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Cited by 293

The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.

Binding of pulmonary surfactant proteins A and D to Aspergillus fumigatus conidia enhances phagocytosis and killing by human neutrophils and alveolar macrophages

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Madan, T, Eggleton, P, Kishore, U, Strong, P, Aggrawal, S S, Sarma, P U, Reid, K B·1997·Infection and Immunity
DOI 10.1128/iai.65.8.3171-3179.1997
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Abstract

To determine whether the lung surfactant proteins A (SP-A) and D (SP-D) are involved in the initial protective immunity against opportunistic pulmonary fungal infections caused by Aspergillus fumigatus, we performed a series of in vitro functional studies to see if SP-A and SP-D enhanced binding, phagocytosis, activation, and killing of A. fumigatus conidia by human alveolar macrophages and circulating neutrophils. Both SP-A and SP-D bound to carbohydrate structures on A. fumigatus conidia in a calcium-dependent manner. SP-A and SP-D were also chemoattractant and significantly enhanced agglutination and binding of conidia to alveolar macrophages and neutrophils. Furthermore, in the presence of SP-A and SP-D, the phagocytosis, oxidative burst, and killing of A. fumigatus conidia by neutrophils were significantly increased. These findings indicate that SP-A and SP-D may have an important immunological role in the early antifungal defense responses in the lung, through inhibiting infectivity of conidia by agglutination and by enhancing uptake and killing of A. fumigatus by phagocytic cells.

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Metadata

Authors
Madan, T., Eggleton, P., Kishore, U., Strong, P., Aggrawal, S. S., Sarma, P. U., & Reid, K. B.
Venue
Infection and Immunity
Publisher
American Society for Microbiology
Published
1997-08
Volume
65
Issue
8
Pages
3171-3179
ISSN
  • 0019-9567 (ISSN-L)
  • 1098-5522
DOI
10.1128/iai.65.8.3171-3179.1997
OpenAlex
W2129710186
Cited by
293
References
24
FWCI
11.93
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Binding of pulmonary surfactant proteins A and D to Aspergillus fumigatus conidia enhances phagocytosis and killing by human neutrophils and alveolar macrophages. https://app.cochat.ai/papers/10.1128/iai.65.8.3171-3179.1997
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Madan, T., Eggleton, P., Kishore, U., Strong, P., Aggrawal, S. S., Sarma, P. U., & Reid, K. B. (1997). Binding of pulmonary surfactant proteins A and D to Aspergillus fumigatus conidia enhances phagocytosis and killing by human neutrophils and alveolar macrophages. Infection and Immunity. https://doi.org/10.1128/iai.65.8.3171-3179.1997

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.