Dynamics of Anti‐VAR2CSA Immunoglobulin G Response in a Cohort of Senegalese Pregnant Women
Abstract
BACKGROUND: Pregnancy-associated malaria (PAM) is precipitated by the accumulation of parasites in the placental intervillous spaces and causes maternal anemia and low birth weight. In PAM, placental parasites adhere to chondroitin sulfate A (CSA) through a unique set of variant surface antigens (VSAPAM). Several studies have shown that 1 var gene, var2csa, is transcribed at high levels and expressed in CSA-binding Plasmodium falciparum parasites. METHODS: Plasma levels of anti-VAR2CSA immunoglobulin G (IgG) in Senegalese women were measured during pregnancy by enzyme-linked immunosorbent assay, using 3 recombinant proteins representing 3 domains of the var2csa gene product. RESULTS: The 3 recombinant proteins were specifically recognized by plasma from pregnant women but not by control plasma. A parity-dependent recognition pattern was observed with 2 of the 3 VAR2CSA antigens. A kinetic study demonstrated that a single P. falciparum infection was able to trigger a VAR2CSA-specific antibody response. Among women with infected placentas, women with high anti-VAR2CSA IgG levels at enrollment were more likely to present with a past infection than with an acute/chronic infection. CONCLUSIONS: Anti-VAR2CSA IgGs are involved in clinical protection against pregnancy-associated malaria and strengthens the hope for making a VAR2CSA-based vaccine.
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Levels of adhesion-inhibitory antibody correlate with levels of anti-DBL5ε antibodies.
“Levels of adhesion-inhibitory antibody correlated with levels of anti-DBL5ε antibodies [41]”
From Differential recognition of P. falciparum VAR2CSA domains by naturally acquired antibodies in pregnant women from a malaria endemic area (2010) · cites this paper as [41]
VAR2CSA antibodies are associated with protection from placental malaria and other adverse delivery outcomes.
“These antibodies can block adhesion of IEs to CSA in vitro (4,5) and are associated with protection from placental malaria and other adverse delivery outcomes (6,7).”
From Clinical outcomes of submicroscopic infections and correlates of protection of VAR2CSA antibodies in a longitudinal study of pregnant women in Colombia (2018) · cites this paper as [7]
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Self-citationMayor, A. G., Dobaño, C., Nhabomba, A. J., Guinovart, C., Jiménez, A., Manaca, M. N., Aguilar, R., Barbosa, A., Rodríguez, M. H., Cisteró, P., et al. (2018) · Malaria Journal · doi:10.1186/s12936-018-2331-4 · Cited by 13 · see citing works
Travassos, M. A., Coulibaly, D. M., Bailey, J. A., Niangaly, A., Adams, M., Nyunt, M. M., Ouattara, A., Lyke, K. E., Laurens, M. B., Pablo, J. V., et al. (2015) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.14-0524 · Cited by 14 · see citing works
Various carrier system(s)- mediated genetic vaccination strategies against malaria - Retracted
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RetractedGangnard, S., Ndam, N. T., Gnidehou, S., Quiviger, M., Juillerat, A., Faure, G., Baron, B., Viwami, F., Deloron, P., & Bentley, G. A. (2010) · Molecular and Biochemical Parasitology · doi:10.1016/j.molbiopara.2010.05.014 · Cited by 12 · see citing works
Self-citationPfEMP1-Specific Immunoglobulin G Reactivity Among Beninese Pregnant Women With Sickle Cell Trait
Lopez-Perez, M., Viwami, F., Seidu, Z., Jensen, A. T. R., Doritchamou, J., Ndam, N. T., & Hviid, L. (2021) · Open Forum Infectious Diseases · doi:10.1093/ofid/ofab527 · Cited by 10 · see citing works
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VAR2CSA Antibodies in Non-Pregnant Populations
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Chauvet, M., Tétard, M., Cottrell, G., Aussenac, F., Brossier, E., Denoyel, L., Hanny, M., Lohezic, M., Milet, J., Ndam, N. T., et al. (2019) · Open Forum Infectious Diseases · doi:10.1093/ofid/ofz156 · Cited by 7 · see citing works
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Gbédandé, K., Cottrell, G., Vianou, B., Ibitokou, S. A., Fernando, A., Troye‐Blomberg, M., Salanti, A., Moutairou, K. A., Massougbodji, A., Ndam, N. T., et al. (2016) · Malaria Journal · doi:10.1186/s12936-016-1525-x · Cited by 1 · see citing works
Self-citationPathogenesis of malaria in pregnancy
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Do Antibodies to Malaria Surface Antigens Play a Role in Protecting Mothers From Maternal Anemia?
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Antigens for a Vaccine That Prevents Severe Malaria
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Various carrier system(s) -mediated genetic vaccination strategies against malaria - Retracted
Tyagi, R. K., & Sharma, P. (2011) · Expert Review of Vaccines · doi:10.1586/erv.11.116
RetractedGavina, K. (2018) · ERA: Education and Research Archive (University of Alberta) · doi:10.7939/r3w08wz46
Mitran, C. J. (2021) · ERA: Education and Research Archive (University of Alberta) · doi:10.7939/r3-qs9p-em57
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Physiopathology of Malaria During Pregnancy: Pregnancy-Specific Malaria Immune Responses
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- Authors
- Tuikue Ndam, N. G., Salanti, A., Le‐Hesran, J. ‐., Cottrell, G., Fievet, N., Turner, L., Sow, S., Dangou, J. ‐., Theander, T., & Deloron, P.
- Affiliations
- University of Copenhagen (DK)
- Institut de Recherche pour le Développement (FR)
- Cheikh Anta Diop University (SN)
- Venue
- The Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2006-03
- Volume
- 193
- Issue
- 5
- Pages
- 713-720
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2102283103
- Cited by
- 89
- References
- 26
- Citations by year
- 2025: 1 · 2021: 7 · 2020: 4 · 2019: 2 · 2018: 3 · 2017: 3 · 2016: 3 · 2015: 9 · 2014: 5 · 2013: 7 · 2012: 7
- FWCI
- 7.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Infectious Diseases (publishedVersion)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Malaria Research and Control
- Health Sciences › Medicine › Hematology › Blood groups and transfusion
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Keywords
- VAR2CSA, malaria in pregnancy, Plasmodium falciparum, placental malaria, chondroitin sulfate A, variant surface antigens, antibody kinetics, parity, placental infection, malaria vaccine
- MeSH terms
- Adolescent, Adult, Animals, Antibodies, Protozoan, Antigens, Protozoan, Enzyme-Linked Immunosorbent Assay, Female, Humans, Immunoglobulin G, Placenta, Plasmodium falciparum, Pregnancy, Chondroitin Sulfate Proteoglycans, Recombinant Proteins, Senegal, Pregnancy Complications, Parasitic, Malaria, Falciparum, Protein Structure, Tertiary
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