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Neisseria meningitidis Induces Pathology-Associated Cellular and Molecular Changes in Trigeminal Schwann Cells

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Delbaz, Ali, Chen, Mo, Jen, Freda E.-C., Schulz, Benjamin L., Gorse, Alain-Dominique, Jennings, Michael P., St John, James A., Ekberg, Jenny A. K.·2020·Infection and Immunity
DOI 10.1128/iai.00955-19PMC PMC7093114
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Abstract

Neisseria meningitidis , a common cause of sepsis and bacterial meningitis, infects the meninges and central nervous system (CNS), primarily via paracellular traversal across the blood-brain barrier (BBB) or blood-cerebrospinal fluid barrier. N. meningitidis is often present asymptomatically in the nasopharynx, and the nerves extending between the nasal cavity and the brain constitute an alternative route by which the meningococci may reach the CNS. To date, the cellular mechanisms involved in nerve infection are not fully understood.

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  • One key mechanism is thought to be the ability of certain pathogens to infect and survive in OECs, TgSCs and astrocytes, as well as in microglia.

    “Whilst it is largely unknown why certain infectious agents can infect the CNS via cranial nerves, one key mechanism is thought to be the ability of these pathogens to infect and survive in OECs, TgSCs and astrocytes, as well as in microglia (the main phagocytes inside CNS tissue)20,27,28,34,35.”

    From Chlamydia pneumoniae can infect the central nervous system via the olfactory and trigeminal nerves and contributes to Alzheimer’s disease risk (2022) · cites this paper as [35]

    The Discussion (page unavailable) reports that N. meningitidis infected trigeminal Schwann cells and proposes this as a possible route to the CNS. The Introduction also describes other pathogens surviving within Schwann cells. This paper does not establish the claimed mechanism across OECs, astrocytes and microglia, or demonstrate that N. meningitidis survives within trigeminal Schwann cells. (LLM, conf=0.86)

    Experimental — accuracy not yet measured

  • The capacity to infect and survive inside glial cells is thought to be a key mechanism for the ability of bacteria to invade the CNS via cranial nerves.

    “The capacity to infect and survive inside glial cells is thought to be a key mechanism for the ability of bacteria to invade the CNS via cranial nerves34,35.”

    From Chlamydia pneumoniae can infect the central nervous system via the olfactory and trigeminal nerves and contributes to Alzheimer’s disease risk (2022) · cites this paper as [35]

