Biological Trojan Horse: Antigen 43 Provides Specific Bacterial Uptake and Survival in Human Neutrophils
Open accessAbstract
Escherichia coli is a versatile pathogen causing millions of infections in humans every year. This bacterium can form multicellular aggregates when it expresses a self-associating protein, antigen 43 (Ag43), on its surface. We have discovered that Ag43-expressing E. coli cells are efficiently taken up by human defense cells, polymorphonuclear neutrophils (PMNs), in an opsonin-independent manner. Surprisingly, the phagocytosed bacteria were not immediately killed but resided as tight aggregates within the PMNs. Our observations indicate that Ag43-mediated uptake and survival in PMNs constitute a mechanism to subvert one of the primary defense mechanisms of the human body.
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Autoaggregation and microcolony formation may play a role in protection from the host immune system.
“Autoaggregation and microcolony formation may also play a role in protection from the host immune system [13],[14].”
From Bacterial autoaggregation (2018) · cites this paper as [13]
Aggregation increases survival within phagosomes.
“Aggregation has also been shown to influence pathogenesis by increasing tolerance against antimicrobial agents [3],[11],[114], elevating invasion frequency as well as invasion efficiency of host cells [42], impeding phagocytosis by cells of the host immune system [14], or increasing survival within phagosomes [13].”
From Bacterial autoaggregation (2018) · cites this paper as [13]
Ag43-mediated autoaggregation protected bacteria against killing by neutrophils, although aggregated cells were more efficiently phagocytosed.
“Further, Ag43-mediated autoaggregation protected the bacteria against killing by neutrophils, although the aggregated cells were more efficiently phagocytosed [13].”
From Bacterial autoaggregation (2018) · cites this paper as [13]
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- Authors
- Fexby, S., Bjarnsholt, T., Jensen, P. Ø., Roos, V., Høiby, N., Givskov, M., & Klemm, P.
- Affiliations
- Technical University of Denmark (DK)
- Rigshospitalet (DK)
- Corresponding author
- Klemm, Per
- Venue
- Infection and Immunity
- Publisher
- American Society for Microbiology
- Published
- 2007-01
- Volume
- 75
- Issue
- 1
- Pages
- 30-34
- ISSN
- 0019-9567 (ISSN-L)
- 1098-5522
- PMC
- PMC1828374
- OpenAlex
- W2170369942
- Cited by
- 58
- References
- 28
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 4 · 2023: 3 · 2021: 4 · 2020: 4 · 2019: 1 · 2018: 2 · 2017: 3 · 2016: 1 · 2015: 2 · 2014: 7 · 2013: 4 · 2012: 1
- FWCI
- 2.38
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Infection and Immunity (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Technical University of Denmark, DTU Orbit (Technical University of Denmark, DTU) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Escherichia coli research studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
- Keywords
- antigen 43, Escherichia coli, neutrophils, bacterial internalization, bacterial survival in host cells, bacterial aggregation, host-pathogen interaction, bacterial virulence
- MeSH terms
- Antigens, Bacterial, Bacterial Outer Membrane Proteins, Cells, Cultured, Escherichia coli, Escherichia coli Infections, Humans, Neutrophils, Phagocytosis, Adhesins, Bacterial, Adhesins, Escherichia coli, Escherichia coli Proteins
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