Cited by 1,483Inflammatory Bowel DiseaseGut microbiota and healthT-cell and B-cell Immunology

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Resident Enteric Bacteria Are Necessary for Development of Spontaneous Colitis and Immune System Activation in Interleukin-10-Deficient Mice

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Sellon, Rance K., Tonkonogy, Susan, Schultz, Michael, Dieleman, Levinus A., Grenther, Wetonia, Balish, Ed, Rennick, Donna M., Sartor, R. Balfour·1998·Infection and Immunity

DOI 10.1128/iai.66.11.5224-5231.1998PMC PMC108652

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Abstract

Mice with targeted deletion of the gene for interleukin-10 (IL-10) spontaneously develop enterocolitis when maintained in conventional conditions but develop only colitis when kept in specific-pathogen-free (SPF) environments. This study tested the hypothesis that enteric bacteria are necessary for the development of spontaneous colitis and immune system activation in IL-10-deficient mice. IL-10-deficient mice were maintained in either SPF conditions or germfree conditions or were populated with bacteria known to cause colitis in other rodent models. IL-10-deficient mice kept in SPF conditions developed colitis in all segments of the colon (cecum and proximal and distal colon). These mice exhibited immune system activation as evidenced by increased expression of CD44 on CD4 + T cells; increased mesenteric lymph node cell numbers; and increased production of immunoglobulin A (IgA), IgG1, and IL-12 p40 from colon fragment cultures. Mice populated with bacterial strains, including Bacteroides vulgatus , known to induce colitis in other rodent models had minimal colitis. Germfree IL-10-deficient mice had no evidence of colitis or immune system activation. We conclude therefore that resident enteric bacteria are necessary for the development of spontaneous colitis and immune system activation in IL-10-deficient mice.

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Interleukin-10-deficient mice develop chronic enterocolitis
Kühn, R., Löhler, J., Rennick, D. M., Rajewsky, K., & Müller, W. (1993) · Cell · doi:10.1016/0092-8674(93)80068-p · Cited by 4,248
Self-citation
IL-10 inhibits cytokine production by activated macrophages
Fiorentino, D. F., Zlotnik, A., Mosmann, T. R., Howard, M., & O’Garra, A. (1991) · The Journal of Immunology · doi:10.4049/jimmunol.147.11.3815 · Cited by 2,888
CD44 is the principal cell surface receptor for hyaluronate
Aruffo, A. A., Stamenkovic, I., Melnick, M., Underhill, C. B., & Seed, B. (1990) · Cell · doi:10.1016/0092-8674(90)90694-a · Cited by 2,439
Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation.
Cella, M., Scheidegger, D., Palmer-Lehmann, K., Lane, P. J. L., Lanzavecchia, A., & Alber, G. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.184.2.747 · Cited by 1,982
Interleukin-10
Moore, K. W., O’Garra, A., Malefyt, R. D. W., Vieira, P., & Mosmann, T. R. (1993) · Annual Review of Immunology · doi:10.1146/annurev.iy.11.040193.001121 · Cited by 1,883
IL-10 acts on the antigen-presenting cell to inhibit cytokine production by Th1 cells
Fiorentino, D. F., Zlotnik, A., Vieira, P., Mosmann, T. R., Howard, M., Moore, K. W., & O’Garra, A. (1991) · The Journal of Immunology · doi:10.4049/jimmunol.146.10.3444 · Cited by 1,866
Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene
Sadlack, B., Merz, H., Schorle, H., Schimpl, A., Feller, A. C., & Horak, I. D. (1993) · Cell · doi:10.1016/0092-8674(93)80067-o · Cited by 1,744
Identification of a monoclonal antibody specific for a murine T3 polypeptide.
Léo, O., Foo, M., Sachs, D. H., Samelson, L. E., & Bluestone, J. A. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.5.1374 · Cited by 1,596
Interleukin 10 (IL-10) inhibits human lymphocyte interferon gamma-production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells.
D’Andrea, A., Aste-Amézaga, M., Valiante, N. M., Ma, X., Kubin, M. Z., & Trinchieri, G. (1993) · The Journal of Experimental Medicine · doi:10.1084/jem.178.3.1041 · Cited by 1,367
Antibodies to interleukin 12 abrogate established experimental colitis in mice.
Neurath, M., Fuss, I. J., Kelsall, B. L., Stuber, E. R., & Strober, W. (1995) · The Journal of Experimental Medicine · doi:10.1084/jem.182.5.1281 · Cited by 1,334

Show all 56 references

Research works printed but not linked: 1

MacDonald T. T. Carter P. B. Contact sensitivity in germfree mice.J. Reticuloendothel. Soc.241978287293

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Kobayashi, T., Matsuoka, K., Sheikh, S. Z., Russo, S. M., Mishima, Y., Collins, C. B., de Zoeten, E. F., Karp, C. L., Ting, J. P. ‐., Sartor, R. B., et al. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1200042 · Cited by 83
Self-citation
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Wang, H., Meng, R., Li, Z., Yang, B., Liu, Y., Huang, F., Zhang, J., Chen, H., & Wu, C. Y. (2010) · Immunology Letters · doi:10.1016/j.imlet.2010.11.007 · Cited by 88
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Kolling, G. L., Wu, M., & Guerrant, R. L. (2012) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2012.00114 · Cited by 84
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Cuív, P. Ó., de Wouters, T., Giri, R., Mondot, S., Smith, W. J. M., Blottière, H. M., Begun, J., & Morrison, M. (2017) · Anaerobe · doi:10.1016/j.anaerobe.2017.06.002 · Cited by 81
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Bristol, I. J., Farmer, M. A., Cong, Y., Zheng, X. X., Strom, T. B., Elson, C. O., Sundberg, J. P., & Leiter, E. H. (2000) · Inflammatory Bowel Diseases · doi:10.1002/ibd.3780060407 · Cited by 81
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Toyonaga, T., Matsuura, M., Mori, K., Honzawa, Y., Minami, N., Yamada, S., Kobayashi, T., Hibi, T., & Nakase, H. (2016) · Scientific Reports · doi:10.1038/srep35014 · Cited by 75
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Mann, E. A., & Saeed, S. A. (2011) · Current Opinion in Gastroenterology · doi:10.1097/mog.0b013e32834c453e · Cited by 79
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Meißner, Y., & Lamprecht, A. (2007) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.21216 · Cited by 78
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Toro-Londoño, M., Bedoya-Urrego, K., García-Montoya, G., Galván-Díaz, A. L., & Álzate, J. F. (2019) · PeerJ · doi:10.7717/peerj.6200 · Cited by 84
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Kole, A., & Maloy, K. J. (2014) · Current topics in microbiology and immunology · doi:10.1007/978-3-662-43492-5_2 · Cited by 79
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He, Q., Wang, L., Wang, F., Wang, C., Tang, C. X., Li, Q., Li, J., & Zhao, Q. (2013) · BMC Microbiology · doi:10.1186/1471-2180-13-289 · Cited by 77
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Paassen, N. B., Loonen, L. M. P., Witte‐Bouma, J., Male, A. K.-V., de Bruijn, A. C. J. M., van der Sluis, M., Lü, P., van Goudoever, J. B., Wells, J. M., Dekker, J. P., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0038798 · Cited by 77
Propionibacterium freudenreichii component 1.4-dihydroxy-2-naphthoic acid (DHNA) attenuates dextran sodium sulphate induced colitis by modulation of bacterial flora and lymphocyte homing
Okada, Y., Tsuzuki, Y., Miyazaki, J., Matsuzaki, K., Hokari, R., Komoto, S., Kato, S., Kawaguchi, A., Nagao, S., Itoh, K., et al. (2005) · Gut · doi:10.1136/gut.2005.070490 · Cited by 77
Dichotomy between Lactobacillus rhamnosus and Klebsiella pneumoniae on dendritic cell phenotype and function
Braat, H., de Jong, E. C., van den Brande, J. M. H., Kapsenberg, M. L., Peppelenbosch, M. P., van Tol, E. A. F., & van Deventer, S. J. H. (2003) · Journal of Molecular Medicine · doi:10.1007/s00109-003-0509-9 · Cited by 77
Molecular Cloning of aBacteroides caccaeTonB-Linked Outer Membrane Protein Identified by an Inflammatory Bowel Disease Marker Antibody
Wei, B., Dalwadi, H. N., Gordon, L. K., Landers, C. J., Bruckner, D. A., Targan, S. R., & Braun, J. G. (2001) · Infection and Immunity · doi:10.1128/iai.69.10.6044-6054.2001 · Cited by 77
Role of bacteria in the etiopathogenesis of inflammatory bowel disease
Barnich, N. (2007) · World Journal of Gastroenterology · doi:10.3748/wjg.v13.i42.5571 · Cited by 77
The genetic jigsaw of inflammatory bowel disease
Watts, D., & Satsangi, J. (2002) · Gut · doi:10.1136/gut.50.suppl_3.iii31 · Cited by 77
The Nature of Inflammatory Bowel Disease in Patients With Coexistent Colonic Diverticulosis
Sultan, K. S., Fields, S. W., Panagopoulos, G., & Korelitz, B. I. (2006) · Journal of Clinical Gastroenterology · doi:10.1097/01.mcg.0000210095.44123.6d · Cited by 76

Authors: Sellon, R. K., Tonkonogy, S., Schultz, M., Dieleman, L. A., Grenther, W., Balish, E., Rennick, D. M., & Sartor, R. B.
Affiliations: Department of Companion Animal and Special Species1 and
North Carolina State University (US)
University of North Carolina at Chapel Hill (US)
Departments of Surgery and Microbiology, University of Wisconsin, Madison, Wisconsin,4 and
Department of Immunology, DNAX Corporation, Palo Alto, California5
ORCID: Schultz, Michael
Dieleman, Levinus A.
Sartor, R. Balfour
Venue: Infection and Immunity
Publisher: American Society for Microbiology
Published: 1998-11
Volume: 66
Issue: 11
Pages: 5224-5231
ISSN: 0019-9567 (ISSN-L)
1098-5522
DOI: 10.1128/iai.66.11.5224-5231.1998
PMC: PMC108652
OpenAlex: W2165528446
Cited by: 1,483
References: 56
Citations by year: 2026: 24 · 2025: 26 · 2024: 37 · 2023: 34 · 2022: 48 · 2021: 48 · 2020: 42 · 2019: 71 · 2018: 61 · 2017: 55 · 2016: 61 · 2015: 73 · 2014: 89 · 2013: 77 · 2012: 70
FWCI: 15.03
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Infection and Immunity (publishedVersion)
PubMed Central (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Keywords: interleukin-10 deficiency, spontaneous colitis, enteric bacteria, germ-free mice, specific pathogen-free mice, immune activation, Bacteroides vulgatus, CD4+ T cells, CD44, mesenteric lymph nodes, immunoglobulin A, IL-12p40
MeSH terms: Animals, Colitis, Disease Models, Animal, Enterobacteriaceae, Immune System, Inflammation, Intestine, Large, Lymphocyte Activation, Mice, Inbred C57BL, Specific Pathogen-Free Organisms, Interleukin-10, Mice, Knockout, Mice

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Resident Enteric Bacteria Are Necessary for Development of Spontaneous Colitis and Immune System Activation in Interleukin-10-Deficient Mice

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