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  1. [1]Dando SJ, Mackay-Sim A, Norton R, Currie BJ, St John JA, Ekberg JA, Batzloff M, Ulett GC, Beacham IR 2014 Pathogens penetrating the central nervous system: infection pathways and the cellular and molecular mechanisms of invasion. Clin Microbiol Rev 27: 691– 726. doi: 10.1128/CMR.00118-13. 25278572 PMC4187632 · DOI · Paper page
  2. [2]Nazareth L, Lineburg KE, Chuah MI, Tello Velasquez J, Chehrehasa F, St John JA, Ekberg JA 2015 Olfactory ensheathing cells are the main phagocytic cells that remove axon debris during early development of the olfactory system. J Comp Neurol 523: 479– 494. doi: 10.1002/cne.23694. 25312022 · DOI · Paper page
  3. [3]Brooks R, Woods CW, Benjamin DK Jr, Rosenstein NE 2006 Increased case-fatality rate associated with outbreaks of Neisseria meningitidis infection, compared with sporadic meningococcal disease, in the United States, 1994–2002. Clin Infect Dis 43: 49– 54. doi: 10.1086/504804. 16758417 · DOI · Paper page
  4. [4]Christensen H, May M, Bowen L, Hickman M, Trotter CL 2010 Meningococcal carriage by age: a systematic review and meta-analysis. Lancet Infect Dis 10: 853– 861. doi: 10.1016/S1473-3099(10)70251-6. 21075057 · DOI
  5. [5]Coureuil M, Jamet A, Bille E, Lecuyer H, Bourdoulous S, Nassif X 2019 Molecular interactions between Neisseria meningitidis and its human host. Cell Microbiol 21: e13063. doi: 10.1111/cmi.13063:e13063. 31167044 PMC6899865 · DOI
  6. [6]Bille E, Zahar JR, Perrin A, Morelle S, Kriz P, Jolley KA, Maiden MC, Dervin C, Nassif X, Tinsley CR 2005 A chromosomally integrated bacteriophage in invasive meningococci. J Exp Med 201: 1905– 1913. doi: 10.1084/jem.20050112. 15967821 PMC2212043 · DOI
  7. [7]Maiden MC, Bygraves JA, Feil E, Morelli G, Russell JE, Urwin R, Zhang Q, Zhou J, Zurth K, Caugant DA, Feavers IM, Achtman M, Spratt BG 1998 Multilocus sequence typing: a portable approach to the identification of clones within populations of pathogenic microorganisms. Proc Natl Acad Sci U S A 95: 3140– 3145. doi: 10.1073/pnas.95.6.3140. 9501229 PMC19708 · DOI
  8. [8]Brouwer MC, de Gans J, Heckenberg SG, Zwinderman AH, van der Poll T, van de Beek D 2009 Host genetic susceptibility to pneumococcal and meningococcal disease: a systematic review and meta-analysis. Lancet Infect Dis 9: 31– 44. doi: 10.1016/S1473-3099(08)70261-5. 19036641 · DOI
  9. [9]van Sorge NM, Doran KS 2012 Defense at the border: the blood–brain barrier versus bacterial foreigners. Future Microbiol 7: 383– 394. doi: 10.2217/fmb.12.1. 22393891 PMC3589978 · DOI
  10. [10]Nassif X, Bourdoulous S, Eugene E, Couraud PO 2002 How do extracellular pathogens cross the blood-brain barrier? Trends Microbiol 10: 227– 232. doi: 10.1016/s0966-842x(02)02349-1. 11973156 · DOI
  11. [11]Quagliarello V, Scheld WM 1992 Bacterial meningitis: pathogenesis, pathophysiology, and progress. N Engl J Med 327: 864– 872. doi: 10.1056/NEJM199209173271208. 1508247 · DOI
  12. [12]Carbonnelle E, Hill DJ, Morand P, Griffiths NJ, Bourdoulous S, Murillo I, Nassif X, Virji M 2009 Meningococcal interactions with the host. Vaccine 27(Suppl 2): B78– B89. doi: 10.1016/j.vaccine.2009.04.069. 19481311 · DOI
  13. [13]Virji M 2009 Pathogenic neisseriae: surface modulation, pathogenesis and infection control. Nat Rev Microbiol 7: 274– 286. doi: 10.1038/nrmicro2097. 19287450 · DOI
  14. [14]Simonis A, Schubert-Unkmeir A 2016 Interactions of meningococcal virulence factors with endothelial cells at the human blood-cerebrospinal fluid barrier and their role in pathogenicity. FEBS Lett 590: 3854– 3867. doi: 10.1002/1873-3468.12344. 27498906 · DOI
  15. [15]Coureuil M, Bourdoulous S, Marullo S, Nassif X 2014 Invasive meningococcal disease: a disease of the endothelial cells. Trends Mol Med 20: 571– 578. doi: 10.1016/j.molmed.2014.08.002. 25178566 · DOI
