Pseudomonas aeruginosa lasR Transcription Correlates with the Transcription of lasA , lasB , and toxA in Chronic Lung Infections Associated with Cystic Fibrosis

Storey, Douglas G.; Ujack, Eva E.; Rabin, Harvey R.; Mitchell, Ian

doi:10.1128/iai.66.6.2521-2528.1998

Cited by 138Bacterial biofilms and quorum sensingCystic Fibrosis Research AdvancesPlant Pathogenic Bacteria Studies

Pseudomonas aeruginosa lasR Transcription Correlates with the Transcription of lasA , lasB , and toxA in Chronic Lung Infections Associated with Cystic Fibrosis

Open access

Storey, Douglas G., Ujack, Eva E., Rabin, Harvey R., Mitchell, Ian·1998·Infection and Immunity

DOI 10.1128/iai.66.6.2521-2528.1998PMC PMC108233

Open this paper in CoChat — free account

Abstract

The role of Pseudomonas aeruginosa quorum-sensing systems in the lung infections associated with cystic fibrosis (CF) has not been examined. The purpose of this study was to determine if genes regulated by the LasR-LasI quorum-sensing system were coordinately regulated by the P. aeruginosa populations during the lung infections associated with CF. We also wanted to ascertain if there was a relationship between the expression of lasR , a transcriptional regulator, and some P. aeruginosa virulence factors during these infections. We extracted RNAs from the bacterial populations of 131 sputa taken from 23 CF patients. These RNAs were blotted and hybridized with probes to P. aeruginosa lasA , lasB , and toxA . The hybridization signals from each probe were ranked, and the rankings were analyzed by a Spearman rank correlation to determine if there was an association between the population transcript accumulations for the three genes. The correlations between the transcript accumulation patterns of pairs of the genes suggested that lasA , lasB , and toxA might be coordinately regulated during CF lung infections. To determine if this coordinate regulation might be due to regulation by LasR, we probed RNAs, extracted from 84 sputa, with the lasR , lasA , lasB , toxA , and algD probes. Statistical analysis indicated that lasR transcript accumulation correlated to lasA , lasB , toxA , and algD transcript accumulations. These results indicated that lasR may at least partially regulate or be coordinately regulated with lasA , lasB , toxA , and algD during the lung infections associated with CF. These results also suggested that the LasR-LasI quorum-sensing system may control the expression of at least some virulence factors in the lungs of patients with CF.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1128/iai.66.6.2521-2528.1998

Cites

50 of 50 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

LasI-LasR and RhlI-RhlR have been shown to regulate the expression of virulence factors such as exoenzyme S (ExoS) and exotoxin A (ToxA) which can further induce apoptosis in macrophages and neutrophils.
“LasI-LasR and RhlI-RhlR have been shown to regulate the expression of virulence factors such as exoenzyme S (ExoS) and exotoxin A (ToxA) which can further induce apoptosis in macrophages and neutrophils [33], [34], [35], [36].”
From Interactions of Methicillin Resistant Staphylococcus aureus USA300 and Pseudomonas aeruginosa in Polymicrobial Wound Infection (2013) · cites this paper as [35]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

