Efflux pump proteins in antifungal resistance

Epidemiology of Invasive Candidiasis: a Persistent Public Health Problem

Pfaller, M. A., & Diekema, D. J. (2007) · Clinical Microbiology Reviews · doi:10.1128/cmr.00029-06 · Cited by 4,174 · cited 3× · see citing works

Proton-dependent multidrug efflux systems

Paulsen, I. T., Brown, M. H., & Skurray, R. A. (1996) · Microbiological Reviews · doi:10.1128/mr.60.4.575-608.1996 · Cited by 1,089 · see citing works

A major superfamily of transmembrane facilitators that catalyse uniport, symport and antiport

Marger, M. D., & Saier, M. H. (1993) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(93)90081-w · Cited by 954 · see citing works

TCDB: the Transporter Classification Database for membrane transport protein analyses and information

Saier, M. H. (2005) · Nucleic Acids Research · doi:10.1093/nar/gkj001 · Cited by 848 · see citing works

The ATP switch model for ABC transporters

Higgins, C. F., & Linton, K. J. (2004) · Nature Structural & Molecular Biology · doi:10.1038/nsmb836 · Cited by 752 · see citing works

Efflux-Mediated Antifungal Drug Resistance

Cannon, R. D., Lamping, E., Holmes, A. R., Niimi, K., Baret, P. V., Keniya, M. V., Tanabe, K., Niimi, M., Goffeau, A., & Monk, B. C. (2009) · Clinical Microbiology Reviews · doi:10.1128/cmr.00051-08 · Cited by 608 · see citing works

Cloning of Candida albicans genes conferring resistance to azole antifungal agents: characterization of CDR2, a new multidrug ABC transporter gene

Sanglard, D., Ischer, F., Monod, M., & Bille, J. (1997) · Microbiology · doi:10.1099/00221287-143-2-405 · Cited by 587 · see citing works

Changing patterns and trends in systemic fungal infections

Richardson, M. D. (2005) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dki218 · Cited by 525 · see citing works

Molecular cloning and characterization of a novel gene of Candida albicans, CDR1, conferring multiple resistance to drugs and antifungals

Prasad, R., De Wergifosse, P., Goffeau, A., & Balzi, E. (1995) · Current Genetics · doi:10.1007/bf00352101 · Cited by 486 · see citing works

Proton-dependent multidrug efflux systems.

Paulsen, I. T., Brown, M. H., & Skurray, R. A. (1996) · Microbiological Reviews · doi:10.1128/mmbr.60.4.575-608.1996 · Cited by 448 · see citing works

ATPase and Multidrug Transport Activities of the Overexpressed Yeast ABC Protein Yor1p

Decottignies, A., Grant, A. M., Nichols, J. L., de Wet, H., McIntosh, D. B., & Goffeau, A. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.20.12612 · Cited by 385 · see citing works

A Human-Curated Annotation of the Candida albicans Genome

Braun, B. R., van het Hoog, M., d'Enfert, C., Martchenko, M., Dungan, J., Kuo, A., Inglis, D. O., Uhl, M. A., Hogues, H., Berriman, M., et al. (2005) · PLoS Genetics · doi:10.1371/journal.pgen.0010001 · Cited by 342 · see citing works

Current Perspectives on Echinocandin Class Drugs

Perlin, D. S. (2011) · Future Microbiology · doi:10.2217/fmb.11.19 · Cited by 274 · see citing works

Fungal echinocandin resistance

Walker, L. A., Gow, N. A. R., & Munro, C. A. (2010) · Fungal Genetics and Biology · doi:10.1016/j.fgb.2009.09.003 · Cited by 267 · see citing works

Yeast ATP-Binding Cassette Transporters Conferring Multidrug Resistance

Prasad, R., & Goffeau, A. (2012) · Annual Review of Microbiology · doi:10.1146/annurev-micro-092611-150111 · Cited by 221 · see citing works

Multidrug Resistance in Yeast Candida

Prasad, R., & Kapoor, K. (2004) · International review of cytology · doi:10.1016/s0074-7696(04)42005-1 · Cited by 182 · see citing works

Fungal PDR transporters: Phylogeny, topology, motifs and function

Lamping, E., Baret, P. V., Holmes, A. R., Monk, B. C., Goffeau, A., & Cannon, R. D. (2009) · Fungal Genetics and Biology · doi:10.1016/j.fgb.2009.10.007 · Cited by 161 · see citing works

The ATP Binding Cassette Transporters Pdr5 and Snq2 of Saccharomyces cerevisiae Can Mediate Transport of Steroids in Vivo

Mahé, Y., Lemoine, Y., & Kuchler, K. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.41.25167 · Cited by 153 · see citing works

Genetic Separation of FK506 Susceptibility and Drug Transport in the Yeast Pdr5 ATP-binding Cassette Multidrug Resistance Transporter

Egner, R., Rosenthal, F. E., Kralli, A., Sanglard, D., & Kuchler, K. (1998) · Molecular Biology of the Cell · doi:10.1091/mbc.9.2.523 · Cited by 153 · see citing works

Candida albicans gene encoding resistance to benomyl and methotrexate is a multidrug resistance gene

Ben-Yaacov, R., Knoller, S., Caldwell, G. A., Becker, J. M., & Koltin, Y. (1994) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.38.4.648 · Cited by 144 · see citing works

Topology, structure and evolution of two families of proteins involved in antibiotic and antiseptic resistance in eukaryotes and prokaryotes — an analysis

Paulsen, I. T., & Skurray, R. A. (1993) · Gene · doi:10.1016/0378-1119(93)90755-r · Cited by 137 · see citing works

Functional Characterization of <i>Candida albicans</i> ABC Transporter Cdr1p

Shukla, S., Saini, P., Smriti, Jha, S., Ambudkar, S. V., & Prasad, R. (2003) · Eukaryotic Cell · doi:10.1128/ec.2.6.1361-1375.2003 · Cited by 135 · see citing works

ABC transporters Cdr1p, Cdr2p and Cdr3p of a human pathogen Candida albicans are general phospholipid translocators

Smriti, S., Krishnamurthy, S., Dixit, B. L., Gupta, C. M., Milewski, S., & Prasad, R. (2002) · Yeast · doi:10.1002/yea.818 · Cited by 113 · see citing works

MFS transportome of the human pathogenic yeast Candida albicans

Gaur, M., Puri, N., Manoharlal, R., Rai, V., Mukhopadhayay, G., Choudhury, D., & Prasad, R. (2008) · BMC Genomics · doi:10.1186/1471-2164-9-579 · Cited by 105 · see citing works

The Candida albicans CDR3 gene codes for an opaque-phase ABC transporter

Balan, I., Alarco, A., & Raymond, M. (1997) · Journal of Bacteriology · doi:10.1128/jb.179.23.7210-7218.1997 · Cited by 102 · see citing works

Structure and Function Analysis of CaMdr1p, a Major Facilitator Superfamily Antifungal Efflux Transporter Protein of Candida albicans : Identification of Amino Acid Residues Critical for Drug/H + Transport

Pasrija, R., Banerjee, D., & Prasad, R. (2007) · Eukaryotic Cell · doi:10.1128/ec.00315-06 · Cited by 91 · see citing works