  16. [16]Coureuil M, Join-Lambert O, Lecuyer H, Bourdoulous S, Marullo S, Nassif X 2012 Mechanism of meningeal invasion by Neisseria meningitidis. Virulence 3: 164– 172. doi: 10.4161/viru.18639. 22366962 PMC3396695 · DOI
  17. [17]Nikulin J, Panzner U, Frosch M, Schubert-Unkmeir A 2006 Intracellular survival and replication of Neisseria meningitidis in human brain microvascular endothelial cells. Int J Med Microbiol 296: 553– 558. doi: 10.1016/j.ijmm.2006.06.006. 17010667 · DOI
  18. [18]Rosenstein NE, Perkins BA, Stephens DS, Popovic T, Hughes JM 2001 Meningococcal disease. N Engl J Med 344: 1378– 1388. doi: 10.1056/NEJM200105033441807. 11333996 · DOI
  19. [19]Stephens DS, Greenwood B, Brandtzaeg P 2007 Epidemic meningitis, meningococcaemia, and Neisseria meningitidis. Lancet 369: 2196– 2210. doi: 10.1016/S0140-6736(07)61016-2. 17604802 · DOI · Paper page
  20. [20]Sjölinder H, Jonsson A-B 2010 Olfactory nerve—a novel invasion route of neisseria meningitidis to reach the meninges. PLoS One 5: e14034. doi: 10.1371/journal.pone.0014034. 21124975 PMC2987801 · DOI
  21. [21]St John J, Walkden H, Nazareth L, Beagley K, Ulett G, Batzloff MR, Beacham I, Ekberg J 2016 Burkholderia pseudomallei rapidly infects the brain stem and spinal cord via the trigeminal nerve after intranasal inoculation. Infect Immun 84: 2681– 2688. doi: 10.1128/IAI.00361-16. 27382023 PMC4995904 · DOI
  22. [22]Dons L, Jin Y, Kristensson K, Rottenberg ME 2007 Axonal transport of Listeria monocytogenes and nerve-cell-induced bacterial killing. J Neurosci Res 85: 2529– 2537. doi: 10.1002/jnr.21256. 17387705 · DOI
  23. [23]Byndloss MX, Tsolis RM 2016 Chronic bacterial pathogens: mechanisms of persistence. Microbiol Spectr 4. doi: 10.1128/microbiolspec.VMBF-0020-2015. PMC4888878 27227304 · DOI
  24. [24]Panni P, Ferguson IA, Beacham I, Mackay-Sim A, Ekberg JA, St John JA 2013 Phagocytosis of bacteria by olfactory ensheathing cells and Schwann cells. Neurosci Lett 539: 65– 70. doi: 10.1016/j.neulet.2013.01.052. 23415759 · DOI
  25. [25]Neal JW, Gasque P 2016 The role of primary infection of Schwann cells in the aetiology of infective inflammatory neuropathies. J Infect 73: 402– 418. doi: 10.1016/j.jinf.2016.08.006. 27546064 · DOI
  26. [26]Windus LC, Claxton C, Allen CL, Key B, St John JA 2007 Motile membrane protrusions regulate cell-cell adhesion and migration of olfactory ensheathing glia. Glia 55: 1708– 1719. doi: 10.1002/glia.20586. 17893920 · DOI
  27. [27]Tello Velasquez J, Nazareth L, Quinn RJ, Ekberg JA, St John JA 2016 Stimulating the proliferation, migration and lamellipodia of Schwann cells using low-dose curcumin. Neuroscience 324: 140– 150. doi: 10.1016/j.neuroscience.2016.02.073. 26955781 · DOI
  28. [29]Ko KR, Frampton JP 2016 Developments in 3D neural cell culture models: the future of neurotherapeutics testing? Expert Rev Neurother 16: 739– 741. doi: 10.1586/14737175.2016.1166053. 26972892 · DOI
  29. [30]D’Aiuto L, Naciri J, Radio N, Tekur S, Clayton D, Apodaca G, Di Maio R, Zhi Y, Dimitrion P, Piazza P, Demers M, Wood J, Chu C, Callio J, McClain L, Yolken R, McNulty J, Kinchington P, Bloom D, Nimgaonkar V 2018 Generation of three-dimensional human neuronal cultures: application to modeling CNS viral infections. Stem Cell Res Ther 9: 134. doi: 10.1186/s13287-018-0881-6. 29751846 PMC5948884 · DOI
  30. [31]Chen M, Shah MP, Shelper TB, Nazareth L, Barker M, Tello Velasquez J, Ekberg JAK, Vial M-L, St John JA 2019 Naked liquid marbles: a robust three-dimensional low-volume cell-culturing system. ACS Appl Mater Interfaces 11: 9814– 9823. doi: 10.1021/acsami.8b22036. 30724549 · DOI
  31. [32]Hopkins AM, DeSimone E, Chwalek K, Kaplan DL 2015 3D in vitro modeling of the central nervous system. Prog Neurobiol 125: 1– 25. doi: 10.1016/j.pneurobio.2014.11.003. 25461688 PMC4324093 · DOI