CENSUS AND CONSENSUS IN BACTERIAL ECOSYSTEMS: The LuxR-LuxI Family of Quorum-Sensing Transcriptional Regulators
Fuqua, C., Winans, S. C., & Greenberg, E. P. (1996) · Annual Review of Microbiology · doi:10.1146/annurev.micro.50.1.727 · Cited by 1,217 · see citing works
Structure of the autoinducer required for expression of Pseudomonas aeruginosa virulence genes.
Pearson, J. P., Gray, K. M., Passador, L., Tucker, K. D., Eberhard, A., Iglewski, B. H., & Greenberg, E. P. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.1.197 · Cited by 992 · see citing works
Structural identification of autoinducer of Photobacterium fischeri luciferase
Eberhard, A., Burlingame, A. L., Eberhard, C., Kenyon, G. L., Nealson, K. H., & Oppenheimer, N. J. (1981) · Biochemistry · doi:10.1021/bi00512a013 · Cited by 985 · see citing works
Bacterial bioluminescence: Isolation and genetic analysis of functions from Vibrio fischeri
Engebrecht, J., Nealson, K. H., & Silverman, M. R. (1983) · Cell · doi:10.1016/0092-8674(83)90063-6 · Cited by 907 · see citing works
Regulation of las and rhl quorum sensing in Pseudomonas aeruginosa
Pesci, E. C., Pearson, J. P., Seed, P. C., & Iglewski, B. H. (1997) · Journal of Bacteriology · doi:10.1128/jb.179.10.3127-3132.1997 · Cited by 892 · see citing works
Expression of Pseudomonas aeruginosa Virulence Genes Requires Cell-to-Cell Communication
Passador, L., Cook, J. M., Gambello, M. J., et al. (1993) · Science · doi:10.1126/science.8493556 · Cited by 876 · see citing works
Environmental signals controlling expression of virulence determinants in bacteria
Mekalanos, J. J. (1992) · Journal of Bacteriology · doi:10.1128/jb.174.1.1-7.1992 · Cited by 796 · see citing works
A second N-acylhomoserine lactone signal produced by Pseudomonas aeruginosa.
Pearson, J. P., Passador, L., Iglewski, B. H., & Greenberg, E. P. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.5.1490 · Cited by 786 · see citing works
A hierarchical quorum‐sensing cascade in Pseudomonas aeruginosa links the transcriptional activators LasR and RhIR (VsmR) to expression of the stationary‐phase sigma factor RpoS
Latifi, A., Foglino, M., Tanaka, K., et al. (1996) · Molecular Microbiology · doi:10.1046/j.1365-2958.1996.00063.x · Cited by 727 · see citing works
Cloning and characterization of the Pseudomonas aeruginosa lasR gene, a transcriptional activator of elastase expression
Gambello, M. J., & Iglewski, B. H. (1991) · Journal of Bacteriology · doi:10.1128/jb.173.9.3000-3009.1991 · Cited by 710 · see citing works
CYSTIC FIBROSIS: GENOTYPIC AND PHENOTYPIC VARIATIONS
Zielenski, J., & Tsui, L. (1995) · Annual Review of Genetics · doi:10.1146/annurev.ge.29.120195.004021 · Cited by 636 · see citing works
Identification of genes and gene products necessary for bacterial bioluminescence.
Engebrecht, J., & Silverman, M. R. (1984) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.81.13.4154 · Cited by 627 · see citing works
Coordinate Regulation and Sensory Transduction in the Control of Bacterial Virulence
Miller, J. F., Mekalanos, J. J., & Falkow, S. (1989) · Science · doi:10.1126/science.2537530 · Cited by 607 · see citing works
Synthesis of multiple exoproducts in Pseudomonas aeruginosa is under the control of RhlR-RhlI, another set of regulators in strain PAO1 with homology to the autoinducer-responsive LuxR-LuxI family
Brint, J. M., & Ohman, D. E. (1995) · Journal of Bacteriology · doi:10.1128/jb.177.24.7155-7163.1995 · Cited by 579 · see citing works
Autoinducer-mediated regulation of rhamnolipid biosurfactant synthesis in Pseudomonas aeruginosa.
Ochsner, U. A., & Reiser, J. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.14.6424 · Cited by 579 · see citing works
Multiple N-acyl-L-homoserine lactone signal molecules regulate production of virulence determinants and secondary metabolites in Pseudomonas aeruginosa.
Winson, M. K., Cámara, M., Latifi, A., et al. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.20.9427 · Cited by 539 · see citing works
A LuxR-LuxI type regulatory system activates Agrobacterium Ti plasmid conjugal transfer in the presence of a plant tumor metabolite
Fuqua, W. C., & Winans, S. C. (1994) · Journal of Bacteriology · doi:10.1128/jb.176.10.2796-2806.1994 · Cited by 499 · see citing works
Multiple homologues of LuxR and LuxI control expression of virulence determinants and secondary metabolites through quorum sensing in Pseudomonas aeruginosa PAO1
Latifi, A., Winson, M. K., Foglino, M., et al. (1995) · Molecular Microbiology · doi:10.1111/j.1365-2958.1995.mmi_17020333.x · Cited by 492 · see citing works
