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Lactobacilli and Streptococci Induce Interleukin-12 (IL-12), IL-18, and Gamma Interferon Production in Human Peripheral Blood Mononuclear Cells
Open accessAbstract
Human peripheral blood mononuclear cells (PBMC) were stimulated with three nonpathogenic Lactobacillus strains and with one pathogenic Streptococcus pyogenes strain, and cytokine gene expression and protein production were analyzed. All bacteria strongly induced interleukin-1β (IL-1β), IL-6, and tumor necrosis factor alpha mRNA expression and protein production.S. pyogenes was the most potent inducer of secretion of IL-12 and gamma interferon (IFN-γ), and two of three Lactobacillus strains induced IL-12 and IFN-γ production. All strains induced IL-18 protein production. IL-10 and IL-4 production was induced weakly and not at all, respectively. Our data show that nonpathogenic lactobacilli and pathogenic streptococci can induce Th1 type cytokines IL-12, IL-18, and IFN-γ in human PBMC.
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de Waal Malefyt, R., Abrams, J., Bennett, B., Figdor, C. G., & de Vries, J. E. (1991) · The Journal of experimental medicine · doi:10.1084/jem.174.5.1209 · Cited by 3,762
Cited by
Probiotic potential of Lactobacillus strains isolated from dairy products
Maragkoudakis, P. A., Zoumpopoulou, G., Miaris, C., Kalantzopoulos, G., Pot, B., & Tsakalidou, E. (2006) · International Dairy Journal · doi:10.1016/j.idairyj.2005.02.009 · Cited by 618
Mechanisms of action of probiotics: Recent advances
Ng, S. C., Hart, A. L., Kamm, M. A., Stagg, A. J., & Knight, S. C. (2009) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20602 · Cited by 596
Adolfsson, O., Meydani, S. N., & Russell, R. M. (2004) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/80.2.245 · Cited by 531
Borchers, A. T., Selmi, C., Meyers, F. J., Keen, C. L., & Gershwin, M. E. (2009) · Journal of Gastroenterology · doi:10.1007/s00535-008-2296-0 · Cited by 499
Viljanen, M., Savilahti, E., Haahtela, T., Juntunen‐Backman, K., Korpela, R., Poussa, T., Tuure, T., & Kuitunen, M. (2005) · Allergy · doi:10.1111/j.1398-9995.2004.00514.x · Cited by 478
Metadata
- Authors
- Miettinen, M., Matikainen, S., Vuopio-Varkila, J., Pirhonen, J., Varkila, K., Kurimoto, M., & Julkunen, I.
- Venue
- Infection and Immunity
- Publisher
- American Society for Microbiology
- Published
- 1998-12
- Volume
- 66
- Issue
- 12
- Pages
- 6058-6062
- ISSN
- 0019-9567 (ISSN-L)
- 1098-5522
- OpenAlex
- W1896084611
- Cited by
- 343
- References
- 1
- FWCI
- 26.23
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Lactobacilli and Streptococci Induce Interleukin-12 (IL-12), IL-18, and Gamma Interferon Production in Human Peripheral Blood Mononuclear Cells. https://app.cochat.ai/papers/10.1128/iai.66.12.6058-6062.1998
- The paper
- Miettinen, M., Matikainen, S., Vuopio-Varkila, J., Pirhonen, J., Varkila, K., Kurimoto, M., & Julkunen, I. (1998). Lactobacilli and Streptococci Induce Interleukin-12 (IL-12), IL-18, and Gamma Interferon Production in Human Peripheral Blood Mononuclear Cells. Infection and Immunity. https://doi.org/10.1128/iai.66.12.6058-6062.1998
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