The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
The Flavonoid Quercetin Inhibits Proinflammatory Cytokine (Tumor Necrosis Factor Alpha) Gene Expression in Normal Peripheral Blood Mononuclear Cells via Modulation of the NF-κβ System
Open accessAbstract
The flavonoids comprise a large class of low-molecular-weight plant metabolites ubiquitously distributed in food plants. These dietary antioxidants exert significant antitumor, antiallergic, and anti-inflammatory effects. The molecular mechanisms of their biological effects remain to be clearly understood. We investigated the anti-inflammatory potentials of a safe, common dietary flavonoid component, quercetin, for its ability to modulate the production and gene expression of the proinflammatory cytokine tumor necrosis factor alpha (TNF-α) by human peripheral blood mononuclear cells (PBMC). Our results showed that quercetin significantly inhibited TNF-α production and gene expression in a dose-dependent manner. Our results provide direct evidence of the anti-inflammatory effects of quercetin by PBMC, which are mediated by the inhibition of the proinflammatory cytokine TNF-α via modulation of NF-κβ1 and Iκβ.
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Cites
Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
Chomczynski, P., & Sacchi, N. (1987) · Analytical Biochemistry · doi:10.1016/0003-2697(87)90021-2 · Cited by 46,426
Middleton, E., Kandaswami, C., & Theoharides, T. C. (2000) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01472-8 · Cited by 4,882
Self-citationCurrent Protocols in Immunology
(2018) · Current Protocols in Immunology · doi:10.1002/(issn)1934-368x · Cited by 3,566
The TNF receptor 1-associated protein TRADD signals cell death and NF-κB activation
Hsu, H., Xiong, J., & Goeddel, D. V. (1995) · Cell · doi:10.1016/0092-8674(95)90070-5 · Cited by 2,012
Polyphenols: Antioxidants and beyond
Scalbert, A., Johnson, I. T., & Saltmarsh, M. (2005) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/81.1.215s · Cited by 1,836
Osborn, L., Kunkel, S., & Nabel, G. J. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.7.2336 · Cited by 1,621
Activation of Transcription Factor NF-κB Is Suppressed by Curcumin (Diferuloylmethane)
Singh, S., & Aggarwal, B. B. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.42.24995 · Cited by 1,386
Anti-inflammatory Plant Flavonoids and Cellular Action Mechanisms
Kim, H. P., Son, K. H., Chang, H. W., & Kang, S. S. (2004) · Journal of Pharmacological Sciences · doi:10.1254/jphs.crj04003x · Cited by 1,014
Duh, E. J., Maury, W. J., Folks, T. M., Fauci, A. S., & Rabson, A. B. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.15.5974 · Cited by 767
Effect of Plant Flavonoids on Immune and Inflammatory Cell Function
Middleton, E. (1998) · Advances in Experimental Medicine and Biology · doi:10.1007/978-1-4615-5335-9_13 · Cited by 734
Cited by
Health effects of quercetin: From antioxidant to nutraceutical
Boots, A. W., Haenen, G. R. M. M., & Bast, A. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2008.03.008 · Cited by 2,121
Egert, S., Bosy-Westphal, A., Seiberl, J., Kürbitz, C., Settler, U., Plachta-Danielzik, S., Wagner, A. E., Frank, J., Schrezenmeir, J., Rimbach, G., et al. (2009) · British Journal of Nutrition · doi:10.1017/s0007114509359127 · Cited by 579
Fruit polyphenols, immunity and inflammation
González-Gallego, J., García-Mediavilla, M. V., Sánchez-Campos, S., & Tuñón, M. J. (2010) · British Journal Of Nutrition · doi:10.1017/s0007114510003910 · Cited by 387
Egert, S., Wolffram, S., Bosy-Westphal, A., Boesch-Saadatmandi, C., Wagner, A. E., Frank, J., Rimbach, G., & Mueller, M. J. (2008) · The Journal of Nutrition · doi:10.1093/jn/138.9.1615 · Cited by 334
In vitro and ex vivo anti-inflammatory activity of quercetin in healthy volunteers
Boots, A. W., Wilms, L. C., Swennen, E. L. R., Kleinjans, J. C. S., Bast, A., & Haenen, G. R. M. M. (2008) · Nutrition · doi:10.1016/j.nut.2008.03.023 · Cited by 270
Metadata
- Authors
- Nair, M. P., Mahajan, S., Reynolds, J. L., Aalinkeel, R., Nair, H., Schwartz, S. A., & Kandaswami, C.
- Venue
- Clinical and Vaccine Immunology
- Publisher
- American Society for Microbiology
- Published
- 2006-03
- Volume
- 13
- Issue
- 3
- Pages
- 319-328
- ISSN
- 1556-679X (ISSN-L)
- 1556-6811
- OpenAlex
- W2114839157
- Cited by
- 398
- References
- 39
- FWCI
- 8.30
- Type
- journal article
- Language
- en
- Open access
- diamond
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- The paper
- Nair, M. P., Mahajan, S., Reynolds, J. L., Aalinkeel, R., Nair, H., Schwartz, S. A., & Kandaswami, C. (2006). The Flavonoid Quercetin Inhibits Proinflammatory Cytokine (Tumor Necrosis Factor Alpha) Gene Expression in Normal Peripheral Blood Mononuclear Cells via Modulation of the NF-κβ System. Clinical and Vaccine Immunology. https://doi.org/10.1128/cvi.13.3.319-328.2006
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