Fruit polyphenols, immunity and inflammation

González-Gallego, Javier; García-Mediavilla, M. Victoria; Sánchez-Campos, Sonia; Tuñón, María J.

doi:10.1017/s0007114510003910

Cited by 387Phytochemicals and Antioxidant ActivitiesExercise and Physiological ResponsesFlavonoids in Medical Research

Fruit polyphenols, immunity and inflammation

Open access

González-Gallego, Javier, García-Mediavilla, M. Victoria, Sánchez-Campos, Sonia, Tuñón, María J.·2010·British Journal Of Nutrition

DOI 10.1017/s0007114510003910

Open this paper in CoChat — free account Open PDF

Abstract

Flavonoids are a large class of naturally occurring compounds widely present in fruits, vegetables and beverages derived from plants. These molecules have been reported to possess a wide range of activities in the prevention of common diseases, including CHD, cancer, neurodegenerative diseases, gastrointestinal disorders and others. The effects appear to be related to the various biological/pharmacological activities of flavonoids. A large number of publications suggest immunomodulatory and anti-inflammatory properties of these compounds. However, almost all studies are in vitro studies with limited research on animal models and scarce data from human studies. The majority of in vitro research has been carried out with single flavonoids, generally aglycones, at rather supraphysiological concentrations. Few studies have investigated the anti-inflammatory effects of physiologically attainable flavonoid concentrations in healthy subjects, and more epidemiological studies and prospective randomised trials are still required. This review summarises evidence for the effects of fruit and tea flavonoids and their metabolites in inflammation and immunity. Mechanisms of effect are discussed, including those on enzyme function and regulation of gene and protein expression. Animal work is included, and evidence from epidemiological studies and human intervention trials is reviewed. Biological relevance and functional benefits of the reported effects, such as resistance to infection or exercise performance, are also discussed.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1017/s0007114510003910

