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M-Cell Surface β1 Integrin Expression and Invasin-Mediated Targeting of Yersinia pseudotuberculosis to Mouse Peyer’s Patch M Cells

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Clark, M. Ann, Hirst, Barry H., Jepson, Mark A.·1998·Infection and Immunity

Abstract

Quantitative analysis of Yersinia pseudotuberculosis infection of murine gut loops revealed that significantly more wild-type bacteria associated with Peyer’s patch M cells than with dome enterocytes or goblet cells. An invasin-deficient mutant was significantly attenuated for M-cell invasion, while β1 integrin expression was demonstrated in the apical membranes of M cells but not enterocytes. M-cell targeting by Yersinia pseudotuberculosis in vivo may, therefore, be mediated primarily by the interaction of invasin with cell surface β1 integrins.

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Metadata

Authors
Clark, M. A., Hirst, B. H., & Jepson, M. A.
Venue
Infection and Immunity
Published
1998-03
Volume
66
Issue
3
Pages
1237-1243
ISSN
  • 0019-9567 (ISSN-L)
  • 1098-5522
OpenAlex
W2126197220
Cited by
363
References
0
FWCI
10.62
Type
journal article
Language
en
Open access
bronze
Licence
journals.asm.org/non-commercial-tdm-license (tdm)

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CoChat. (2026). Citation check: M-Cell Surface β1 Integrin Expression and Invasin-Mediated Targeting of Yersinia pseudotuberculosis to Mouse Peyer’s Patch M Cells. https://app.cochat.ai/papers/10.1128/iai.66.3.1237-1243.1998
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Clark, M. A., Hirst, B. H., & Jepson, M. A. (1998). M-Cell Surface β1 Integrin Expression and Invasin-Mediated Targeting of Yersinia pseudotuberculosis to Mouse Peyer’s Patch M Cells. Infection and Immunity. https://doi.org/10.1128/iai.66.3.1237-1243.1998

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