Resident Enteric Bacteria Are Necessary for Development of Spontaneous Colitis and Immune System Activation in Interleukin-10-Deficient Mice

Interleukin-10-deficient mice develop chronic enterocolitis

Kühn, R., Löhler, J., Rennick, D. M., Rajewsky, K., & Müller, W. (1993) · Cell · doi:10.1016/0092-8674(93)80068-p · Cited by 4,248

IL-10 inhibits cytokine production by activated macrophages

Fiorentino, D. F., Zlotnik, A., Mosmann, T. R., Howard, M., & O’Garra, A. (1991) · The Journal of Immunology · doi:10.4049/jimmunol.147.11.3815 · Cited by 2,888

CD44 is the principal cell surface receptor for hyaluronate

Aruffo, A. A., Stamenkovic, I., Melnick, M., Underhill, C. B., & Seed, B. (1990) · Cell · doi:10.1016/0092-8674(90)90694-a · Cited by 2,439

Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation.

Cella, M., Scheidegger, D., Palmer-Lehmann, K., Lane, P. J. L., Lanzavecchia, A., & Alber, G. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.184.2.747 · Cited by 1,982

Interleukin-10

Moore, K. W., O’Garra, A., Malefyt, R. D. W., Vieira, P., & Mosmann, T. R. (1993) · Annual Review of Immunology · doi:10.1146/annurev.iy.11.040193.001121 · Cited by 1,883

IL-10 acts on the antigen-presenting cell to inhibit cytokine production by Th1 cells

Fiorentino, D. F., Zlotnik, A., Vieira, P., Mosmann, T. R., Howard, M., Moore, K. W., & O’Garra, A. (1991) · The Journal of Immunology · doi:10.4049/jimmunol.146.10.3444 · Cited by 1,866

Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene

Sadlack, B., Merz, H., Schorle, H., Schimpl, A., Feller, A. C., & Horak, I. D. (1993) · Cell · doi:10.1016/0092-8674(93)80067-o · Cited by 1,744

Identification of a monoclonal antibody specific for a murine T3 polypeptide.

Léo, O., Foo, M., Sachs, D. H., Samelson, L. E., & Bluestone, J. A. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.5.1374 · Cited by 1,596

Interleukin 10 (IL-10) inhibits human lymphocyte interferon gamma-production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells.

D’Andrea, A., Aste-Amézaga, M., Valiante, N. M., Ma, X., Kubin, M. Z., & Trinchieri, G. (1993) · The Journal of Experimental Medicine · doi:10.1084/jem.178.3.1041 · Cited by 1,367

Antibodies to interleukin 12 abrogate established experimental colitis in mice.

Neurath, M., Fuss, I. J., Kelsall, B. L., Stuber, E. R., & Strober, W. (1995) · The Journal of Experimental Medicine · doi:10.1084/jem.182.5.1281 · Cited by 1,334

Engineered and wild-type L. lactis promote anti-inflammatory cytokine signalling in inflammatory bowel disease patient’s mucosa

Simčič, S., Berlec, A., Stopinšek, S., Štrukelj, B., & Orel, R. (2019) · World Journal of Microbiology and Biotechnology · doi:10.1007/s11274-019-2615-z · Cited by 23

Reshaping of bacterial molecular hydrogen metabolism contributes to the outgrowth of commensal E. coli during gut inflammation

Hughes, E. R., Winter, M. G., da Silva, L. A., Muramatsu, M. K., Jimenez, A. G., Gillis, C. C., Spiga, L., Chanin, R. B., Santos, R. L., Zhu, W., et al. (2021) · eLife · doi:10.7554/elife.58609 · Cited by 21

Need for a comprehensive medical approach to the neuro-immuno-gastroenterology of irritable bowel syndrome.