The lux autoinducer regulates the production of exoenzyme virulence determinants in Erwinia carotovora and Pseudomonas aeruginosa.
Jones, S., Yu, B., Bainton, N. J., et al. (1993) · The EMBO Journal · doi:10.1002/j.1460-2075.1993.tb05902.x · Cited by 466 · see citing works
A small diffusible signal molecule is responsible for the global control of virulence and exoenzyme production in the plant pathogen Erwinia carotovora.
Pirhonen, M., Flego, D., Heikinheimo, R., & Palva, E. T. (1993) · The EMBO Journal · doi:10.1002/j.1460-2075.1993.tb05901.x · Cited by 457 · see citing works
Agrobacterium conjugation and gene regulation by N-acyl-L-homoserine lactones
Zhang, L., Murphy, P. J., Kerr, A., & Tate, M. E. (1993) · Nature · doi:10.1038/362446a0 · Cited by 441 · see citing works
Contribution of specific Pseudomonas aeruginosa virulence factors to pathogenesis of pneumonia in a neonatal mouse model of infection
Tang, H. B., DiMango, E., Bryan, R. A., Gambello, M. J., Iglewski, B. H., Goldberg, J. B., & Prince, A. S. (1996) · Infection and Immunity · doi:10.1128/iai.64.1.37-43.1996 · Cited by 401 · see citing works
LasR of Pseudomonas aeruginosa is a transcriptional activator of the alkaline protease gene (apr) and an enhancer of exotoxin A expression
Gambello, M. J., Kaye, S., & Iglewski, B. H. (1993) · Infection and Immunity · doi:10.1128/iai.61.4.1180-1184.1993 · Cited by 383 · see citing works
Activation of the Pseudomonas aeruginosa lasI gene by LasR and the Pseudomonas autoinducer PAI: an autoinduction regulatory hierarchy
Seed, P. C., Passador, L., & Iglewski, B. H. (1995) · Journal of Bacteriology · doi:10.1128/jb.177.3.654-659.1995 · Cited by 344 · see citing works
Isolation and characterization of Pseudomonas aeruginosa PAO mutant that produces altered elastase
Ohman, D. E., Cryz, S. J., & Iglewski, B. H. (1980) · Journal of Bacteriology · doi:10.1128/jb.142.3.836-842.1980 · Cited by 342 · see citing works
Isolation, characterization, and expression in Escherichia coli of the Pseudomonas aeruginosa rhlAB genes encoding a rhamnosyltransferase involved in rhamnolipid biosurfactant synthesis.
Ochsner, U. A., Fiechter, A., & Reiser, J. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)32089-6 · Cited by 341 · see citing works
Capsular polysaccharide biosynthesis and pathogenicity in Erwinia stewartii require induction by an N-acylhomoserine lactone autoinducer
von Bodman, S. B., & Farrand, S. K. (1995) · Journal of Bacteriology · doi:10.1128/jb.177.17.5000-5008.1995 · Cited by 292 · see citing works
Inactivation of rsmA leads to overproduction of extracellular pectinases, cellulases, and proteases in Erwinia carotovora subsp. carotovora in the absence of the starvation/cell density-sensing signal, N-(3-oxohexanoyl)-L-homoserine lactone
Chatterjee, A., Cui, Y., Liu, Y. J., et al. (1995) · Applied and Environmental Microbiology · doi:10.1128/aem.61.5.1959-1967.1995 · Cited by 287 · see citing works
A general role for the lux autoinducer in bacterial cell signalling: control of antibiotic biosynthesis in Erwinia
Bainton, N. J., Bycroft, B. W., Chhabra, S. R., et al. (1992) · Gene · doi:10.1016/0378-1119(92)90633-z · Cited by 262 · see citing works
Epidemiology Of Chronic Pseudomonas aeruginosa Infections In Cystic Fibrosis
Römling, U., Fiedler, B., Boßhammer, J., et al. (1994) · The Journal of Infectious Diseases · doi:10.1093/infdis/170.6.1616 · Cited by 256 · see citing works
TraI, a LuxI homologue, is responsible for production of conjugation factor, the Ti plasmid N-acylhomoserine lactone autoinducer.
Hwang, I., Li, P. L., Zhang, L., et al. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.11.4639 · Cited by 226 · see citing works
Identification of a global repressor gene, rsmA, of Erwinia carotovora subsp. carotovora that controls extracellular enzymes, N-(3-oxohexanoyl)-L-homoserine lactone, and pathogenicity in soft-rotting Erwinia spp
Cui, Y., Chatterjee, A., Liu, Y. J., et al. (1995) · Journal of Bacteriology · doi:10.1128/jb.177.17.5108-5115.1995 · Cited by 225 · see citing works
Pseudomonas aeruginosa LasA: a second elastase under the transcriptional control of lasR
Toder, D. S., Gambello, M. J., & Iglewski, B. H. (1991) · Molecular Microbiology · doi:10.1111/j.1365-2958.1991.tb00822.x · Cited by 189 · see citing works
Carbapenem antibiotic production in Erwinia carotovora is regulated by CarR, a homologue of the LuxR transcriptional activator
