The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Hypoxia and Fungal Pathogenesis: To Air or Not To Air?
Open accessAbstract
Over the last 3 decades, the frequency of life-threatening human fungal infections has increased as advances in medical therapies, solid-organ and hematopoietic stem cell transplantations, an increasing geriatric population, and HIV infections have resulted in significant rises in susceptible patient populations. Although significant advances have been made in understanding how fungi cause disease, the dynamic microenvironments encountered by fungi during infection and the mechanisms by which they adapt to these microenvironments are not fully understood. As inhibiting and preventing in vivo fungal growth are main goals of antifungal therapies, understanding in vivo fungal metabolism in these host microenvironments is critical for the improvement of existing therapies or the design of new approaches. In this minireview, we focus on the emerging appreciation that pathogenic fungi like Candida albicans , Cryptococcus neoformans , and Aspergillus fumigatus are exposed to oxygen-limited or hypoxic microenvironments during fungal pathogenesis. The implications of these in vivo hypoxic microenvironments for fungal metabolism and pathogenesis are discussed with an aim toward understanding the potential impact of hypoxia on invasive fungal infection outcomes.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Eltzschig, H. K., & Carmeliet, P. (2011) · New England Journal of Medicine · doi:10.1056/nejmra0910283 · Cited by 2,061
Nonfilamentous C. albicans Mutants Are Avirulent
Lo, H.-J., Köhler, J. R., DiDomenico, B., Loebenberg, D., Cacciapuoti, A., & Fink, G. R. (1997) · Cell · doi:10.1016/s0092-8674(00)80358-x · Cited by 1,809
Growth of Candida albicans hyphae
Sudbery, P. E. (2011) · Nature Reviews Microbiology · doi:10.1038/nrmicro2636 · Cited by 1,110
Interdependence of hypoxic and innate immune responses
Nizet, V., & Johnson, R. S. (2009) · Nature Reviews Immunology · doi:10.1038/nri2607 · Cited by 708
Epithelial hypoxia-inducible factor-1 is protective in murine experimental colitis
Karhausen, J., Furuta, G. T., Tomaszewski, J. E., Johnson, R. S., Colgan, S. P., & Haase, V. H. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200421086 · Cited by 655
A molecular timescale of eukaryote evolution and the rise of complex multicellular life
Hedges, S. B., Blair, J. E., Venturi, M. L., & Shoe, J. L. (2004) · BMC Evolutionary Biology · doi:10.1186/1471-2148-4-2 · Cited by 578
Distinct Roles for Intra- and Extracellular Siderophores during Aspergillus fumigatus Infection
Schrettl, M., Bignell, E., Kragl, C., Sabiha, Y., Loss, O., Eisendle, M., Wallner, A., Arst, H. N., Haynes, K., & Haas, H. (2007) · PLoS Pathogens · doi:10.1371/journal.ppat.0030128 · Cited by 405
He, G., Shankar, R. A., Chzhan, M., Samouilov, A., Kuppusamy, P., & Zweier, J. L. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.8.4586 · Cited by 383
Steroids, triterpenoids and molecular oxygen
Summons, R. E., Bradley, A. S., Jahnke, L. L., & Waldbauer, J. R. (2006) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2006.1837 · Cited by 364 · cited 1×
“Molecular oxygen plays an essential role as an electron acceptor in the generation of chemical energy via mitochondrial respiration but is also critical for the biosynthesis of sterols, mono- and polyunsaturated fatty acids, NAD, and porphyrin and in other metabolic and biosynthetic pathways (41, 94, 115).”
BackgroundWillger, S. D., Puttikamonkul, S., Kim, K.-H., Burritt, J. B., Grahl, N., Metzler, L. J., Barbuch, R., Bard, M., Lawrence, C. B., & Cramer, R. A. (2008) · PLoS Pathogens · doi:10.1371/journal.ppat.1000200 · Cited by 345
Self-citation
Cited by
Dadar, M., Tiwari, R., Karthik, K., Chakraborty, S., Shahali, Y., & Dhama, K. (2018) · Microbial Pathogenesis · doi:10.1016/j.micpath.2018.02.028 · Cited by 332
Hommel, B., Mukaremera, L., Cordero, R. J. B., Coelho, C., Desjardins, C. A., Sturny-Leclère, A., Janbon, G., Perfect, J. R., Fraser, J. A., Casadevall, A., et al. (2018) · PLoS Pathogens · doi:10.1371/journal.ppat.1006982 · Cited by 143
Pradhan, A., Avelar, G. M., Bain, J. M., Childers, D. S., Larcombe, D. E., Netea, M. G., Shekhova, E., Munro, C. A., Brown, G. D., Erwig, L. P., et al. (2018) · mBio · doi:10.1128/mbio.01318-18 · Cited by 133
Evasion of Immune Surveillance in Low Oxygen Environments Enhances Candida albicans Virulence
Lopes, J. P., Stylianou, M., Backman, E., Holmberg, S., Jass, J., Claesson, R., & Urban, C. F. (2018) · mBio · doi:10.1128/mbio.02120-18 · Cited by 88
Dietl, A.-M., Amich, J., Leal, S., Beckmann, N., Binder, U., Beilhack, A., Pearlman, E., & Haas, H. (2016) · Virulence · doi:10.1080/21505594.2016.1146848 · Cited by 77
Metadata
- Authors
- Grahl, N., Shepardson, K. M., Chung, D., & Cramer, R. A.
- Venue
- Eukaryotic Cell
- Publisher
- American Society for Microbiology
- Published
- 2012-05
- Volume
- 11
- Issue
- 5
- Pages
- 560-570
- ISSN
- 1535-9778 (ISSN-L)
- 1535-9786
- OpenAlex
- W2115978411
- Cited by
- 179
- References
- 27
- FWCI
- 4.88
- Type
- journal article
- Language
- en
- Open access
- diamond
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Hypoxia and Fungal Pathogenesis: To Air or Not To Air? https://app.cochat.ai/papers/10.1128/ec.00031-12
- The paper
- Grahl, N., Shepardson, K. M., Chung, D., & Cramer, R. A. (2012). Hypoxia and Fungal Pathogenesis: To Air or Not To Air? Eukaryotic Cell. https://doi.org/10.1128/ec.00031-12
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
