The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
The Link between Phylogeny and Virulence in Escherichia coli Extraintestinal Infection
Open accessAbstract
Previous studies suggesting a link between Escherichia coli phylogenetic groups and extraintestinal virulence have been hampered by the difficulty in establishing the intrinsic virulence of a bacterial strain. Indeed, unidentified virulence factors do exist, and the susceptibility of the host to infection is highly variable. To overcome these difficulties, we have developed a mouse model of extraintestinal virulence to test the virulence of the strains under normalized conditions. We then assessed the phylogenetic relationships compared to the E. coli reference (ECOR) collection, the presence of several known virulence determinants, and the lethality to mice of 82 human adult E. coli strains isolated from normal feces and during the course of extraintestinal infections. Commensal strains belong mainly to phylogenetic groups A and B1, are devoid of virulence determinants, and do not kill the mice. Strains exhibiting the same characteristics as the commensal strains can be isolated under pathogenic conditions, thus indicating the role of host-dependent factors, such as susceptibility linked to underlying disease, in the development of infection. Some strains of phylogenetic groups A, B1, and D are able to kill the mice, their virulence being most often correlated with the presence of virulence determinants. Lastly, strains of the B2 phylogenetic group represent a divergent lineage of highly virulent strains which kill the mice at high frequency and possess the highest level of virulence determinants. The observed link between virulence and phylogeny could correspond to the necessity of virulence determinants in a genetic background that is adequate for the emergence of a virulent clone, an expression of the interdependency of pathogenicity and metabolic activities in pathogenic bacteria.
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“strains responsible for extra-intestinal infection were far more likely to be members of phylogroups B2 than A [143, 144]”
From Selection, Comparative Genomics, and Potential Probiotic Features of Escherichia coli 5C, a pks-Negative Strain Isolated from Healthy Infant Donor Feces (2026) · cites this paper as [143]
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Metadata
- Authors
- Picard, B., Garcia, J. S., Gouriou, S., Duriez, P., Brahimi, N., Bingen, E., Elion, J., & Denamur, E.
- Affiliations
- Centre Hospitalier Régional Universitaire de Brest (FR)
- <!--label omitted: 2-->Laboratoire de Microbiologie, Hôpital Cochin, Assistance Publique—Hôpitaux de Paris,2
- Inserm (FR)
- <!--label omitted: 4-->Laboratoire de Recherche en Bactériologie Pédiatrique (JE 2255), Université Denis Diderot-Paris 7,4 Hôpital Robert Debré, Paris, France
- <!--label omitted: 3-->INSERM U 4583 and
- Venue
- Infection and Immunity
- Publisher
- American Society for Microbiology
- Published
- 1999-02
- Volume
- 67
- Issue
- 2
- Pages
- 546-553
- ISSN
- 0019-9567 (ISSN-L)
- 1098-5522
- PMC
- PMC96353
- OpenAlex
- W2125201618
- Cited by
- 794
- References
- 42
- Citations by year
- 2026: 13 · 2025: 17 · 2024: 32 · 2023: 27 · 2022: 43 · 2021: 39 · 2020: 46 · 2019: 33 · 2018: 29 · 2017: 34 · 2016: 39 · 2015: 46 · 2014: 52 · 2013: 38 · 2012: 36
- FWCI
- 8.54
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Infection and Immunity (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Microbiology › Escherichia coli research studies
- Life Sciences › Immunology and Microbiology › Microbiology › Enterobacteriaceae and Cronobacter Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Keywords
- Escherichia coli, phylogenetic groups, extraintestinal infections, bacterial virulence, virulence factors, commensal strains, host susceptibility, pathogenicity, virulent clones
- MeSH terms
- Adult, Animals, Disease Models, Animal, Escherichia coli, Escherichia coli Infections, Female, Humans, Phylogeny, Virulence, Mice
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