Colonization of the large bowel by Clostridium difficile in healthy infants: quantitative study

Stark, P L; Lee, A; Parsonage, B D

doi:10.1128/iai.35.3.895-899.1982

Cited by 104Clostridium difficile and Clostridium perfringens researchGut microbiota and healthInfant Nutrition and Health

Colonization of the large bowel by Clostridium difficile in healthy infants: quantitative study

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Stark, P L, Lee, A, Parsonage, B D·1982·Infection and Immunity

DOI 10.1128/iai.35.3.895-899.1982PMC PMC351131

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Abstract

Colonization of the large bowel of healthy infants by Clostridium difficile was studied. Feces were collected from five breast-fed aand five formula-fed infants throughout the first year of life, and levels of C. difficile were quantitated. Three breast-fed and five formula-fed infants were colonized for periods of between 8 and 42 weeks, and another infant harbored the organism only during week 1. Colonization of breast-fed infants commenced before or during weaning, with levels reaching 10(3) to 10(5) organisms per g of wet feces. Colonization of formula-fed infants commenced before solid foods were given, with levels of 10(3) to 10(7) organisms per g of wet feces. Isolates from eight of the babies were shown to produce cytotoxin in vitro. Single fecal specimens from 60 more children aged up to 4 years were also examined, and it was found that the carriage rate of C. difficile fell sharply after 1 year of age, although in the second year it was still higher than in adults. These findings are discussed in relation to the microbial ecology of the large bowel and the paradox that levels of C. difficile in the large bowel of healthy infants are similar to those causing pseudomembranous colitis in patients.

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Multiple studies show decreased Clostridia colonization in breast-fed infants, including colonization with Clostridium difficile.
“multiple studies have shown a decrease in Clostridia colonization of breast-fed infants19, 20 including colonization with Clostridium difficile 21.”
From Diet and the Intestinal Microbiome: Associations, Functions, and Implications for Health and Disease (2014) · cites this paper as [21]

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Authors: Stark, P. L., Lee, A., & Parsonage, B. D.
Venue: Infection and Immunity
Publisher: American Society for Microbiology
Published: 1982-03
Volume: 35
Issue: 3
Pages: 895-899
ISSN: 0019-9567 (ISSN-L)
1098-5522
DOI: 10.1128/iai.35.3.895-899.1982
PMC: PMC351131
OpenAlex: W2102086074
Cited by: 104
References: 24
Citations by year: 2024: 2 · 2022: 3 · 2020: 3 · 2019: 2 · 2018: 3 · 2016: 2 · 2015: 5 · 2014: 5 · 2013: 3 · 2012: 5
FWCI: 10.57
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Infection and Immunity (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Infectious Diseases › Clostridium difficile and Clostridium perfringens research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
Keywords: Clostridium difficile, intestinal colonization, infants, breastfeeding, bottle feeding, weaning, cytotoxin production, carriage rate, pseudomembranous colitis, fecal carriage
MeSH terms: Bacterial Toxins, Clostridium, Cytotoxins, Feces, Humans, Infant, Infant, Newborn, Intestine, Large, Prospective Studies, Time Factors

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Colonization of the large bowel by Clostridium difficile in healthy infants: quantitative study

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