McGowan, S. J., Sebaihia, M., Jones, S., et al. (1995) · Microbiology · doi:10.1099/13500872-141-3-541 · Cited by 174 · see citing works
Bacteriocin small of Rhizobium leguminosarum belongs to the class of N-acyl-L-homoserine lactone molecules, known as autoinducers and as quorum sensing co-transcription factors
Schripsema, J., de Rudder, K. E. E., van Vliet, T. B., et al. (1996) · Journal of Bacteriology · doi:10.1128/jb.178.2.366-371.1996 · Cited by 169 · see citing works
Cell-to-cell signaling in the symbiotic nitrogen-fixing bacterium Rhizobium leguminosarum: autoinduction of a stationary phase and rhizosphere-expressed genes
Gray, K. M., Pearson, J. P., Downie, J. A., et al. (1996) · Journal of Bacteriology · doi:10.1128/jb.178.2.372-376.1996 · Cited by 163 · see citing works
Characterization and Use of a DNA Probe as an Epidemiological Marker for Pseudomonas aeruginosa
Ogle, J. W., Janda, J. M., Woods, D. E., et al. (1987) · The Journal of Infectious Diseases · doi:10.1093/infdis/155.1.119 · Cited by 161 · see citing works
Sputum changes associated with therapy for endobronchial exacerbation in cystic fibrosis
Smith, A. L., Redding, G. J., Doershuk, C. F., et al. (1988) · The Journal of Pediatrics · doi:10.1016/s0022-3476(88)80165-3 · Cited by 146 · see citing works
Antibodies to Proteases and Exotoxin A of Pseudomonas aeruginosa in Patients with Cystic Fibrosis: Demonstration by Radioimmunoassay
Klinger, J. D., Straus, D. C., Hilton, C. B., et al. (1978) · The Journal of Infectious Diseases · doi:10.1093/infdis/138.1.49 · Cited by 129 · see citing works
Prospective study of serum antibodies to Pseudomonas aeruginosa exoproteins in cystic fibrosis
Hollsing, A. E., Granström, M., Vasil, M. L., et al. (1987) · Journal of Clinical Microbiology · doi:10.1128/jcm.25.10.1868-1874.1987 · Cited by 100 · see citing works
Relation between Antibody Response to Pseudomonas aeruginosa Exoproteins and Colonization/Infection in Patients with Cystic Fibrosis
Granström, M., Ericsson, A., Strandvik, B., et al. (1984) · Acta Paediatrica · doi:10.1111/j.1651-2227.1984.tb17774.x · Cited by 76 · see citing works
Differential regulation by iron of regA and toxA transcript accumulation in Pseudomonas aeruginosa
Frank, D. W., Storey, D. G., Hindahl, M. S., & Iglewski, B. H. (1989) · Journal of Bacteriology · doi:10.1128/jb.171.10.5304-5313.1989 · Cited by 70 · see citing works
Self-citation
Kinetics of toxA and regA mRNA accumulation in Pseudomonas aeruginosa
Frank, D. W., & Iglewski, B. H. (1988) · Journal of Bacteriology · doi:10.1128/jb.170.10.4477-4483.1988 · Cited by 67 · see citing works
Association of systemic immune complexes, complement activation, and antibodies to Pseudomonas aeruginosa lipopolysaccharide and exotoxin A with mortality in cystic fibrosis.
Moss, R. B., Hsu, Y. P., Lewiston, N. J., et al. (1986) · PubMed · doi:10.1164/arrd.1986.133.4.648 · Cited by 63 · see citing works
Effect of iron on accumulation of exotoxin A-specific mRNA in Pseudomonas aeruginosa
Lory, S. (1986) · Journal of Bacteriology · doi:10.1128/jb.168.3.1451-1456.1986 · Cited by 62 · see citing works
Use of a pilin gene probe to study molecular epidemiology of Pseudomonas aeruginosa
Speert, D. P., Campbell, M. E., Farmer, S. W., et al. (1989) · Journal of Clinical Microbiology · doi:10.1128/jcm.27.11.2589-2593.1989 · Cited by 57 · see citing works
Detection by enzyme-linked immunosorbent assays of antibody specific for Pseudomonas proteases and exotoxin A in sera from cystic fibrosis patients
Jagger, K. S., Robinson, D. L., Franz, M. N., et al. (1982) · Journal of Clinical Microbiology · doi:10.1128/jcm.15.6.1054-1058.1982 · Cited by 56 · see citing works
Population transcript accumulation of Pseudomonas aeruginosa exotoxin A and elastase in sputa from patients with cystic fibrosis
Storey, D. G., Ujack, E., & Rabin, H. R. (1992) · Infection and Immunity · doi:10.1128/iai.60.11.4687-4694.1992 · Cited by 40 · see citing works
Self-citation
Positive correlation of algD transcription to lasB and lasA transcription by populations of Pseudomonas aeruginosa in the lungs of patients with cystic fibrosis
Storey, D. G., Ujack, E. E., Mitchell, I., & Rabin, H. R. (1997) · Infection and Immunity · doi:10.1128/iai.65.10.4061-4067.1997 · Cited by 35 · see citing works
Self-citation
Association between transcript levels of the Pseudomonas aeruginosa regA, regB, and toxA genes in sputa of cystic fibrosis patients
Raivio, T. L., Ujack, E., Rabin, H. R., et al. (1994) · Infection and Immunity · doi:10.1128/iai.62.8.3506-3514.1994 · Cited by 15 · see citing works
Self-citation

