The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Drug Resistance in Leishmaniasis
Open accessAbstract
SUMMARY: Leishmaniasis is a complex disease, with visceral and cutaneous manifestations, and is caused by over 15 different species of the protozoan parasite genus Leishmania. There are significant differences in the sensitivity of these species both to the standard drugs, for example, pentavalent antimonials and miltefosine, and those on clinical trial, for example, paromomycin. Over 60% of patients with visceral leishmaniasis in Bihar State, India, do not respond to treatment with pentavalent antimonials. This is now considered to be due to acquired resistance. Although this class of drugs has been used for over 60 years for leishmaniasis treatment, it is only in the past 2 years that the mechanisms of action and resistance have been identified, related to drug metabolism, thiol metabolism, and drug efflux. With the introduction of new therapies, including miltefosine in 2002 and paromomycin in 2005-2006, it is essential that there be a strategy to prevent the emergence of resistance to new drugs; combination therapy, monitoring of therapy, and improved diagnostics could play an essential role in this strategy.
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Cites
Multidrug resistance in cancer: role of ATP–dependent transporters
Gottesman, M. M., Fojo, T., & Bates, S. E. (2002) · Nature Reviews Cancer · doi:10.1038/nrc706 · Cited by 5,536
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Cited by
Ghosh, J., Bose, M., Roy, S., & Bhattacharyya, S. N. (2013) · Cell Host & Microbe · doi:10.1016/j.chom.2013.02.005 · Cited by 191
“Manifesto” for Advancing the Control and Elimination of Neglected Tropical Diseases
Hotez, P. J., & Pecoul, B. (2010) · PLoS Neglected Tropical Diseases · doi:10.1371/journal.pntd.0000718 · Cited by 138
Amphibian antimicrobial peptides and Protozoa: Lessons from parasites
Rivas, L., Luque-Ortega, J. R., & Andreu, D. (2009) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2008.11.002 · Cited by 121
A new, rapid and sensitive bioluminescence assay for drug screening on Leishmania
Paloque, L., Vidal, N., Casanova, M., Dumètre, A., Verhaeghe, P., Parzy, D., & Azas, N. (2013) · Journal of Microbiological Methods · doi:10.1016/j.mimet.2013.09.006 · Cited by 26
Bhaumik, S. K., Paul, J., Naskar, K., Karmakar, S., & De, T. (2012) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkr575 · Cited by 20
Metadata
- Authors
- Croft, S. L., Sundar, S., & Fairlamb, A. H.
- Venue
- Clinical Microbiology Reviews
- Publisher
- American Society for Microbiology
- Published
- 2006-01
- Volume
- 19
- Issue
- 1
- Pages
- 111-126
- ISSN
- 0893-8512 (ISSN-L)
- 1098-6618
- OpenAlex
- W1963542761
- Cited by
- 1,663
- References
- 2
- FWCI
- 64.94
- Type
- journal article
- Language
- en
- Open access
- green
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