Characterization of CD8+T-Cell Responses in the Peripheral Blood and Skin Injection Sites of Melanoma Patients Treated with mRNA Electroporated Autologous Dendritic Cells (TriMixDC-MEL)

Benteyn, D., Nuffel, A. M. T. V., Wilgenhof, S., Corthals, J., Heirman, C., Neyns, B., Thielemans, K., & Bonehill, A. (2013) · BioMed Research International · doi:10.1155/2013/976383 · Cited by 89 · see citing works

Expression of CDR1, a multidrug resistance gene of Candida albicans: transcriptional activation by heat shock, drugs and human steroid hormones

Krishnamurthy, S., Gupta, V., Prasad, R., Panwar, S. L., & Prasad, R. (1998) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.1998.tb12910.x · Cited by 89 · see citing works

Complete Inventory of ABC Proteins in Human Pathogenic Yeast, Candida albicans

Gaur, M., Choudhury, D., & Prasad, R. (2005) · Microbial Physiology · doi:10.1159/000088141 · Cited by 85 · see citing works

Identification of polymorphic mutant alleles of CaMDR1, a major facilitator of Candida albicans which confers multidrug resistance, and its in vitro transcriptional activation

Gupta, V., Kohli, A., Krishnamurthy, S., Puri, N., Aalamgeer, S., Panwar, S. L., & Prasad, R. (1998) · Current Genetics · doi:10.1007/s002940050385 · Cited by 80 · see citing works

Mutations Define Cross-talk between the N-terminal Nucleotide-binding Domain and Transmembrane Helix-2 of the Yeast Multidrug Transporter Pdr5

Sauna, Z. E., Bohn, S. S., Rutledge, R. M., Dougherty, M. P., Cronin, S., May, L., Xia, D., Ambudkar, S. V., & Golin, J. E. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m806446200 · Cited by 66 · see citing works

Drug resistance in yeasts — an emerging scenario

Prasad, R., Panwar, S. L., & Smriti, S. (2002) · Advances in microbial physiology/Advances in Microbial Physiology · doi:10.1016/s0065-2911(02)46004-3 · Cited by 64 · see citing works

A fourth gene from the Candida albicans CDR family of ABC transporters

Franz, R., Michel, S., & Morschhäuser, J. (1998) · Gene · doi:10.1016/s0378-1119(98)00412-0 · Cited by 64 · see citing works

Characterisation of human steroid hormone transport mediated by Cdr1p, a multidrug transporter of Candida albicans, belonging to the ATP binding cassette super family

Krishnamurthy, S., Gupta, V., Snehlata, P., & Prasad, R. (1998) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.1998.tb12802.x · Cited by 62 · see citing works

Functional analysis of a vacuolar ABC transporter in wild‐type Candida albicans reveals its involvement in virulence

Theiß, S., Kretschmar, M., Nichterlein, T., Hof, H., Agabian, N. M., Hacker, J. H., & Köhler, G. A. (2002) · Molecular Microbiology · doi:10.1046/j.1365-2958.2002.02769.x · Cited by 55 · see citing works

A Ste6p/P‐glycoprotein homologue from the asexual yeast Candida albicans transports the a‐factor mating pheromone in Saccharomyces cerevisiae

Raymond, M., Dignard, D., Alarco, A., Mainville, N., Magee, B. B., & Thomas, D. Y. (1998) · Molecular Microbiology · doi:10.1046/j.1365-2958.1998.00704.x · Cited by 53 · see citing works

The TetA(K) Tetracycline/H + Antiporter from Staphylococcus aureus : Mutagenesis and Functional Analysis of Motif C

Ginn, S. L., Brown, M. H., & Skurray, R. A. (2000) · Journal of Bacteriology · doi:10.1128/jb.182.6.1492-1498.2000 · Cited by 51 · see citing works

Specific interactions between the Candida albicans ABC transporter Cdr1p ectodomain and a d ‐octapeptide derivative inhibitor

Niimi, K., Harding, D. R. K., Holmes, A. R., Lamping, E., Niimi, M., Tyndall, J. D. A., Cannon, R. D., & Monk, B. C. (2012) · Molecular Microbiology · doi:10.1111/j.1365-2958.2012.08140.x · Cited by 50 · see citing works

Insight into Pleiotropic Drug Resistance ATP-binding Cassette Pump Drug Transport through Mutagenesis of Cdr1p Transmembrane Domains*

Rawal, M. K., Khan, M. F., Kapoor, K., Goyal, N., Sen, S., Saxena, A. K., Lynn, A. M., Tyndall, J. D. A., Monk, B. C., Cannon, R. D., et al. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.488353 · Cited by 50 · see citing works

Purification and Characterization of the N-Terminal Nucleotide Binding Domain of an ABC Drug Transporter of Candida albicans: Uncommon Cysteine 193 of Walker A Is Critical for ATP Hydrolysis

Jha, S., Karnani, N., Dhar, S. K., Mukhopadhayay, K., Shukla, S., Saini, P., Mukhopadhayay, G., & Prasad, R. (2003) · Biochemistry · doi:10.1021/bi0345900 · Cited by 49 · see citing works

Alanine scanning of transmembrane helix 11 of Cdr1p ABC antifungal efflux pump of Candida albicans: identification of amino acid residues critical for drug efflux

Saini, P., Prasad, T., Gaur, N. A., Shukla, S., Jha, S., Komath, S. S., Khan, L. A., Haq, Q. M. R., & Prasad, R. (2005) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dki183 · Cited by 47 · see citing works

The Signaling Interface of the Yeast Multidrug Transporter Pdr5 Adopts a Cis Conformation, and There Are Functional Overlap and Equivalence of the Deviant and Canonical Q-Loop Residues

Ananthaswamy, N., Rutledge, R. M., Sauna, Z. E., Ambudkar, S. V., Dine, E., Nelson, E., Xia, D., & Golin, J. E. (2010) · Biochemistry · doi:10.1021/bi100394j · Cited by 45 · see citing works

The central cytoplasmic loop of the major facilitator superfamily of transport proteins governs efficient membrane insertion

Weinglass, A. B., & Kaback, H. R. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.140224497 · Cited by 44 · see citing works

Isolation and sequence analysis of the gene for translation elongation factor 3 fromCandida albicans

Myers, K. K., Fonzi, W. A., & Sypherd, P. S. (1992) · Nucleic Acids Research · doi:10.1093/nar/20.7.1705 · Cited by 44 · see citing works

Characterization of Cdr1p, A Major Multidrug Efflux Protein of Candida albicans: Purified Protein Is Amenable to Intrinsic Fluorescence Analysis

Shukla, S., Rai, V., Banerjee, D., & Prasad, R. (2006) · Biochemistry · doi:10.1021/bi0519147 · Cited by 42 · see citing works

Families and superfamilies of transport proteins common to prokaryotes and eukaryotes

Saier, M. H., & Reizer, J. (1991) · Current Opinion in Structural Biology · doi:10.1016/0959-440x(91)90034-q · Cited by 38 · see citing works

ABC multidrug transporter Cdr1p of has divergent nucleotide-binding domains which display functional asymmetry

Jha, S., Dabas, N., Karnani, N., SAINI, P., & PRASAD, R. (2004) · FEMS Yeast Research · doi:10.1016/j.femsyr.2004.07.002 · Cited by 37 · see citing works

The Transmission Interface of the Saccharomyces cerevisiae Multidrug Transporter Pdr5: Val-656 Located in Intracellular Loop 2 Plays a Major Role in Drug Resistance

Downes, M. T., Mehla, J., Ananthaswamy, N., Schonbrun, A., Lamonde, M., Dine, E., Ambudkar, S. V., & Golin, J. E. (2012) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.02133-12 · Cited by 36 · see citing works

The multidrug transporter Pdr5: a molecular diode?

