The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Local Chemokine Paralysis, a Novel Pathogenic Mechanism for Porphyromonas gingivalis
Open accessAbstract
Periodontitis, which is widespread in the adult population, is a persistent bacterial infection associated with Porphyromonas gingivalis. Gingival epithelial cells are among the first cells encountered by both P. gingivalis and commensal oral bacteria. The chemokine interleukin 8 (IL-8), a potent chemoattractant and activator of polymorphonuclear leukocytes, was secreted by gingival epithelial cells in response to components of the normal oral flora. In contrast,P. gingivalis was found to strongly inhibit IL-8 accumulation from gingival epithelial cells. Inhibition was associated with a decrease in mRNA for IL-8. Antagonism of IL-8 accumulation did not occur in KB cells, an epithelial cell line that does not support high levels of intracellular invasion by P. gingivalis. Furthermore, a noninvasive mutant of P. gingivalis was unable to antagonize IL-8 accumulation. Invasion-dependent destruction of the gingival IL-8 chemokine gradient at sites of P. gingivalis colonization (local chemokine paralysis) will severely impair mucosal defense and represents a novel mechanism for bacterial colonization of host tissue.
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Cites
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Cited by
The Oral Microbiota: Dynamic Communities and Host Interactions
Lamont, R. J., Koo, H., & Hajishengallis, G. (2018) · Nature Reviews Microbiology · doi:10.1038/s41579-018-0089-x · Cited by 2,217
The keystone-pathogen hypothesis
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Self-citationPeriodontitis: a polymicrobial disruption of host homeostasis
Darveau, R. P. (2010) · Nature Reviews Microbiology · doi:10.1038/nrmicro2337 · Cited by 1,688
Self-citationHajishengallis, G., & Lamont, R. J. (2012) · Molecular Oral Microbiology · doi:10.1111/j.2041-1014.2012.00663.x · Cited by 1,267
Self-citationHajishengallis, G., Liang, S., Payne, M. A., Hashim, A., Jotwani, R., Eskan, M. A., McIntosh, M. L., Alsam, A., Kirkwood, K. L., Lambris, J. D., et al. (2011) · Cell Host & Microbe · doi:10.1016/j.chom.2011.10.006 · Cited by 1,154
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Metadata
- Authors
- Darveau, R. P., Belton, C. M., Reife, R. A., & Lamont, R. J.
- Venue
- Infection and Immunity
- Publisher
- American Society for Microbiology
- Published
- 1998-04
- Volume
- 66
- Issue
- 4
- Pages
- 1660-1665
- ISSN
- 0019-9567 (ISSN-L)
- 1098-5522
- OpenAlex
- W2137486650
- Cited by
- 344
- References
- 40
- FWCI
- 20.63
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Local Chemokine Paralysis, a Novel Pathogenic Mechanism for Porphyromonas gingivalis. https://app.cochat.ai/papers/10.1128/iai.66.4.1660-1665.1998
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- Darveau, R. P., Belton, C. M., Reife, R. A., & Lamont, R. J. (1998). Local Chemokine Paralysis, a Novel Pathogenic Mechanism for Porphyromonas gingivalis. Infection and Immunity. https://doi.org/10.1128/iai.66.4.1660-1665.1998
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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