Relationship between Candida albicans Virulence during Experimental Hematogenously Disseminated Infection and Endothelial Cell Damage In Vitro
Open accessAbstract
Candida albicans must penetrate the endothelial cell lining of the vasculature to invade the deep tissues during a hematogenously disseminated infection. We compared 27 C. albicans mutants with their wild-type parent for their capacity to damage endothelial cells in vitro and cause a lethal infection in mice following tail vein inoculation. Of 10 mutants with significantly impaired capacity to damage endothelial cells, all had attenuated virulence. Therefore, the endothelial cell damage assay can be used as a screen to identify some virulence factors relevant to hematogenously disseminated candidiasis.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
C. albicans mutants with defects in the signal transduction pathways that govern hyphal formation have a significantly reduced capacity to invade both endothelial and oral epithelial cells in vitro.
“We have found previously that C. albicans mutants with defects in the signal transduction pathways that govern hyphal formation have a significantly reduced capacity to invade both endothelial and oral epithelial cells in vitro [5][6][7].”
From Als3 Is a Candida albicans Invasin That Binds to Cadherins and Induces Endocytosis by Host Cells (2007) · cites this paper as [6]
The passage labeled Abstract says that mutants in hyphal-formation signaling pathways have impaired endothelial-cell damage and reports that two strains have reduced capacity to invade endothelial cells. It does not address invasion of oral epithelial cells, and its statement of reduced endothelial invasion does not specify statistical significance. (LLM, conf=0.87)
Experimental — accuracy not yet measuredHost cell invasion and damage are likely critical virulence attributes of C. albicans because mutants with defects in these processes in vitro are highly likely to have attenuated virulence in experimental animal models of hematogenously disseminated or oropharyngeal candidiasis.
“Host cell invasion and damage are likely critical virulence attributes of C. albicans because mutants with defects in these processes in vitro are highly likely to have attenuated virulence in experimental animal models of hematogenously disseminated or oropharyngeal candidiasis [5][6][7][8].”
From Als3 Is a Candida albicans Invasin That Binds to Cadherins and Induces Endocytosis by Host Cells (2007) · cites this paper as [6]
Split into 2 atoms — 1 confirmed, 1 partially supported, 0 disputed, 0 misattributed, 0 unverifiable. Expand the claim to see per-atom verdicts.
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Nonfilamentous C. albicans Mutants Are Avirulent
Lo, H.-J., Köhler, J. R., DiDomenico, B., Loebenberg, D., Cacciapuoti, A., & Fink, G. R. (1997) · Cell · doi:10.1016/s0092-8674(00)80358-x · Cited by 1,809 · see citing works
Isogenic strain construction and gene mapping in Candida albicans.
Fonzi, W. A., & Irwin, M. Y. (1993) · Genetics · doi:10.1093/genetics/134.3.717 · Cited by 1,695 · see citing works
Yeast-enhanced green fluorescent protein (yEGFP): a reporter of gene expression in Candida albicans
Cormack, B. P., Bertram, G., Egerton, M., Gow, N. A. R., Falkow, S., & Brown, A. J. P. (1997) · Microbiology · doi:10.1099/00221287-143-2-303 · Cited by 593 · see citing works
Linkage of adhesion, filamentous growth, and virulence in Candida albicans to a single gene, INT1.
Gale, C. A., Bendel, C. M., McClellan, M., Hauser, M., Becker, J. M., Berman, J., & Hostetter, M. K. (1998) · Science · doi:10.1126/science.279.5355.1355 · Cited by 356 · see citing works
Hube, B., Sanglard, D., Odds, F. C., Hess, D., Monod, M., Schäfer, W., Brown, A. J. P., & Gow, N. A. R. (1997) · Infection and Immunity · doi:10.1128/iai.65.9.3529-3538.1997 · Cited by 311 · see citing works
Identification and Characterization of <i>TUP1</i>-Regulated Genes in <i>Candida albicans</i>
Braun, B. R., Head, W. S., Wang, M. X., & Johnson, A. D. (2000) · Genetics · doi:10.1093/genetics/156.1.31 · Cited by 306 · see citing works
RIM101-Dependent and -Independent Pathways Govern pH Responses in Candida albicans
Davis, D. A., Wilson, R. B., & Mitchell, A. P. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.3.971-978.2000 · Cited by 285 · see citing works
Self-citationKöhler, J. R., & Fink, G. R. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.23.13223 · Cited by 283 · see citing works
Sanglard, D., Hube, B., Monod, M., Odds, F. C., & Gow, N. A. R. (1997) · Infection and Immunity · doi:10.1128/iai.65.9.3539-3546.1997 · Cited by 282 · see citing works
Candida albicans RIM101 pH Response Pathway Is Required for Host-Pathogen Interactions
Davis, D. A., Edwards, J. E., Mitchell, A. P., & Ibrahim, A. S. (2000) · Infection and Immunity · doi:10.1128/iai.68.10.5953-5959.2000 · Cited by 276 · see citing works
Self-citation<i>PHR1</i> , a pH-Regulated Gene of <i>Candida albicans</i> , is Required for Morphogenesis
Saporito-Irwin, S. M., Birse, C. E., Sypherd, P. S., & Fonzi, W. A. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.2.601 · Cited by 264 · see citing works
Brown, D. H., Jr., Giusani, A. D., Chen, X., & Kumamoto, C. A. (1999) · Molecular Microbiology · doi:10.1046/j.1365-2958.1999.01619.x · Cited by 262 · see citing works
Schweizer, A., Rupp, S., Taylor, B. N., Röllinghoff, M., & Schröppel, K. (2000) · Molecular Microbiology · doi:10.1046/j.1365-2958.2000.02132.x · Cited by 232 · see citing works
Cloning and Sequencing of a Candida albicans Catalase Gene and Effects of Disruption of This Gene
Wysong, D. R., Christin, L., Sugar, A. M., Robbins, P. W., & Diamond, R. D. (1998) · Infection and Immunity · doi:10.1128/iai.66.5.1953-1961.1998 · Cited by 201 · see citing works
Virulence and hyphal formation of Candida albicans require the Ste20p-like protein kinase CaCla4p
Leberer, E., Ziegelbauer, K. B., Schmidt, A., Harcus, D., Dignard, D., Ash, J., Johnson, L., & Thomas, D. Y. (1997) · Current Biology · doi:10.1016/s0960-9822(06)00252-1 · Cited by 193 · see citing works
Protein kinase A encoded by TPK2 regulates dimorphism of Candida albicans
Sonneborn, A., Bockmühl, D. P., Gerads, M., Kurpanek, K., Sanglard, D., & Ernst, J. F. (2000) · Molecular Microbiology · doi:10.1046/j.1365-2958.2000.01705.x · Cited by 187 · see citing works
Davis, D. A., Bruno, V. M., Loza, L., Filler, S. G., & Mitchell, A. P. (2002) · Genetics · doi:10.1093/genetics/162.4.1573 · Cited by 184 · see citing works
Self-citationPenetration and damage of endothelial cells by Candida albicans
Filler, S. G., Swerdloff, J. N., Hobbs, C., & Luckett, P. M. (1995) · Infection and Immunity · doi:10.1128/iai.63.3.976-983.1995 · Cited by 184 · see citing works
Self-citationRole of Hyphal Formation in Interactions of <i>Candida albicans</i> with Endothelial Cells
Phan, Q. T., Belanger, P. H., & Filler, S. G. (2000) · Infection and Immunity · doi:10.1128/iai.68.6.3485-3490.2000 · Cited by 181 · cited 3× · see citing works
“with endothelial cells isolated from human umbilical cord veins, as described previously (24).”
BackgroundMethodInfluentialSelf-citationVirulence genes in the pathogenic yeastCandida albicans
Navarro-García, F., Sánchez, M., Nombela, C., & Plá, J. (2001) · FEMS Microbiology Reviews · doi:10.1111/j.1574-6976.2001.tb00577.x · Cited by 170 · see citing works
Sharkey, L. L., McNemar, M. D., Saporito-Irwin, S. M., Sypherd, P. S., & Fonzi, W. A. (1999) · Journal of Bacteriology · doi:10.1128/jb.181.17.5273-5279.1999 · Cited by 168 · see citing works
Multiple Functions of Pmt1p-mediated ProteinO-Mannosylation in the Fungal Pathogen Candida albicans
Timpel, C., Strahl-Bolsinger, S., Ziegelbauer, K., & Ernst, J. F. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.33.20837 · Cited by 161 · see citing works
Rotrosen, D., Edwards, J. E., Gibson, T. R., Moore, J. C., Cohen, A. H., & Green, I. (1985) · Journal of Infectious Diseases · doi:10.1093/infdis/152.6.1264 · Cited by 146 · see citing works
Self-citationTsuchimori, N., Sharkey, L. L., Fonzi, W., French, S., Edwards, J., & Filler, S. (2000) · Infection and Immunity · doi:10.1128/iai.68.4.1997-2002.2000 · Cited by 138 · see citing works
Self-citationAdherence and penetration of vascular endothelium by Candida yeasts
Klotz, S. A., Drutz, D. J., Harrison, J. L., & Huppert, M. (1983) · Infection and Immunity · doi:10.1128/iai.42.1.374-384.1983 · Cited by 136 · see citing works
Sundstrom, P., Cutler, J., & Staab, J. (2002) · Infection and Immunity · doi:10.1128/iai.70.6.3281-3283.2002 · Cited by 128 · see citing works
Lane, S., Zhou, S., Pan, T., Dai, Q., & Liu, H. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.19.6418-6428.2001 · Cited by 118 · see citing works
Timpel, C., Zink, S., Strahl‐Bolsinger, S., Schröppel, K., & Ernst, J. F. (2000) · Journal of Bacteriology · doi:10.1128/jb.182.11.3063-3071.2000 · Cited by 101 · see citing works
URA3 as a selectable marker for disruption and virulence assessment of Candida albicans genes
Staab, J. F., & Sundstrom, P. (2003) · Trends in Microbiology · doi:10.1016/s0966-842x(02)00029-x · Cited by 96 · see citing works
Ura-status-dependent adhesion of Candida albicans mutants
Bain, J. M., Stubberfield, C. R., & Gow, N. A. R. (2001) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.2001.tb10905.x · Cited by 63 · see citing works
Ibrahim, A. S., Filler, S. G., Sanglard, D., Edwards, J. E., & Hube, B. (1998) · Infection and Immunity · doi:10.1128/iai.66.6.3003-3005.1998 · Cited by 62 · see citing works
Candida albicans Stimulates Endothelial Cell Eicosanoid Production
Filler, S. G., Ibe, B. O., Luckett, P. M., Raj, J. U., & Edwards, J. E. (1991) · The Journal of Infectious Diseases · doi:10.1093/infdis/164.5.928 · Cited by 60 · see citing works
Self-citationEndothelial cell contraction increases Candida adherence to exposed extracellular matrix
Klotz, S. A., & Maca, R. D. (1988) · Infection and Immunity · doi:10.1128/iai.56.9.2495-2498.1988 · Cited by 52 · see citing works
Burgert, S. J., Classen, D. C., Burke, J. P., & Blatter, D. D. (1995) · Clinical Infectious Diseases · doi:10.1093/clinids/21.1.202 · Cited by 46 · see citing works
Fratti, R. A., Ghannoum, M. A., Edwards, J. E., & Filler, S. G. (1996) · Infection and Immunity · doi:10.1128/iai.64.11.4714-4718.1996 · Cited by 46 · see citing works
Self-citationBelanger, P. H., Johnston, D. A., Fratti, R. A., Zhang, M., & G. Filler, S. (2002) · Cellular Microbiology · doi:10.1046/j.1462-5822.2002.00232.x · Cited by 34 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Als3 Is a Candida albicans Invasin That Binds to Cadherins and Induces Endocytosis by Host Cells
Phan, Q. T., Myers, C. L., Fu, Y., Sheppard, D. C., Yeaman, M. R., Welch, W. H., Ibrahim, A. S., Edwards, J. E., & Filler, S. G. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050064 · Cited by 641 · see citing works
Self-citationGenetic control of Candida albicans biofilm development
Finkel, J. S., & Mitchell, A. P. (2010) · Nature Reviews Microbiology · doi:10.1038/nrmicro2475 · Cited by 613 · see citing works
Self-citationCritical Role of Bcr1-Dependent Adhesins in C. albicans Biofilm Formation In Vitro and In Vivo
Nobile, C. J., Andes, D. R., Nett, J. E., Smith, F. J., Yue, F., Phan, Q.-T., Edwards, J. E., Filler, S. G., & Mitchell, A. P. (2006) · PLoS Pathogens · doi:10.1371/journal.ppat.0020063 · Cited by 507 · see citing works
“CAI4-URA3 ura3D::kimm434 ARG4::pARG4-URA3 [38]”
BackgroundSelf-citationRegulation of Cell-Surface Genes and Biofilm Formation by the C. albicans Transcription Factor Bcr1p
Nobile, C. J., & Mitchell, A. P. (2005) · Current Biology · doi:10.1016/j.cub.2005.05.047 · Cited by 464 · see citing works
Self-citationLin, L., Ibrahim, A., Xu, X., Farber, J., Avanesian, V., Baquir, B., Fu, Y., French, S., Edwards, J., & Spellberg, B. (2009) · PLoS Pathogens · doi:10.1371/journal.ppat.1000703 · Cited by 479 · see citing works
“albicans [6,50,51], as evidenced by the superior efficacy seen in the current study with another clinical bloodstream isolate of C.”
BackgroundSelf-citationDispersion as an Important Step in the Candida albicans Biofilm Developmental Cycle
Uppuluri, P., Chaturvedi, A. K., Srinivasan, A., Banerjee, M., Ramasubramaniam, A. K., Köhler, J. R., Kadosh, D., & Lopez-Ribot, J. L. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1000828 · Cited by 432 · see citing works
“albicans biofilms display enhanced adhesion to endothelial cells and cause increased endothelial cell damage Establishment of metastatic foci of infection of Candida species, a critical step in the pathogenesis of deep organ candidiasis, is presumably dependent on the fungus traversing the vascular endothelium [41,42].”
BackgroundFunction of <i>Candida albicans</i> Adhesin Hwp1 in Biofilm Formation
Nobile, C. J., Nett, J. E., Andes, D. R., & Mitchell, A. P. (2006) · Eukaryotic Cell · doi:10.1128/ec.00194-06 · Cited by 395 · see citing works
“HWP1) (20), CAI4-URA3 (reference strain) (15), CAYF178U (als3/als3)”
Self-citationCandida albicans Als3, a multifunctional adhesin and invasin
Liu, Y., & Filler, S. G. (2011) · Eukaryotic Cell · doi:10.1128/ec.00279-10 · Cited by 354 · see citing works
“albicans mutants with impaired capacity to invade and damage host cells in vitro frequently have attenuated virulence in murine models of oropharyngeal and hematogenously disseminated candidiasis (12, 39, 43, 51, 61).”
BackgroundSelf-citationHost Cell Invasion and Virulence Mediated by Candida albicans Ssa1
Sun, J. N., Solis, N. V., Phan, Q. T., Bajwa, J. S., Kashleva, H., Thompson, A., Liu, Y., Dongari-Bagtzoglou, A., Edgerton, M., & Filler, S. G. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1001181 · Cited by 220 · see citing works
“The virulence of the various strains was tested in the mouse model of hematogenously disseminated candidiasis as described previously [26].”
BackgroundSelf-citationPark, H., Myers, C. L., Sheppard, D. C., Phan, Q. T., Sanchez, A. A., E. Edwards, J., & Filler, S. G. (2004) · Cellular Microbiology · doi:10.1111/j.1462-5822.2004.00476.x · Cited by 207 · see citing works
“Fu (Sanchez et al., 2004) HLC67 efg1D::hisG/efg1D::hisG G.”
MethodInfluentialSelf-citationThewes, S., Kretschmar, M., Park, H., Schaller, M., Filler, S. G., & Hube, B. (2007) · Molecular Microbiology · doi:10.1111/j.1365-2958.2007.05614.x · Cited by 140 · see citing works
“To induce haematogenously disseminated candidiasis, male Balb/C mice were infected via the lateral tail vein with 5 ¥ 105 blastospores of C. albicans as previously described (Sanchez et al., 2004).”
MethodSelf-citationAspergillus fumigatus MedA governs adherence, host cell interactions and virulence
Gravelat, F., Ejzykowicz, D. E., Chiang, L. Y., Chabot, J., Urb, M., Macdonald, K., al-Bader, N., Filler, S., & Sheppard, D. C. (2009) · Cellular Microbiology · doi:10.1111/j.1462-5822.2009.01408.x · Cited by 144 · see citing works
“…sexual development often directly regulate the expression of key virulence factors (Lo et al., 1997; Lengeler et al., 2000; Phan et al., 2000; Sonneborn et al., 2000; Bahn and Sundstrom, 2001, Felk et al., 2002; Fu et al., 2002; Garcia-Sanchez et al., 2004; Sanchez et al., 2004; Park et al., 2005).”
BackgroundSelf-citationDijck, P. V., Sjollema, J., Cammue, B. P. A., Lagrou, K., Berman, J. G., d’Enfert, C., Andes, D. R., Arendrup, M. C., Brakhage, A. A., Calderone, R., et al. (2018) · Microbial Cell · doi:10.15698/mic2018.07.638 · Cited by 129 · see citing works
“as well as other fungal pathogens [292-294].”
Self-citationRequirement for Candida albicans Sun41 in Biofilm Formation and Virulence
Norice, C. T., Smith, F. J., Solis, N. V., Filler, S. G., & Mitchell, A. P. (2007) · Eukaryotic Cell · doi:10.1128/ec.00314-07 · Cited by 121 · see citing works
“Second, the sun41 /sun41 mutant had no defect in endothelial cell damage, while all other hypha-defective mutants tested have such a defect (41).”
BackgroundSelf-citationCandida albicansand cancer: Can this yeast induce cancer development or progression?
Ramirez‐Garcia, A., Rementerı́a, A., Urízar, J. M. A., Moragues, M. D., Antoran, A., Pellón, A., Abad, A., & Hernando, F. L. (2014) · Critical Reviews in Microbiology · doi:10.3109/1040841x.2014.913004 · Cited by 120 · see citing works
“…et al., 1995, 1996; Glee et al., 2001; Grubb et al., 2009; Jong et al., 2003; Kurihara et al., 2003; Lim et al., 2011; Mayer et al., 2012; Orozco et al., 2000; Park et al., 2009; Phan et al., 2000;Ramirez-Garcia et al., 2011, 2013; Sanchez et al., 2004; Seidl et al., 2012; Zhao et al., 2007).”
BackgroundSherwani, M. A., Tufail, S., Khan, A. A., & Owais, M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0131684 · Cited by 114 · see citing works
“Besides assisting host defence evasion, hyphal transformants are lethal to macrophages and endothelial cells [35, 36].”
BackgroundSwidergall, M., Khalaji, M., Solis, N. V., Moyes, D. L., Drummond, R. A., Hube, B., Lionakis, M. S., Murdoch, C., Filler, S. G., & Naglik, J. R. (2019) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiz322 · Cited by 113 · see citing works
“Virulence of the C albicans strains was tested in the mouse model of HDC using 6- to 7-week-old male and female BALB/c mice (Taconics) as previously described [35].”
MethodSelf-citationDivergent Targets of Candida albicans Biofilm Regulator Bcr1 <i>In Vitro</i> and <i>In Vivo</i>
Fanning, S., Xu, W., Solis, N., Woolford, C. A., Filler, S. G., & Mitchell, A. P. (2012) · Eukaryotic Cell · doi:10.1128/ec.00103-12 · Cited by 106 · see citing works
Self-citationActivation and Alliance of Regulatory Pathways in C. albicans during Mammalian Infection
Xu, W., Solis, N. V., Ehrlich, R. L., Woolford, C. A., Filler, S. G., & Mitchell, A. P. (2015) · PLOS Biology · doi:10.1371/journal.pbio.1002076 · Cited by 103 · see citing works
“albicans were inoculated intravenously with 5 × 10(5) yeastphase cells that had been grown in YPD at 30°C to saturation as described previously [46].”
MethodSelf-citationMayer, F. L., Wilson, D., Jacobsen, I. D., Miramón, P., Slesiona, S., Bohovych, I., Brown, A. J. P., & Hube, B. (2012) · PLoS ONE · doi:10.1371/journal.pone.0038584 · Cited by 100 · see citing works
“[22,108,109,110].”
Mechanisms of Candida albicans Trafficking to the Brain
Liu, Y., Mittal, R., Solis, N. V., Prasadarao, N. V., & Filler, S. G. (2011) · PLoS Pathogens · doi:10.1371/journal.ppat.1002305 · Cited by 93 · see citing works
“albicans strains [50] and then monitored for survival three times daily.”
BackgroundSelf-citationInvasive Phenotype of Candida albicans Affects the Host Proinflammatory Response to Infection
Villar, C. C., Kashleva, H., Mitchell, A. P., & Dongari-Bagtzoglou, A. (2005) · Infection and Immunity · doi:10.1128/iai.73.8.4588-4595.2005 · Cited by 98 · see citing works
“albicans to host cells (32, 44); therefore, downregulation of these proteins in the rim101 /rim101 mutant might contribute to its reduced ability to invade and damage host cells and tissues, as demonstrated in this study and by other workers (11, 42).”
BackgroundResultSelf-citationRouabhia, M., Schaller, M., Corbucci, C., Vecchiarelli, A., Prill, S. K. ‐., Giasson, L., & Ernst, J. F. (2005) · Infection and Immunity · doi:10.1128/iai.73.8.4571-4580.2005 · Cited by 90 · see citing works
“Reduced virulence of the pmt1 mutant was expected because of its significant defect in hyphal morphogenesis, its leakage of cell wall proteins, including chitinase, its supersensitivity to antifungal agents directed against wall components, its lack of adhesion to Caco-2 cells, and its lower virulence in an HDC model…”
BackgroundResultGrubb, S. E. W., Murdoch, C., Sudbery, P. E., Saville, S. P., Lopez-Ribot, J. L., & Thornhill, M. H. (2008) · Infection and Immunity · doi:10.1128/iai.00332-08 · Cited by 87 · see citing works
“albicans is necessary for the organism to damage endothelial cells (22, 67) and that substances that inhibit germination block C.”
BackgroundLü, Y., Su, C., Solis, N. V., Filler, S. G., & Liu, H. (2013) · Cell Host & Microbe · doi:10.1016/j.chom.2013.10.008 · Cited by 87 · see citing works
“The virulence of the various strains was analyzed in the mouse model of hematogenously disseminated candidiasis as described previously (Sanchez et al., 2004; Sun et al., 2010).”
BackgroundSelf-citationNew signaling pathways govern the host response to C. albicans infection in various nichesPreprint
Liu, Y., Shetty, A. C., Schwartz, J. A. J., Bradford, L. L., Xu, W., Phan, Q. T., Kumari, P., Mahurkar, A., Mitchell, A. P., Ravel, J., et al. (2015) · Genome Research · doi:10.1101/gr.187427.114 · Cited by 86 · see citing works
“The observation that invasion-defective C. albicans mutants display attenuated virulence in murine models of OPC and HDC is evidence of the critical importance of invasion to virulence (Phan et al. 2000; Sanchez et al. 2004; Park et al. 2005; Chiang et al. 2007).”
BackgroundSelf-citationMartínez-López, R., Park, H., Myers, C., Gil, C., & Filler, S. (2006) · Eukaryotic Cell · doi:10.1128/ec.5.1.140-147.2006 · Cited by 81 · see citing works
“albicans that are endocytosed poorly and cause little damage to endothelial cells and oral epithelial cells have significantly reduced virulence in mouse models of hematogenously disseminated or oropharyngeal candidiasis (20, 21, 25).”
BackgroundSelf-citationGlucose Sensing Network in Candida albicans : a Sweet Spot for Fungal Morphogenesis
Sabina, J., & Brown, V. E. (2009) · Eukaryotic Cell · doi:10.1128/ec.00138-09 · Cited by 81 · see citing works
“vitro (90), and efg1 null mutants show reduced virulence during blood infections (78).”
Iron metabolism in aerobes: Managing ferric iron hydrolysis and ferrous iron autoxidation
Kosman, D. J. (2012) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2012.06.030 · Cited by 77 · see citing works
Mai, H., Champion, L., Ouali, N., Hertig, A., Péraldi, M., Glotz, D., Rondeau, É., Costa, M.-A., Snanoudj, R., Benoît, G., et al. (2006) · Transplantation · doi:10.1097/01.tp.0000239188.27153.23 · Cited by 74 · see citing works
“The reasons why some cases of Candida contamination led to mycotic arteritis while others did not are not clear, although the difference in Candida virulence that determines its capacity to penetrate endothelial cells may be one of the explanations (13).”
BackgroundBrand, A., Vacharaksa, A., Bendel, C. M., Norton, J., Haynes, P. R., Henry‐Stanley, M. J., Wells, C. L., Ross, K., Gow, N. A. R., & Gale, C. A. (2008) · Eukaryotic Cell · doi:10.1128/ec.00453-07 · Cited by 71 · see citing works
“albicans strains reported to have reduced cytotoxicity are unable to form hyphae (41, 51, 53).”
BackgroundToenjes, K. A., Munsee, S. M., Ibrahim, A. S., Jeffrey, R., Edwards, J. E., & Johnson, D. I. (2005) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.49.3.963-972.2005 · Cited by 72 · see citing works
“albicans virulence during experimental hematogenously disseminated infection and endothelial cell damage in vitro (35).”
BackgroundMatignon, M., Botterel, F., Audard, V., Dunogué, B., Dahan, K., Lang, P., Bretagne, S., & Grimbert, P. (2008) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2007.02112.x · Cited by 70 · see citing works
“glabrata, tropicalis or krusei have been reported (17,18).”
BackgroundAdhesion of Candida albicans to Endothelial Cells under Physiological Conditions of Flow
Grubb, S. E. W., Murdoch, C., Sudbery, P. E., Saville, S. P., Lopez-Ribot, J. L., & Thornhill, M. H. (2009) · Infection and Immunity · doi:10.1128/iai.00518-09 · Cited by 66 · see citing works
The Novel Candida albicans Transporter Dur31 Is a Multi-Stage Pathogenicity Factor
Mayer, F. L., Wilson, D., Jacobsen, I. D., Miramón, P., Große, K., & Hube, B. (2012) · PLoS Pathogens · doi:10.1371/journal.ppat.1002592 · Cited by 61 · see citing works
“albicans mutants with reduced capacity to damage endothelial cells in vitro, often display reduced virulence in mice models of hematogenously disseminated candidiasis [56].”
BackgroundTranscriptional Responses of Candida albicans to Epithelial and Endothelial Cells
Park, H., Liu, Y., Solis, N. V., Spotkov, J., Hamaker, J. J., Blankenship, J. R., Yeaman, M. R., Mitchell, A. P., Liu, H., & Filler, S. G. (2009) · Eukaryotic Cell · doi:10.1128/ec.00165-09 · Cited by 58 · see citing works
“Strain CAI4-URA, which was originally derived from the clinical isolate SC5314 (59), was used as the reference strain, and its response to both oral epithelial cells and endothelial cells was determined.”
BackgroundMethodInfluentialSelf-citationCandida albicans protein kinase CK2 governs virulence during oropharyngeal candidiasis
Chiang, L. Y., Sheppard, D. C., Bruno, V. M., Mitchell, A. P., Edwards, J. E., & Filler, S. G. (2007) · Cellular Microbiology · doi:10.1111/j.1462-5822.2006.00784.x · Cited by 59 · see citing works
“The endothelial cell damage defect and attenuated virulence of the mds3 insertion mutant in the mouse model of haematogenously disseminated candidiasis have been reported previously (Sanchez et al., 2004).”
BackgroundMethodInfluentialSelf-citationVonk, A. G., Netea, M. G., van der Meer, J. W. M., & Kullberg, B. J. (2006) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.6.9.891 · Cited by 54 · see citing works
“albicans factors other than the ability to form long hyphae may be necessary for the organism to damage endothelial cells [22].”
BackgroundDesai, C., Mavrianos, J., & Chauhan, N. (2011) · FEMS Yeast Research · doi:10.1111/j.1567-1364.2011.00743.x · Cited by 52 · see citing works
“In a screen for mutants defective in damage to endothelial cell, Sanchez et al (2004) reported that C. albicans mutants, which caused less damage to endothelial cells, were also less virulent in a mouse model of disseminated candidiasis.”
BackgroundAnimal models in the analysis of Candida host–pathogen interactions
de Repentigny, L. (2004) · Current Opinion in Microbiology · doi:10.1016/j.mib.2004.06.001 · Cited by 69 · see citing works
Lagree, K., Woolford, C. A., Huang, M. Y., May, G. E., McManus, C. J., Solis, N. V., Filler, S. G., & Mitchell, A. P. (2020) · PLoS Genetics · doi:10.1371/journal.pgen.1008582 · Cited by 51 · see citing works
“We also assayed host cell interaction through the ability of the mutant strains to cause endothelial cell damage [50], using primary human umbilical vein endothelial cells.”
BackgroundSelf-citationFungicidal and Cytotoxic Activity of a Capsicum chinense Defensin Expressed by Endothelial Cells
Anaya-López, J. L., López-Meza, J. E., Baizabal-Aguirre, V. M., Cano-Camacho, H., & Ochoa‐Zarzosa, A. (2006) · Biotechnology Letters · doi:10.1007/s10529-006-9060-4 · Cited by 51 · see citing works
“Adhesion, invasion and damage of C. albicans to endothelial cells have been demonstrated using in vivo and in vitro models (Jong et al. 2001; Sánchez et al. 2004).”
MethodRole of Arf GTPases in fungal morphogenesis and virulence
Labbaoui, H., Bogliolo, S., Ghugtyal, V., Solis, N. V., Filler, S. G., Arkowitz, R. A., & Bassilana, M. (2017) · PLoS Pathogens · doi:10.1371/journal.ppat.1006205 · Cited by 47 · see citing works
“To induce haematogenously disseminated candidiasis (HDC), 8 Balb/C mice per strain were injected via the tail vein with an inoculum of 5x10(5) cells [83].”
Self-citationNisin Z inhibits the growth ofCandida albicansand its transition from blastospore to hyphal form
Lay, C., Akerey, B., Fliss, I., Subirade, M., & Rouabhia, M. (2008) · Journal of Applied Microbiology · doi:10.1111/j.1365-2672.2008.03908.x · Cited by 47 · see citing works
“Host cell invasion and damage are likely critical virulence attributes of C. albicans (Phan et al. 2000; Sanchez et al. 2004; Park et al. 2005; Chiang et al. 2007).”
BackgroundSeman, B. G., Moore, J. L., Scherer, A. K., Blair, B. A., Manandhar, S., Jones, J. M., & Wheeler, R. T. (2018) · Infection and Immunity · doi:10.1128/iai.00415-18 · Cited by 44 · see citing works
“This enabled noninvasive quantification of morphology, invasion, yeast proliferation, and dissemination frequency; of these, only invasion has been quantified in vitro previously, through damage assays (56).”
BackgroundIn vitroinfection models to study fungal–host interactions
Last, A., Maurer, M., Mosig, A. S., Gresnigt, M. S., & Hube, B. (2021) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuab005 · Cited by 43 · see citing works
Owais, M., Khan, A. A., Zubair, S., & Zia, Q. (2015) · International Journal of Nanomedicine · doi:10.2147/ijn.s63155 · Cited by 44 · see citing works
“96,97 A reduction in hyphal content as well as lower fungal viability (Figures 8 and 9) makes the AmB−PGA nanoformulation a promising strategy for dealing with bio-films.”
Candida albicans: Molecular interactions with Pseudomonas aeruginosa and Staphylococcus aureus
Lindsay, A. K., & Hogan, D. A. (2014) · Fungal Biology Reviews · doi:10.1016/j.fbr.2014.10.002 · Cited by 42 · see citing works
Transcriptome Profile of the Vascular Endothelial Cell Response toCandida albicans
Barker, K. S., Park, H., Phan, Q. T., Xu, L., Homayouni, R., Rogers, P. D., & Filler, S. G. (2008) · The Journal of Infectious Diseases · doi:10.1086/589516 · Cited by 41 · see citing works
“albicans induces significant EC damage (figure 1B) [4, 5, 8, 13], thus, it was interesting that the genes related to the response to stress or wounding were overrepresented in response to SC5314 (table 1).”
BackgroundSelf-citationPeroumal, D., Sahu, S. R., Kumari, P., Utkalaja, B. G., & Acharya, N. (2022) · Microbiology Spectrum · doi:10.1128/spectrum.02462-22 · Cited by 40 · see citing works
“albicans: additionally, it requires immunosuppression of the host and damage to the mucosal layer (13).”
BackgroundSR-Like RNA-Binding Protein Slr1 Affects Candida albicans Filamentation and Virulence
Ariyachet, C., Solis, N. V., Liu, Y., Prasadarao, N. V., Filler, S. G., & McBride, A. E. (2013) · Infection and Immunity · doi:10.1128/iai.00864-12 · Cited by 38 · see citing works
“Therefore, the impaired growth of the slr1 / mutant likely played a minor role in its reduced virulence in the mouse model of HDC.”
BackgroundInfluentialSelf-citationSSD1 Is Integral to Host Defense Peptide Resistance in Candida albicans
Gank, K. D., Yeaman, M. R., Kojima, S., Yount, N. Y., Park, H., Edwards, J. E., Filler, S. G., & Fu, Y. (2008) · Eukaryotic Cell · doi:10.1128/ec.00402-07 · Cited by 37 · see citing works
“3 ml of phosphate-buffered saline (31).”
BackgroundMethodInfluentialSelf-citationFungal complications afterCandidapreservation fluid contamination in liver transplant recipients
Levesque, É., Paugam‐Burtz, C., Saliba, F., Khoy-Ear, L., Merle, J., Jung, B., Stecken, L., Ferrandière, M., Mihaïla-Amrouche, L., & Botterel, F. (2015) · Transplant International · doi:10.1111/tri.12633 · Cited by 36 · see citing works
“endothelial cells, leading to the destruction of vascular structures [21,22].”
BackgroundFunctional diversification accompanies gene family expansion of MED2 homologs in Candida albicans
Dunn, M. J., Kinney, G. M., Washington, P. M., Berman, J. G., & Anderson, M. Z. (2018) · PLoS Genetics · doi:10.1371/journal.pgen.1007326 · Cited by 34 · see citing works
Seidl, K., Bayer, A. S., McKinnell, J. A., Ellison, S., Filler, S. G., & Xiong, Y. Q. (2011) · Cellular Microbiology · doi:10.1111/j.1462-5822.2011.01639.x · Cited by 33 · see citing works
“Candida albicans and Aspergillus fumigatus (Sanchez et al., 2004; Chiang et al., 2008).”
BackgroundSelf-citationSeidl, K., Solis, N. V., Bayer, A. S., Abdelhady, W., Ellison, S., Klashman, M. C., Xiong, Y. Q., & Filler, S. G. (2012) · PLoS ONE · doi:10.1371/journal.pone.0039633 · Cited by 31 · see citing works
“aureus to damage HUVECs in vitro is directly correlated with their virulence in animal models of hematogenous infection [13,14].”
BackgroundMethodSelf-citationCandida Infections and Modelling Disease
MacCallum, D. M. (2009) · Springer eBooks · doi:10.1007/978-3-642-03150-2_3 · Cited by 30 · see citing works
Candida arteritis in kidney transplant recipients: case report and review of the literature
Dębska-Ślizień, A. M., Chrobak, Ł., Bzoma, B., Perkowska, A., Zadrożny, D., Chamienia, A. L., Kostro, J., Milecka, A., Bronk, M., Śledziński, Z., et al. (2015) · Transplant Infectious Disease · doi:10.1111/tid.12388 · Cited by 30 · see citing works
“The reasons why some cases of Candida contamination led to mycotic arteritis, while others did not, are not clear, although differences in Candida virulence that determine its capacity to penetrate endothelial cells may be one explanation (13).”
BackgroundRole of Aspergillus fumigatus DvrA in Host Cell Interactions and Virulence
Ejzykowicz, D. E., Solis, N. V., Gravelat, F. N., Chabot, J. C., Li, X., Sheppard, D. C., & Filler, S. G. (2010) · Eukaryotic Cell · doi:10.1128/ec.00055-10 · Cited by 30 · see citing works
“albicans strains to damage endothelial cells in vitro is a fairly good predictor of their virulence in the mouse model of disseminated candidiasis (32).”
BackgroundSelf-citationJung, S., Rodriguez, N. S., Irrizary, J., Liboro, K., Bogarin, T., Macias, M., Eivers, E., Porter, E. M., Filler, S. G., & Park, H. (2017) · PLoS ONE · doi:10.1371/journal.pone.0187721 · Cited by 29 · see citing works
Self-citationSen, M., Shah, B., Rakshit, S., Singh, V., Padmanabhan, B., Ponnusamy, M., Pari, K., Vishwakarma, R. A., Nandi, D., & Sadhale, P. P. (2011) · PLoS Pathogens · doi:10.1371/journal.ppat.1002384 · Cited by 25 · see citing works
“locus. This is consistent with earlier reports that the DAY286 strain is ∼70% as virulent as compared to SC5314”
ResultCandida Species Contamination of Preservation Fluid—Outcome of Renal Transplantation in 6 Patients
Rodrigues, B. F., Natário, A., Vizinho, R., Jorge, C. R. D. F. M., Weigert, A. L. L., Martinho, A., Toscano, C., Marques, T. T., & Machado, D. (2013) · Transplantation Proceedings · doi:10.1016/j.transproceed.2013.03.024 · Cited by 25 · see citing works
“This phenomenon may be explained by the ability of C albicans to adhere, invade, and damage human vascular endothelial cells.(24,25) Our affected patients showed clinical presentations similar to those previously described in the literature: some patients have an abrupt onset with hypovolemic shock requiring emergency…”
ResultAdhesins in Opportunistic Fungal Pathogens
Zordan, R., & Cormack, B. (2012) · ASM Press eBooks · doi:10.1128/9781555817176.ch16 · Cited by 28 · see citing works
Li, S.-X., Song, Y.-J., Zhang, Y.-S., Wu, H.-T., Guo, H., Zhu, K.-J., Li, D.-M., & Zhang, H. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.00285 · Cited by 25 · see citing works
“Shake cultures were grown at 30◦C and OD600 of each strain was measured every two hours.”
BackgroundMethodCanaud, G., Timsit, M., Zuber, J., Bougnoux, M., Méjean, A., Thervet, É., Snanoudj, R., Sberro‐Soussan, R., Martinez, F., Legendre, C., et al. (2008) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfn622 · Cited by 24 · see citing works
“albicans, has the ability to penetrate endothelial cells and lead to arteritis [3,4].”
BackgroundAlarmin(g) the innate immune system to invasive fungal infections
Caffrey, A. K., & Obar, J. J. (2016) · Current Opinion in Microbiology · doi:10.1016/j.mib.2016.06.002 · Cited by 22 · see citing works
Characterization of carboxylate nanoparticle adhesion with the fungal pathogen Candida albicans
Lyden, A., Lombardi, L., Sire, W., Li, P., Simpson, J. C., Butler, G., & Lee, G. U. (2017) · Nanoscale · doi:10.1039/c7nr04724j · Cited by 21 · see citing works
Cryopreserved Venous Allografts in Supra-inguinal Reconstructions: A Single Centre Experience
Heinola, I., Kantonen, I., Mattila, I. P., Albäck, A., & Venermo, M. A. (2019) · European Journal of Vascular and Endovascular Surgery · doi:10.1016/j.ejvs.2019.06.024 · Cited by 19 · see citing works
Hgc1 Independence of Biofilm Hyphae in Candida albicans
Sharma, A., Solis, N. V., Huang, M. Y., Lanni, F., Filler, S. G., & Mitchell, A. P. (2023) · mBio · doi:10.1128/mbio.03498-22 · Cited by 18 · see citing works
“Because hyphal defects are associated with endothelial cell damage defects (4, 27), these results are consistent with current understanding of Hgc1 function.”
ResultSelf-citationBasante-Bedoya, M. A., Bogliolo, S., García‐Rodas, R., Zaragoza, Ó., Arkowitz, R. A., & Bassilana, M. (2022) · PLoS Genetics · doi:10.1371/journal.pgen.1010549 · Cited by 17 · see citing works
Functional Dichotomy for a Hyphal Repressor in Candida albicans
Mao, Y., Solis, N. V., Filler, S. G., & Mitchell, A. P. (2023) · mBio · doi:10.1128/mbio.00134-23 · Cited by 17 · see citing works
“albicans for 3 h, after which the extent of host cell damage was determined using a (51)Cr release assay, following standard methods (21).”
BackgroundMethodSelf-citationToward a Molecular Understanding ofCandida albicansVirulence
Odds, F. C., Gow, N. A. R., & Brown, A. J. P. (2014) · ASM Press eBooks · doi:10.1128/9781555815776.ch22 · Cited by 17 · see citing works
Levesque, É., Suet, G., Merle, J., Compagnon, P., Amathieu, R., Féray, C., Botterel, F., Foulet, F., Azoulay, D., & Dhonneur, G. (2014) · Transplant Infectious Disease · doi:10.1111/tid.12260 · Cited by 17 · see citing works
“albicans, to penetrate into endothelial cells leading to destruction of vascular structures (11).”
BackgroundZhou, X., Hilk, A. L., Solis, N. V., de Sá, N. P., Hogan, B. M., Bierbaum, T. A., Poeta, M. D., Filler, S. G., Burrack, L. S., & Selmecki, A. M. (2024) · PLoS Pathogens · doi:10.1371/journal.ppat.1012389 · Cited by 18 · see citing works
Self-citationPharmacokinetics of Murine p75-Fc Fusion Protein and MP6-XT22 Anti-Murine TNF-α mAb in Mice
Filler, S. G., Solis, N. V., Guo, J., Doellgast, G. J., Ruiz-Garcı́a, A., & Pan, W. (2007) · Journal of Investigative Dermatology Symposium Proceedings · doi:10.1038/sj.jidsymp.5650036 · Cited by 15 · see citing works
Self-citationStaniszewska, M., Bondaryk, M., Malewski, T., & Schaller, M. (2014) · Open Life Sciences · doi:10.2478/s11535-014-0311-4 · Cited by 14 · see citing works
García‐Rodas, R., Labbaoui, H., Orange, F., Solis, N. V., Zaragoza, Ó., Filler, S. G., Bassilana, M., & Arkowitz, R. A. (2022) · mBio · doi:10.1128/mbio.03873-21 · Cited by 13 · see citing works
“HDC was induced in 10 BALB/c mice (Charles River, Italy) per group by injecting the lateral tail vein with an inoculum of 5 10(5) cells (59).”
MethodSelf-citationPark, H., Solis, N. V., Louie, J. S., Spellberg, B., Rodriguez, N., & Filler, S. G. (2014) · Virulence · doi:10.4161/viru.29699 · Cited by 11 · see citing works
Self-citationNeonatal candidiasis in Venezuela: clinical and epidemiological aspects.
de Capriles, C. H., Mata‐Essayag, S., Azpiróz, A., Ponente, A., Magaldi, S., Pérez, C., Roselló, A., Colella, M. T., & Machuca, J. (2005) · PubMed · Cited by 11 · see citing works
Use of the Iron-Responsive RBT5 Promoter for Regulated Expression in Candida albicans
Mao, Y., Solis, N. V., Sharma, A., Cravener, M. V., Filler, S. G., & Mitchell, A. P. (2022) · mSphere · doi:10.1128/msphere.00305-22 · Cited by 10 · see citing works
Self-citationSerum bridging molecules drive candidal invasion of human but not mouse endothelial cells
Phan, Q., Solis, N., Lin, J., Swidergall, M., Singh, S., Liu, H., Sheppard, D., Ibrahim, A., Mitchell, A., & Filler, S. (2022) · PLoS Pathogens · doi:10.1371/journal.ppat.1010681 · Cited by 10 · see citing works
“When wild-type C . albicans is endocytosed by endothelial cells, it damages these cells, likely by releasing candidalysin into the invasion pocket [6,29–31].”
Self-citationHost albumin redirects Candida albicans metabolism to engage an alternative pathogenicity pathway
Hitzler, S. U. J., Fernández-Fernández, C., Günther, K., Dietschmann, A., Hovhannisyan, H., Möslinger, A., Austermeier, S., Cristóvão, B., Vascelli, G., Zelante, T., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-61701-5 · Cited by 7 · see citing works
Yang, C., Li, G.-L., Zhang, Q., Bai, W., Li, Q.-Q., Zhang, P.-P., & Zhang, J.-Y. (2024) · mBio · doi:10.1128/mbio.00445-24 · Cited by 5 · see citing works
“The virulence of the various strains was tested in the mouse model of hematogenously disseminated candidiasis as described previously (50).”
BackgroundA novel renal epithelial cell in vitro assay to assessCandida albicansvirulence
Szabo, E. K., & MacCallum, D. M. (2013) · Virulence · doi:10.4161/viru.27046 · Cited by 6 · see citing works
“The escape of fungi from the bloodstream during systemic candidiasis has been modeled in vitro using endothelial cells.(28-30,53) Endothelial cell damage and cytokine production was induced only by live, germinated fungal cells,(53) and those C.”
BackgroundInfluentialMolecular Basis of Fungal Adherence to Endothelial and Epithelial Cells
Filler, S., Sheppard, D., & Edwards, J. (2006) · ASM Press eBooks · doi:10.1128/9781555815776.ch13 · Cited by 7 · see citing works
Self-citationZhou, X., Hilk, A. L., Solis, N. V., Hogan, B. M., Bierbaum, T. A., Filler, S. G., Burrack, L. S., & Selmecki, A. M. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.03.06.583770 · Cited by 5 · see citing works
Self-citationMacrophage-derived CD36 + exosome subpopulations as novel biomarkers of Candida albicans infection
Li, S., Xv, Y., Sun, Y., Shen, Z., Hao, R., Yan, J., Liu, M., Liu, Z., Jing, T., Li, X., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-60032-7 · Cited by 4 · see citing works
“Endocytosis mediated by endothelial cells via N-cadherin plays a role in the internalization of C. albicans 28 , which can subsequently escape through vesicle phagocytosis or endothelial cell loss 29 .”
BackgroundSamaranayake, D., Atencio, D. P., Morse, R. H., Wade, J. T., Chaturvedi, V. P., & Hanes, S. D. (2013) · PLoS ONE · doi:10.1371/journal.pone.0059094 · Cited by 5 · see citing works
“The CAI4 (ura(2)) parent strain is a poorly-filamenting strain, presumably due to its uracil auxotrophy [60].”
BackgroundEncounters with Mammalian Cells: Survival Strategies of Candida Species
Vylkova, S., & Lorenz, M. (2012) · ASM Press eBooks · doi:10.1128/9781555817176.ch17 · Cited by 8 · see citing works
Shining a light on Candida -induced epithelial damage with a luciferase reporter
Tesfamariam, M., Vij, R., Trümper, V., Hube, B., & Brunke, S. (2024) · mSphere · doi:10.1128/msphere.00509-24 · Cited by 3 · see citing works
“Methods like detection of LDH release (6, 7), release of radiolabeled chromium ( 51 Cr) (8, 9), and fluorescence microscopy of propidium iodide (PI)-stained nuclei of dying cells (10), have all been used in the past with great success, for example, in the discovery of the fungal peptide toxin…”
Molecular Pathogenesis of Fungal Infections
Segal, B. (2006) · Humana Press eBooks · doi:10.1007/978-1-59259-963-9_95 · Cited by 2 · see citing works
Matignon, M., Botterel, F., Audard, V., Dunogué, B., Dahan, K., Lang, P., Bretagne, S., & Grimbert, P. (2008) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2007.02092.x · Cited by 2 · see citing works
Innate and Adaptive Immunity to Systemic Candida albicans Infection
Romani, L. R. (2005) · Springer eBooks · doi:10.1007/0-387-25445-5_19 · Cited by 2 · see citing works
Candida graft arteritis after kidney transplantation: two cases and literature review
Kumar, T. P., Prabhu, R., Kiran, P., Chawla, A. K., Priya, P. S., Singh, B. M. K., & Gupta, N. R. (2025) · Oxford Medical Case Reports · doi:10.1093/omcr/omaf172 · Cited by 1 · see citing works
“Its phospholipase activity and stimulation of prostaglandin production contribute to endothelial injury [21, 22].”
In vitro models of hematogenously disseminated candidiasis
Filler, S. (2014) · Virulence · doi:10.4161/viru.27453 · Cited by 1 · see citing works
“The correlation between host cell damage and virulence has been demonstrated most clearly using the human umbilical vein endothelial cell model.(19,36-38) However, some mutant strains have significantly impaired capacity to damage endothelial cells in vitro, yet have normal or even increased virulence during dissemina…”
BackgroundSelf-citationIn vitro models to analyse fungal infection
Gola, S., Arana, D. M., Alonso‐Monge, R., Román, E., & Plá, J. (2007) · Springer eBooks · doi:10.1007/978-1-4020-6397-8_2 · Cited by 1 · see citing works
Phan, Q., Solis, N., Lin, J., Swidergall, M., Singh, S., Liu, H., Sheppard, D., Ibrahim, A., Mitchell, A., & Filler, S. (2021) · bioRxiv · doi:10.1101/2021.09.18.460925 · Cited by 1 · see citing works
“likely by releasing candidalysin into the invasion pocket (6, 29-31).”
BackgroundSelf-citationInteractions of Fungi with Endothelial Cells
Filler, S., & Sheppard, D. (2005) · Springer eBooks · doi:10.1007/0-387-25445-5_20
“Other multiple mutants of C. albicans have been identified that have reduced capacity to injure endothelial cells (Davis et al., 2000; Phan et al., 2000; Bensen et al., 2002; Blankenship et al., 2003; Sanchez et al., 2004 ).”
BackgroundResultSelf-citationCandida Albicans: New Insights in Infection, Disease, and Treatment
MacCallum, D. M. (2007) · Springer eBooks · doi:10.1007/978-1-4020-6397-8_5
MINIREVIEWS Glucose Sensing Network in Candida albicans: a Sweet Spot for Fungal Morphogenesis
Sabina, J., & Brown, V. E. (2009)
- Authors
- Sanchez, A. A., Johnston, D. A., Myers, C., Edwards, J. E., Mitchell, A. P., & Filler, S. G.
- Affiliations
- University of California, Los Angeles (US)
- Columbia University (US)
- Corresponding author
- Filler, Scott G.
- Venue
- Infection and Immunity
- Publisher
- American Society for Microbiology
- Published
- 2004-01
- Volume
- 72
- Issue
- 1
- Pages
- 598-601
- ISSN
- 0019-9567 (ISSN-L)
- 1098-5522
- PMC
- PMC344013
- OpenAlex
- W2133054734
- Cited by
- 101
- References
- 36
- Citations by year
- 2025: 2 · 2024: 5 · 2023: 2 · 2022: 5 · 2021: 2 · 2020: 1 · 2019: 2 · 2018: 3 · 2017: 4 · 2016: 1 · 2015: 6 · 2014: 11 · 2013: 5 · 2012: 5
- FWCI
- 3.13
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Infection and Immunity (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Allergy and Infectious Diseases (P01 AI-37194, R29AI040636, R01AI019990, R01AI050931, R01-AI19990, R01 AI 50931, P01AI037194)
- National Institute of Dental and Craniofacial Research (R01DE013974, R01 DE 13974)
- National Center for Research Resources (M01RR000425, M01-RR00425)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
- Keywords
- Candida albicans, virulence factors, endothelial injury, fungal mutants
- MeSH terms
- Animals, Candida albicans, Candidiasis, Cytotoxicity Tests, Immunologic, Endothelium, Vascular, Male, Mice, Inbred BALB C, Mutation, Umbilical Cord, Virulence, Virulence Factors, Endothelial Cells, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