  32. [33]Watson PMD, Kavanagh E, Allenby G, Vassey M 2017 Bioengineered 3D glial cell culture systems and applications for neurodegeneration and neuroinflammation. SLAS Discov 22: 583– 601. doi: 10.1177/2472555217691450. 28346104 · DOI · Paper page
  33. [34]Urbańska K, Sokołowska J, Szmidt M, Sysa P 2014 Glioblastoma multiforme—an overview. Contemp Oncol (Pozn) 18: 307– 312. doi: 10.5114/wo.2014.40559. 25477751 PMC4248049 · DOI
  34. [35]Winger MJ, Macdonald DR, Cairncross JG 1989 Supratentorial anaplastic gliomas in adults. The prognostic importance of extent of resection and prior low-grade glioma. J Neurosurg 71: 487– 493. doi: 10.3171/jns.1989.71.4.0487. 2552044 · DOI
  35. [36]Arcot R, Ramakrishnan K, Rao S 2012 Peripheral and cranial nerve sheath tumors—a clinical spectrum. Indian J Surg 74: 371– 375. doi: 10.1007/s12262-011-0392-5. 24082588 PMC3477413 · DOI
  36. [37]Baderca F, Cojocaru S, Lazăr E, Lăzureanu C, Faur A, Lighezan R, Alexa A, Raica M, Vălean M, Balica N 2008 Schwannoma of the lip: case report and review of the literature. Rom J Morphol Embryol 49: 391– 398. 18758646
  37. [38]Chandra S, Jerva MJ, Clemis JD 1975 Ultrastructural characteristics of human neurilemoma cell nuclei. Cancer Res 35: 2000– 2006. 167942
  38. [39]Chebib I, Hornicek FJ, Nielsen GP, Deshpande V 2015 Cytomorphologic features that distinguish schwannoma from other low-grade spindle cell lesions. Cancer Cytopathol 123: 171– 179. doi: 10.1002/cncy.21506. 25641870 · DOI
  39. [40]Kim BH, Cho WS, Han BS 2011 Spontaneous multicentric malignant schwannoma in a male Fischer 344 rat. Toxicol Res 27: 149– 152. doi: 10.5487/TR.2011.27.3.149. 24278565 PMC3834381 · DOI
  40. [41]Shaktawat SS, Golka D 2007 Floret-like multinucleated giant cells in neurofibroma. Diagn Pathol 2: 47. doi: 10.1186/1746-1596-2-47. 18067673 PMC2225390 · DOI
  41. [42]Taungjaruwinai WM, Goldberg LJ 2009 Multinucleate giant cells in neurofibromas: a clue to the diagnosis of neurofibromatosis. J Cutan Pathol 36: 1164– 1167. doi: 10.1111/j.1600-0560.2009.01249.x. 19281485 · DOI
  42. [43]Brodbeck WG, Anderson JM 2009 Giant cell formation and function. Curr Opin Hematol 16: 53– 57. doi: 10.1097/MOH.0b013e32831ac52e. 19057205 PMC2679387 · DOI
  43. [44]McNally AK, Anderson JM 2011 Macrophage fusion and multinucleated giant cells of inflammation. Adv Exp Med Biol 713: 97– 111. doi: 10.1007/978-94-007-0763-4_7. 21432016 · DOI
  44. [45]Fujita M, Mizuno M, Nagasaka T, Wakabayashi T, Maeda K, Ishii D, Arima T, Kawajiri A, Inagaki M, Yoshida J 2004 Aurora-B dysfunction of multinucleated giant cells in glioma detected by site-specific phosphorylated antibodies. J Neurosurg 101: 1012– 1017. doi: 10.3171/jns.2004.101.6.1012. 15597762 · DOI
  45. [46]Marquet G, Dameron O, Saikali S, Mosser J, Burgun A 2007 Grading glioma tumors using OWL-DL and NCI Thesaurus. AMIA Annu Symp Proc 2007: 508– 512. PMC2655830 18693888
  46. [47]Walker C, Baborie A, Crooks D, Wilkins S, Jenkinson MD 2011 Biology, genetics and imaging of glial cell tumours. Br J Radiol 84: S90– S106. doi: 10.1259/bjr/23430927. 22433833 PMC3473897 · DOI
  47. [48]Temme A, Geiger KD, Wiedemuth R, Conseur K, Pietsch T, Felsberg J, Reifenberger G, Tatsuka M, Hagel C, Westphal M, Berger H, Simon M, Weller M, Schackert G 2010 Giant cell glioblastoma is associated with altered Aurora B expression and concomitant p53 mutation. J Neuropathol Exp Neurol 69: 632– 642. doi: 10.1097/NEN.0b013e3181e4c06e. 20467329 · DOI
  48. [49]Elwell C, Mirrashidi K, Engel J 2016 Chlamydia cell biology and pathogenesis. Nat Rev Microbiol 14: 385– 400. doi: 10.1038/nrmicro.2016.30. 27108705 PMC4886739 · DOI
  49. [50]Benanti EL, Nguyen CM, Welch MD 2015 Virulent Burkholderia species mimic host actin polymerases to drive actin-based motility. Cell 161: 348– 360. doi: 10.1016/j.cell.2015.02.044. 25860613 PMC4393530 · DOI