Flagged first, then by citations

Research works printed but not linked: 2

[40]40. Ryan, B. F., and B. L. Joiner. 1994. Minitab handbook. Duxbury Press, Belmont, Calif.
[50]50. Zar, J. H. 1974. Rank correlation, p. 243-245. In W. D. McElroy and C. P. Swanson (ed.), Biostatistical analysis. Prentice-Hall, Inc., Englewood Cliffs, N.J.

Sorted by citations

Interactions of Methicillin Resistant Staphylococcus aureus USA300 and Pseudomonas aeruginosa in Polymicrobial Wound Infection
Pastar, I., Nusbaum, A. G., Gil, J., Patel, S. B., Chen, J., Valdes, J., Stojadinovic, O., Plano, L. R., Tomic-Canic, M., & Davis, S. C. (2013) · PLoS ONE · doi:10.1371/journal.pone.0056846 · Cited by 391 · see citing works
Analysis of quorum sensing-deficient clinical isolates of Pseudomonas aeruginosa
Schaber, J. A., Carty, N. L., McDonald, N. A., Graham, E. D., Cheluvappa, R., Griswold, J. A., & Hamood, A. N. (2004) · Journal of Medical Microbiology · doi:10.1099/jmm.0.45617-0 · Cited by 224 · see citing works
Pseudomonas aeruginosa secreted factors impair biofilm development in Candida albicans
Holcombe, L. J., McAlester, G., Munro, C. A., Enjalbert, B., Brown, A. J. P., Gow, N. A. R., Ding, C., Butler, G., O'Gara, F., & Morrissey, J. P. (2010) · Microbiology · doi:10.1099/mic.0.037549-0 · Cited by 82 · see citing works
Contribution of quorum sensing to the virulence of <i>Pseudomonas aeruginosa</i> in pressure ulcer infection in rats
Nakagami, G., Morohoshi, T., Ikeda, T., Ohta, Y., Sagara, H., Huang, L., Nagase, T., Sugama, J., & Sanada, H. (2011) · Wound Repair and Regeneration · doi:10.1111/j.1524-475x.2010.00653.x · Cited by 34 · see citing works