Katiraei, P., & Bultron, G. (2011) · PubMed Central · doi:10.3748/wjg.v17.i23.2791 · Cited by 27

Exacerbation of Type 1 Diabetes in Perinatally Genistein Exposed Female Non-Obese Diabetic (NOD) Mouse Is Associated With Alterations of Gut Microbiota and Immune Homeostasis

Huang, G., Xu, J., Cai, D., Chen, S., Nagy, T., & Guo, T. L. (2018) · Toxicological Sciences · doi:10.1093/toxsci/kfy162 · Cited by 23

The Probiotic Effectiveness in Preventing Experimental Colitis Is Correlated With Host Gut Microbiota

Suwal, S., Wu, Q., Liu, W., Liu, Q., Sun, H., Ming, L., Gao, J., Zhang, B., Kou, Y., Liu, Z., et al. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.02675 · Cited by 25

Mechanisms regulating the development and function of natural regulatory T cells

Gupta, S., Shang, W., & Sun, Z. (2008) · Archivum Immunologiae et Therapiae Experimentalis · doi:10.1007/s00005-008-0015-4 · Cited by 23

Anti- and proinflammatory cytokines in the pathogenesis of tissue damage in Crohnʼs disease

Hommes, D. W., & van Deventer, S. J. H. (2000) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/00075197-200005000-00005 · Cited by 23

Recombinant interleukin 10 for the treatment of active Crohn's disease: Lessons in biologic therapy

Bickston, S. J., & Cominelli, F. (2000) · Gastroenterology · doi:10.1053/gast.2000.20822 · Cited by 23

Pathogen- and Microbial- Associated Molecular Patterns (PAMPs/MAMPs) and the Innate Immune Response in Crohn’s Disease

Schaefer, A. K., Melnyk, J. E., He, Z., del Rosario, J. F., & Grimes, C. L. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-805417-8.00014-7 · Cited by 22

Microbiome-Mediated Immune Signaling in Inflammatory Bowel Disease and Colorectal Cancer: Support From Meta-omics Data

Pratt, M., Forbes, J. D., Knox, N., Bernstein, C. N., & Domselaar, G. V. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.716604 · Cited by 23

Interleukin-37 exacerbates experimental colitis in an intestinal microbiome-dependent fashion

Cong, J., Wu, D., Dai, H., Ma, Y., Liao, C., Li, L., Ye, L., & Huang, Z. W. (2022) · Theranostics · doi:10.7150/thno.69616 · Cited by 22

Cutaneous immune-related adverse events to immune checkpoint inhibitors: from underlying immunological mechanisms to multi-omics prediction

Cao, T., Zhou, X., Wu, X., & Zou, Y. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1207544 · Cited by 24

Enterohepatic Helicobacter other than Helicobacter pylori

Muñoz, B. M., de la Serna, J. P., de León, A. R., Falcón, B. S., Francés, S. C., Velasco, A. C., & Díaz-Rubio, E. R. (2013) · Revista Española de Enfermedades Digestivas · doi:10.4321/s1130-01082013000800006 · Cited by 22

Aberrant response to commensal Bacteroides thetaiotaomicron in Crohnʼs disease

Edwards, L. A., Lucas, M., Edwards, E. A., Torrente, F., Heuschkel, R. B., Klein, N. J., MURCH, S. H., Bajaj‐Elliott, M., & Phillips, A. D. (2010) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21501 · Cited by 22

Induction of inflammatory bowel disease accelerates adenoma formation in Min +/− mice

Huang, E. H., PARK, J., Appelman, H. D., Weinberg, A. M., BANERJEE, M., LOGSDON, C., & SCHMIDT, A. (2006) · Surgery · doi:10.1016/j.surg.2005.11.005 · Cited by 22

Genetics of ulcerative colitis: the come-back of interleukin 10

Louis, E., Libioulle, C., Reenaers, C., Belaiche, J., & Georges, M. (2009) · Gut · doi:10.1136/gut.2008.169235 · Cited by 22

A Model for Dextran Sodium Sulfate (DSS)-induced Mouse Colitis: Bacterial Degradation of DSS Does Not Occur after Incubation with Mouse Cecal Contents.

Kitajima, S., MORIMOTO, M., & Sagara, E. (2002) · EXPERIMENTAL ANIMALS · doi:10.1538/expanim.51.203 · Cited by 22

Update on the Management of Crohn’s Disease

Buchner, A. M., Blonski, W. C., & Lichtenstein, G. R. (2011) · Current Gastroenterology Reports · doi:10.1007/s11894-011-0220-x · Cited by 22

Rodent Intestinal Epithelial Carcinogenesis

Ward, J. M., & Treuting, P. M. (2013) · Toxicologic Pathology · doi:10.1177/0192623313505156 · Cited by 22

Impact of a probiotic Enterococcus faecalis in a gnotobiotic mouse model of experimental colitis.

Hoffmann, M., Messlik, A., Kim, S. C., Sartor, R., & Haller, D. (2011) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201000361 · Cited by 25

Recent Advances and Understanding of Using Probiotic-Based Interventions to Restore Homeostasis of the Microbiome for the Prevention/Therapy of Bacterial Diseases

Suchodolski, J. S., & Jergens, A. E. (2016) · Microbiology Spectrum · doi:10.1128/microbiolspec.vmbf-0025-2015 · Cited by 25

S100A4 contributes to colitis development by increasing the adherence of Citrobacter rodentium in intestinal epithelial cells

Zhang, J., Jiao, Y., Hou, S., Tian, T., Yuan, Q., Hao, H., Wu, Z., & Bao, X. (2017) · Scientific Reports · doi:10.1038/s41598-017-12256-z · Cited by 23

Monocyte and Alveolar Macrophage Skewing Is Associated with the Development of Pulmonary Arterial Hypertension in a Primate Model of HIV Infection

Schweitzer, F., Tarantelli, R., Rayens, E. A., Kling, H. M., Mattila, J. T., & Norris, K. A. (2018) · AIDS Research and Human Retroviruses · doi:10.1089/aid.2018.0132 · Cited by 20

Intestinal Organoids as a Novel Complementary Model to Dissect Inflammatory Bowel Disease

Schulte, L.-A., Hohwieler, M., Müller, M., & Klaus, J. (2019) · Stem Cells International · doi:10.1155/2019/8010645 · Cited by 22

Effects of monocolonization withEscherichia coli strains O6K13 and nissle 1917 on the development of experimentally induced acute and chronic intestinal inflammation in germ-free immunocompetent and immunodeficient mice

Hudcovic, T., Štëpánková, R., Kozáková, H., Hrnčíř, T., & Tlaskalová‐Hogenová, H. (2007) · Folia Microbiologica · doi:10.1007/bf02932191 · Cited by 22

Regulatory T Cells in Experimental Colitis

Gad, M. (2005) · Current topics in microbiology and immunology · doi:10.1007/3-540-27702-1_9 · Cited by 22

COX-2: promoting tolerance

Morteau, O. (1999) · Nature Medicine · doi:10.1038/11301 · Cited by 22

Aronia berry (Aronia mitschurinii ‘Viking’) inhibits colitis in mice and inhibits T cell tumour necrosis factor-α secretion

Martin, D., Smyth, J. A., Liu, Z., & Bolling, B. W. (2018) · Journal of Functional Foods · doi:10.1016/j.jff.2018.02.025 · Cited by 23

Fecal Microbiota Transplantation in Inflammatory Bowel Disease: A Primer for Internists

Syal, G., Kashani, A., & Shih, D. Q. (2018) · The American Journal of Medicine · doi:10.1016/j.amjmed.2018.03.010 · Cited by 21

The effects of prebiotics on growth performance and in vitro immune biomarkers in weaned pigs1

Andres, J. V. S., Mastromano, G., Li, Y., Tran, H., Bundy, J. W., Miller, P. S., & Burkey, T. E. (2019) · Translational Animal Science · doi:10.1093/tas/txz129 · Cited by 21

Physical Activity Shapes the Intestinal Microbiome and Immunity of Healthy Mice but Has No Protective Effects against Colitis in MUC2 −/− Mice

Estaki, M., Morck, D. W., Ghosh, S., Quin, C., Pither, J., Barnett, J. A., Gill, S. K., & Gibson, D. L. (2020) · mSystems · doi:10.1128/msystems.00515-20 · Cited by 22

It takes a village: microbiota, parainflammation, paligenosis and bystander effects in colorectal cancer initiation

Wang, X., Undi, R. B., Ali, N., & Huycke, M. M. (2021) · Disease Models & Mechanisms · doi:10.1242/dmm.048793 · Cited by 20

Telmisartan attenuates the inflamed mesenteric adipose tissue in spontaneous colitis by mechanisms involving regulation of neurotensin/microRNA-155 pathway

Li, Y. Z., Zuo, L., Zhu, W., Gong, J., Zhang, W., Guo, Z., Gu, L., Li, N., & Li, J. (2015) · Biochemical Pharmacology · doi:10.1016/j.bcp.2014.12.020 · Cited by 21

Microbial and Dietary Factors in the Pathogenesis of Chronic, Immune-Mediated Intestinal Inflammation

Sartor, R. B. (2006) · Advances in experimental medicine and biology · doi:10.1007/0-387-33778-4_4 · Cited by 21

Expanded TCRβ CDR3 clonotypes distinguish Crohn's disease and ulcerative colitis patients

Wu, J., Pendegraft, A. H., Byrne-Steele, M. L., Yang, Q., Wang, C., Pan, W., Lucious, T. D., Seay, T., Cui, X., Elson, C. O., et al. (2018) · Mucosal Immunology · doi:10.1038/s41385-018-0046-z · Cited by 21

Triclocarban Exposure Exaggerates Spontaneous Colonic Inflammation in Il-10−/− Mice

Xie, M., Zhang, H., Wang, W., Sherman, H. L., Minter, L. M., Cai, Z., & Zhang, G. (2019) · Toxicological Sciences · doi:10.1093/toxsci/kfz248 · Cited by 21

Microbial regulation of SAA3 expression in mouse colon and adipose tissue

Reigstad, C. S., & Bäckhed, F. (2010) · Gut Microbes · doi:10.4161/gmic.1.1.10514 · Cited by 21

What Is the Role of the Metabolic Activity of the Gut Microbiota in Inflammatory Bowel Disease? Probing for Answers With Stable Isotopes

Barclay, A. R., Morrison, D. J., & Weaver, L. T. (2008) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0b013e3181615b3a · Cited by 21

Fecal Stream Diversion Changes Intestinal Environment, Modulates Mucosal Barrier, and Attenuates Inflammatory Cells in Crohn’s Disease

Watanabe, Y., Mizushima, T., Okumura, R., Fujino, S., Ogino, T., Miyoshi, N., Takahashi, H., Uemura, M., Matsuda, C., Yamamoto, H., et al. (2021) · Digestive Diseases and Sciences · doi:10.1007/s10620-021-07060-9 · Cited by 20

Immune Inhibitory Properties and Therapeutic Prospects of Transforming Growth Factor-Beta and Interleukin 10 in Autoimmune Hepatitis

Czaja, A. J. (2021) · Digestive Diseases and Sciences · doi:10.1007/s10620-021-06968-6 · Cited by 21

Intestine-Specific NHE3 Deletion in Adulthood Causes Microbial Dysbiosis

Xue, J., Dominguez, J. A., Thomas, L., White, J. R., & Rieg, T. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.896309 · Cited by 20

Effect of ginsenoside compound K on alleviating colitis via modulating gut microbiota

Wang, L., Shao, L., Chen, M., Wang, L., Zhang, W., Tan, F., & Huang, W. (2022) · Chinese Medicine · doi:10.1186/s13020-022-00701-9 · Cited by 20

Microbiota as key factors in inflammatory bowel disease

White, Z., Cabrera, I., Kapustka, I., & Sano, T. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1155388 · Cited by 21

Pathobiont-induced suppressive immune imprints thwart T cell vaccine responses

Hajam, I., Tsai, C.-M., Gonzalez, C., Caldera, J. R., Díez, M. L., Du, X., Aralar, A., Lin, B., Duong, W., & Liu, G. Y. (2024) · Nature Communications · doi:10.1038/s41467-024-54644-w · Cited by 17

Isolation of Helicobacter spp. from mice with rectal prolapses.

Miller, C. L., Muthupalani, S., Shen, Z., & Fox, J. G. (2014) · PubMed Central · Cited by 20

Paracellular entry of interleukin-10 producing Lactococcus lactis in inflamed intestinal mucosa in mice

Waeytens, A., Ferdinande, L., Neirynck, S., Rottiers, P., Vos, M. D., Steidler, L., & Cuvelier, C. A. (2007) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20346 · Cited by 20

Intestinal epithelial expression of TNFAIP3 results in microbial invasion of the inner mucus layer and induces colitis in IL-10-deficient mice

Murphy, S. F., Rhee, L., Grimm, W. A., Weber, C. R., Messer, J. S., Lodolce, J. P., Chang, J. E., Bartulis, S. J., Nero, T. M., Kukla, R. A., et al. (2014) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00020.2014 · Cited by 21

Helicobacter bilis Infection Alters Mucosal Bacteria and Modulates Colitis Development in Defined Microbiota Mice

Atherly, T. A., Mosher, C., Wang, C., Hostetter, J. M., Proctor, A., Brand, M. W., Phillips, G. J., Wannemuehler, M. J., & Jergens, A. E. (2016) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000944 · Cited by 20

Antimicrobial peptide LL-37 forms complex with bacterial DNA to facilitate blood translocation of bacterial DNA and aggravate ulcerative colitis

Duan, Z., Fang, Y., Sun, Y., Luan, N., Chen, X., Chen, M., Han, Y., Yin, Y., Mwangi, J., Niu, J., et al. (2018) · 中国科学通报：英文版 · doi:10.1016/j.scib.2018.09.014 · Cited by 20

ER stress abrogates the immunosuppressive effect of IL-10 on human macrophages through inhibition of STAT3 activation

Hansen, I. S., Schoonejans, J. M., Sritharan, L., van Burgsteden, J. A., Ambarus, C. A., Baeten, D., & den Dunnen, J. (2019) · Inflammation Research · doi:10.1007/s00011-019-01261-9 · Cited by 21

Cesarean section increases sensitivity to oxazolone-induced colitis in C57BL/6 mice

Zachariassen, L. F., Hansen, A. K., Krych, Ł., Nielsen, D. S., Holm, T. L., Tougaard, P., & Hansen, C. H. F. (2019) · Mucosal Immunology · doi:10.1038/s41385-019-0207-8 · Cited by 20

Oral exposure to bisphenols induced food intolerance and colitis in vivo by modulating immune response in adult mice

Malaisé, Y., Lencina, C., Placide, F., Bacquie, V., Cartier, C., Olier, M., Büettner, M., Wallbrecht, M., Ménard, S., & Guzylack‐Piriou, L. (2020) · Food and Chemical Toxicology · doi:10.1016/j.fct.2020.111773 · Cited by 20

Dendritic cell immunoreceptor 1 alters neutrophil responses in the development of experimental colitis

Tokieda, S., Komori, M., Ishiguro, T., Iwakura, Y., Takahara, K., & Inaba, K. (2015) · BMC Immunology · doi:10.1186/s12865-015-0129-5 · Cited by 20

Transcription of the Tollip gene is elevated in intestinal epithelial cells through impaired O-GlcNAcylation-dependent nuclear translocation of the negative regulator Elf-1

Sugi, Y., Takahashi, K., Nakano, K., Hosono, A., & Kaminogawa, S. (2011) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2011.08.035 · Cited by 20

Embryonic stem cells ameliorate piroxicam-induced colitis in IL10−/− KO mice

Srivastava, A., Feng, Z., Mishra, R., Malhotra, R., Kim, H. S., & Carrier, E. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.07.139 · Cited by 20

Epithelial Cells

Edelblum, K. L., & Turner, J. R. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-415847-4.00012-4 · Cited by 20

The microbiome and rodent models of immune mediated diseases

Hansen, A. K., & Hansen, C. H. F. (2021) · Mammalian Genome · doi:10.1007/s00335-021-09866-4 · Cited by 22

Glutamyl-prolyl-tRNA synthetase 1 coordinates early endosomal anti-inflammatory AKT signaling

Lee, E.-Y., Kim, S., Hwang, J. H., Jang, S. Y., Park, S., Choi, S.-H., Lee, G. S., Hwang, J., Moon, J. H., Fox, P. L., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-34226-4 · Cited by 20

Sterility testing of germ-free mouse colonies

Dremova, O., Mimmler, M., Paeslack, N., Khuu, M. P., Gao, Z., Bosmann, M., Garo, L. P., Schön, N., Mechler, A., Beneich, Y., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1275109 · Cited by 19

Targeting gut microbiota dysbiosis in inflammatory bowel disease: a systematic review of current evidence

Farah, A., Paul, P., Khan, A. S., Sarkar, A., Laws, S., & Châari, A. (2025) · Frontiers in Medicine · doi:10.3389/fmed.2025.1435030 · Cited by 24

Function, Regulation, and Pathophysiological Relevance of the POT Superfamily, Specifically PepT1 in Inflammatory Bowel Disease

Viennois, É., Pujada, A., Zen, J., & Merlin, D. (2018) · Comprehensive physiology · doi:10.1002/j.2040-4603.2018.tb00024.x · Cited by 19

Dietary β-Glucan Regulates the Levels of Inflammatory Factors, Inflammatory Cytokines, and Immunoglobulins in Interleukin-10 Knockout Mice

Ye, M. B., Bak, J. P., An, C. S., Jin, H. L., Kim, J. M., Kweon, H.-J., Choi, D., Park, P., Kim, Y. J., & Lim, B. O. (2011) · Journal of Medicinal Food · doi:10.1089/jmf.2010.1197 · Cited by 19

Indigo Naturalis Ameliorates Oxazolone-Induced Dermatitis but Aggravates Colitis by Changing the Composition of Gut Microflora

Adachi, S., Hoshi, N., Inoue, J., Yasutomi, E., Otsuka, T., Dhakhwa, R., Wang, Z., Koo, Y., Takamatsu, T., Matsumura, Y., et al. (2017) · International Archives of Allergy and Immunology · doi:10.1159/000471923 · Cited by 19

Phospholipase A2 of Microbiota as Pathogenetic Determinant to Induce Inflammatory States in Ulcerative Colitis: Therapeutic Implications of Phospholipase A2 Inhibitors

Stremmel, W., Staffer, S., Stuhrmann, N., Gan‐Schreier, H., Gauss, A., Burger, N., & Hornuß, D. (2017) · Inflammatory Intestinal Diseases · doi:10.1159/000486858 · Cited by 19

Validation studies for germ-free Smad3 -/- mice as a bio-assay to test the causative role of fecal microbiomes in IBD

Paik, J., Meeker, S. M., Hsu, C. C., Seamons, A., Pershutkina, O. V., Snyder, J. M., Brabb, T., & Maggio‐Price, L. (2019) · Gut Microbes · doi:10.1080/19490976.2019.1611151 · Cited by 19

An imbalance in mucosal cytokine profile causes transient intestinal inflammation following an animal's first exposure to faecal bacteria and antigens

Sydora, B. C., MacFarlane, S. M., Lupicki, M., Dmytrash, A. L., Dieleman, L. A., & Fedorak, R. N. (2010) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2010.04140.x · Cited by 19

Expression profiles of cytokines and chemokines in murine MDR1a-/- colitis

Masunaga, Y., Noto, T., Suzuki, K., Takahashi, K., Shimizu, Y., & Morokata, T. (2007) · Inflammation Research · doi:10.1007/s00011-007-6078-6 · Cited by 19

IL-10-deficiency unmasks unique immune system defects and reveals differential regulation of organ-specific autoimmunity in non-obese diabetic mice

Rajagopalan, G., Kudva, Y. C., Sen, M. M., Marietta, E. V., Murali, N. S., Nath, K. R. D., Moore, J., & David, C. S. (2006) · Cytokine · doi:10.1016/j.cyto.2006.04.006 · Cited by 19

Clostridium difficileinfection aggravates colitis in interleukin 10-deficient mice

Kim, M. N. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i45.17084 · Cited by 19

Azithromycin and erythromycin ameliorate the extent of colonic damage induced by acetic acid in rats

Mahgoub, A. A., El-Medany, A. H., Mustafa, A., Arafah, M., & Moursi, M. (2004) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2004.09.012 · Cited by 19

Gab2 and Gab3 Redundantly Suppress Colitis by Modulating Macrophage and CD8+ T-Cell Activation

Wang, Z., Vaughan, T. Y., Zhu, W., Chen, Y., Fu, G., Medrzycki, M., Nishio, H., Bunting, S. T., Hankey-Giblin, P. A., Nusrat, A., et al. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00486 · Cited by 18

Enhanced microbiota profiling in patients with quiescent Crohn’s disease through comparison with paired healthy first-degree relatives

Chen, W., Li, Y., Wang, W., Gao, S., Hu, J. X., Xiang, B., Wu, D., Jiao, N., Xu, T., Zhi, M., et al. (2024) · Cell Reports Medicine · doi:10.1016/j.xcrm.2024.101624 · Cited by 29

The Intertwining Roads between Psychological Distress and Gut Microbiota in Inflammatory Bowel Disease

Gîlcă-Blanariu, G.-E., Șchiopu, C. G., Ștefănescu, G., Mihai, C., Diaconescu, S., Afrăsânie, V. A., Lupu, V. V., Lupu, A., Boloș, A., & Ștefănescu, C. (2023) · Microorganisms · doi:10.3390/microorganisms11092268 · Cited by 20

α-Ketoglutarate for Preventing and Managing Intestinal Epithelial Dysfunction

Iniguez, A. B., Du, ‬., & Zhu, M. J. (2024) · Advances in Nutrition · doi:10.1016/j.advnut.2024.100200 · Cited by 21

Diversity of caecal bacteria is altered in interleukin-10 gene-deficient mice before and after colitis onset and when fed polyunsaturated fatty acids

Knoch, B., Nones, K., Barnett, M. P. G., McNabb, W. C., & Roy, N. C. (2010) · Microbiology · doi:10.1099/mic.0.041723-0 · Cited by 18

Transient activation of mucosal effector immune responses by resident intestinal bacteria in normal hosts is regulated by interleukin‐10 signalling

Wu, C., Sartor, R. B., Huang, K., & Tonkonogy, S. L. (2016) · Immunology · doi:10.1111/imm.12612 · Cited by 18

Microbial Physiology of the Digestive Tract and Its Role in Inflammatory Bowel Diseases

Messer, J. S., & Chang, E. B. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-809954-4.00036-0 · Cited by 19

Phosphoinositide 3-Kinase P110δ-Signaling Is Critical for Microbiota-Activated IL-10 Production by B Cells that Regulate Intestinal Inflammation

Oka, A., Mishima, Y., Liu, B., Herzog, J., Steinbach, E. C., Kobayashi, T., Plevy, S. E., & Sartor, R. B. (2019) · Cells · doi:10.3390/cells8101121 · Cited by 18

Infection with murine gammaherpesvirus 68 exacerbates inflammatory bowel disease in IL-10-deficient mice

Nelson, D. A., Petty, C. C., & Bost, K. L. (2009) · Inflammation Research · doi:10.1007/s00011-009-0059-x · Cited by 18

The Yin and Yang of host-commensal mutualism

Tchaptchet, S., & Hansen, J. J. (2011) · Gut Microbes · doi:10.4161/gmic.19089 · Cited by 22

Microbial Sensing by the Intestinal Epithelium in the Pathogenesis of Inflammatory Bowel Disease

Scharl, M. M., & Rogler, G. (2010) · International Journal of Inflammation · doi:10.4061/2010/671258 · Cited by 18

Effects of kiwifruit extracts on colonic gene and protein expression levels in IL-10 gene-deficient mice

Edmunds, S. J., Roy, N. C., Davy, M. W., Cooney, J. M., Barnett, M. P. G., Zhu, S., Park, Z. A., Love, D. R., & Laing, W. A. (2011) · British Journal Of Nutrition · doi:10.1017/s0007114511005241 · Cited by 18

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Kanmani, P., Ansari, A., Villena, J., & Kim, H. (2019) · Journal of Immunology Research · doi:10.1155/2019/3876896 · Cited by 18

Potential therapeutic role for cytokine or adhesion molecule manipulation in Crohn's disease: in the shadow of infliximab?

Shand, A. G., & Forbes, A. (2003) · International Journal of Colorectal Disease · doi:10.1007/s00384-002-0431-6 · Cited by 18

NECROTIZING ENTEROCOLITIS AND HEMATOPOIETIC CYTOKINES

Ledbetter, D. J., & Juul, S. E. (2000) · Clinics in Perinatology · doi:10.1016/s0095-5108(05)70046-4 · Cited by 18

The gut microbiota predicts and time-restricted feeding delays experimental colitis

Ruple, H. K., Haasis, E., Bettenburg, A., Maier, C., Fritz, C., Schüle, L., Löcker, S., Soltow, Y., Schintgen, L., Schmidt, N. S., et al. (2025) · Gut Microbes · doi:10.1080/19490976.2025.2453019 · Cited by 18

OTUD3 prevents ulcerative colitis by inhibiting microbiota-mediated STING activation

Li, B., Sakaguchi, T., Tani, H., Ito, T., Murakami, M., Okumura, R., Kobayashi, M., Okuzaki, D., Motooka, D., Ikeuchi, H., et al. (2025) · Science Immunology · doi:10.1126/sciimmunol.adm6843 · Cited by 17

The effect of a hydrolyzed protein diet on the fecal microbiota in cats with chronic enteropathy

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Current Status and Prospects of Intestinal Microbiome Studies

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Complementary and alternative medicine and gastrointestinal diseases

Haas, L., McClain, C. J., & Varilek, G. W. (2000) · Current Opinion in Gastroenterology · doi:10.1097/00001574-200003000-00016 · Cited by 17

Anti-Saccharomyces cerevisiae antibodies in inflammatory bowel disease

Norman, G. L. (2001) · Clinical and Applied Immunology Reviews · doi:10.1016/s1529-1049(01)00040-x · Cited by 17

Recent Progress in Engineering Human-Associated Microbiomes

Yaung, S. J., Church, G. M., & Wang, H. H. (2014) · Methods in molecular biology · doi:10.1007/978-1-4939-0554-6_1 · Cited by 16

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Wun, K., Theriault, B. R., Pierre, J. F., Chen, E. B., Leone, V., Harris, K. G., Xiong, L., Jiang, Q., Spedale, M., Eskandari, O. M., et al. (2018) · PLoS ONE · doi:10.1371/journal.pone.0208426 · Cited by 17

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Rath, H. C. (2003) · European Journal of Gastroenterology & Hepatology · doi:10.1097/00042737-200306000-00006 · Cited by 17

Nod2 is required for antigen-specific humoral responses against antigens orally delivered using a recombinant Lactobacillus vaccine platform

Bumgardner, S., Zhang, L., LaVoy, A. S., Andre, B., Frank, C., Kajikawa, A., Klaenhammer, T. R., & Dean, G. A. (2018) · PLoS ONE · doi:10.1371/journal.pone.0196950 · Cited by 17

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Ulcerative Colitis

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Lipopolysaccharide Induces CD25-Positive, IL-10-Producing Lymphocytes Without Secretion of Proinflammatory Cytokines in the Human Colon: Low MD-2 mRNA Expression in Colonic Macrophages

Shirai, Y., Hashimoto, M., Kato, R., Kawamura, Y. I., Kirikae, T., Yano, H., Takashima, J., Kirihara, Y., Saitō, Y., Fujino, M., et al. (2004) · Journal of Clinical Immunology · doi:10.1023/b:joci.0000018062.01980.ba · Cited by 17

Resident enteric bacteria are necessary for development of spontaneous colitis and immune system activation in interleukin-10-deficient mice. Infect. Immun

Sellon, R. K., Tonkonogy, S. L., Schultz, M., Rennick, M., Sartor, R. B., Schultz, M., Dieleman, L. A., Grenther, W. B., & Rennick, D. M. (1998)

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Variable phenotypes of enterocolitis in interleukin 10-deficient mice monoassociated with two different commensal bacteria

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