  50. [51]Stevens JM, Ulrich RL, Taylor LA, Wood MW, Deshazer D, Stevens MP, Galyov EE 2005 Actin-binding proteins from Burkholderia mallei and Burkholderia thailandensis can functionally compensate for the actin-based motility defect of a Burkholderia pseudomallei bimA mutant. J Bacteriol 187: 7857– 7862. doi: 10.1128/JB.187.22.7857-7862.2005. 16267310 PMC1280302 · DOI
  51. [52]Tamura A 2016 Tuberculosis and lung cancer. Kekkaku 91: 17– 25. 27192776
  52. [53]Vento S, Lanzafame M 2011 Tuberculosis and cancer: a complex and dangerous liaison. Lancet Oncol 12: 520– 522. doi: 10.1016/S1470-2045(11)70105-X. 21624773 · DOI
  53. [54]Chaturvedi AK, Gaydos CA, Agreda P, Holden JP, Chatterjee N, Goedert JJ, Caporaso NE, Engels EA 2010 Chlamydia pneumoniae infection and risk for lung cancer. Cancer Epidemiol Biomarkers Prev 19: 1498– 1505. doi: 10.1158/1055-9965.EPI-09-1261. 20501758 · DOI
  54. [55]Zhan P, Suo LJ, Qian Q, Shen XK, Qiu LX, Yu LK, Song Y 2011 Chlamydia pneumoniae infection and lung cancer risk: a meta-analysis. Eur J Cancer 47: 742– 747. doi: 10.1016/j.ejca.2010.11.003. 21194924 · DOI
  55. [56]Josefson D 2001 Chlamydia increases risk of cervical cancer. BMJ 322: 71. doi: 10.1136/bmj.322.7278.71. 11203732 PMC1119381 · DOI
  56. [57]Madeleine MM, Anttila T, Schwartz SM, Saikku P, Leinonen M, Carter JJ, Wurscher M, Johnson LG, Galloway DA, Daling JR 2007 Risk of cervical cancer associated with Chlamydia trachomatis antibodies by histology, HPV type and HPV cofactors. Int J Cancer 120: 650– 655. doi: 10.1002/ijc.22325. 17096345 PMC4049152 · DOI
  57. [58]Wittenmayer N, Jandrig B, Rothkegel M, Schlüter K, Arnold W, Haensch W, Scherneck S, Jockusch BM 2004 Tumor suppressor activity of profilin requires a functional actin binding site. Mol Biol Cell 15: 1600– 1608. doi: 10.1091/mbc.e03-12-0873. 14767055 PMC379259 · DOI
  58. [59]Tonnetti L, Netzel-Arnett S, Darnell GA, Hayes T, Buzza MS, Anglin IE, Suhrbier A, Antalis TM 2008 SerpinB2 protection of retinoblastoma protein from calpain enhances tumor cell survival. Cancer Res 68: 5648– 5657. doi: 10.1158/0008-5472.CAN-07-5850. 18632617 PMC2561898 · DOI
  59. [60]Gao Y, Chen Y, Xu D, Wang J, Yu G 2014 Differential expression of ANXA1 in benign human gastrointestinal tissues and cancers. BMC Cancer 14: 520– 520. doi: 10.1186/1471-2407-14-520. 25038797 PMC4223377 · DOI
  60. [61]Slanina H, Hebling S, Hauck CR, Schubert-Unkmeir A 2012 Cell invasion by Neisseria meningitidis requires a functional interplay between the focal adhesion Kinase, Src and cortactin. PLoS One 7: e39613. doi: 10.1371/journal.pone.0039613. 22768099 PMC3387252 · DOI
  61. [62]Galmiche A, Sauzay C, Chevet E, Pluquet O 2017 Role of the unfolded protein response in tumor cell characteristics and cancer outcome. Curr Opin Oncol 29: 41– 47. doi: 10.1097/CCO.0000000000000339. 27845970 · DOI
  62. [63]Rozpedek W, Pytel D, Mucha B, Leszczynska H, Diehl JA, Majsterek I 2016 The role of the PERK/eIF2α/ATF4/CHOP signaling pathway in tumor progression during endoplasmic reticulum stress. Curr Mol Med 16: 533– 544. doi: 10.2174/1566524016666160523143937. 27211800 PMC5008685 · DOI
  63. [64]Johswich KO, Gray-Owen SD 2019 Modeling Neisseria meningitidis infection in mice: methods and logistical considerations for nasal colonization and invasive disease. Methods Mol Biol 1969: 149– 168. doi: 10.1007/978-1-4939-9202-7_11. 30877676 · DOI
  64. [65]Mackinnon FG, Gorringe AR, Funnell SG, Robinson A 1992 Intranasal infection of infant mice with Neisseria meningitidis. Microb Pathog 12: 415– 420. doi: 10.1016/0882-4010(92)90004-8. 1522796 · DOI
  65. [66]Chauhan VS, Sterka DG Jr, Gray DL, Bost KL, Marriott I 2008 Neurogenic exacerbation of microglial and astrocyte responses to Neisseria meningitidis and Borrelia burgdorferi. J Immunol 180: 8241– 8249. doi: 10.4049/jimmunol.180.12.8241. 18523290 PMC2507752 · DOI