Comparison of antibiotic susceptibility patterns in Pseudomonas aeruginosa isolated from adult patients with cystic fibrosis (CF) with invasive Pseudomonas aeruginosa from non-CF patients
Rao, P., McCaughan, J., McCalmont, M., et al. (2012) · Journal of Cystic Fibrosis · doi:10.1016/j.jcf.2012.01.002 · Cited by 13 · see citing works
P119 Does pyocyanin production negatively correlate with clinical parameters in people with cystic fibrosis (PWCF) who have infection with Pseudomonas aeruginosa (Pa)?
Allen, D., Sherrard, L. J., Einarsson, G. G., et al. (2020) · Journal of Cystic Fibrosis · doi:10.1016/s1569-1993(20)30454-9
P149 Home environment as a reservoir of Pseudomonas aeruginosa infection in patients with cystic fibrosis
Siyanova, E. A., Chernukha, M. Y., Avetisyan, L. R., et al. (2023) · Journal of Cystic Fibrosis · doi:10.1016/s1569-1993(23)00524-6
P089 Synergistic activities of an efflux pump inhibitor and antibiotics against Pseudomonas aeruginosa isolates from cystic fibrosis patients
Gbian, D. L., & Omri, A. (2018) · Journal of Cystic Fibrosis · doi:10.1016/s1569-1993(18)30385-0
Polysaccharides serve as scaffold of biofilms formed by mucoidPseudomonas aeruginosa
Yang, L., Hengzhuang, W., Wu, H. W., Damkiær, S., Jochumsen, N., Song, Z., Givskov, M., Høiby, N., & Molin, S. (2012) · FEMS Immunology & Medical Microbiology · doi:10.1111/j.1574-695x.2012.00936.x · Cited by 84 · see citing works

Authors: Storey, D. G., Ujack, E. E., Rabin, H. R., & Mitchell, I.
Affiliations: Departments of Biological Sciences,1
Foothills Medical Centre (CA)
University of Calgary (CA)
ORCID: Storey, Douglas G.
Rabin, Harvey R.
Venue: Infection and Immunity
Publisher: American Society for Microbiology
Published: 1998-06
Volume: 66
Issue: 6
Pages: 2521-2528
ISSN: 0019-9567 (ISSN-L)
1098-5522
DOI: 10.1128/iai.66.6.2521-2528.1998
PMC: PMC108233
OpenAlex: W2113890225
Cited by: 138
References: 50
Citations by year: 2026: 2 · 2025: 3 · 2024: 2 · 2023: 4 · 2022: 3 · 2021: 2 · 2020: 5 · 2019: 5 · 2018: 2 · 2017: 4 · 2016: 6 · 2015: 4 · 2014: 6 · 2013: 7 · 2012: 5
FWCI: 1.40
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Infection and Immunity (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cystic Fibrosis Research Advances
Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Pathogenic Bacteria Studies
Keywords: Pseudomonas aeruginosa, LASA, lasB, ToxA, algD, virulence factors, cystic fibrosis lung infection, transcriptional regulation
MeSH terms: Pseudomonas aeruginosa Exotoxin A, Adolescent, Bacterial Proteins, Bacterial Toxins, Chronic Disease, Cystic Fibrosis, DNA-Binding Proteins, Exotoxins, Female, Half-Life, Humans, Lung Diseases, Male, Metalloendopeptidases, Nucleic Acid Hybridization, Pseudomonas Infections, Respiratory Tract Infections, RNA, Bacterial, RNA, Messenger, Sensitivity and Specificity, Transcription, Genetic, Trans-Activators, ADP Ribose Transferases, Virulence Factors

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Pseudomonas aeruginosa lasR Transcription Correlates with the Transcription of lasA , lasB , and toxA in Chronic Lung Infections Associated with Cystic Fibrosis

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks