Factors Governing Adherence of Candida Species to Plastic Surfaces
Open accessAbstract
The ability of Candida albicans and Candida spp. to adhere to inert polymeric surfaces may allow these organisms direct ingress into the human host. Biophysical characterization of this adherence shows that the forces responsible for such adherence are attractive London-van der Waals forces (or hydrophobic forces) and electrostatic forces. The hydrophobic affinity of yeasts was determined by (i) a water-hydrocarbon two-phase assay and by (ii) measurement of the contact angle (theta) of a liquid droplet on a monolayer of yeast cells. The hydrophobicity of the yeasts correlated with the tendency of yeasts to adhere to polystyrene and was reduced in the presence of Tween 20. The adherence of yeasts to polymers of increasing hydrophobicity (determined by the contact angle method) was directly proportional to theta. Yeast surface charges were altered by selectively blocking amino and carboxyl groups. The more positively charged yeasts adhered in greater numbers. Increasing the molarity of NaCl increased yeast adherence. These forces probably contribute to the negative cooperativity (determined by Scatchard and Hill plot) that characterizes the adherence of yeasts to polymers.
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Adhesion is an extremely important step in biofilm formation and in infection processes.
“Adhesion is an extremely important step, not only in the biofilm formation, but also in the infections processes”
From Candida glabrata Biofilms: How Far Have We Come? (2017) · cites this paper as [45]
The extent of Candida glabrata adhesion depends on Candida glabrata cell characteristics and host and/or abiotic surface properties, such as cell-surface hydrophobicity and cell wall composition.
“the extent of adhesion is dependent on C. glabrata cells’ characteristics, and host and/or abiotic surface properties, such as cell-surface hydrophobicity and cell wall composition [4,45].”
From Candida glabrata Biofilms: How Far Have We Come? (2017) · cites this paper as [45]
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- Authors
- Klotz, S. A., Drutz, D. J., & Zajic, J. E.
- Affiliations
- United States Department of Veterans Affairs (US)
- ORCID
- Klotz, S A
- Venue
- Infection and Immunity
- Publisher
- American Society for Microbiology
- Published
- 1985-10
- Volume
- 50
- Issue
- 1
- Pages
- 97-101
- ISSN
- 0019-9567 (ISSN-L)
- 1098-5522
- PMC
- PMC262141
- OpenAlex
- W1942723893
- Cited by
- 353
- References
- 30
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 11 · 2023: 6 · 2022: 9 · 2021: 9 · 2020: 6 · 2019: 9 · 2018: 11 · 2017: 14 · 2016: 10 · 2015: 10 · 2014: 14 · 2013: 14 · 2012: 20
- FWCI
- 7.87
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Infection and Immunity (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Allergy and Infectious Diseases (AI 06594)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Physical Sciences › Materials Science › Surfaces, Coatings and Films › Polymer Surface Interaction Studies
- Keywords
- Candida albicans, Candida, yeast adherence, plastic surfaces, hydrophobicity, contact angle, polystyrene, Tween 20, surface charge, sodium chloride, London-van der Waals forces, electrostatic forces, negative cooperativity
- MeSH terms
- Adhesiveness, Candida albicans, Electricity, Kinetics, Plastics, Structure-Activity Relationship, Surface Properties, Water
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