  66. [67]Jen FE, Warren MJ, Schulz BL, Power PM, Swords WE, Weiser JN, Apicella MA, Edwards JL, Jennings MP 2013 Dual pili post-translational modifications synergize to mediate meningococcal adherence to platelet activating factor receptor on human airway cells. PLoS Pathog 9: e1003377. doi: 10.1371/journal.ppat.1003377. 23696740 PMC3656113 · DOI
  67. [68]Srikhanta YN, Dowideit SJ, Edwards JL, Falsetta ML, Wu HJ, Harrison OB, Fox KL, Seib KL, Maguire TL, Wang AH, Maiden MC, Grimmond SM, Apicella MA, Jennings MP 2009 Phasevarions mediate random switching of gene expression in pathogenic Neisseria. PLoS Pathog 5: e1000400. doi: 10.1371/journal.ppat.1000400. 19390608 PMC2667262 · DOI
  68. [69]Chen M, Vial ML, Tello Velasquez J, Barker M, St John JA 2 11 2017, filing date Naked liquid marbles: a robust three-dimensional low-volume cell culturing system. Australian Government IP number 2017904456. 30724549
  69. [70]Peak IR, Chen A, Jen FEC, Jennings C, Schulz BL, Saunders NJ, Khan A, Seifert HS, Jennings MP 2016 Neisseria meningitidis lacking the major porins PorA and PorB are viable and modulate apoptosis and the oxidative burst of neutrophils. J Proteome Res 15: 2356– 2365. doi: 10.1021/acs.jproteome.5b00938. 26562068 PMC5203797 · DOI
  70. [71]Zacchi LF, Schulz BL 2016 SWATH-MS glycoproteomics reveals consequences of defects in the glycosylation machinery. Mol Cell Proteomics 15: 2435– 2447. doi: 10.1074/mcp.M115.056366. 27094473 PMC4937515 · DOI
  71. [72]Kerr ED, Phung TK, Caboche CH, Fox GP, Platz GJ, Schulz BL 2019 The intrinsic and regulated proteomes of barley seeds in response to fungal infection. Anal Biochem 580: 30– 35. doi: 10.1016/j.ab.2019.06.004. 31181183 · DOI
  72. [73]Choi M, Chang CY, Clough T, Broudy D, Killeen T, MacLean B, Vitek O 2014 MSstats: an R package for statistical analysis of quantitative mass spectrometry-based proteomic experiments. Bioinformatics 30: 2524– 2526. doi: 10.1093/bioinformatics/btu305. 24794931 · DOI
  73. [74]Godlewski J, Krichevsky AM, Johnson MD, Chiocca EA, Bronisz A 2015 Belonging to a network—microRNAs, extracellular vesicles, and the glioblastoma microenvironment. Neuro Oncol 17: 652– 662. doi: 10.1093/neuonc/nou292. 25301812 PMC4482852 · DOI
  74. [75]MacDonald BT, Tamai K, He X 2009 Wnt/β-catenin signaling: components, mechanisms, and diseases. Dev Cell 17: 9– 26. doi: 10.1016/j.devcel.2009.06.016. 19619488 PMC2861485 · DOI · Paper page
  75. [76]Kim N-G, Koh E, Chen X, Gumbiner BM 2011 E-cadherin mediates contact inhibition of proliferation through Hippo signaling-pathway components. Proc Natl Acad Sci U S A 108: 11930– 11935. doi: 10.1073/pnas.1103345108. 21730131 PMC3141988 · DOI
  76. [77]Sagheer U, Gong J, Chung C 2015 Pigment epithelium-derived factor (PEDF) is a determinant of stem cell fate: lessons from an ultra-rare disease. J Dev Biol 3: 112– 128. doi: 10.3390/jdb3040112. 27239449 PMC4883593 · DOI
  77. [78]Hou J, Ge C, Cui M, Liu T, Liu X, Tian H, Zhao F, Chen T, Cui Y, Yao M, Li J, Li H 2017 Pigment epithelium-derived factor promotes tumor metastasis through an interaction with laminin receptor in hepatocellular carcinomas. Cell Death Dis 8: e2969. doi: 10.1038/cddis.2017.359. 28771223 PMC5596550 · DOI
  78. [79]de Haas CJ 1999 New insights into the role of serum amyloid P component, a novel lipopolysaccharide-binding protein. FEMS Immunol Med Microbiol 26: 197– 202. doi: 10.1111/j.1574-695X.1999.tb01390.x. 10575130 · DOI
  79. [80]Skinner M, Cohen AS 1988 Amyloid P component. Methods Enzymol 163: 523– 536. doi: 10.1016/0076-6879(88)63048-5. 3237088 · DOI
  80. [81]Levo Y, Wollner S, Treves AJ 1986 Serum amyloid P-component levels in patients with malignancy. Scand J Immunol 24: 147– 151. doi: 10.1111/j.1365-3083.1986.tb02080.x. 3749812 · DOI