Cites

131 of 131 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

A proposed anti-inflammatory mechanism of phenolic compounds is an ability to inhibit activation of NADPH oxidase and subsequent generation of ROS in activated glia.
“an ability to inhibit the activation of NADPH oxidase and subsequent generation of ROS in activated glia”
From Multi-Target Mechanisms of Phytochemicals in Alzheimer’s Disease: Effects on Oxidative Stress, Neuroinflammation and Protein Aggregation (2022) · cites this paper as [158]
A proposed anti-inflammatory mechanism of phenolic compounds is an inhibitory role in the release of cytokines such as IL-1β and TNF-α from activated glia.
“an inhibitory role in the release of cytokines, such as IL-1β and TNF-α, from activated glia”
From Multi-Target Mechanisms of Phytochemicals in Alzheimer’s Disease: Effects on Oxidative Stress, Neuroinflammation and Protein Aggregation (2022) · cites this paper as [158]
A proposed anti-inflammatory mechanism of phenolic compounds is an inhibitory action against iNOS induction and subsequent NO production in response to glial activation.
“an inhibitory action against inducible nitric oxide synthase (iNOS) induction and subsequent NO production in response to glial activation”
From Multi-Target Mechanisms of Phytochemicals in Alzheimer’s Disease: Effects on Oxidative Stress, Neuroinflammation and Protein Aggregation (2022) · cites this paper as [158]
A proposed anti-inflammatory mechanism of phenolic compounds is inhibitory activity regulation of pro-inflammatory transcription factors such as NF-κB through modulation of various glial and neuronal signaling pathways.
“an inhibitory activity regulation of pro-inflammatory transcription factors such as nuclear factor (NF)-κB through the modulation of various glial and neuronal signaling pathways [158,159].”
From Multi-Target Mechanisms of Phytochemicals in Alzheimer’s Disease: Effects on Oxidative Stress, Neuroinflammation and Protein Aggregation (2022) · cites this paper as [158]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Flavonoids: antioxidants or signalling molecules?
Williams, R. J., Spencer, J. P. E., & Rice-Evans, C. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.01.001 · Cited by 2,016 · see citing works
Tea catechins and polyphenols: Health effects, metabolism, and antioxidant functions
Higdon, J. V., & Frei, B. (2003) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408690390826464 · Cited by 1,854 · cited 1× · see citing works
“There is some evidence that green tea at high levels of intake may provide some benefit in preventing cancers of the digestive tract, especially gastric cancer((103)).”
Background
Flavonoid intake and risk of chronic diseases
Knekt, P., Kumpulainen, J. T., Järvinen, R., Rissanen, H. A., Heliövaara, M., Reunanen, A., Hakulinen, T., & Aromaa, A. (2002) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/76.3.560 · Cited by 1,748 · see citing works
Flavonoids in Food and Their Health Benefits
Yao, L., JIANG, Y. M., SHI, J., Tomás-Barberán, F. A., Datta, N., Singanusong, R., & CHEN, S. S. (2004) · Plant Foods for Human Nutrition · doi:10.1007/s11130-004-0049-7 · Cited by 1,561 · see citing works
A review of anti-infective and anti-inflammatory chalcones
Nowakowska, Z. (2006) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2006.09.019 · Cited by 1,082 · see citing works
Anti-inflammatory Plant Flavonoids and Cellular Action Mechanisms
Kim, H. P., Son, K. H., Chang, H. W., & Kang, S. S. (2004) · Journal of Pharmacological Sciences · doi:10.1254/jphs.crj04003x · Cited by 1,018 · see citing works
Anti-Inflammatory Effects of Flavonoids: Genistein, Kaempferol, Quercetin, and Daidzein Inhibit STAT-1 and NF- κ B Activations, Whereas Flavone, Isorhamnetin, Naringenin, and Pelargonidin Inhibit only NF- κ B Activation along with Their Inhibitory Effect on iNOS Expression and NO Production in Activated Macrophages
Hämäläinen, M., Nieminen, R. M., Vuorela, P. M., Heinonen, M., & Moilanen, E. (2007) · Mediators of Inflammation · doi:10.1155/2007/45673 · Cited by 946 · see citing works
Dietary Flavonoids and the Risk of Lung Cancer and Other Malignant Neoplasms
Knekt, P., rvinen, R. J., nen, R. S., vaara, M. H., Teppo, L., Pukkala, ., & Aromaa, A. (1997) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a009257 · Cited by 770 · see citing works
In vivo quercitrin anti‐inflammatory effect involves release of quercetin, which inhibits inflammation through down‐regulation of the NF‐κB pathway
Comalada, M., Camuesco, D., Sierra, S., Ballester, I., Xaus, J., Gálvez, J., & Zarzuelo, A. (2005) · European Journal of Immunology · doi:10.1002/eji.200425778 · Cited by 650 · see citing works
Suppression of inducible cyclooxygenase and inducible nitric oxide synthase by apigenin and related flavonoids in mouse macrophages
Liang, Y., Huang, Y.-T., Tsai, S., Lin‐Shiau, S., Chen, C.-F., & Lin, J.-K. (1999) · Carcinogenesis · doi:10.1093/carcin/20.10.1945 · Cited by 574 · see citing works
The anti-inflammatory flavones quercetin and kaempferol cause inhibition of inducible nitric oxide synthase, cyclooxygenase-2 and reactive C-protein, and down-regulation of the nuclear factor kappaB pathway in Chang Liver cells
García‐Mediavilla, M. V., Crespo, I., Collado, P. S., Esteller, A., Sánchez‐Campos, S., Tuñón, M. J., & González‐Gallego, J. (2006) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2006.11.014 · Cited by 563 · see citing works
Self-citation
Antioxidant Effects of Tea: Evidence from Human Clinical Trials
Rietveld, A. G., & Wiseman, S. A. (2003) · Journal of Nutrition · doi:10.1093/jn/133.10.3285s · Cited by 501 · see citing works
Fruit and vegetable consumption and its relation to markers of inflammation and oxidative stress in adolescents
Holt, E. M., Steffen, L. M., Moran, A., Basu, S., Steinberger, J., Ross, J. A., Hong, C.-P., & Sinaiko, A. R. (2009) · Journal of the American Dietetic Association · doi:10.1016/j.jada.2008.11.036 · Cited by 496 · cited 14× · see citing works
“In Caco-2 cells, procyanidins inhibit NF-kB translocation and TNF-a-induced IkB phosphorylation and degradation(49).”
BackgroundInfluential
Analytical Chemistry of Fruit BioflavonoidsA Review
Robards, K., & Antolovich, M. (1997) · The Analyst · doi:10.1039/a606499j · Cited by 470 · see citing works
Phase II Study of Pomegranate Juice for Men with Rising Prostate-Specific Antigen following Surgery or Radiation for Prostate Cancer
Pantuck, A. J., Leppert, J. T., Zomorodian, N., Aronson, W. J., Hong, J., Barnard, R. J., Seeram, N. P., Liker, H. R., Wang, H., Elashoff, R. M., et al. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-05-2290 · Cited by 463 · see citing works
Inhibition of inducible nitric oxide synthase and cyclooxygenase-2 expression by flavonoids in macrophage J774A.1
Raso, G. M., Meli, R., Carlo, G. D., Pacilio, M., & Carlo, R. D. (2001) · Life Sciences · doi:10.1016/s0024-3205(00)00999-1 · Cited by 448 · see citing works