Gupta, R. P., Kueppers, P., Schmitt, L., & Ernst, R. (2011) · Biological Chemistry · doi:10.1515/bc.2011.011 · Cited by 35 · see citing works

Analysis of physico-chemical properties of substrates of ABC and MFS multidrug transporters of pathogenic Candida albicans

Puri, N., Prakash, O., Manoharlal, R., Sharma, M., Ghosh, I., & Prasad, R. (2010) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2010.07.050 · Cited by 34 · see citing works

Efflux-mediated resistance to fluconazole could be modulated by sterol homeostasis in Saccharomyces cerevisiae

Kontoyiannis, D. P. (2000) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/46.2.199 · Cited by 33 · see citing works

Functionally Relevant Residues of Cdr1p: A Multidrug ABC Transporter of Human Pathogenic Candida albicans

Prasad, R., Sharma, M., & Rawal, M. K. (2011) · Journal of Amino Acids · doi:10.4061/2011/531412 · Cited by 32 · see citing works

Specificity of drug transport mediated byCaMDR1: A major facilitator ofCandida albicans

Kohli, A., Gupta, V., Krishnamurthy, S., Hasnain, S. E., & Prasad, R. (2001) · Journal of Biosciences · doi:10.1007/bf02703742 · Cited by 31 · see citing works

Conserved Asp327 of Walker B Motif in the N-Terminal Nucleotide Binding Domain (NBD-1) of Cdr1p ofCandida albicansHas Acquired a New Role in ATP Hydrolysis

Rai, V., Gaur, M., Shukla, S., Shukla, S., Ambudkar, S. V., Komath, S. S., & Prasad, R. (2006) · Biochemistry · doi:10.1021/bi061535t · Cited by 30 · see citing works

A key structural domain of the Candida albicans Mdr1 protein

Mandal, A., Kumar, A., Singh, A., Lynn, A. M., Kapoor, K., & Prasad, R. (2012) · Biochemical Journal · doi:10.1042/bj20120190 · Cited by 29 · see citing works

Mapping of Interdomain Interfaces Required for the Functional Architecture of Yor1p, a Eukaryotic ATP-binding Cassette (ABC) Transporter

Pagant, S., Brovman, E. Y., Halliday, J. J., & Miller, E. A. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m803912200 · Cited by 27 · see citing works

Cytoplasmic domains of the reduced folate carrier are essential for trafficking, but not function

Sadlish, H., Williams, F. M., & Flintoff, W. F. (2002) · Biochemical Journal · doi:10.1042/bj20011361 · Cited by 27 · see citing works

Chemical Specificity of thePDR5Multidrug Resistance Gene Product ofSaccharomyces cerevisiaeBased on Studies with Tri-n-Alkyltin Chlorides

Golin, J. E., Barkatt, A., Cronin, S., Eng, G., & May, L. (2000) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.44.1.134-138.2000 · Cited by 27 · see citing works

Chimeras of the ABC drug transporter Cdr1p reveal functional indispensability of transmembrane domains and nucleotide-binding domains, but transmembrane segment 12 is replaceable with the corresponding homologous region of the non-drug transporter Cdr3p

Saini, P., Gaur, N. A., & Prasad, R. (2006) · Microbiology · doi:10.1099/mic.0.28471-0 · Cited by 24 · see citing works

Functional Characterization of N-Terminal Nucleotide Binding Domain (NBD-1) of a Major ABC Drug Transporter Cdr1p of Candida albicans: Uncommon but Conserved Trp326 of Walker B Is Important for ATP Binding

Rai, V., Shukla, S., Jha, S., Komath, S. S., & Prasad, R. (2005) · Biochemistry · doi:10.1021/bi0474160 · Cited by 23 · see citing works

Intragenic Suppressing Mutations Correct the Folding and Intracellular Traffic of Misfolded Mutants of Yor1p, a Eukaryotic Drug Transporter

Pagant, S., Halliday, J. J., Kougentakis, C. M., & Miller, E. A. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.142760 · Cited by 23 · see citing works

Divergent signature motifs of nucleotide binding domains of ABC multidrug transporter, CaCdr1p of pathogenic Candida albicans, are functionally asymmetric and noninterchangeable

Kumar, A., Shukla, S., Mandal, A., Shukla, S., Ambudkar, S. V., & Prasad, R. (2010) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2010.05.017 · Cited by 22 · see citing works

The amino acid residues of transmembrane helix 5 of multidrug resistance protein CaCdr1p of Candida albicans are involved in substrate specificity and drug transport

Puri, N., Gaur, M., Sharma, M., Shukla, S., Ambudkar, S. V., & Prasad, R. (2009) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2009.04.009 · Cited by 21 · see citing works

Ketoconazole binds to the intracellular corticosteroid-binding protein in Candida albicans

Stover, E. P., Loose, D. S., Stevens, D. A., & Feldman, D. (1983) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(83)91538-3 · Cited by 20 · see citing works

Disruption studies of a Candida albicans gene, ELF1: a member of the ATP-binding cassette family

Sturtevant, J. E., Cihlar, R. L., & Calderone, R. (1998) · Microbiology · doi:10.1099/00221287-144-8-2311 · Cited by 20 · see citing works

Employing Information Theoretic Measures and Mutagenesis to Identify Residues Critical for Drug-Proton Antiport Function in Mdr1p of Candida albicans

Kapoor, K., Rehan, M., Lynn, A. M., & Prasad, R. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011041 · Cited by 19 · see citing works

Steroid binding protein(s) in yeasts.

Das, M., & Datta, A. (1985) · PubMed · Cited by 19 · see citing works

The Large Cytoplasmic Loop of the Glucose Transporter GLUT1 Is an Essential Structural Element for Function

Monden, I., Olsowski, A., Krause, G., & Keller, K. (2001) · Biological Chemistry · doi:10.1515/bc.2001.189 · Cited by 15 · see citing works

A novel catalytic mechanism for ATP hydrolysis employed by the N-terminal nucleotide-binding domain of Cdr1p, a multidrug ABC transporter of Candida albicans

Rai, V., Gaur, M., Kumar, A., Shukla, S., Komath, S. S., & Prasad, R. (2008) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2008.04.010 · Cited by 14 · see citing works

A Mutation in Intracellular Loop 4 Affects the Drug-Efflux Activity of the Yeast Multidrug Resistance ABC Transporter Pdr5p

Guo, X., Li, J., Wang, T., Liu, Z., Chen, X., Li, Y., Gu, Z., Mao, X., Guan, W., & Li, Y. (2012) · PLoS ONE · doi:10.1371/journal.pone.0029520 · Cited by 10 · see citing works

Sorting Signals within the Saccharomyces cerevisiae Sporulation-Specific Dityrosine Transporter, Dtr1p, C Terminus Promote Golgi-to-Prospore Membrane Transport

