Resident Enteric Bacteria Are Necessary for Development of Spontaneous Colitis and Immune System Activation in Interleukin-10-Deficient Mice

Interleukin-10-deficient mice develop chronic enterocolitis

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Autocrine action of IL-10 suppresses proinflammatory mediators and inflammation in the HSV-1-infected cornea

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IL-17-driven induction of Paneth cell antimicrobial functions protects the host from microbiota dysbiosis and inflammation in the ileum

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Comparative Variation within the Genome of Campylobacter jejuni NCTC 11168 in Human and Murine Hosts

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Diet, gut microbes, and genetics in immune function: can we leverage our current knowledge to achieve better outcomes in inflammatory bowel diseases?

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Antibiotics exacerbated colitis by affecting the microbiota, Treg cells and SCFAs in IL10-deficient mice

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Environmental Microbial Factors Determine the Pattern of Inflammatory Lesions in a Murine Model of Crohn’s Disease–Like Inflammation

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Genetically engineered mucin mouse models for inflammation and cancer

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Alterations to chromatin in intestinal macrophages link IL‐10 deficiency to inappropriate inflammatory responses

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Colon lamina propria dendritic cells induce a proinflammatory cytokine response in lamina propria T cells in the SCID mouse model of colitis

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Colitic Scid Mice Fed Lactobacillus spp. Show an Ameliorated Gut Histopathology and an Altered Cytokine Profile by Local T Cells

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Immunogenicity and pathogenicity of Helicobacter infections of veterinary animals

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Mouse models of colorectal cancer

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Lack of Interleukin-10-Mediated Anti-Inflammatory Signals and Upregulated Interferon Gamma Production Are Linked to Increased Intestinal Epithelial Cell Apoptosis in Pathogenic Simian Immunodeficiency Virus Infection

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Osteopontin Deficiency Accelerates Spontaneous Colitis in Mice with Disrupted Gut Microbiota and Macrophage Phagocytic Activity

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Microbial–Host Interactions in Inflammatory Bowel Diseases and Experimental Colitis

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Network Pharmacology and Molecular Docking Analysis on Molecular Mechanism of Qingzi Zhitong Decoction in the Treatment of Ulcerative Colitis

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Characterization of T‐regulatory cells, induced by immature dendritic cells, which inhibit enteroantigen‐reactive colitis‐inducing T‐cell responses in vitro and in vivo

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Guillain Barré Syndrome is induced in Non-Obese Diabetic (NOD) mice following Campylobacter jejuni infection and is exacerbated by antibiotics

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Gut microbiota in chronic inflammatory disorders: A focus on pediatric inflammatory bowel diseases and juvenile idiopathic arthritis

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Interferon-gamma (IFN-γ) and prostaglandin E2 (PGE2) regulate differently IL-12 production in human intestinal lamina propria mononuclear cells (LPMC)

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Microflora reactive IL-10 producing regulatory T cells are present in the colon of IL-2 deficient mice but lack efficacious inhibition of IFN-γ and TNF-α production

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KSR1 Protects From Interleukin-10 Deficiency-Induced Colitis in Mice by Suppressing T-Lymphocyte Interferon-γ Production

Goettel, J. A., Algood, H. M. S., Olivares–Villagómez, D., Washington, M. K., Chaturvedi, R., Wilson, K. T., Kaer, L. V., & Polk, D. B. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.09.041 · Cited by 29

Colonic Expression of the Peptide Transporter PEPT1 Is Downregulated During Intestinal Inflammation and Is Not Required for NOD2-dependent Immune Activation

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Akkermansia deficiency and mucin depletion are implicated in intestinal barrier dysfunction as earlier event in the development of inflammation in interleukin-10-deficient mice

López-Cauce, B., Puerto, M., García‐Rodríguez, J. J., Alonso, M. P., Becerra-Aparicio, F., del Campo, R., Peligros, I., Fernández‐Aceñero, M. J., Gómez-Navarro, Y., de Lara, J. M. T., et al. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.1083884 · Cited by 31

Intestinal Immune Regulation as a Potential Diet-Modifiable Feature of Gut Inflammation and Autoimmunity

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Host gene expression in the colon of gnotobiotic interleukin-2-deficient mice colonized with commensal colitogenic or noncolitogenic bacterial strains: Common patterns and bacteria strain specific signatures

Bohn, E., Bechtold, O., Zahir, N., Frick, J.-S., Reimann, J., Jilge, B., & Autenrieth, I. B. (2006) · Inflammatory Bowel Diseases · doi:10.1097/01.mib.0000231574.73559.75 · Cited by 30

PPARδ agonist enhances colitis-associated colorectal cancer

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Amelioration of Murine Colitis by Feeding a Solution of LysedEscherichia coli

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Novel Players in Inflammatory Bowel Disease Pathogenesis

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Introducing Murine Microbiome Database (MMDB): A Curated Database with Taxonomic Profiling of the Healthy Mouse Gastrointestinal Microbiome

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Crypt residing bacteria and proximal colonic carcinogenesis in a mouse model of Lynch syndrome

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Gut microbiota shape the inflammatory response in mice with an epithelial defect

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Review article: distinctions between ileal and colonic Crohn's disease: from physiology to pathology

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Therapeutic effect of Lactobacillus plantarum JS19 on mice with dextran sulfate sodium induced acute and chronic ulcerative colitis

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Biotin Deficiency Induces Intestinal Dysbiosis Associated with an Inflammatory Bowel Disease-like Phenotype

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Induction of chronic colitis in IL-10 deficient mice requires IL-4

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The dual nature of interleukin-10 in pemphigus vulgaris

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Targeted 25-hydroxyvitamin D3 1α-hydroxylase Adoptive Gene Therapy Ameliorates DSS-induced Colitis Without Causing Hypercalcemia in Mice

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Fate of Goblet Cells in Experimental Colitis

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Species-specific oligonucleotide probes for the detection and identification ofLactobacillusisolated from mouse faeces

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Intestinal E. coli-produced yersiniabactin promotes profibrotic macrophages in Crohn’s disease

Ahn, J.-H., Pedrosa, M. D. S., Lopez, L. R., Tibbs, T., Jeyachandran, J. N., Vignieri, E. E., Rothemich, A., Cumming, I., Irmscher, A. D., Haswell, C. J., et al. (2024) · Cell Host & Microbe · doi:10.1016/j.chom.2024.11.012 · Cited by 30

Inhibition of Interleukin-10 Signaling Induces Microbiota-dependent Chronic Colitis in Apolipoprotein E Deficient Mice

Singh, V., Kumar, M., Yeoh, B. S., Xiao, X., Saha, P., Kennett, M. J., & Vijay–Kumar, M. (2016) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000699 · Cited by 28

The gut microbiota and gut disease

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D-Tryptophan suppresses enteric pathogen and pathobionts and prevents colitis by modulating microbial tryptophan metabolism

Seki, N., Kimizuka, T., Gondo, M., Yamaguchi, G., Sugiura, Y., Akiyama, M., Yakabe, K., Uchiyama, J., Higashi, S., Haneda, T., et al. (2022) · iScience · doi:10.1016/j.isci.2022.104838 · Cited by 29

Crohn’s disease in endoscopic remission, obesity, and cases of high genetic risk demonstrate overlapping shifts in the colonic mucosal-luminal interface microbiome

Jacobs, J. P., Goudarzi, M., Lagishetty, V., Li, D., Mak, T. D., Tong, M., Ruegger, P. M., Haritunians, T., Landers, C. J., Fleshner, P. R., et al. (2022) · Genome Medicine · doi:10.1186/s13073-022-01099-7 · Cited by 29

Antibiotic Therapy for Crohn’s Disease: A Review

Lal, S., & Steinhart, A. H. (2006) · Canadian Journal of Gastroenterology · doi:10.1155/2006/250490 · Cited by 28

Intestinal Epithelial-Derived TAK1 Signaling Is Essential for Cytoprotection against Chemical-Induced Colitis

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Disruption of Pten Speeds Onset and Increases Severity of Spontaneous Colitis in Il10−/− Mice

Im, E., Jung, J., Pothoulakis, C., & Rhee, S. H. (2014) · Gastroenterology · doi:10.1053/j.gastro.2014.05.034 · Cited by 28

Gene Expression Profiling Identifies Mechanisms of Protection to Recurrent Trinitrobenzene Sulfonic Acid Colitis Mediated by Probiotics

Mariman, R., Kremer, B. H. A., van Erk, M., Lagerweij, T., Koning, F., & Nagelkerken, L. M. (2011) · Inflammatory Bowel Diseases · doi:10.1002/ibd.22849 · Cited by 28

MAG-EPA reduces severity of DSS-induced colitis in rats

Morin, C., Blier, P. U., & Fortin, S. (2016) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00136.2015 · Cited by 28

Probiotic Bacteria and Enteric Infections

Paton, A., Morona, R., & Paton, J. (2011) · Springer eBooks · doi:10.1007/978-94-007-0386-5 · Cited by 30

Antibiotic Treatment Induces Long-lasting Changes in the Fecal Microbiota that Protect Against Colitis

Ward, N. L., Phillips, C. D., Nguyen, D. D., Shanmugam, N. K. N., Song, Y., Hodin, R. A., Shi, H. N., Cherayil, B. J., & Goldstein, A. M. (2016) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000914 · Cited by 27

Interleukin-4 and Interleukin-10 Gene Polymorphisms in Patients with Inflammatory Bowel Disease

Daryani, N. E., Saghazadeh, A., Moossavi, S., Sadr, M., Shahkarami, S., Soltani, S., Farhadi, E., & Rezaei, N. (2017) · Immunological Investigations · doi:10.1080/08820139.2017.1360343 · Cited by 28

Environment as a Critical Factor for the Pathogenesis and Outcome of Gastrointestinal Disease: Experimental and Human Inflammatory Bowel Disease and Helicobacter-Induced Gastritis

Bleich, A., & Mähler, M. (2005) · Pathobiology · doi:10.1159/000091327 · Cited by 28

Staphylococcal Enterotoxin B Stimulates Expansion of Autoreactive T Cells That Induce Apoptosis in Intestinal Epithelial Cells: Regulation of Autoreactive Responses by IL-10

Ito, K., Takaishi, H., Jin, Y., Song, F., Denning, T. L., & Ernst, P. B. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.6.2994 · Cited by 28

AMPK is essential for IL-10 expression and for maintaining balance between inflammatory and cytoprotective signaling

Guragain, D., Gurung, P., Chang, J., Katila, N., Chang, H. W., Jeong, B., Choi, D., & Kim, J. (2020) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2020.129631 · Cited by 27

Gut-associated cGMP mediates colitis and dysbiosis in a mouse model of an activating mutation in GUCY2C

Mishra, V., Bose, A., Kiran, S., Banerjee, S., Shah, I. A., Chaukimath, P., Reshi, M. M., Srinivas, S., Barman, A., & Visweswariah, S. S. (2021) · The Journal of Experimental Medicine · doi:10.1084/jem.20210479 · Cited by 27

Panax notoginseng Alleviates Colitis via the Regulation of Gut Microbiota

Wang, L., Shao, L., Chen, M., Wang, L., Yang, P., Tan, F., Zhang, W., & Huang, W. (2022) · The American Journal of Chinese Medicine · doi:10.1142/s0192415x23500076 · Cited by 27

Association with Selected Bacteria Does Not Cause Enterocolitis in IL-10 Gene-Deficient Mice Despite a Systemic Immune Response

Sydora, B. C., Tavernini, M. M., Doyle, J. S. G., & Fedorak, R. N. (2005) · Digestive Diseases and Sciences · doi:10.1007/s10620-005-2663-0 · Cited by 27

1,4-Dihydroxy-2-naphthoic acid fromPropionibacterium freudenreichiireduces inflammation in interleukin-10-deficient mice with colitis by suppressing macrophage-derived proinflammatory cytokines

Okada, Y., Tsuzuki, Y., Narimatsu, K., Sato, H., Ueda, T., Hozumi, H., Sato, S., Hokari, R., Kurihara, C., Komoto, S., et al. (2013) · Journal of Leukocyte Biology · doi:10.1189/jlb.0212104 · Cited by 27

The effect of intestinal alkaline phosphatase on intestinal epithelial cells, macrophages and chronic colitis in mice

Lee, C., Chun, J., Hwang, S. W., Kang, S. J., Im, J. P., & Kim, J. S. (2014) · Life Sciences · doi:10.1016/j.lfs.2014.02.003 · Cited by 27

Efficacy profiles for different concentrations ofLactobacillus acidophilusin experimental colitis

Chen, L.-L. (2013) · World Journal of Gastroenterology · doi:10.3748/wjg.v19.i32.5347 · Cited by 27

The role of Blastocystis hominis in the activation of ulcerative colitis

Kök, M., Çekın, Y., Çekın, A. H., Uyar, S., Harmandar, F. A., & Şahintürk, Y. (2018) · The Turkish Journal of Gastroenterology · doi:10.5152/tjg.2018.18498 · Cited by 27

Abnormalities in the handling of intracellular bacteria in Crohn’s disease: a link between infectious etiology and host genetic susceptibility

Glasser, A.-L., & Darfeuille–Michaud, A. (2008) · Archivum Immunologiae et Therapiae Experimentalis · doi:10.1007/s00005-008-0026-1 · Cited by 29

Probiotics for the maintenance of remission in Crohn's disease

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Colorectal Cancer in Inflammatory Bowel Disease: A Review of the Role of Gut Microbiota and Bacterial Biofilms in Disease Pathogenesis

Pedrogo, D. A. M., Sears, C. L., & Melia, J. (2024) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjae061 · Cited by 30

Mouse adaptation of human inflammatory bowel diseases microbiota enhances colonization efficiency and alters microbiome aggressiveness depending on the recipient colonic inflammatory environment

Gray, S. M., Moss, A. D., Herzog, J., Kashiwagi, S., Liu, B., Young, J. B., Sun, S., Bhatt, A. P., Fodor, A. A., & Sartor, R. B. (2024) · Microbiome · doi:10.1186/s40168-024-01857-2 · Cited by 26

Helicobacter saguini, a Novel Helicobacter Isolated from Cotton-Top Tamarins with Ulcerative Colitis, Has Proinflammatory Properties and Induces Typhlocolitis and Dysplasia in Gnotobiotic IL-10 −/− Mice

Shen, Z., Mannion, A. J., Whary, M. T., Muthupalani, S., Sheh, A., Feng, Y., Gong, G., Vandamme, P. A. R., Holcombe, H. R., Paster, B. J., et al. (2016) · Infection and Immunity · doi:10.1128/iai.00235-16 · Cited by 26

Induction of cellular and molecular immunomodulatory pathways by vitamin A and flavonoids

Patel, S. P., & Vajdy, M. (2015) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.2015.1066331 · Cited by 26

Animal models of intestinal inflammation: ineffective communication between coalition members

Lorenz, R. G., McCracken, V. J., & Elson, C. O. (2005) · Springer Seminars in Immunopathology · doi:10.1007/s00281-005-0208-4 · Cited by 26

Efficacy of antibiotic combination therapy in patients with active ulcerative colitis, including refractory or steroid‐dependent cases

Uehara, T., Kato, K., Ohkusa, T., Sugitani, M., Ishii, Y., Nemoto, N., & Moriyama, M. (2010) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2010.06231.x · Cited by 26

The Role of Neuropeptides in Mouse Models of Colitis

Padua, D. M., Vu, J. P., Germano, P. M., & Pisegna, J. R. (2015) · Journal of Molecular Neuroscience · doi:10.1007/s12031-015-0688-1 · Cited by 26

Rifaximin is an effective alternative to metronidazole for the treatment of chronic enteropathy in dogs: a randomised trial

Menozzi, A., Dall’Aglio, M., Quintavalla, F., Dallavalle, L., Meucci, V., & Bertini, S. (2016) · BMC Veterinary Research · doi:10.1186/s12917-016-0851-0 · Cited by 26

Comparative Effect of the I3.1 Probiotic Formula in Two Animal Models of Colitis

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