Secreted Aspartyl Proteinases and Interactions of Candida albicans with Human Endothelial Cells

Ibrahim, Ashraf S.; Filler, Scott G.; Sanglard, Dominique; Edwards, John E.; Hube, Bernhard

doi:10.1128/iai.66.6.3003-3005.1998

Cited by 62Antifungal resistance and susceptibilityFungal and yeast genetics researchFungal Infections and Studies

Secreted Aspartyl Proteinases and Interactions of Candida albicans with Human Endothelial Cells

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Ibrahim, Ashraf S., Filler, Scott G., Sanglard, Dominique, Edwards, John E., Hube, Bernhard·1998·Infection and Immunity

DOI 10.1128/iai.66.6.3003-3005.1998PMC PMC108304

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Abstract

The endothelial cell interactions of homozygous null mutants of Candida albicans that were deficient in secreted aspartyl proteinase 1 (Sap1), Sap2, or Sap3 were investigated. Only Sap2 was found to contribute to the ability of C. albicans to damage endothelial cells and stimulate them to express E-selectin. None of the Saps studied appears to play a role in C. albicans adherence to endothelial cells.

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Different attributes, including adhesion factors, the yeast-to-hyphal transition and hydrolytic enzyme secretion, are necessary for penetration of C. albicans through epithelial and endothelial layers.
“Different attributes, among which are adhesion factors, the yeast-to-hyphal transition and hydrolytic enzyme secretion, are necessary for penetration of C. albicans through the epithelial and endothelial layers (Hube et al ., 1997;Sanglard et al ., 1997;Ibrahim et al ., 1998;Brown and Gow, 1999;Sundstrom, 1999;Ernst, 2000;Phan et al ., 2000;Felk et al ., 2002).”
From Stage‐specific gene expression of Candida albicans in human blood (2003) · cites this paper as Ibrahim et al., 1998

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The Secreted Aspartyl Proteinases Sap1 and Sap2 Cause Tissue Damage in an In Vitro Model of Vaginal Candidiasis Based on Reconstituted Human Vaginal Epithelium
Schaller, M., Bein, M., Körting, H. C., Baur, S., Hamm, G., Monod, M., Beinhauer, S., & Hube, B. (2003) · Infection and Immunity · doi:10.1128/iai.71.6.3227-3234.2003 · Cited by 190 · see citing works
Altered adherence in strains of Candida albicans harbouring null mutations in secreted aspartic proteinase genes
Watts, H. J., Cheah, F.-K., Hube, B., Sanglard, D., & Gow, N. A. R. (1998) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.1998.tb12851.x · Cited by 80 · see citing works

Authors: Ibrahim, A. S., Filler, S. G., Sanglard, D., Edwards, J. E., & Hube, B.
Affiliations: University of California, Los Angeles (US)
Centre Hospitalier Universitaire Vaudois (CH)
Universität Hamburg (DE)
ORCID: Ibrahim, Ashraf S.
Filler, Scott G.
Sanglard, Dominique
Edwards, John E.
Hube, Bernhard
Venue: Infection and Immunity
Publisher: American Society for Microbiology
Published: 1998-06
Volume: 66
Issue: 6
Pages: 3003-3005
ISSN: 0019-9567 (ISSN-L)
1098-5522
DOI: 10.1128/iai.66.6.3003-3005.1998
PMC: PMC108304
OpenAlex: W1838815905
Cited by: 62
References: 15
Citations by year: 2026: 2 · 2025: 2 · 2023: 2 · 2021: 1 · 2017: 1 · 2015: 1 · 2014: 1 · 2013: 1
FWCI: 3.01
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Infection and Immunity (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
IRIS (submittedVersion)
SERVAL (Université de Lausanne) (submittedVersion)
Funders: American Heart Association
Toyota USA
National Institutes of Health (RR00425)
National Institute of Allergy and Infectious Diseases (R01AI019990, P01AI037194)
National Center for Research Resources (MO1-RR00425, M01RR000425)
Topics: Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
Keywords: Candida albicans, secreted aspartyl proteinases, SAP-1, SAP2, endothelial cells, fungal adhesion, endothelial injury, knockout mutants
MeSH terms: Candida albicans, Cell Adhesion, Endothelium, Vascular, Fungal Proteins, Humans, Aspartic Acid Endopeptidases, E-Selectin

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Secreted Aspartyl Proteinases and Interactions of Candida albicans with Human Endothelial Cells

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