IgG Responses to the Plasmodium falciparum Antigen VAR2CSA in Colombia Are Restricted to Pregnancy and Are Not Induced by Exposure to Plasmodium vivax
Open accessAbstract
Clinical immunity to malaria is associated with the acquisition of IgG specific for members of the Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) family of clonally variant antigens on the surface of infected erythrocytes (IEs). The VAR2CSA subtype of PfEMP1 mediates IE binding in the placenta.
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Lopez-Perez et al. (2018) found that men and children often have high levels of functional VAR2CSA-specific IgG.
“Accordingly, Lopez-Perez et al. (2018) conducted a study in Colombia and found that men and children often have high levels of functional VAR2CSA-specific IgG.”
From Current update on malaria in pregnancy: a systematic review (2025) · cites this paper as Lopez-Perez et al. (2018)
The Results (page not provided) found frequent IgG reactivity in Colombian men and children to an insect-cell-produced recombinant protein, but only 7% of their samples had IgG to its native counterpart above the cutoff. The Discussion (page not provided) cautions that recombinant-protein reactivity need not reflect recognition of native VAR2CSA. The paper therefore does not find that men and children often have high levels of functional VAR2CSA-specific IgG; it argues against that interpretation. (LLM, conf=0.91)
Checked by a reasoning model — may be wrong.
Experimental — accuracy not yet measuredIgG responses to the P.falciparum antigen VAR2CSA are specific to pregnancy and are not triggered by exposure to P.vivax.
“This study concluded that IgG responses to the P.falciparum antigen VAR2CSA are specific to pregnancy and are not triggered by exposure to P.vivax [112].”
From Current update on malaria in pregnancy: a systematic review (2025) · cites this paper as [112]
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Mitran, C. J. (2021) · ERA: Education and Research Archive (University of Alberta) · doi:10.7939/r3-qs9p-em57
- Authors
- Lopez-Perez, M., Larsen, M. D., Bayarri-Olmos, R., Ampomah, P., Stevenson, L., Arévalo-Herrera, M., Herrera, S., & Hviid, L.
- Affiliations
- University of Copenhagen (DK)
- Laboratory of Molecular Medicine, Department of Clinical Immunology, Rigshospitalet, Copenhagen, Denmark
- University of Cape Coast (GH)
- Caucaseco Scientific Research Center, Cali, Colombia
- Corresponding author
- Hviid, Lars
- Venue
- Infection and Immunity
- Publisher
- American Society for Microbiology
- Published
- 2018-08
- Volume
- 86
- Issue
- 8
- ISSN
- 0019-9567 (ISSN-L)
- 1098-5522
- PMC
- PMC6056870
- OpenAlex
- W2803388430
- Cited by
- 24
- References
- 57
- Citations by year
- 2025: 3 · 2024: 2 · 2022: 5 · 2021: 6 · 2020: 4 · 2019: 4
- FWCI
- 3.34
- Type
- journal article
- Language
- en
- Update notices
- expression_of_concern (2025-01-13)
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Infection and Immunity (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (publishedVersion, cc-by)
- Greater South Information System
- Funders
- Independent Research Fund Denmark (DFF-4183-00539, DFF-6110-00489)
- Colciencias (360-2011, 458-2012, 719-2013)
- Consultative Committee for Development Research (DFC-12-081RH)
- Ghana Educational Trust Fund
- Commission of the European Communities (242095)
- Sven Andersen Research Foundation
- Colombian Presidential Agency of International Cooperation (045-2013)
- HHS | NIH | NIH Office of the Director (U19AI089702, 5R01HL086488)
- Novo Nordisk (NNF15OC0017654)
- Rigshospitalet (R102-A4174)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Malaria Research and Control
- Health Sciences › Medicine › Hematology › Blood groups and transfusion
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Keywords
- VAR2CSA, Plasmodium falciparum, PfEMP1, Duffy binding protein, Plasmodium vivax, malaria in pregnancy, IgG antibody response, placental malaria, antibody specificity
- MeSH terms
- Adolescent, Adult, Aged, Animals, Antibodies, Protozoan, Antigens, Protozoan, Child, Child, Preschool, Colombia, False Positive Reactions, Female, Glycosylation, Humans, Immunoglobulin G, Immunoassay, Male, Middle Aged, Pregnancy, Pregnancy Complications, Infectious, Recombinant Proteins, Malaria, Falciparum, Malaria, Vivax, Mice, Young Adult
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