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Cited by 124Microbial Metabolites in Food BiotechnologyGut microbiota and healthProbiotics and Fermented Foods

Prebiotics from acorn and sago prevent high-fat-diet-induced insulin resistance via microbiome–gut–brain axis modulation

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Ahmadi, Shokouh, Nagpal, Ravinder, Wang, Shaohua, Gagliano, Jason, Kitzman, Dalane W, Soleimanian-Zad, Sabihe, Sheikh-Zeinoddin, Mahmoud, Read, Russel +1 more·2019·The Journal of Nutritional Biochemistry
DOI 10.1016/j.jnutbio.2019.01.011PMC PMC6520164
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Abstract

Role of gut microbiome in obesity and type 2 diabetes (T2D) became apparent from several independent studies indicating that gut microbiome modulators like prebiotics may improve microbiome perturbations (dysbiosis) to ameliorate metabolic derangements. We herein isolate water soluble, nondigestible polysaccharides from five plant-based foods (acorn, quinoa, sunflower, pumpkin seeds and sago) and assess their impact on human fecal microbiome and amelioration of high-fat-diet (HFD)-induced obesity/T2D in mice. During polysaccharide isolation, purification, biochemical and digestion resistance characterization, and fermentation pattern by human fecal microbiome, we select acorn- and sago-derived prebiotics (on the basis of relatively higher purity and yield and lower protein contamination) and examine their effects in comparison to inulin. Prebiotics treatments in human fecal microbiome culture system not only preserve microbial diversity but also appear to foster beneficial bacteria and short-chain fatty acids (SCFAs). Feeding of acorn- and sago-derived prebiotics ameliorates HFD-induced glucose intolerance and insulin resistance in mice, with effects comparatively superior to those seen in inulin-fed mice. Feeding of both of novel prebiotics as well as inulin increases SCFAs levels in the mouse gut. Interestingly, gut hyperpermeability and mucosal inflammatory markers were significantly reduced upon prebiotics feeding in HFD-fed mice. Hypothalamic energy signaling in terms of increased expression of pro-opiomelanocortin was also modulated by prebiotics administration. Results demonstrate that these (and/or such) novel prebiotics can ameliorate HFD-induced defects in glucose metabolism via positive modulation of gut-microbiome-brain axis and hence could be useful in preventing/treating diet-induced obesity/T2D.

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  • Administration of prebiotics that shifts the gut microbiome toward increased production of butyrate has beneficial effects associated with higher levels of GLP-1, as well as hypothalamic expression of pro-opiomelanocortin, thereby influencing the hunger-satiety cycle in rodents.

    “Studies in rodents show that the administration of prebiotics that influences a shift in the gut microbiome toward increased production of butyrate has beneficial effects associated with higher levels of GLP-1 (193–195), as well as hypothalamic expression of pro-opiomelanocortin (196), thereby influencing the hunger-satiety cycle.”

    From The Role of Short-Chain Fatty Acids From Gut Microbiota in Gut-Brain Communication (2020) · cites this paper as [196]

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  1. [62]Nagpal R, Shively CA, Appt SA,. Register TC, Michalson KT, Vitolins MZ, Yadav H. Gut Microbiome Composition in Non-human Primates Consuming a Western or Mediterranean Diet. Frontiers in Nutrition 2018. PMC5996930 29922651

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Authors
Ahmadi, S., Nagpal, R., Wang, S., Gagliano, J., Kitzman, D. W., Soleimanian-Zad, S., Sheikh-Zeinoddin, M., Read, R., & Yadav, H.
Affiliations
  • Isfahan University of Technology (IR)
  • Atrium Health Wake Forest Baptist (US)
  • Forsyth Technical Community College (US)
  • Wake Forest University Health Sciences (US)
Corresponding author
Yadav, Hariom
ORCID
Venue
The Journal of Nutritional Biochemistry
Publisher
Elsevier BV
Published
2019-05
Volume
67
Pages
1-13
ISSN
0955-2863 (ISSN-L)
DOI
10.1016/j.jnutbio.2019.01.011
PMC
PMC6520164
OpenAlex
W2912702610
Cited by
124
References
76
Citations by year
2026: 4 · 2025: 20 · 2024: 16 · 2023: 16 · 2022: 18 · 2021: 18 · 2020: 22 · 2019: 9
FWCI
12.75
Type
journal article
Language
en
Open access
Licence
Locations
  • The Journal of Nutritional Biochemistry (acceptedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • Center for Diabetes, Obesity and Metabolism
  • Kermit Glenn Phillips II Chair in Cardiovascular Medicine
  • Claude D. Pepper Older Americans Center (P30AG12232)
  • Clinical and Translational Science Center (R01AG18915, UL1TR001420)
  • Department of Defense’s Discovery Award (W81XWH-18-1-0118)
  • Iran National Science Foundation (96001117)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Keywords
prebiotics, high-fat diet, insulin resistance, type 2 diabetes, obesity, gut microbiota, microbiome-gut-brain axis, short-chain fatty acids, impaired glucose tolerance, intestinal permeability, mucosal inflammation, proopiomelanocortin, inulin, plant-based foods
MeSH terms
Gastrointestinal Microbiome, Animals, Brain, Fatty Acids, Volatile, Feces, Humans, Hypothalamus, Insulin Resistance, Inulin, Mice, Inbred C57BL, Obesity, Polysaccharides, Seeds, Arecaceae, Quercus, Prebiotics, Diet, High-Fat, Dysbiosis

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