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Cited by 1,014

The DOI matches its Crossref record; 91 of the 91 references it cites were found in a registry or an index.

Anti-inflammatory Plant Flavonoids and Cellular Action Mechanisms

Open access
Kim, Hyun Pyo, Son, Kun Ho, Chang, Hyeun Wook, Kang, Sam Sik·2004·Journal of Pharmacological Sciences
DOI 10.1254/jphs.crj04003x
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Abstract

Plant flavonoids show anti-inflammatory activity in vitro and in vivo. Although not fully understood, several action mechanisms are proposed to explain in vivo anti-inflammatory action. One of the important mechanisms is an inhibition of eicosanoid generating enzymes including phospholipase A2, cyclooxygenases, and lipoxygenases, thereby reducing the concentrations of prostanoids and leukotrienes. Recent studies have also shown that certain flavonoids, especially flavone derivatives, express their anti-inflammatory activity at least in part by modulation of proinflammatory gene expression such as cyclooxygenase-2, inducible nitric oxide synthase, and several pivotal cytokines. Due to these unique action mechanisms and significant in vivo activity, flavonoids are considered to be reasonable candidates for new anti-inflammatory drugs. To clearly establish the therapeutic value in inflammatory disorders, in vivo anti-inflammatory activity, and action mechanism of varieties of flavonoids need to be further elucidated. This review summarizes the effect of flavonoids on eicosanoid and nitric oxide generating enzymes and the effect on expression of proinflammatory genes. In vivo anti-inflammatory activity is also discussed. As natural modulators of proinflammatory gene expression, certain flavonoids have a potential for new anti-inflammatory agents.

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Citations

Cites

Show all 91 references

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Metadata

Authors
Kim, H. P., Son, K. H., Chang, H. W., & Kang, S. S.
Venue
Journal of Pharmacological Sciences
Publisher
Japanese Pharmacological Society
Published
2004
Volume
96
Issue
3
Pages
229-245
ISSN
  • 1347-8613 (ISSN-L)
  • 1347-8648
DOI
10.1254/jphs.crj04003x
OpenAlex
W2031690762
Cited by
1,014
References
91
FWCI
11.34
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Anti-inflammatory Plant Flavonoids and Cellular Action Mechanisms. https://app.cochat.ai/papers/10.1254/jphs.crj04003x
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Kim, H. P., Son, K. H., Chang, H. W., & Kang, S. S. (2004). Anti-inflammatory Plant Flavonoids and Cellular Action Mechanisms. Journal of Pharmacological Sciences. https://doi.org/10.1254/jphs.crj04003x

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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