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Authors
Delbaz, A., Chen, M., Jen, F. E.-C., Schulz, B. L., Gorse, A.-D., Jennings, M. P., St John, J. A., & Ekberg, J. A. K.
Affiliations
  • Griffith University (AU)
  • The University of Queensland (AU)
  • Clem Jones Centre for Neurobiology and Stem Cell Research, Griffith University, Brisbane, QLD, Australia
Corresponding author
Ekberg, Jenny A. K.
ORCID
Venue
Infection and Immunity
Publisher
American Society for Microbiology
Published
2020-03-23
Volume
88
Issue
4
ISSN
  • 0019-9567 (ISSN-L)
  • 1098-5522
DOI
10.1128/iai.00955-19
PMC
PMC7093114
OpenAlex
W2998828249
Cited by
18
References
1
Citations by year
2026: 4 · 2025: 1 · 2024: 2 · 2023: 1 · 2022: 4 · 2021: 5 · 2020: 1
FWCI
1.98
Type
journal article
Language
en
Open access
Licence
Locations
  • Infection and Immunity (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Griffith Research Online (submittedVersion, cc-by)
Funders
  • Griffith University (International Postgraduate Research Scholarships)
  • Department of Education and Training | Australian Research Council (DP150104495, LE150100161)
  • Clem Jones Foundation
Topics
  • Life Sciences › Immunology and Microbiology › Microbiology › Bacterial Infections and Vaccines
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Escherichia coli research studies
  • Life Sciences › Immunology and Microbiology › Microbiology › Microbial infections and disease research
Keywords
Neisseria meningitidis, bacterial meningitis, blood-brain barrier, central nervous system infection, nasopharyngeal carriage, host-pathogen interaction
MeSH terms
Animals, Cells, Cultured, Mice, Transgenic, Neisseria meningitidis, Schwann Cells, Trigeminal Nerve, Proteome, Proteomics, Host-Pathogen Interactions

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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