The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Aggregation substance of Enterococcus faecalis mediates adhesion to cultured renal tubular cells
Open accessAbstract
The sex pheromone system of Enterococcus faecalis is a unique, highly efficient plasmid collection mechanism for this species. A crucial role in this system is played by an adhesin called aggregation substance which enables the cell-cell contact between donor and recipient strains. The existence of the amino acid motif Arg-Gly-Asp-Ser in the adhesin prompted us to look for a possible binding of E. faecalis cells expressing aggregation substance to eucaryotic cells. We were able to show that the adhesin mediated binding to cultured renal tubular cells (porcine cell line LLC-PK1) via light microscopic, electron microscopic, and enzyme-linked immunosorbent assay-based studies. Synthesis of the adhesin was induced by some component(s) of serum. These data are interpreted to mean that aggregation substance is an adhesin mediating not only cell-cell contact between different E. faecalis strains but also binding of E. faecalis to eucaryotic cells, and therefore it might contribute to virulence.
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Cites
New Perspectives in Cell Adhesion: RGD and Integrins
Ruoslahti, E., & Pierschbacher, M. D. (1987) · Science · doi:10.1126/science.2821619 · Cited by 4,865
The origin and characteristics of a pig kidney cell strain, LLC-PK1
Hull, R. N., Cherry, W. R., & Weaver, G. W. (1976) · In Vitro · doi:10.1007/bf02797469 · Cited by 597
Mobley, H. L., Green, D. M., Trifillis, A. L., Johnson, D. E., Chippendale, G. R., Lockatell, C. V., Jones, B. D., & Warren, J. W. (1990) · Infection and Immunity · doi:10.1128/iai.58.5.1281-1289.1990 · Cited by 561
Dunny, G. M., Brown, B. L., & Clewell, D. B. (1978) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.75.7.3479 · Cited by 548
Plasmid transfer in Streptococcus faecalis: Production of multiple sex pheromones by recipients
Dunny, G. M., Craig, R. A., Carron, R. L., & Clewell, D. B. (1979) · Plasmid · doi:10.1016/0147-619x(79)90029-5 · Cited by 267
Korhonen, M., Ylänne, J., Laitinen, L., & Virtanen, I. (1990) · The Journal of cell biology · doi:10.1083/jcb.111.3.1245 · Cited by 261
Galli, D., Lottspeich, F., & Wirth, R. (1990) · Molecular Microbiology · doi:10.1111/j.1365-2958.1990.tb00662.x · Cited by 173
Self-citationIke, Y., & Clewell, D. B. (1984) · Journal of Bacteriology · doi:10.1128/jb.158.3.777-783.1984 · Cited by 151
Ehrenfeld, E. E., & Clewell, D. B. (1987) · Journal of Bacteriology · doi:10.1128/jb.169.8.3473-3481.1987 · Cited by 101
A beta 1-integrin receptor for fibronectin in human kidney glomeruli.
Kerjaschki, D., Ojha, P. P., Susani, M., Horvat, R., Binder, S., Hovorka, A., Hillemanns, P., & Pytela, R. (1989) · Europe PMC (PubMed Central) · Cited by 99
Cited by
Enterococci as probiotics and their implications in food safety
Franz, C. M. A. P., Huch, M., Abriouel, H., Holzapfel, W., & Gálvez, A. (2011) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2011.08.014 · Cited by 788
Vankerckhoven, V., Van Autgaerden, T., Vael, C., Lammens, C., Chapelle, S., Rossi, R., Jabes, D., & Goossens, H. (2004) · Journal of Clinical Microbiology · doi:10.1128/jcm.42.10.4473-4479.2004 · Cited by 594
Fiore, E., Van Tyne, D., & Gilmore, M. S. (2019) · Microbiology Spectrum · doi:10.1128/microbiolspec.gpp3-0053-2018 · Cited by 503
Shankar, V., Baghdayan, A. S., Huycke, M. M., Lindahl, G., & Gilmore, M. S. (1999) · Infection and Immunity · doi:10.1128/iai.67.1.193-200.1999 · Cited by 435
Enterococcal infections: host response, therapeutic, and prophylactic possibilities
Koch, S., Hufnagel, M., Theilacker, C., & Huebner, J. (2004) · Vaccine · doi:10.1016/j.vaccine.2003.11.027 · Cited by 159
Metadata
- Authors
- Kreft, B., Marre, R., Schramm, U., & Wirth, R.
- Venue
- Infection and Immunity
- Publisher
- American Society for Microbiology
- Published
- 1992-01
- Volume
- 60
- Issue
- 1
- Pages
- 25-30
- ISSN
- 0019-9567 (ISSN-L)
- 1098-5522
- OpenAlex
- W1901904957
- Cited by
- 278
- References
- 18
- FWCI
- 6.66
- Type
- journal article
- Language
- en
- Open access
- green
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- Kreft, B., Marre, R., Schramm, U., & Wirth, R. (1992). Aggregation substance of Enterococcus faecalis mediates adhesion to cultured renal tubular cells. Infection and Immunity. https://doi.org/10.1128/iai.60.1.25-30.1992
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