Morishita, M., & Engebrecht, J. (2008) · Eukaryotic Cell · doi:10.1128/ec.00151-08 · Cited by 7 · see citing works

Alanine scanning of all cysteines and construction of a functional cysteine-less Cdr1p, a multidrug ABC transporter of Candida albicans

Prasad, R., Shah, A. H., Sanwal, H., & Kapoor, K. (2011) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2011.11.150 · Cited by 6 · see citing works

Functional Role of the Intracellular Loop Linking Transmembrane Domains 6 and 7 of the Human Dipeptide Transporter hPEPT1

Xu, L., Li, Y., Haworth, I. S., & Davies, D. L. (2010) · The Journal of Membrane Biology · doi:10.1007/s00232-010-9317-7 · Cited by 6 · see citing works

Antifungal Therapy: New Advances in the Understanding and Treatment of Mycosis

Scorzoni, L., de Paula e Silva, A. C. A., Marcos, C. M., Assato, P. A., de Melo, W. C. M. A., de Oliveira, H. C., Costa-Orlandi, C. B., Mendes-Giannini, M. J. S., & Fusco-Almeida, A. M. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.00036 · Cited by 418 · see citing works

Candida Infections and Therapeutic Strategies: Mechanisms of Action for Traditional and Alternative Agents

Santos, G. C. D. O., Vasconcelos, C. C., Lopes, A. J. O., Cartágenes, M. D. S. D. S., Filho, A. K. D. B., do Nascimento, F. R. F., Ramos, R. M., Pires, E. R. R. B., de Andrade, M. S., Rocha, F. M. G., et al. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.01351 · Cited by 357 · see citing works

Antifungal tolerance is a subpopulation effect distinct from resistance and is associated with persistent candidemia

Rosenberg, A., Ene, I. V., Bibi, M., Zakin, S., Segal, E. S., Ziv, N., Dahan, A. M., Colombo, A. L., Bennett, R. J., & Berman, J. (2018) · Nature Communications · doi:10.1038/s41467-018-04926-x · Cited by 270 · see citing works

Membrane transporter engineering in industrial biotechnology and whole cell biocatalysis

Kell, D. B., Swainston, N., Pir, P., & Oliver, S. G. (2015) · Trends in biotechnology · doi:10.1016/j.tibtech.2015.02.001 · Cited by 195 · see citing works

Drug resistance in eukaryotic microorganisms

Fairlamb, A. H., Gow, N. A. R., Matthews, K. R., & Waters, A. P. (2016) · Nature Microbiology · doi:10.1038/nmicrobiol.2016.92 · Cited by 152 · see citing works

UDP-galactose and acetyl-CoA transporters as Plasmodium multidrug resistance genes

Lim, M. Y.-X., LaMonte, G., Lee, M., Reimer, C., Tan, B. H., Corey, V. C., Tjahjadi, B. F., Chua, A. C. Y., Nachon, M., Wintjens, R. T., et al. (2016) · Nature Microbiology · doi:10.1038/nmicrobiol.2016.166 · Cited by 143 · see citing works

The ABCs of Candida albicans multidrug transporter Cdr1

Prasad, R., Banerjee, A., Khandelwal, N. K., & Dhamgaye, S. (2015) · Eukaryotic Cell · doi:10.1128/ec.00137-15 · Cited by 123 · see citing works

Fungal Drug Response and Antimicrobial Resistance

Osset-Trénor, P., Pascual‐Ahuir, A., & Proft, M. (2023) · Journal of Fungi · doi:10.3390/jof9050565 · Cited by 103 · see citing works

The roles of CDR1, CDR2, and MDR1 in kaempferol-induced suppression with fluconazole-resistant Candida albicans

Shao, J., Zhang, M.-X., Wang, T., Li, Y., & Wang, C. (2015) · Pharmaceutical Biology · doi:10.3109/13880209.2015.1091483 · Cited by 86 · see citing works

Fungicidal action of geraniol against Candida albicans is potentiated by abrogated CaCdr1p drug efflux and fluconazole synergism

Singh, S., Fatima, Z., Ahmad, K., & Hameed, S. (2018) · PLoS ONE · doi:10.1371/journal.pone.0203079 · Cited by 80 · see citing works

Azole Resistance Mechanisms in Pathogenic Malassezia furfur

Leong, C., Chan, J. W. K., Lee, S. M., Lam, Y. I., Goh, J. P. Z., Ianiri, G., & Dawson, T. L. (2021) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01975-20 · Cited by 80 · see citing works

OMICS and Other Advanced Technologies in Mycological Applications

Wijayawardene, N., Boonyuen, N., Ranaweera, C., de Zoysa, H. K. S., Padmathilake, R. E., Nifla, F., Dai, D.-Q., Liu, Y., Suwannarach, N., Kumla, J., et al. (2023) · Journal of Fungi · doi:10.3390/jof9060688 · Cited by 58 · see citing works

A One Health approach to overcoming fungal disease and antifungal resistance

Woods, M., McAlister, J. A., & Geddes‐McAlister, J. (2023) · WIREs Mechanisms of Disease · doi:10.1002/wsbm.1610 · Cited by 68 · see citing works

Anticandidal Effect and Mechanisms of Monoterpenoid, Perillyl Alcohol against Candida albicans

Ansari, M. A., Fatima, Z., & Hameed, S. (2016) · PLoS ONE · doi:10.1371/journal.pone.0162465 · Cited by 66 · see citing works

Understanding the mechanisms of resistance to azole antifungals in Candida species

Li, Y., Hind, C. K., Furner-Pardoe, J., Sutton, J. M., & Rahman, K. M. (2025) · JAC-Antimicrobial Resistance · doi:10.1093/jacamr/dlaf106 · Cited by 66 · see citing works

Microbial resistance: The role of efflux pump superfamilies and their respective substrates

Garcia, I., Garcia, F. A. D. O., Pereira, P. S., Coutinho, H. D. M., Siyadatpanah, A., Norouzi, R., Wilairatana, P., Pereira, M. D. L., Nissapatorn, V., Tintino, S. R., et al. (2022) · Life Sciences · doi:10.1016/j.lfs.2022.120391 · Cited by 62 · see citing works

Repurposing approach identifies pitavastatin as a potent azole chemosensitizing agent effective against azole-resistant Candida species

Eldesouky, H. E., Salama, E. A., Li, X., Hazbun, T. R., Mayhoub, A. S., & Seleem, M. N. (2020) · Scientific Reports · doi:10.1038/s41598-020-64571-7 · Cited by 55 · see citing works

The Candida albicans Histone Acetyltransferase Hat1 Regulates Stress Resistance and Virulence via Distinct Chromatin Assembly Pathways

Tscherner, M., Zwolanek, F., Jenull, S., Sedlazeck, F. J., Petryshyn, A., Frohner, I. E., Mavrianos, J., Chauhan, N., von Haeseler, A., & Kuchler, K. (2015) · PLOS Pathogens · doi:10.1371/journal.ppat.1005218 · Cited by 57 · see citing works

Loss of C-5 Sterol Desaturase Activity Results in Increased Resistance to Azole and Echinocandin Antifungals in a Clinical Isolate of Candida parapsilosis

Rybak, J. M., Dickens, C. M., Parker, J. E., Caudle, K. E., Manigaba, K., Whaley, S. G., Nishimoto, A. T., Luna-Tapia, A., Roy, S., Zhang, Q., et al. (2017) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00651-17 · Cited by 53 · see citing works

Augmenting Azoles with Drug Synergy to Expand the Antifungal Toolbox

Kane, A., & Carter, D. A. (2022) · Pharmaceuticals · doi:10.3390/ph15040482 · Cited by 55 · see citing works

Multidrug Resistance in Mammals and Fungi—From MDR to PDR: A Rocky Road from Atomic Structures to Transport Mechanisms

Khunweeraphong, N., & Kuchler, K. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094806 · Cited by 54 · see citing works

Abrogation of pathogenic attributes in drug resistant Candida auris strains by farnesol

Srivastava, V., & Ahmad, A. (2020) · PLoS ONE · doi:10.1371/journal.pone.0233102 · Cited by 49 · see citing works

Antifungal activity and mechanism of action of natural product derivates as potential environmental disinfectants

Silva-Beltrán, N. P., Boon, S., Ijaz, M. K., McKinney, J., & Gerba, C. P. (2023) · Journal of Industrial Microbiology & Biotechnology · doi:10.1093/jimb/kuad036 · Cited by 51 · see citing works

Reassessing the Use of Undecanoic Acid as a Therapeutic Strategy for Treating Fungal Infections

Rossi, A., Martins, M. P., Bitencourt, T. A., Peres, N. T. A., Rocha, C. H. L., Rocha, F. M. G., Neves‐da‐Rocha, J., Lopes, M. E. R., Sanches, P. R., Bortolossi, J. C., et al. (2021) · Mycopathologia · doi:10.1007/s11046-021-00550-4 · Cited by 46 · see citing works

Synergistic Effect of Berberine Hydrochloride and Fluconazole Against Candida albicans Resistant Isolates

Yong, J., Zu, R., Huang, X., Ge, Y., & Li, Y. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.01498 · Cited by 43 · see citing works

Parallel evolution of multiple mechanisms for demethylase inhibitor fungicide resistance in the barley pathogen Pyrenophora teres f. sp. maculata

Mair, W. J., Thomas, G. J., Dodhia, K. N., Hills, A. L., Jayasena, K. W., Ellwood, S. R., Oliver, R. P., & López-Ruiz, F. J. (2020) · Fungal Genetics and Biology · doi:10.1016/j.fgb.2020.103475 · Cited by 39 · see citing works

Novel 2,4-Disubstituted-1,3-Thiazole Derivatives: Synthesis, Anti-Candida Activity Evaluation and Interaction with Bovine Serum Albumine

Pricopie, A., Focşan, M., Ionuţ, I. A., Marc, G., Vlase, L., Găină, L., Vodnar, D. C., Simon, E., Barta, G., Pı̂rnău, A., et al. (2020) · Molecules · doi:10.3390/molecules25051079 · Cited by 37 · see citing works

Characterization of a promiscuous cadmium and arsenic resistance mechanism in Thermus thermophilus HB27 and potential application of a novel bioreporter system

Antonucci, I., Gallo, G., Limauro, D., Contursi, P., Ribeiro, A. L., Blesa, A., Berenguer, J., Bartolucci, S., & Fiorentino, G. (2018) · Microbial Cell Factories · doi:10.1186/s12934-018-0918-7 · Cited by 35 · see citing works

Targeting Candida spp. to develop antifungal agents

Salci, T. P., Negri, M., Abadio, A. K. R., Svidzinski, T. I. E., & Kioshima, É. S. (2018) · Drug Discovery Today · doi:10.1016/j.drudis.2018.01.003 · Cited by 35 · see citing works

Proton pump inhibitors act synergistically with fluconazole against resistant Candida albicans

Lü, M., Yan, H., Yu, C., Yuan, L., & Sun, S. (2020) · Scientific Reports · doi:10.1038/s41598-019-57174-4 · Cited by 34 · see citing works

Ambroxol Hydrochloride Combined with Fluconazole Reverses the Resistance of Candida albicans to Fluconazole

Li, X., Zhao, Y., Huang, X., Yu, C., Yang, Y., & Sun, S. (2017) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2017.00124 · Cited by 33 · see citing works

Ospemifene displays broad-spectrum synergistic interactions with itraconazole through potent interference with fungal efflux activities

Eldesouky, H. E., Salama, E. A., Hazbun, T. R., Mayhoub, A. S., & Seleem, M. N. (2020) · Scientific Reports · doi:10.1038/s41598-020-62976-y · Cited by 33 · see citing works

ABC transportome inventory of human pathogenic yeast Candida glabrata: Phylogenetic and expression analysis

Kumari, S., Kumar, M., Khandelwal, N., Kumari, P., Varma, M., Vishwakarma, P., Shahi, G., Sharma, S., Lynn, A. M., Prasad, R., et al. (2018) · PLoS ONE · doi:10.1371/journal.pone.0202993 · Cited by 31 · see citing works

Candida Efflux ATPases and Antiporters in Clinical Drug Resistance

Prasad, R., Rawal, M. K., & Shah, A. H. (2016) · Advances in Experimental Medicine and Biology · doi:10.1007/978-3-319-25304-6_15 · Cited by 30 · see citing works

Linear Epitopes of Paracoccidioides brasiliensis and Other Fungal Agents of Human Systemic Mycoses As Vaccine Candidates

Travassos, L. R., & Taborda, C. P. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00224 · Cited by 31 · see citing works

The molecular mechanism of azole resistance in Aspergillus fumigatus: from bedside to bench and back

Wei, X., Zhang, Y., & Lü, L. (2015) · The Journal of Microbiology · doi:10.1007/s12275-015-5014-7 · Cited by 31 · see citing works

Eucalyptal D Enhances the Antifungal Effect of Fluconazole on Fluconazole-Resistant Candida albicans by Competitively Inhibiting Efflux Pump

Xu, J., Liu, R., Sun, F., An, L., Shang, Z., Kong, L., & Yang, M. (2019) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2019.00211 · Cited by 31 · see citing works

Repurposing of Ribavirin as an Adjunct Therapy against Invasive Candida Strains in an In Vitro Study

Yousfi, H., Cassagne, C., Ranque, S., Rolain, J., & Bittar, F. (2019) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00263-19 · Cited by 30 · see citing works

How can We Bolster the Antifungal Drug Discovery Pipeline?

Jampílek, J. (2016) · Future Medicinal Chemistry · doi:10.4155/fmc-2016-0124 · Cited by 30 · see citing works

Influence of subinhibitory antifungal concentrations on extracellular hydrolases and biofilm production by Candida albicans recovered from Egyptian patients

El-Houssaini, H. H., Elnabawy, O. M., Nasser, H. A., & Elkhatib, W. F. (2019) · BMC Infectious Diseases · doi:10.1186/s12879-019-3685-0 · Cited by 29 · see citing works

Polymer “ruthenium-cyclopentadienyl” conjugates - New emerging anti-cancer drugs

Moreira, T., Francisco, R., Comsa, E., Duban‐Deweer, S., Labas, V., Teixeira‐Gomes, A., Combes‐Soia, L., Marques, F., Matos, A., Favrelle, A., et al. (2019) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2019.02.061 · Cited by 29 · see citing works

Tackling multi-drug resistant fungi by efflux pump inhibitors

Engle, K., & Kumar, G. (2024) · Biochemical Pharmacology · doi:10.1016/j.bcp.2024.116400 · Cited by 28 · see citing works

Repurposing pantoprazole and haloperidol as efflux pump inhibitors in azole resistant clinical Candida albicans and non-albicans isolates

El-Ganiny, A. M., Kamel, H. A., Yossef, N. E., Mansour, B., & El-Baz, A. M. (2022) · Saudi Pharmaceutical Journal · doi:10.1016/j.jsps.2022.01.011 · Cited by 28 · see citing works

Characterization of Three Pleiotropic Drug Resistance Transporter Genes and Their Participation in the Azole Resistance of Mucor circinelloides

Nagy, G., Kiss, S. A., Varghese, R., Bauer, K., Szebenyi, C., Kocsubé́, S., Homa, M., Bodai, L., Zsindely, N., Nagy, G., et al. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.660347 · Cited by 27 · see citing works

Multi-site fungicides suppress banana Panama disease, caused by Fusarium oxysporum f. sp. cubense Tropical Race 4

Cannon, S. J., Kay, W. T., Kilaru, S., Schuster, M., Gurr, S. J., & Steinberg, G. (2022) · PLoS Pathogens · doi:10.1371/journal.ppat.1010860 · Cited by 30 · see citing works

Synergistic in vitro activity of sodium houttuyfonate with fluconazole against clinical Candida albicans strains under planktonic growing conditions

Shao, J., Cui, Y., Zhang, M.-X., Wang, T., Wu, D., & Wang, C. (2016) · Pharmaceutical Biology · doi:10.1080/13880209.2016.1237977 · Cited by 27 · see citing works

Learning from fungicide resistance: Evolutionary insights to guide RNAi-based control of fungal crop pathogens

Alkemade, J., Hawkins, N. J., Baraldi, E., Buddie, A. G., Cockerton, H. M., Corkley, I., FRAAIJE, B. A., Gaya, E., Gifford, D. R., Hartig, F., et al. (2025) · Fungal Biology Reviews · doi:10.1016/j.fbr.2025.100443 · Cited by 26 · see citing works

The response strategies of Colletotrichum gloeosporioides s.s. due to the stress caused by biological control agent Bacillus amyloliquefaciens deciphered by transcriptome analyses

Wang, Q., Ji, Y., Qu, Y.-Y., Qi, Y.-K., Li, D., Liu, Z., & Wu, X. (2020) · Biological Control · doi:10.1016/j.biocontrol.2020.104372 · Cited by 25 · see citing works

Pesticides and antimicrobial resistance: from environmental compartments to animal and human infections

Curuțiu, C., Lazăr, V., & Chifiriuc, M. C. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-804299-1.00011-4 · Cited by 26 · see citing works

Enhancing Drug Efficacy and Therapeutic Index through Cheminformatics-Based Selection of Small Molecule Binary Weapons That Improve Transporter-Mediated Targeting: A Cytotoxicity System Based on Gemcitabine

Grixti, J. M., O’Hagan, S., Day, P. J., & Kell, D. B. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00155 · Cited by 27 · see citing works

Current and promising pharmacotherapeutic options for candidiasis

Scorzoni, L., Fuchs, B. B., Junqueira, J. C., & Mylonakis, E. E. (2021) · Expert Opinion on Pharmacotherapy · doi:10.1080/14656566.2021.1873951 · Cited by 28 · see citing works

Management of Candida Biofilms: State Of Knowledge and New Options for Prevention and Eradication

Bujdáková, H. (2016) · Future Microbiology · doi:10.2217/fmb.15.139 · Cited by 25 · see citing works

A Comparative Review of Eugenol and Citral Anticandidal Mechanisms: Partners in Crimes Against Fungi

Shahina, Z., & Dahms, T. E. S. (2024) · Molecules · doi:10.3390/molecules29235536 · Cited by 29 · see citing works

Glutamine metabolism modulates azole susceptibility in Trypanosoma cruzi amastigotes

Dumoulin, P. C., Vollrath, J., Tomko, S. S., Wang, J. X., & Burleigh, B. A. (2020) · eLife · doi:10.7554/elife.60226 · Cited by 23 · see citing works

Alpha2,3-sialyltransferase III knockdown sensitized ovarian cancer cells to cisplatin-induced apoptosis

Wang, X., Zhang, Y., Lin, H., Liu, Y., Tan, Y., Lin, J., Gao, F., & Lin, S. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.11.107 · Cited by 23 · see citing works

A newly identified amino acid substitution T123I in the 14α-demethylase (Erg11p) of Candida albicans confers azole resistance

Wu, Y., Gao, N., Li, C., Gao, J. Q., & Ying, C. (2017) · FEMS Yeast Research · doi:10.1093/femsyr/fox012 · Cited by 23 · see citing works

Antifungal Activity of Mexican Propolis on Clinical Isolates of Candida Species

Rivera-Yañez, C. R., Ruiz-Hurtado, P. A., Reyes‐Reali, J., Mendoza‐Ramos, M. I., Vargas-Dı́az, M. E., Hernández-Sánchez, K. M., Pozo‐Molina, G., Méndez-Catalá, C. F., García-Romo, G. S., Pedroza‐González, A., et al. (2022) · Molecules · doi:10.3390/molecules27175651 · Cited by 24 · see citing works

Vaginitis: Review on Drug Resistance

Rigo, G. V., & Tasca, T. (2020) · Current Drug Targets · doi:10.2174/1389450121666200804112340 · Cited by 21 · see citing works

Small molecules restore azole activity against drug-tolerant and drug-resistant Candida isolates

Alabi, P., Gautier, C., Murphy, T. P., Gu, X., Lepas, M., Aimanianda, V., Sello, J. K., & Ene, I. V. (2023) · mBio · doi:10.1128/mbio.00479-23 · Cited by 21 · see citing works

Physical Interaction of Sodium Houttuyfonate With β-1,3-Glucan Evokes Candida albicans Cell Wall Remodeling

Da, W., Shao, J., Li, Q., Shi, G., Wang, T., Wu, D., & Wang, C. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.00034 · Cited by 22 · see citing works

Antifungal Styryloquinolines as Candida albicans Efflux Pump Inhibitors: Styryloquinolines are ABC Transporter Inhibitors

Cieślik, W., Szczepaniak, J., Krasowska, A., & Musioł, R. (2020) · Molecules · doi:10.3390/molecules25020345 · Cited by 21 · see citing works

Efflux Pump Inhibition Controls Growth and Enhances Antifungal Susceptibility of Fusarium Solani Species Complex

Cordeiro, R. D. A., Portela, F. V. M., Pereira, L. M., de Andrade, A. R. C., de Sousa, J. K., Aguiar, A. L. R., Pergentino, M. L. M., Sales, G., de Oliveira, J. S., Medrano, D. J. A., et al. (2020) · Future Microbiology · doi:10.2217/fmb-2019-0186 · Cited by 20 · see citing works

Prevalence and Fluconazole Susceptibility Profile of Candida spp. Clinical Isolates in a Brazilian Tertiary Hospital in Minas Gerais, Brazil

Neves, A., Cartágenes-Pinto, A. C., Rocha, D. A. S., de Sá, L. F. R., Junqueira, M. D. L., & Ferreira‐Pereira, A. (2015) · Anais da Academia Brasileira de Ciências · doi:10.1590/0001-3765201520140717 · Cited by 20 · see citing works

Biguanides enhance antifungal activity against Candida glabrata

Xu, S., Feliu, M., Lord, A. K., Lukason, D. P., Negoro, P. E., Khan, N. S., Dagher, Z., Feldman, M. B., Reedy, J. L., Steiger, S. N., et al. (2018) · Virulence · doi:10.1080/21505594.2018.1475798 · Cited by 20 · see citing works

Clonal spread and azole-resistant mechanisms of non-susceptible Candida albicans isolates from vulvovaginal candidiasis patients in three Shanghai maternity hospitals

Wu, Y., Li, C., Wang, Z., Gao, J. Q., Tang, Z., Chen, H., & Ying, C. (2017) · Medical Mycology · doi:10.1093/mmy/myx099 · Cited by 19 · see citing works

Genomics insights of candidiasis: mechanisms of pathogenicity and drug resistance

Huang, X., Dong, Q., Zhou, Q., Fang, S., Xu, Y., Hu, L., Chen, J., Li, X. Y., Qin, H., Mu, D., et al. (2025) · Frontiers in Microbiology · doi:10.3389/fmicb.2025.1531543 · Cited by 20 · see citing works

Design and synthesis of purine analogues as highly specific ligands for FcyB, a ubiquitous fungal nucleobase transporter

Lougiakis, N., Gavriil, E.-S., Kairis, M., Sioupouli, G., Lambrinidis, G., Benaki, D. C., Krypotou, E., Mikros, E., Marakos, P., Pouli, N., et al. (2016) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2016.09.055 · Cited by 18 · see citing works

Alternative Splicing in Trichophyton rubrum Occurs in Efflux Pump Transcripts in Response to Antifungal Drugs

Lopes, M. E. R., Bitencourt, T. A., Sanches, P. R., Martins, M. P., de Oliveira, V. M., Rossi, A., & Martinez-Rossi, N. M. (2022) · Journal of Fungi · doi:10.3390/jof8080878 · Cited by 18 · see citing works

Pentamidine Inhibits the Growth of Sporothrix Schenckii Complex and Exhibits Synergism With Antifungal Agents

Brilhante, R. S., Pereira, V. S., de Oliveira, J. S., Lopes, R. G. P., Rodrigues, A. M., Camargo, Z. P. D., Pereira‐Neto, W. D. A., Castelo‐Branco, D. D. S. C. M., Cordeiro, R. D. A., Sidrim, J. J. C., et al. (2018) · Future Microbiology · doi:10.2217/fmb-2018-0070 · Cited by 18 · see citing works

TKTL1 modulates the response of paclitaxel-resistant human ovarian cancer cells to paclitaxel

Zheng, X., & Li, H. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.06.011 · Cited by 17 · see citing works

Decoding the antifungal resistance mechanisms in biofilms of emerging, ubiquitous and multidrug-resistant species belonging to the Scedosporium/Lomentospora genera

de Mello, T. P., Oliveira, S. S. C., Branquinha, M. H., & dos Santos, A. L. S. (2022) · Medical Mycology · doi:10.1093/mmy/myac036 · Cited by 16 · see citing works

Vanillin confers antifungal drug synergism in Candida albicans by impeding CaCdr2p driven efflux

Saibabu, V., Fatima, Z., Singh, S., Khan, L. A., & Hameed, S. (2020) · Journal de Mycologie Médicale · doi:10.1016/j.mycmed.2019.100921 · Cited by 16 · see citing works

SWL-1 Reverses Fluconazole Resistance in Candida albicans by Regulating the Glycolytic Pathway

Li, X.-N., Zhang, L., Wang, Y., Zhang, Y., Jin, Z., Li, J., Wang, R., & Xiao, W. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.572608 · Cited by 16 · see citing works

Identification of an indole–triazole–amino acid conjugate as a highly effective antifungal agent

Pawar, K., Yadav, A., Prasher, P., Mishra, S., Singh, B., Singh, P., & Komath, S. S. (2015) · MedChemComm · doi:10.1039/c5md00156k · Cited by 15 · see citing works

Biofilm Formation by Chromoblastomycosis Fungi Fonsecaea pedrosoi and Phialophora verrucosa: Involvement with Antifungal Resistance

Sousa, I. S., de Mello, T. P., Paiva-Pereira, E., Granato, M. Q., Alviano, C. S., dos Santos, A. L. S., & Kneipp, L. F. (2022) · Journal of Fungi · doi:10.3390/jof8090963 · Cited by 15 · see citing works

Multidrug ABC transporter Cdr1 of Candida albicans harbors specific and overlapping binding sites for human steroid hormones transport

Baghel, P., Rawal, M. K., Khan, M. F., Sen, S., Siddiqui, M. H., Chaptal, V., Falson, P., & Prasad, R. (2017) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2017.05.011 · Cited by 14 · see citing works

Identifying novel inhibitors against drug-resistant mutant CYP-51 Candida albicans: A computational study to combat fungal infections

Jabeen, S., Khan, M. U., Ejaz, H., Waqar, S., Farhana, A., Alruwaili, M., Alruwaili, Y. S., Abdalla, A. E., Mudassar, S., & Ali, Q. (2025) · PLoS ONE · doi:10.1371/journal.pone.0318539 · Cited by 14 · see citing works

Efflux, Signaling and Warfare in a Polymicrobial World

Moore-Machacek, A., Gloe, A., O’Leary, N. D., & Reen, F. J. (2023) · Antibiotics · doi:10.3390/antibiotics12040731 · Cited by 14 · see citing works

Extracellular vesicles as novel assay tools to study cellular interactions of anti-infective compounds – A perspective

Richter, R., & Lehr, C. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.04.010 · Cited by 14 · see citing works

β-Lapachone enhances the antifungal activity of fluconazole against a Pdr5p-mediated resistant Saccharomyces cerevisiae strain

de Moraes, D. C., Cardoso, K. M., Domingos, L. T. S., Pinto, M. D. C. F. R., Monteiro, R. Q., & Ferreira‐Pereira, A. (2020) · Brazilian Journal of Microbiology · doi:10.1007/s42770-020-00254-9 · Cited by 13 · see citing works

Anticandidal Agent for Multiple Targets: The Next Paradigm in the Discovery of Proficient Therapeutics/Overcoming Drug Resistance

Jha, A., & Kumar, A. (2019) · Future Medicinal Chemistry · doi:10.4155/fmc-2018-0479 · Cited by 12 · see citing works

Target shortage and less explored multiple targeting: hurdles in the development of novel antifungals but overcome/addressed effectively through structural bioinformatics

Jha, A., Vimal, A., & Kumar, A. (2020) · Briefings in Bioinformatics · doi:10.1093/bib/bbaa343 · Cited by 12 · see citing works

Efflux systems driving resistance and virulence across biological domains

da Silva, P. E. A., von Groll, A., Ramis, I. B., Reis, A. J., Ramos, D. F., & Viveiros, M. (2025) · PeerJ · doi:10.7717/peerj.20360 · Cited by 12 · see citing works

New arsenals for old armour: Biogenic nanoparticles in the battle against drug-resistant Candida albicans

Padmavathi, A. R., Reddy, G. K. K., Murthy, P. S., & Nancharaiah, Y. V. (2024) · Microbial Pathogenesis · doi:10.1016/j.micpath.2024.106800 · Cited by 11 · see citing works

Clinical pharmacology of antifungal agents to overcome drug resistance in pediatric patients

Stergiopoulou, T., & Walsh, T. J. (2015) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.2015.1000302 · Cited by 11 · see citing works

Identification and functional characterization ofPenicillium marneffeipleiotropic drug resistance transportersABC1andABC2

Panapruksachat, S., Iwatani, S., Oura, T., Vanittanakom, N., Chindamporn, A., Niimi, K., Niimi, M., Lamping, E., Cannon, R. D., & Kajiwara, S. (2016) · Medical Mycology · doi:10.1093/mmy/myv117 · Cited by 11 · see citing works

Cigarette smoke condensate alters Saccharomyces cerevisiae efflux transporter mRNA and activity and increases caffeine toxicity

Sayyed, K., Vée, M. L., Chamieh, H., Fardel, O., & Abdel‐Razzak, Z. (2018) · Toxicology · doi:10.1016/j.tox.2018.08.005 · Cited by 11 · see citing works

Global study of MFS superfamily transporters in arabidopsis and grapes reveals their functional diversity in plants

Patil, S. S., Prashant, R., Kadoo, N. Y., Upadhyay, A., & Gupta, V. S. (2019) · Plant Gene · doi:10.1016/j.plgene.2019.100179 · Cited by 11 · see citing works

Development and Validation of a New HPLC Method for Quantification of a Novel Antifungal Drug Based on 1,3,4-Thiadiazole and its Impurities

Sipkina, N. Y., Polyakova, M. V., & Yakovlev, I. P. (2019) · Chromatographia · doi:10.1007/s10337-019-03794-x · Cited by 11 · see citing works

Engineering a Cysteine-Deficient Functional Candida albicans Cdr1 Molecule Reveals a Conserved Region at the Cytosolic Apex of ABCG Transporters Important for Correct Folding and Trafficking of Cdr1

Madani, G., Lamping, E., & Cannon, R. D. (2021) · mSphere · doi:10.1128/msphere.01318-20 · Cited by 11 · see citing works

Newly identified motifs in Candida albicans Cdr1 protein nucleotide binding domains are pleiotropic drug resistance subfamily-specific and functionally asymmetric

Rawal, M. K., Banerjee, A., Shah, A. H., Khan, M. F., Sen, S., Saxena, A. K., Monk, B. C., Cannon, R. D., Bhatnagar, R., Mondal, A. K., et al. (2016) · Scientific Reports · doi:10.1038/srep27132 · Cited by 10 · see citing works

Management of patients with digestive diseases during the COVID-19 pandemic. Clinical Practice Guidelines by the Russian scientific medical society of internal medicine (RSMSIM) and the Gastroenterological Scientific Society of Russia (2nd edition)

Grinevich, V. B., Kravchuk, Y. A., Ped, V. I., Sas, E. I., Петровна, С. С., Владимировна, Г. И., Ei, T., Sitkin, S. I., Lazebnik, L. B., Голованова, Е. В., et al. (2021) · Экспериментальная и клиническая гастроэнтерология · doi:10.31146/1682-8658-ecg-187-3-5-82 · Cited by 11 · see citing works

Fungal Infections as an Uprising Threat to Human Health: Chemosensitization of Fungal Pathogens With AFP From Aspergillus giganteus

Dhandapani, K., Sivarajan, K., Ravindhiran, R., & Sekar, J. N. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.887971 · Cited by 10 · see citing works

Resistance to Site-Specific Succinate Dehydrogenase Inhibitor Fungicides Is Pervasive in Populations of Black and Yellow Sigatoka Pathogens in Banana Plantations from Southeastern Brazil

Silva, T. C., Moreira, S. I., de Souza, D. M., Christiano, F. S., Gasparoto, M. C. D. G., FRAAIJE, B. A., Goldman, G. H., & Ceresini, P. C. (2024) · Agronomy · doi:10.3390/agronomy14040666 · Cited by 9 · see citing works

Update on the structure and function of Candida albicans drug efflux protein, Cdr1

Ibe, C., & Pohl, C. H. (2024) · Fungal Genetics and Biology · doi:10.1016/j.fgb.2024.103938 · Cited by 11 · see citing works

Expression of ERG11 and efflux pump genes CDR1, CDR2 and SNQ2 in voriconazole susceptible and resistant Candida glabrata strains

Navarro-Rodríguez, P., Martín‐Vicente, A., López‐Fernández, L., Guarro, J., & Capilla, J. (2019) · Medical Mycology · doi:10.1093/mmy/myz014 · Cited by 9 · see citing works

pHluorin enables insights into the transport mechanism of antiporter Mdr1: R215 is critical for drug/H+ antiport

Redhu, A. K., Khandelwal, N., Banerjee, A., Moréno, A., Falson, P., & Prasad, R. (2016) · Biochemical Journal · doi:10.1042/bcj20160407 · Cited by 9 · see citing works

Characterization of Defensin-like Protein 1 for Its Anti-Biofilm and Anti-Virulence Properties for the Development of Novel Antifungal Drug against Candida auris

Kamli, M. R., Sabir, J. S. M., Malik, M. A., & Ahmad, A. (2022) · Journal of Fungi · doi:10.3390/jof8121298 · Cited by 8 · see citing works

Discovering interrelated natural mutations of efflux pump KmrA from Klebsiella pneumoniae that confer increased multidrug resistance

Li, Y., & Ge, X. (2022) · Protein Science · doi:10.1002/pro.4323 · Cited by 8 · see citing works

Exploring the antifungal potential of novel carbazate derivatives as promising drug candidates against emerging superbug, Candida auris

Fatima, T., Fatima, Z., Billamboz, M., & Hameed, S. (2024) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2024.107782 · Cited by 7 · see citing works

Candida Efflux ATPases and Antiporters in Clinical Drug Resistance

Prasad, R., Rawal, M. K., & Shah, A. H. (2016) · Advances in Experimental Medicine and Biology · doi:10.1007/978-3-319-25304-6_15 · Cited by 30 · see citing works

Efflux Pumps in Drug Resistance of Candida

Prasad, R., Gaur, N., Gaur, M., & Komath, S. (2006) · Infectious Disorders - Drug Targets · doi:10.2174/187152606784112164 · Cited by 64 · see citing works

Multidrug transporters of fungal pathogen Candida

Kumar, A., & Jha, A. (2023) · Elsevier eBooks · doi:10.1016/b978-0-443-18744-5.00005-8

Multidrug Resistance and Transporters

Kumar, A., & Jha, A. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-811311-0.00005-3 · Cited by 1 · see citing works

MFS transporters of Candida species and their role in clinical drug resistance

Redhu, A. K., Shah, A. H., & Prasad, R. (2016) · FEMS Yeast Research · doi:10.1093/femsyr/fow043 · Cited by 64 · see citing works