Jain, R., Savla, H. M., Naik, I., Maniar, J., Punjabi, K., Vaidya, S. P., & Menon, M. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-813351-4.00034-1 · Cited by 9
Rise of Clinical Microbial Proteogenomics: A Multiomics Approach to Nontuberculous Mycobacterium—The Case of Mycobacterium abscessus UC22
Advani, J., Verma, R., Chatterjee, O., Balaya, R. D. A., Najar, M. A., Ravishankara, N., Suresh, S., Pachouri, P. K., Gupta, U. D., Pinto, S. M., et al. (2018) · OMICS A Journal of Integrative Biology · doi:10.1089/omi.2018.0116 · Cited by 9
Screening of Anti-mycobacterial Phytochemical Compounds for Potential Inhibitors against Mycobacterium Tuberculosis Isocitrate Lyase
Tiwari, A. K., Kumar, A., Srivastava, G., & Sharma, A. K. (2019) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026619666190304125603 · Cited by 9
DNA flowerstructure co-localizes with human pathogens in infected macrophages
Franch, O., Gutiérrez-Corbo, C., Domínguez-Asenjo, B., Boesen, T. P., Jensen, P. B., Nejsum, L. N., Keller, J. G., Nielsen, S. P., Singh, P. R., Jha, R., et al. (2020) · Nucleic Acids Research · doi:10.1093/nar/gkaa341 · Cited by 9
Therapeutic Efficacy of Bacteriophages
Ramasamy, P., & Dayanithi, G. (2021) · IntechOpen eBooks · doi:10.5772/intechopen.97619 · Cited by 9
Pulmonary and peritoneal tuberculosis in a CAPD patient
Canbakan, B., Ergün, İ., Ekmekçi, Y., Ateş, K., & Karatan, O. (2006) · International Urology and Nephrology · doi:10.1007/s11255-006-9135-0 · Cited by 9
Physiology ofMycobacterium tuberculosis
Warner, D. F., & Mizrahi, V. (2008) · Wiley eBooks · doi:10.1002/9783527611614.ch3 · Cited by 9
Evaluation of endocranial bony changes in relation to tuberculosis in the Robert J. Terry Anatomical Skeletal Collection (Washington, DC, USA)
Spekker, O. (2018) · SZTE Repository of Dissertations (University of Szeged) · doi:10.14232/phd.9714 · Cited by 9
Synthetic modification of dehydrozingerone and their biological evaluation for anti-tubercular and anti-inflammatory potency
Kumar, C., Mubarak, M. M., Singh, C. P., Chauhan, N., Satti, N. K., Yadav, G., Vishwakarma, R. A., Parry, Z. A., & Ali, A. (2023) · Results in Chemistry · doi:10.1016/j.rechem.2023.100934 · Cited by 8
Research advances in microfluidic collection and detection of virus, bacterial, and fungal bioaerosols
Zhou, X.-Y., Liu, X., Zhao, H., Guo, G., Jiang, X., Liu, S., Sun, X., & Yang, H. (2024) · Microchimica Acta · doi:10.1007/s00604-024-06213-7 · Cited by 9
Sulforaphane Inhibits Oxidative Stress and May Exert Anti-Pyroptotic Effects by Modulating NRF2/NLRP3 Signaling Pathway in Mycobacterium tuberculosis-Infected Macrophages
Chen, G., Shen, L., Hu, H., Feng, Y., Wen, D., Liu, Y., Zhai, H., Sun, W., Wang, M., Lei, X., et al. (2024) · Microorganisms · doi:10.3390/microorganisms12061191 · Cited by 9
Nano-strategies used for combatting the scourge of tuberculosis infections
Fang, R., Jin, Y., Kong, W., Wang, H., Wang, S., Li, X., Xing, J., Zhang, Y., Yang, X., & Song, N. (2024) · Discover Immunity. · doi:10.1007/s44368-024-00007-y · Cited by 8
Reinforcing cancer immunotherapy with engineered porous hollow mycobacterium tuberculosis loaded with tumor neoantigens
Chen, M.-H., Jiang, J., Chen, H., Wu, R.-H., Xie, W., Dai, S.-Z., Zheng, W.-P., Tan, G., & Huang, F. (2025) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2024-010150 · Cited by 8
Recovery of recombinant Mycobacterium tuberculosis antigens fused with cell wall-anchoring motif (LysM) from inclusion bodies using non-denaturing reagent (N-laurylsarcosine)
Mustafa, A. D., Kalyanasundram, J., Sabidi, S., Song, A. A. L., Abdullah, M., Rahim, R. A., & Yusoff, K. (2019) · BMC Biotechnology · doi:10.1186/s12896-019-0522-x · Cited by 8
Reactive arthritis in tuberculosis: A case of Poncet's disease.
Zi, I., Zaiton, A., & Faezah, H. (2013) · Europe PMC (PubMed Central) · Cited by 8
Rapid microarray-based assay for detection of pyrazinamide resistant Mycobacterium tuberculosis
Havlicek, J., Dachsel, B., Slickers, P., Andres, S., Beckert, P., Feuerriegel, S., Niemann, S., Merker, M., & Labugger, I. (2018) · Diagnostic Microbiology and Infectious Disease · doi:10.1016/j.diagmicrobio.2018.12.011 · Cited by 8
Association between genetic variants in CD1A and CD1D genes and pulmonary tuberculosis in an Iranian population
Taheri, M., Danesh, H., Bizhani, F., Bahari, G., Naderi, M., & Hashemi, M. M. (2019) · Biomedical Reports · doi:10.3892/br.2019.1201 · Cited by 8
Thoracic Cardiovascular Complications of Tuberculosis
Restrepo, C. S., Gonzalez, T. V., Brar, R. S., Ocazionez, D., Velasco, M. L., Lopez, R. A., Arias, L., Baxi, A. J., & Carrillo, J. (2020) · Journal of Computer Assisted Tomography · doi:10.1097/rct.0000000000001024 · Cited by 8

Authors: Smith, I.
Affiliations: International Center for Public Health (US)
Corresponding author: Smith, Issar
Venue: Clinical Microbiology Reviews
Publisher: American Society for Microbiology
Published: 2003-07
Volume: 16
Issue: 3
Pages: 463-496
ISSN: 0893-8512 (ISSN-L)
1098-6618
DOI: 10.1128/cmr.16.3.463-496.2003
PMC: PMC164219
OpenAlex: W2157638040
Cited by: 1,154
References: 322
Citations by year: 2026: 29 · 2025: 56 · 2024: 57 · 2023: 87 · 2022: 87 · 2021: 87 · 2020: 84 · 2019: 76 · 2018: 73 · 2017: 54 · 2016: 57 · 2015: 54 · 2014: 46 · 2013: 54 · 2012: 33
FWCI: 3.73
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Clinical Microbiology Reviews (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Heart, Lung, and Blood Institute (R01 HL 68513, R01HL064544, R01 HL 64544, R01HL068513)
National Institute of Allergy and Infectious Diseases (R01 AI 48856, R01AI048856)
Topics: Health Sciences › Medicine › Infectious Diseases › Tuberculosis Research and Epidemiology
Health Sciences › Medicine › Infectious Diseases › Infectious Diseases and Tuberculosis
Health Sciences › Medicine › Epidemiology › Mycobacterium research and diagnosis
Keywords: Mycobacterium tuberculosis, tuberculosis pathogenesis, bacterial virulence factors, host immune response, pulmonary tuberculosis, transmissibility, host genetics, host nutritional status, tuberculosis vaccine, tuberculosis drug targets, tuberculosis diagnosis
MeSH terms: Animals, Antitubercular Agents, Disease Models, Animal, Humans, Macrophages, Mycobacterium tuberculosis, Transcription, Genetic, Tuberculosis, Virulence, Genome, Bacterial, Proteomics

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Mycobacterium tuberculosis Pathogenesis and Molecular Determinants of Virulence

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks