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M-Cell Surface β1 Integrin Expression and Invasin-Mediated Targeting of Yersinia pseudotuberculosis to Mouse Peyer’s Patch M Cells
Open accessAbstract
Quantitative analysis of Yersinia pseudotuberculosis infection of murine gut loops revealed that significantly more wild-type bacteria associated with Peyer’s patch M cells than with dome enterocytes or goblet cells. An invasin-deficient mutant was significantly attenuated for M-cell invasion, while β1 integrin expression was demonstrated in the apical membranes of M cells but not enterocytes. M-cell targeting by Yersinia pseudotuberculosis in vivo may, therefore, be mediated primarily by the interaction of invasin with cell surface β1 integrins.
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Metadata
- Authors
- Clark, M. A., Hirst, B. H., & Jepson, M. A.
- Venue
- Infection and Immunity
- Publisher
- American Society for Microbiology
- Published
- 1998-03
- Volume
- 66
- Issue
- 3
- Pages
- 1237-1243
- ISSN
- 0019-9567 (ISSN-L)
- 1098-5522
- OpenAlex
- W2126197220
- Cited by
- 363
- References
- 0
- FWCI
- 10.62
- Type
- journal article
- Language
- en
- Open access
- bronze
- Licence
- journals.asm.org/non-commercial-tdm-license (tdm)
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- CoChat. (2026). Citation check: M-Cell Surface β1 Integrin Expression and Invasin-Mediated Targeting of Yersinia pseudotuberculosis to Mouse Peyer’s Patch M Cells. https://app.cochat.ai/papers/10.1128/iai.66.3.1237-1243.1998
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- Clark, M. A., Hirst, B. H., & Jepson, M. A. (1998). M-Cell Surface β1 Integrin Expression and Invasin-Mediated Targeting of Yersinia pseudotuberculosis to Mouse Peyer’s Patch M Cells. Infection and Immunity. https://doi.org/10.1128/iai.66.3.1237-1243.1998
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