Inhibition of Pro-inflammatory Markers in Primary Bone Marrow-Derived Mouse Macrophages by Naturally Occurring Flavonoids: Analysis of the Structure-Activity Relationship
Comalada, M., Ballester, I., Bailón, E., Sierra, S., Xaus, J., Gálvez, J., Medina, F. S. D., & Zarzuelo, A. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2006.07.016 · Cited by 440 · see citing works
Quercetin in men with category III chronic prostatitis: a preliminary prospective, double-blind, placebo-controlled trial
Shoskes, D. A., Zeitlin, S. I., SHAHED, A. R., et al. (1999) · Urology · doi:10.1016/s0090-4295(99)00358-1 · Cited by 411 · see citing works
The Flavonoid Quercetin Inhibits Proinflammatory Cytokine (Tumor Necrosis Factor Alpha) Gene Expression in Normal Peripheral Blood Mononuclear Cells via Modulation of the NF-κβ System
Nair, M., Mahajan, S. D., Reynolds, J. L., Aalinkeel, R., Nair, H. N., Schwartz, S. A., & Kandaswami, C. C. (2006) · Clinical and Vaccine Immunology · doi:10.1128/cvi.13.3.319-328.2006 · Cited by 400 · see citing works
Anthocyanins Inhibit Nuclear Factor-κB Activation in Monocytes and Reduce Plasma Concentrations of Pro-Inflammatory Mediators in Healthy Adults , ,3
Karlsen, A. S., Retterstøl, L., Laake, P., Paur, I., Kjølsrud-Bøhn, S., Sandvik, L., & Blomhoff, R. (2007) · Journal of Nutrition · doi:10.1093/jn/137.8.1951 · Cited by 389 · see citing works
Associations of dietary flavonoids with risk of type 2 diabetes, and markers of insulin resistance and systemic inflammation in women: a prospective study and cross-sectional analysis
Song, Y., Manson, J. E., Buring, J. E., Sesso, H. D., & Liu, S. (2005) · Journal of the American College of Nutrition · doi:10.1080/07315724.2005.10719488 · Cited by 389 · see citing works
Luteolin reduces IL-6 production in microglia by inhibiting JNK phosphorylation and activation of AP-1
Jang, S., Kelley, K. W., & Johnson, R. W. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0802865105 · Cited by 365 · see citing works
Cutaneous photoprotection from ultraviolet injury by green tea polyphenols
Elmets, C. A., Singh, D., Tubesing, K., Matsui, M., Katiyar, S., & Mukhtar, H. (2001) · Journal of the American Academy of Dermatology · doi:10.1067/mjd.2001.112919 · Cited by 365 · see citing works
Luteolin suppresses inflammation-associated gene expression by blocking NF-κB and AP-1 activation pathway in mouse alveolar macrophages
Chen, C.-Y., Peng, W.-H., Tsai, K.-D., & Hsu, S.-L. (2007) · Life Sciences · doi:10.1016/j.lfs.2007.09.028 · Cited by 358 · see citing works
Absorption, Metabolism, and Antioxidant Effects of Pomegranate (Punica granatum L.) Polyphenols after Ingestion of a Standardized Extract in Healthy Human Volunteers
Mertens‐Talcott, S. U., Jilma‐Stohlawetz, P., Rios, J., Hingorani, L., & Derendorf, H. (2006) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf061674h · Cited by 353 · see citing works
Cancer-Preventive Effects of Drinking Green Tea among a Japanese Population
Imai, K., Suga, K., & Nakachi, K. (1997) · Preventive Medicine · doi:10.1006/pmed.1997.0242 · Cited by 352 · see citing works
Flavonoids inhibit histamine release and expression of proinflammatory cytokines in mast cells
Park, H.-H., Lee, S., Son, H., Park, S.-B., Kim, M.-S., Choi, E., Singh, T. S. K., Ha, J., Lee, M., Kim, J., et al. (2008) · Archives of Pharmacal Research · doi:10.1007/s12272-001-2110-5 · Cited by 329 · see citing works
Flavonoids inhibit cytokine-induced endothelial cell adhesion protein gene expression.
Gerritsen, M. E., Carley, W. W., Ranges, G. E., Shen, C. P., Phan, S. A., Ligon, G. F., & Perry, C. A. (1995) · Europe PMC (PubMed Central) · Cited by 305 · see citing works
Effects of the wine polyphenolics quercetin and resveratrol on pro-inflammatory cytokine expression in RAW 264.7 macrophages
Wadsworth, T. L., & Koop, D. R. (1999) · Biochemical Pharmacology · doi:10.1016/s0006-2952(99)00002-7 · Cited by 302 · see citing works
Components of the Mediterranean-type food pattern and serum inflammatory markers among patients at high risk for cardiovascular disease
Salas-Salvadó, J., Garcia-Arellano, A., Estruch, R., Marquez-Sandoval, F., Corella, D., Fiol, M., Gómez-Gracia, E., Viñoles, E., Arós, F., Herrera, C., et al. (2008) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1602762 · Cited by 295 · see citing works
Novel anti-inflammatory actions of nobiletin, a citrus polymethoxy flavonoid, on human synovial fibroblasts and mouse macrophages
Lin, N., Sato, T., Takayama, Y., Mimaki, Y., Sashida, Y., Yano, M., & Itô, A. (2003) · Biochemical Pharmacology · doi:10.1016/s0006-2952(03)00203-x · Cited by 291 · see citing works
A Phase II trial of green tea in the treatment of patients with androgen independent metastatic prostate carcinoma
Jatoi, A., Ellison, N. M., Burch, P. A., et al. (2003) · Cancer · doi:10.1002/cncr.11200 · Cited by 287 · see citing works
Green tea polyphenol epigallocatechin-3-gallate inhibits the IL-1β-induced activity and expression of cyclooxygenase-2 and nitric oxide synthase-2 in human chondrocytes
Ahmed, S., Rahman, A., Hasnain, A.-U., Lalonde, M. S., Goldberg, V. M., & Haqqi, T. M. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)01004-3 · Cited by 287 · see citing works
Quercetin Inhibits TNF-Induced NF-κB Transcription Factor Recruitment to Proinflammatory Gene Promoters in Murine Intestinal Epithelial Cells
Ruiz, P. A., Braune, A., Hölzlwimmer, G., Quintanilla-Fend, L., & Haller, D. (2007) · Journal of Nutrition · doi:10.1093/jn/137.5.1208 · Cited by 281 · see citing works
Dietary flavonoids and cancer risk in the Zutphen elderly study
Hertog, M. G. L., Feskens, E. J. M., Hollman, P. C. H., Katan, M., & Kromhout, D. (1994) · Nutrition and Cancer · doi:10.1080/01635589409514342 · Cited by 277 · see citing works
In vitro and ex vivo anti-inflammatory activity of quercetin in healthy volunteers
Boots, A. W., Wilms, L. C., Swennen, E. L. R., Kleinjans, J. C. S., Bast, A., & Haenen, G. R. M. M. (2008) · Nutrition · doi:10.1016/j.nut.2008.03.023 · Cited by 271 · see citing works
Isoliquiritigenin isolated from the roots of Glycyrrhiza uralensis inhibits LPS-induced iNOS and COX-2 expression via the attenuation of NF-κB in RAW 264.7 macrophages
Kim, J., Park, S. J., Yun, K., Cho, Y., Park, H.-J., & Lee, K. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2008.01.032 · Cited by 266 · see citing works
Serum C-reactive protein concentrations are inversely associated with dietary flavonoid intake in U.S. adults
Chun, O. K., Chung, S.-J., Claycombe, K. J., & Song, W. O. (2008) · The Journal of Nutrition · doi:10.1093/jn/138.4.753 · Cited by 263 · see citing works
Comparison of the antioxidant effects of Concord grape juice flavonoids α-tocopherol on markers of oxidative stress in healthy adults
O’Byrne, D., Devaraj, S., Grundy, S. M., & Jialal, I. (2002) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/76.6.1367 · Cited by 258 · see citing works
In vitro and in vivo antioxidant and anti-inflammatory capacities of an antioxidant-rich fruit and berry juice blend. Results of a pilot and randomized, double-blinded, placebo-controlled, crossover study
Jensen, G. S., Wu, X., Patterson, K. M., Barnes, J., Carter, S. G., Scherwitz, L., Beaman, R., Endres, J. R., & Schauss, A. G. (2008) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf8016157 · Cited by 245 · see citing works
Effects of grape seed extract in Type 2 diabetic subjects at high cardiovascular risk: a double blind randomized placebo controlled trial examining metabolic markers, vascular tone, inflammation, oxidative stress and insulin sensitivity
Kar, P. S., Laight, D. W., ROOPRAI, H. K., Shaw, K. M., & Cummings, M. H. (2009) · Diabetic Medicine · doi:10.1111/j.1464-5491.2009.02727.x · Cited by 237 · see citing works
Consumption of Black Tea and Cancer Risk: a Prospective Cohort Study
Goldbohm, R. A., Hertog, M. G. L., Brants, H. A. M., van Poppel, G., & van den Brandt, P. A. (1996) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/88.2.93 · Cited by 235 · see citing works
In vitro and in vivo inhibitory activities of rutin, wogonin, and quercetin on lipopolysaccharide-induced nitric oxide and prostaglandin E2 production
Shen, S., Lee, W.-R., Lin, H.-Y., Huang, H.-C., Ko, C.-H., Yang, L., & Chen, Y. (2002) · European Journal of Pharmacology · doi:10.1016/s0014-2999(02)01792-2 · Cited by 231 · see citing works
Quercetin regulates Th1/Th2 balance in a murine model of asthma
Park, H.-J., Lee, C., Jung, I. D., Lee, J. S., Jeong, Y.-I., Chang, J. H., Chun, S.-H., Kim, M., Choi, I., Ahn, S., et al. (2008) · International Immunopharmacology · doi:10.1016/j.intimp.2008.10.021 · Cited by 228 · see citing works
Potential of Flavonoids as Anti-inflammatory Agents: Modulation of Pro- Inflammatory Gene Expression and Signal Transduction Pathways
Tuñón, M. J., García‐Mediavilla, M. V., Sánchez‐Campos, S., & González‐Gallego, J. (2009) · Current Drug Metabolism · doi:10.2174/138920009787846369 · Cited by 227 · see citing works
Self-citation
Apigenin and luteolin modulate microglial activation via inhibition of STAT1-induced CD40 expression
Rezai-Zadeh, K. P., Ehrhart, J. C., Bai, Y., Sanberg, P. R., Bickford, P. C., Tan, J. R., & Shytle, R. D. (2008) · Journal of Neuroinflammation · doi:10.1186/1742-2094-5-41 · Cited by 217 · see citing works
Green Tea and the Risk of Gastric Cancer in Japan
Tsubono, Y., Nishino, Y., Komatsu, S., Hsieh, C.-C., Kanemura, S., Tsuji, I., Nakatsuka, H., Fukao, A., Satoh, H., & Hisamichi, S. (2001) · New England Journal of Medicine · doi:10.1056/nejm200103013440903 · Cited by 212 · see citing works
Anti-inflammatory properties of dietary flavonoids.
González‐Gallego, J., Sánchez‐Campos, S., & Tuñón, M. J. (2007) · PubMed · Cited by 200 · see citing works
Self-citation
Dietary Flavonoids Attenuate Tumor Necrosis Factor α-induced Adhesion Molecule Expression in Human Aortic Endothelial Cells
LOTITO, S. B., & Frei, B. B. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m606804200 · Cited by 199 · see citing works
Safety and Antioxidant Activity of a Pomegranate Ellagitannin-Enriched Polyphenol Dietary Supplement in Overweight Individuals with Increased Waist Size
Heber, D., Seeram, N. P., Wyatt, H., Henning, S. M., Zhang, Y., Ogden, L. G., Dreher, M. L., & Hill, J. O. (2007) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf071689v · Cited by 197 · see citing works
Comparative effects of dietary supplementation with red grape juice and vitamin E on production of superoxide by circulating neutrophil NADPH oxidase in hemodialysis patients
Castilla, P., Dávalos, A., Teruel, J. L., Cerrato, F., Fernández‐Lucas, M., Merino, J. L., Sánchez-Martín, C. C., Ortuño, J. Á., & Lasunción, M. A. (2008) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.4.1053 · Cited by 194 · see citing works
Quercetin Reduces Illness but Not Immune Perturbations after Intensive Exercise
NIEMAN, D. C., HENSON, D. A., GROSS, S. J., JENKINS, D. P., DAVIS, J. M., MURPHY, E. A., CARMICHAEL, M. D., DUMKE, C. L., UTTER, A. C., MCANULTY, S. R., et al. (2007) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e318076b566 · Cited by 193 · cited 2× · see citing works
“Quercetin Forty trained male cyclists 3 d cycling 57 % work maximum for 3 h 1 g/d per 3 weeks Reduction in upper respiratory tract infections 1⁄4 Polymorphonuclear oxidative burst activity Nieman et al.((129))”
Background
Suppression of cyclooxygenase-2 promoter-dependent transcriptional activity in colon cancer cells by chemopreventive agents with a resorcin-type structure
Mutoh, M. (2000) · Carcinogenesis · doi:10.1093/carcin/21.5.959 · Cited by 190 · see citing works
A comparison of the effects of kaempferol and quercetin on cytokine-induced pro-inflammatory status of cultured human endothelial cells
Crespo, I., García‐Mediavilla, M. V., Gutiérrez, B., Sánchez‐Campos, S., Tuñón, M. J., & González‐Gallego, J. (2008) · British Journal Of Nutrition · doi:10.1017/s0007114508966083 · Cited by 188 · see citing works
Self-citation
Inhibition of LPS‐stimulated pathways in macrophages by the flavonoid luteolin
Xagorari, A., Roussos, C., & Papapetropoulos, A. (2002) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0704803 · Cited by 181 · see citing works
Antioxidants attenuate the plasma cytokine response to exercise in humans
Vassilakopoulos, T., Karatza, M.-H., Katsaounou, P. A., Kollintza, A., Zakynthinos, S. G., & Roussos, C. (2003) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00735.2002 · Cited by 180 · see citing works
Consumption of Bing Sweet Cherries Lowers Circulating Concentrations of Inflammation Markers in Healthy Men and Women ,
Kelley, D. S., Rasooly, R., Jacob, R. A., Kader, A. A., & Mackey, B. E. (2006) · Journal of Nutrition · doi:10.1093/jn/136.4.981 · Cited by 176 · see citing works
Randomized Controlled Trial for an Effect of Green Tea Consumption on Insulin Resistance and Inflammation Markers
Fukino, Y., Shimbo, M., Aoki, N., Okubo, T., & Iso, H. (2005) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.51.335 · Cited by 168 · see citing works
Effects of green tea consumption on inflammation, insulin resistance and pulse wave velocity in type 2 diabetes patients
Ryu, O. H., Lee, J., Lee, K. W., Kim, H. Y., Seo, J. A., Kim, S. G., Kim, N. H., Baik, S. H., Choi, D. S., & Choi, K. M. (2006) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2005.08.001 · Cited by 166 · see citing works
Flavonoids and Colorectal Cancer in Italy
Rossi, M., Negri, E., Talamini, R., Bosetti, C., Parpinel, M. T., Gnagnarella, P., Franceschi, S., Maso, L. D., Montella, M., Giacosa, A., et al. (2006) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-06-0017 · Cited by 166 · see citing works
Effects of black tea consumption on plasma catechins and markers of oxidative stress and inflammation in patients with coronary artery disease
Widlansky, M. E., Duffy, S. J., Hamburg, N. M., Gokce, N., Warden, B. A., Wiseman, S., Keaney, J. F., Frei, B., & Vita, J. A. (2005) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.11.013 · Cited by 162 · see citing works
Consumption of green tea favorably affects oxidative stress markers in weight-trained men
Panza, V. P., Wazlawik, E., Schütz, G. R., Comin, L., Hecht, K. C., & da Silva, E. L. (2008) · Nutrition · doi:10.1016/j.nut.2008.01.009 · Cited by 158 · see citing works
A Dietary Supplement Attenuates IL-6 and CRP after Eccentric Exercise in Untrained Males
Phillips, T., Childs, A. C., Dreon, D. M., Phinney, S. D., & Leeuwenburgh, C. (2003) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000099112.32342.10 · Cited by 157 · see citing works
Phase IIa chemoprevention trial of green tea polyphenols in high-risk individuals of liver cancer: modulation of urinary excretion of green tea polyphenols and 8-hydroxydeoxyguanosine
Luo, H., Tang, L., Tang, M. X., Billam, M., Huang, T., Yu, J., Wei, Z., Liang, Y., Wang, K., Zhang, Z., et al. (2005) · Carcinogenesis · doi:10.1093/carcin/bgi147 · Cited by 156 · see citing works
Oxidative Stress Response to Aerobic Exercise
Bloomer, R. J., Goldfarb, A. H., & MCKENZIE, M. J. (2006) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000222839.51144.3e · Cited by 154 · see citing works
Antioxidant Restriction and Oxidative Stress in Short-Duration Exhaustive Exercise
WATSON, T. A., Callister, R., Taylor, R. D., Sibbritt, D. W., MacDonald‐Wicks, L. K., & Garg, M. L. (2005) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000150016.46508.a1 · Cited by 145 · see citing works
Skin Photoprotection by Green Tea: Antioxidant and Immunomodulatory Effects
Katiyar, S. K. (2003) · Current Drug Targets - Immune Endocrine & Metabolic Disorders · doi:10.2174/1568008033340171 · Cited by 144 · see citing works
Adherence to the Mediterranean diet and fresh fruit intake are associated with improved asthma control
Barros, R., Moreira, A. M., Fonseca, J., de Oliveira, J. F., Delgado, L., Castel-Branco, M. G., Haahtela, T., Lopes, C. M. M., & Moreira, P. A. M. (2008) · Allergy · doi:10.1111/j.1398-9995.2008.01665.x · Cited by 144 · see citing works
Short-term blackcurrant extract consumption modulates exercise-induced oxidative stress and lipopolysaccharide-stimulated inflammatory responses
Lyall, K. A., Hurst, S. M., Cooney, J. M., Jensen, D., Lo, K., Hurst, R. D., & Stevenson, L. M. (2009) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.90740.2008 · Cited by 143 · see citing works
Quercetin's influence on exercise-induced changes in plasma cytokines and muscle and leukocyte cytokine mRNA
Nieman, D. C., Henson, D. A., Davis, J. M., Murphy, E. A., Jenkins, D. P., Gross, S. J., Carmichael, M. D., Quindry, J. C., Dumke, C. L., Utter, A. C., et al. (2007) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00707.2007 · Cited by 142 · see citing works
Quercetin Attenuates Nuclear Factor-κB Activation and Nitric Oxide Production in Interleukin-1β–Activated Rat Hepatocytes
Martínez‐Flórez, S., Gutiérrez-Fernández, B., Sánchez‐Campos, S., González‐Gallego, J., & Tuñón, M. J. (2005) · Journal of Nutrition · doi:10.1093/jn/135.6.1359 · Cited by 140 · see citing works
Self-citation
Quercetin inhibits hydrogen peroxide (H2O2)-induced NF-kappaB DNA binding activity and DNA damage in HepG2 cells
Musonda, C. (1998) · Carcinogenesis · doi:10.1093/carcin/19.9.1583 · Cited by 140 · see citing works
Flavonoids such as Luteolin, Fisetin and Apigenin Are Inhibitors of Interleukin-4 and Interleukin-13 Production by ActivatedHuman Basophils
Hirano, T., Higa, S., Arimitsu, J., Naka, T., Shima, Y., Ohshima, S., Fujimoto, M., Yamadori, T., Kawase, I., & Tanaka, T. (2004) · International Archives of Allergy and Immunology · doi:10.1159/000078498 · Cited by 139 · see citing works
Nobiletin from citrus fruit peel inhibits the DNA-binding activity of NF-κB and ROS production in LPS-activated RAW 264.7 cells
Choi, S., Hwang, J., Ko, H., Park, J., & Kim, S. (2007) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2007.05.021 · Cited by 137 · see citing works
Cocoa: antioxidant and immunomodulator
Ramiro‐Puig, E., & Castell, M. (2009) · British Journal Of Nutrition · doi:10.1017/s0007114508169896 · Cited by 137 · see citing works
Flavonoids Inhibit Tumor Necrosis Factor-α-Induced Up-Regulation of Intercellular Adhesion Molecule-1 (ICAM-1) in Respiratory Epithelial Cells through Activator Protein-1 and Nuclear Factor-κB: Structure-Activity Relationships
Chen, C., Chow, M.-P., Huang, W.-C., Lin, Y.-C., & Chang, Y. (2004) · Molecular Pharmacology · doi:10.1016/s0026-895x(24)05652-9 · Cited by 125 · see citing works
Transitioning From Preclinical to Clinical Chemopreventive Assessments of Lyophilized Black Raspberries: Interim Results Show Berries Modulate Markers of Oxidative Stress in Barrett's Esophagus Patients
Kresty, L. A., Frankel, W. L., Hammond, C. D., et al. (2006) · Nutrition and Cancer · doi:10.1207/s15327914nc5401_15 · Cited by 122 · see citing works
Topical Application of a Bioadhesive Black Raspberry Gel Modulates Gene Expression and Reduces Cyclooxygenase 2 Protein in Human Premalignant Oral Lesions
Mallery, S. R., Zwick, J. C., Pei, P., Tong, M., Larsen, P. E., Shumway, B. S., Lü, B., Fields, H. W., Mumper, R. J., & Stoner, G. D. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-0568 · Cited by 122 · see citing works
Dietary patterns and C-reactive protein in Japanese men and women
Nanri, A., Yoshida, D., Yamaji, T., Mizoue, T., Takayanagi, R., & Kono, S. (2008) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.5.1488 · Cited by 118 · see citing works
The effects of chronic tea intake on platelet activation and inflammation: A double-blind placebo controlled trial
Steptoe, A., Gibson, E. L., Vuononvirta, R., Hamer, M., Wardle, J., Rycroft, J. A., Martin, J. F., & Erusalimsky, J. D. (2006) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2006.08.054 · Cited by 116 · see citing works
Effects of Ginkgo biloba extract (EGb 761) and quercetin on lipopolysaccharide-induced release of nitric oxide
Wadsworth, T. L., & Koop, D. R. (2001) · Chemico-Biological Interactions · doi:10.1016/s0009-2797(01)00208-3 · Cited by 116 · cited 1× · see citing works
“It has been shown that quercetin inhibits iNOS expression through inhibition of p38 MAPK and blocks AP-1 binding in LPS-induced RAW cells by inhibiting c-Jun N-terminal kinase((60)).”
Background
Quercetin and interferon-β modulate immune response(s) in peripheral blood mononuclear cells isolated from multiple sclerosis patients
Sternberg, Z., Chadha, K. C., Lieberman, A., Hojnacki, D. W., Drake, A. S., Zamboni, P., Rocco, P., Grazioli, E., Weinstock‐Guttman, B., & Munschauer, F. E. (2008) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2008.09.008 · Cited by 114 · see citing works
Quercetin Ingestion Does Not Alter Cytokine Changes in Athletes Competing in the Western States Endurance Run
Nieman, D. C., Henson, D. A., Davis, J. M., Dumke, C. L., Gross, S. J., Jenkins, D. P., Murphy, E. A., Carmichael, M. D., Quindry, J. C., McAnulty, S. R., et al. (2007) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2007.0050 · Cited by 114 · see citing works
Low dietary intake of β-carotene, α-tocopherol and ascorbic acid is associated with increased inflammatory and oxidative stress status in a Swedish cohort
Helmersson, J., Ärnlöv, J., Larsson, A. O., & Basu, S. (2008) · British Journal Of Nutrition · doi:10.1017/s0007114508147377 · Cited by 112 · see citing works
Chronic quercetin ingestion and exercise-induced oxidative damage and inflammation
McAnulty, S. R., McAnulty, L. S., Nieman, D. C., Quindry, J. C., Hosick, P. A., Hudson, M. H., Still, L., Henson, D. A., Milne, G. L., Morrow, J. D., et al. (2008) · Applied Physiology Nutrition and Metabolism · doi:10.1139/h07-177 · Cited by 112 · see citing works
Apigenin, a non-mutagenic dietary flavonoid, suppresses lupus by inhibiting autoantigen presentation for expansion of autoreactive Th1 and Th17 cells
Kang, H.-K., Ecklund, D., Liu, M., et al. (2009) · Arthritis Research & Therapy · doi:10.1186/ar2682 · Cited by 112 · see citing works
THE EFFECTS OF PHENOLIC COMPONENTS OF TEA ON THE PRODUCTION OF PRO- AND ANTI-INFLAMMATORY CYTOKINES BY HUMAN LEUKOCYTES IN VITRO
Crouvezier, S., Powell, B., Keir, D., & Yaqoob, P. (2001) · Cytokine · doi:10.1006/cyto.2000.0837 · Cited by 108 · see citing works
Morin regulates the expression of NF-κB-p65, COX-2 and matrix metalloproteinases in diethylnitrosamine induced rat hepatocellular carcinoma
Venkatabalasubramanian, S., & Devaraj, S. N. (2009) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2009.02.004 · Cited by 104 · see citing works
Effects of Antioxidant Supplements Intervention on the Level of Plasma Inflammatory Molecules and Disease Severity of Rheumatoid Arthritis Patients
Bae, S., Jung, W., Lee, E., Yu, R., & Sung, M. (2009) · Journal of the American College of Nutrition · doi:10.1080/07315724.2009.10719762 · Cited by 102 · see citing works
Consumption of black and green tea has no effect on inflammation, haemostasis and endothelial markers in smoking healthy individuals
de Maat, M., Pijl, H., Kluft, C., & Princen, H. (2000) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1601084 · Cited by 101 · see citing works
The effects of an antioxidant-supplemented beverage on exercise-induced oxidative stress: results from a placebo-controlled double-blind study in cyclists
Morillas-Ruiz, J. M., Zafrilla, P., Almar, M., Cuevas, M. J., López, F. J., Abellán, P., Villegas, J. A., & González‐Gallego, J. (2005) · European Journal of Applied Physiology · doi:10.1007/s00421-005-0017-4 · Cited by 101 · see citing works
Self-citation
TNFα-induced NF-κB activation and cell oxidant production are modulated by hexameric procyanidins in Caco-2 cells
Erlejman, A. G., Jaggers, G. K., Fraga, C. G., & Oteiza, P. I. (2008) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2008.01.024 · Cited by 96 · see citing works
Rutin inhibits the proliferation of murine leukemia WEHI-3 cells in vivo and promotes immune response in vivo
Lin, J.-P., Yang, J., Lu, C., et al. (2008) · Leukemia Research · doi:10.1016/j.leukres.2008.09.032 · Cited by 95 · see citing works
Quercetin prevents oxidative stress and NF-κB activation in gastric mucosa of portal hypertensive rats
Moreira, A. J., Fraga, C., Alonso-Chamorro, M., Collado, P. S., Zetller, C., Marroni, C. A., Marroni, N. P., & González‐Gallego, J. (2004) · Biochemical Pharmacology · doi:10.1016/j.bcp.2004.07.016 · Cited by 93 · see citing works
Self-citation
Gender comparisons of exercise-induced oxidative stress: influence of antioxidant supplementation
Goldfarb, A. H., McKenzie, M. J., & Bloomer, R. J. (2007) · Applied Physiology Nutrition and Metabolism · doi:10.1139/h07-078 · Cited by 90 · see citing works
Alterations in Receptor Expression or Agonist Concentration Change the Pathways Gastrin-Releasing Peptide Receptor Uses to Regulate Extracellular Signal-Regulated Kinase
Chen, P.-W., & Kroog, G. S. (2004) · Molecular Pharmacology · doi:10.1124/mol.104.001206 · Cited by 89 · see citing works
Flavonoids and the Risk of Renal Cell Carcinoma
Bosetti, C., Rossi, M., McLaughlin, J. K., Negri, E., Talamini, R., Λάγιου, Π., Montella, M., Ramazzotti, V., Franceschi, S., & Vecchia, C. L. (2007) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-06-0769 · Cited by 88 · see citing works
Immunity and Antioxidant Capacity in Humans Is Enhanced by Consumption of a Dried, Encapsulated Fruit and Vegetable Juice Concentrate
Nantz, M. P., Rowe, C. A., Nieves, C., et al. (2006) · Journal of Nutrition · doi:10.1093/jn/136.10.2606 · Cited by 88 · see citing works
Quercetin Administration Ameliorates Pulmonary Complications of Cirrhosis in Rats
Tieppo, J., Cuevas, M. J., Vercelino, R., et al. (2009) · Journal of Nutrition · doi:10.3945/jn.109.105353 · Cited by 86 · see citing works
Quercetin inhibits IL-1 beta-induced ICAM-1 expression in pulmonary epithelial cell line A549 through the MAPK pathways
Ying, B., Yang, T., Song, X., et al. (2008) · Molecular Biology Reports · doi:10.1007/s11033-008-9386-1 · Cited by 82 · see citing works
Epidemiological evidence for an association between habitual tea consumption and markers of chronic inflammation
De Bacquer, D., Clays, E., Delanghe, J., & De Backer, G. (2006) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2005.12.028 · Cited by 78 · see citing works
Flavonoids and risk of squamous cell esophageal cancer
Rossi, M., Garavello, W., Talamini, R., Vecchia, C. L., Franceschi, S., Λάγιου, Π., Zambon, P., Maso, L. D., Bosetti, C., & Negri, E. (2006) · International Journal of Cancer · doi:10.1002/ijc.22499 · Cited by 77 · see citing works
Genistein modulate immune responses in collagen-induced rheumatoid arthritis model
Wang, J., Zhang, Q., Shi, J., et al. (2008) · Maturitas · doi:10.1016/j.maturitas.2008.04.003 · Cited by 76 · see citing works
Clinical effects of apple polyphenols on persistent allergic rhinitis: A randomized double-blind placebo-controlled parallel arm study.
Enomoto, T., Nagasako-Akazome, Y., Kanda, T., et al. (2006) · PubMed · Cited by 76 · see citing works
Treatment of interstitial cystitis with a quercetin supplement.
Katske, F. A., Shoskes, D. A., Sender, M., et al. (2001) · PubMed · Cited by 74 · see citing works
Acute intake of phenolic-rich juice improves antioxidant status in healthy subjects
García‐Alonso, J., Ros, G., Vidal‐Guevara, M. L., & Periago, M. J. (2006) · Nutrition Research · doi:10.1016/j.nutres.2006.06.004 · Cited by 74 · see citing works
Dietary intake of flavonoids and asthma in adults
García-Larsen, V., Arts, I. C. W., Sterne, J. A. C., et al. (2005) · European Respiratory Journal · doi:10.1183/09031936.05.00142104 · Cited by 74 · see citing works
Prodelphinidin B-4 3′-O-gallate, a tea polyphenol, is involved in the inhibition of COX-2 and iNOS via the downregulation of TAK1-NF-κB pathway
Hou, D., Luo, D., Tanigawa, S., Hashimoto, F., Uto, T., Masuzaki, S., Fujii, M., & Sakata, Y. (2007) · Biochemical Pharmacology · doi:10.1016/j.bcp.2007.06.006 · Cited by 71 · see citing works
No difference in platelet activation or inflammation markers after diets rich or poor in vegetables, berries and apple in healthy subjects
Freese, R., Vaarala, O., Turpeinen, A. M., & Mutanen, M. L. (2004) · European Journal of Nutrition · doi:10.1007/s00394-004-0456-4 · Cited by 71 · see citing works
Theaflavin Ameliorates Cerebral Ischemia‐Reperfusion Injury in Rats Through Its Anti‐Inflammatory Effect and Modulation of STAT‐1
Cai, F., Li, C., Wu, J., Chen, J., Liu, C., Min, Q., Yu, W., Ouyang, C., & Chen, J. (2006) · Mediators of Inflammation · doi:10.1155/mi/2006/30490 · Cited by 71 · see citing works
Quercetin inhibited murine leukemia WEHI‐3 cells in vivo and promoted immune response
Yu, C., Lai, K., Yang, J., Chiang, J., Lu, C., Wu, C., Lin, J.-P., Liao, C., Tang, N.-Y., Wood, W. G., et al. (2009) · Phytotherapy Research · doi:10.1002/ptr.2841 · Cited by 71 · see citing works
Dietary flavones suppresses IgE and Th2 cytokines in OVA-immunized BALB/c mice
Yano, S., Umeda, D., Yamashita, T., et al. (2007) · European Journal of Nutrition · doi:10.1007/s00394-007-0658-7 · Cited by 69 · see citing works
Effects of major dietary antioxidants on inflammatory markers of RAW 264.7 macrophages
Jung, W., & Sung, M. (2004) · BioFactors · doi:10.1002/biof.552210122 · Cited by 67 · see citing works
Oral Quercetin Supplementation and Blood Oxidative Capacity in Response to Ultramarathon Competition
Quindry, J. C., McAnulty, S. R., Hudson, M. B., Hosick, P. A., Dumke, C., McAnulty, L. S., Henson, D. A., Morrow, J. D., & Nieman, D. C. (2008) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.18.6.601 · Cited by 67 · see citing works
Epigallocatechin-3-O-gallate inhibits TNFα-induced monocyte chemotactic protein-1 production from vascular endothelial cells
Ahn, H. Y., Xu, Y., & Davidge, S. T. (2008) · Life Sciences · doi:10.1016/j.lfs.2008.02.018 · Cited by 65 · see citing works
Oral administration of the purple passion fruit peel extract reduces wheeze and cough and improves shortness of breath in adults with asthma
WATSON, R. R., Zibadi, S., Rafatpanah, H., et al. (2008) · Nutrition Research · doi:10.1016/j.nutres.2008.01.003 · Cited by 64 · see citing works
Inhibition of IL-8 Production by Green Tea Polyphenols in Human Nasal Fibroblasts and A549 Epithelial Cells
Kim, I.-B., Kim, D., Lee, S., et al. (2006) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.29.1120 · Cited by 62 · see citing works
Silibinin polarizes Th1/Th2 immune responses through the inhibition of immunostimulatory function of dendritic cells
Lee, J. S., Kim, S. G., Kim, H. K., Lee, T., Jeong, Y., Lee, C., Yoon, M., Na, Y. J., Suh, D., Park, N. C., et al. (2006) · Journal of Cellular Physiology · doi:10.1002/jcp.20852 · Cited by 58 · see citing works
Glabridin Suppresses Intercellular Adhesion Molecule-1 Expression in Tumor Necrosis Factor-α-Stimulated Human Umbilical Vein Endothelial Cells by Blocking Sphingosine Kinase Pathway: Implications of Akt, Extracellular Signal-Regulated Kinase, and Nuclear Factor-κB/Rel Signaling Pathways
Kang, J. S., Yoon, Y. D., Han, M. H., et al. (2005) · Molecular Pharmacology · doi:10.1124/mol.105.017442 · Cited by 56 · see citing works
Flavonoids exert diverse inhibitory effects on the activation of nf-κb
Muraoka, K., Shimizu, K., Sun, X., et al. (2002) · Transplantation Proceedings · doi:10.1016/s0041-1345(02)02795-1 · Cited by 50 · see citing works
Taxifolin glycoside inhibits dendritic cell responses stimulated by lipopolysaccharide and lipoteichoic acid
Kim, Y. J., Choi, S. E., Lee, M. W., et al. (2008) · Journal of Pharmacy and Pharmacology · doi:10.1211/jpp.60.11.0007 · Cited by 50 · see citing works
Post-160-km Race Illness Rates and Decreases in Granulocyte Respiratory Burst and Salivary IgA Output are Not Countered by Quercetin Ingestion
Henson, D. A., Nieman, D. C., Davis, J., Dumke, C. L., Gross, S. J., Murphy, A., Carmichael, M. D., Jenkins, D., Quindry, J. C., McAnulty, S. R., et al. (2008) · International Journal of Sports Medicine · doi:10.1055/s-2007-989424 · Cited by 49 · see citing works
Apigenin, a dietary flavonoid, sensitizes human T cells for activation-induced cell death by inhibiting PKB/Akt and NF-κB activation pathway
Xu, L., Zhang, L., Bertucci, A. M., Pope, R. M., & Datta, S. K. (2008) · Immunology Letters · doi:10.1016/j.imlet.2008.08.004 · Cited by 48 · see citing works
Antioxidant Requirements of Endurance Athletes: Implications for Health
Williams, S., Strobel, N., Lexis, L. A., & Coombes, J. S. (2006) · Nutrition Reviews · doi:10.1111/j.1753-4887.2006.tb00193.x · Cited by 46 · see citing works
Immunosuppressive effect of silibinin in experimental autoimmune encephalomyelitis
Min, K., Yoon, W., Kim, S. K., & Kim, B.-H. (2007) · Archives of Pharmacal Research · doi:10.1007/bf02980267 · Cited by 44 · see citing works
Grape Seed Proanthocyanidin Extracts Inhibit Vascular Cell Adhesion Molecule Expression Induced by Advanced Glycation End Products Through Activation of Peroxisome Proliferators-Activated Receptor γ
Ma, L., Gao, H., Li, B., et al. (2007) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0b013e31803c5616 · Cited by 41 · see citing works
Dietary Quercetin Augments Activator Protein-1 and Does Not Reduce Nuclear Factor-κB in the Renal Cortex of Rats with Established Chronic Glomerular Disease
Rangan, G. K., Wang, Y., & Harris, D. C. H. (2002) · The Nephron journals/Nephron journals · doi:10.1159/000049067 · Cited by 31 · see citing works
Regulatory effects of a fermented food concentrate on immune function parameters in healthy volunteers
Schön, C., Schulz, A., Schweikart, J., Schütt, S., & von Baehr, V. (2009) · Nutrition · doi:10.1016/j.nut.2008.10.022 · Cited by 25 · see citing works
Effect of Increase of Dietary Micronutrient Intake on Oxidative Stress Indicators in HIV/AIDS Patients
Gil, L., Luján, L. M. L., Martı́nez, G., Reyes, A. T., González, I., Alvarez, A., Tápanes, R. D., Giuliani, A., León, O. S., & Pérez, J. (2005) · International Journal for Vitamin and Nutrition Research · doi:10.1024/0300-9831.75.1.19 · Cited by 23 · see citing works
Morin Promotes the Production of Th2 Cytokine by Modulating Bone Marrow-Derived Dendritic Cells
Li, C., Suen, J., Chiang, B., et al. (2006) · The American Journal of Chinese Medicine · doi:10.1142/s0192415x06004193 · Cited by 10 · see citing works
[Apigenin inhibits release and gene expression of monocyte chemoattractant protein 1 (MCP-1) in J774.2 macrophages].
Kowalski, J., Samojedny, A., Paul-Samojedny, M., et al. (2006) · PubMed · Cited by 8 · see citing works

Flagged first, then by citations

Research works printed but not linked: 1

Robards K & Antolovich M (1997) Analytical biochemistry of fruit flavonoids, a review. Analyst 122, 436.

Sorted by citations

Flavonoids as Cytokine Modulators: A Possible Therapy for Inflammation-Related Diseases
Leyva-López, N., Gutierrez-Grijalva, E., Ambriz-Perez, D., & Heredia, J. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17060921 · Cited by 337 · see citing works
Citrus Flavonoids as Regulators of Lipoprotein Metabolism and Atherosclerosis
Mulvihill, E. E., Burke, A. C., & Huff, M. W. (2016) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071715-050718 · Cited by 228 · see citing works
Multi-Target Mechanisms of Phytochemicals in Alzheimer’s Disease: Effects on Oxidative Stress, Neuroinflammation and Protein Aggregation
Sharifi-Rad, J., Rapposelli, S., Sestito, S., Herrera-Bravo, J., Arancibia-Diaz, A., Salazar, L. A., Yeskaliyeva, B., Beyatli, A., Leyva-Gómez, G., González-Contreras, C., et al. (2022) · Journal of Personalized Medicine · doi:10.3390/jpm12091515 · Cited by 125 · see citing works
Influence of a Polyphenol-Enriched Protein Powder on Exercise-Induced Inflammation and Oxidative Stress in Athletes: A Randomized Trial Using a Metabolomics Approach
Nieman, D. C., Gillitt, N. D., Knab, A. M., Shanely, R. A., Pappan, K. L., Jin, F., & Lila, M. A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0072215 · Cited by 119 · see citing works
Dietary plant polyphenols as the potential drugs in neurodegenerative diseases: current evidence, advances, and opportunities
Yan, L., Guo, M.-S., Zhang, Y., Yu, L., Wu, J.-M., Tang, Y., Ai, W., Zhu, F.-D., Law, B. Y.-K., Chen, Q., et al. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/5288698 · Cited by 97 · see citing works
Antioxidant Potential and Antitumour Activities of Nendran Banana Peels in Breast Cancer Cell Line
Kumar, P. S., Durgadevi, S., Saravanan, A., & Uma, S. (2019) · Indian Journal of Pharmaceutical Sciences · doi:10.36468/pharmaceutical-sciences.531 · Cited by 48 · see citing works
The potential role of the Mediterranean Diet for the treatment and management of Polycystic Ovary Syndrome: a review of the pathophysiological mechanisms and clinical evidence.
Scannell, N., Villani, A., Moran, L., & Mantzioris, E. (2025) · Proceedings of the Nutrition Society · doi:10.1017/s0029665124007584 · Cited by 12 · see citing works
“For example, flavonoids are biologically active polyphe-nolic compounds ubiquitously found in plant-based foods with antioxidant and anti-inflammatory effects (140,141) .”

A review on the effects of glucosamine for knee osteoarthritis based on human and animal studies
Chan, K. O. W., & Ng, G. Y. F. (2011) · Hong Kong Physiotherapy Journal · doi:10.1016/j.hkpj.2011.06.004 · Cited by 7 · see citing works
Safety and Efficacy of Shilajit (Mumie, Moomiyo)
Stohs, S. J. (2013) · Phytotherapy Research · doi:10.1002/ptr.5018 · Cited by 65 · see citing works
Monounsaturated fatty acids and immune function
Yaqoob, P. (2002) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1601477 · Cited by 109 · see citing works
Evidence-Based Data From Animal and Human Experimental Studies on Pain Relief With Antidepressants: A Structured Review
Fishbain, D. A., Cutler, R., Rosomoff, H. L., et al. (2000) · Pain Medicine · doi:10.1046/j.1526-4637.2000.00042.x · Cited by 118 · see citing works
Conditioned hormonal responses: A systematic review in animals and humans
Skvortsova, A., Veldhuijzen, D. S., Kloosterman, I. E. M., Meijer, O. C., van Middendorp, H., Pacheco‐López, G., & Evers, A. W. M. (2018) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2018.12.005 · Cited by 15 · see citing works

Authors: González-Gallego, J., García-Mediavilla, M. V., Sánchez-Campos, S., & Tuñón, M. J.
Affiliations: Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (ES)
Corresponding author: Tuñón, María J.
ORCID: Tuñón, María J.
Venue: British Journal Of Nutrition
Publisher: Cambridge University Press (CUP)
Published: 2010-10
Volume: 104
Issue: S3
Pages: S15-S27
ISSN: 0007-1145 (ISSN-L)
1475-2662
DOI: 10.1017/s0007114510003910
OpenAlex: W2107837447
Cited by: 387
References: 131
Citations by year: 2026: 15 · 2025: 12 · 2024: 19 · 2023: 18 · 2022: 35 · 2021: 23 · 2020: 30 · 2019: 20 · 2018: 27 · 2017: 28 · 2016: 24 · 2015: 33 · 2014: 36 · 2013: 27 · 2012: 25
FWCI: 1.92
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.cambridge.org/core/terms (unspecified, 18 d)
Locations: British Journal Of Nutrition (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
Health Sciences › Medicine › Pharmacology › Flavonoids in Medical Research
Keywords: flavonoids, fruit polyphenols, tea flavonoids, immunomodulation, anti-inflammatory activity, inflammation, flavonoid metabolites, gene expression regulation, enzyme regulation, infection resistance, exercise performance, disease prevention
MeSH terms: Animals, Anti-Inflammatory Agents, Diet, Flavonoids, Fruit, Humans, Immunity, Immunologic Factors, Inflammation, Phytotherapy, Phenols, Plant Extracts, Tea, Polyphenols

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Fruit polyphenols, immunity and inflammation

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks